The utility of a peer review application in interdisciplinary teamwork arrangements

Project and challenge-based learning typically require students to navigate personal and professional relationships within a team, in order to collaboratively solve authentic problems. These collaborations are often interdisciplinary in nature – an arrangement that adds increased complexity to the team’s functioning. This is due to distinctions in approaches, epistemologies, ethos or jargon. The ability to provide (and receive) appropriate and constructive feedback to peers, within the team, is a key skill that can enhance team functioning and ultimately, output. Furthermore, it is a competence that aids in lubricating social and work impediments that may be causing bottlenecks to creativity, or the manifestation of ideas. The aim of this study, set within three different interdisciplinary bachelor modules, is to determine to what extent the use of the ‘Buddycheck’ application for peer review, is appreciated by students and teachers. The application, hosted within the learning management system of the university, allows students to rank their peers’ performance according to teacher-set criteria, as well as through flexible open-format feedback; in order to facilitate opportunities for enhanced communication and expectation alignment. We wish to ascertain to what degree team functioning is enhanced through the scaffolded communication opportunities, by highlighting and creating openings to discuss undesirable behaviours, through the feedback application. Preliminary results appear to favour this mode of feedback facilitation, albeit with certain caveats, detailed later. Since teamwork is universal in tertiary education, these insights may be helpful for educators attempting to further improve the evaluation of the process of their projects or challenges

Develop An Interdisciplinary Course Using The Twente Interdisciplinarity Toolbox

The ability to engage in interdisciplinary research and problem-solving are essential skills for contemporary engineers, however designing and delivering effective learning opportunities to reach these ideals, is often not straightforward [1]. Educators are often faced with a plethora of challenges, and interdisciplinary courses often do not run as smoothly as disciplinary ones. In this workshop, the primary goal was to stimulate participants to consider a few common design scenarios modeled on real-life cases and to apply some of the main design concepts and questions employed by a new online platform the Twente Toolbox which aims to assist instructors with interdisciplinary course design. Participants were asked to make certain design choices in response to the cases within teams. The toolbox, funded by the Netherlands Initiative for Education Research (NRO) and developed by researchers at the University of Twente (interdisciplinary-education.utwente.nl) maps out different interdisciplinary course design structures, skill targets and learning goals. These are linked to specific in-class student tasks and assessment tools, which help students achieve those learning goals. In the session, participants were directed to relevant sections within the toolbox that would help inform design decisions of participants

Multi-, inter- and transdisciplinarity in challenge-based engineering education

Challenge-based learning (CBL) offers students in engineering programmes an opportunity to develop communicative and collaborative skills, apply disciplinary knowledge and develop boundary-crossing competencies. Mono-disciplinary approaches to CBL are generally regarded too limited, but whether multi-disciplinary, interdisciplinary, or transdisciplinary approaches should be used is open to discussion. Often, these concepts are used interchangeably, but there are notable differences. In literature, knowledge integration is mostly mentioned to make a distinction, but because of difficulties in applying this concept to education, we focus on tangible differences in educational practices, related to learning objectives, assessment, and the design of challenges. The different forms of CBL are illustrated by three casestudies carried out at a research university in the Netherlands. We found similarities, but also some subtle differences between multi-, inter- and transdisciplinary approaches to CBL. Multidisciplinary CBL projects are relatively pre-structured, with an indication of the knowledge that is to be applied, deepened, or combined. Interdisciplinary CBL is more open-ended, with students made responsible for connecting their disciplinary backgrounds to the project and for integrating disciplinary perspectives. Transdisciplinary CBL focuses more on impact than on integrating disciplinary contributions. Challenges are open-ended from a content and stakeholder perspective, while structure emerges in the interactions between students, teachers and stakeholders. Which form of CBL can best be employed in a course or programme is dependent on the intended learning objectives. Educators should be aware of tradeoffs and of the specific teacher competences required to design and support these different forms of CBL

Indian monsoon variations during three contrasting climatic periods : the Holocene, Heinrich Stadial 2 and the last interglacial-glacial transition

Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Quaternary Science Reviews 125 (2015): 50-60, doi:10.1016/j.quascirev.2015.06.009.In contrast to the East Asian and African monsoons the Indian monsoon is still poorly documented throughout the last climatic cycle (last 135,000 years). Pollen analysis from two marine sediment cores (NGHP-01-16A and NGHP-01-19B) collected from the offshore Godavari and Mahanadi basins, both located in the Core Monsoon Zone (CMZ) reveals changes in Indian summer monsoon variability and intensity during three contrasting climatic periods: the Holocene, the Heinrich Stadial (HS) 2 and the Marine Isotopic Stage (MIS) 5/4 during the ice sheet growth transition. During the first part of the Holocene between 11,300 and 4,200 cal years BP, characterized by high insolation (minimum precession, maximum obliquity), the maximum extension of the coastal forest and mangrove reflects high monsoon rainfall. This climatic regime contrasts with that of the second phase of the Holocene, from 4,200 cal years BP to the present, marked by the development of drier vegetation in a context of low insolation (maximum precession, minimum obliquity). The historical period in India is characterized by an alternation of strong and weak monsoon centennial phases that may reflect the Medieval Climate Anomaly and the Little Ice Age, respectively. During the HS 2, a period of low insolation and extensive iceberg discharge in the North Atlantic Ocean, vegetation was dominated by grassland and dry flora indicating pronounced aridity as the result of a weak Indian summer monsoon. The MIS 5/4 glaciation, also associated with low insolation but moderate freshwater fluxes, was characterized by a weaker reduction of the Indian summer monsoon and a decrease of seasonal contrast as recorded by the expansion of dry vegetation and the development of Artemisia, respectively. Our results support model predictions suggesting that insolation changes control the long term trend of the Indian monsoon precipitation, but its millennial scale variability and intensity are instead modulated by atmospheric teleconnections to remote phenomena in the North Atlantic, Eurasia or the Indian Ocean.The work of C.Z. was supported by the ANR MONOPOL

Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank

Effects of rare kidney diseases on kidney failure: a longitudinal analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) cohort

Background: Individuals with rare kidney diseases account for 5–10% of people with chronic kidney disease, but constitute more than 25% of patients receiving kidney replacement therapy. The National Registry of Rare Kidney Diseases (RaDaR) gathers longitudinal data from patients with these conditions, which we used to study disease progression and outcomes of death and kidney failure. Methods: People aged 0–96 years living with 28 types of rare kidney diseases were recruited from 108 UK renal care facilities. The primary outcomes were cumulative incidence of mortality and kidney failure in individuals with rare kidney diseases, which were calculated and compared with that of unselected patients with chronic kidney disease. Cumulative incidence and Kaplan–Meier survival estimates were calculated for the following outcomes: median age at kidney failure; median age at death; time from start of dialysis to death; and time from diagnosis to estimated glomerular filtration rate (eGFR) thresholds, allowing calculation of time from last eGFR of 75 mL/min per 1·73 m2 or more to first eGFR of less than 30 mL/min per 1·73 m2 (the therapeutic trial window). Findings: Between Jan 18, 2010, and July 25, 2022, 27 285 participants were recruited to RaDaR. Median follow-up time from diagnosis was 9·6 years (IQR 5·9–16·7). RaDaR participants had significantly higher 5-year cumulative incidence of kidney failure than 2·81 million UK patients with all-cause chronic kidney disease (28% vs 1%; p<0·0001), but better survival rates (standardised mortality ratio 0·42 [95% CI 0·32–0·52]; p<0·0001). Median age at kidney failure, median age at death, time from start of dialysis to death, time from diagnosis to eGFR thresholds, and therapeutic trial window all varied substantially between rare diseases. Interpretation: Patients with rare kidney diseases differ from the general population of individuals with chronic kidney disease: they have higher 5-year rates of kidney failure but higher survival than other patients with chronic kidney disease stages 3–5, and so are over-represented in the cohort of patients requiring kidney replacement therapy. Addressing unmet therapeutic need for patients with rare kidney diseases could have a large beneficial effect on long-term kidney replacement therapy demand. Funding: RaDaR is funded by the Medical Research Council, Kidney Research UK, Kidney Care UK, and the Polycystic Kidney Disease Charity

Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility

Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes