A KINETIC ANALYSIS AND RECOMMENDATIONS FOR ELITE SWIMMERS PERFORMING THE SPRINT START

The object of this project was to identify on block characteristics of superior grab starts and identify if these also applied to the track start. Six elite swimmers were selected for the study. The characteristic most closely observed in excellent off block starting ability for the grab start was peak power normalised to body mass. Average power and maximum horizontal propulsive force normalised to body mass were closely linked as was work output, but not as highly as the previous parameters. Horizontal velocity off the block was not a good predictor of off block ability as the angle at which the swimmer left the block played an important role in the outcome. Time off the block and first movement time were poor indicators of starting ability. Similar characteristics, but with completely different force and power profiles, were evident for swimmers that utilised a track start

An open source approach to medium-term data archiving

Medium- to long-term archiving of digital documents, beyond the lifespan of the authoring software/hardware, is a challenging problem. Magnetic and optical media are susceptible to environmental influences and deteriorate over time, often to the point where the archived documents can no longer be retrieved. Previous attempts to address this problem include migration and emulation, both of which have their attendant difficulties. It is the contention of the present study that an Open Source approach offers several advantages. More specifically, by archiving the Open Source application programs (in source code, not executable form) along with the documents in question, in both plain and compressed form, significantly increases the likelihood of being able to retrieve such archives at some future time. The application source code can be recompiled to a form suitable for reading in (Open Source) viewers, thereby presenting to the user the archived document as the original author envisaged it. One set of experiments was undertaken distributing documents together with their (Open Source) authoring software via a Portable Virtual Machine (PVM) program to unused disk space on a network of SUN workstations. The success of this approach was evaluated using the following four measures: (i) lossiness of conversion, (ii) edit-ability, (iii) ability to save back to the original format, and (iv) functionality retention. Another series of experiments was conducted in which artificial (‘speckle’ or salt-and-pepper) noise was deliberately introduced to the archived documents in order to mimic degradation of the storage medium over time. It was found that survivability was heavily dependent on file type: simple text files and MPEG movies were impervious to even 18% introduced noise. Source code programs and JPEG images, by contrast, were intolerant to even the smallest noise levels (it has to be said however that straightforward re-editing of the former led to error-free compilation without much difficulty). Lastly, it was found that decompression (specifically the publicly available RAR decompressor) further enhanced the file recovery process. We conclude that an Open Source approach to the preservation of digital archives has considerable potential

Remediation of chromium(VI) at polypyrrole-coated titanium

The application of conducting polypyrrole (PPy) and polyaniline (PAni) coated substrates in remediation of chromium, Cr(VI), is an area of considerable interest. Here, we discuss the implementation of PPy-coated titanium as a new material for the reduction of Cr(VI) to the less toxic trivalent state, Cr(III). An alkaline-peroxide based etching process was used to ensure the adhesion of the PPy coatings to the underlying titanium. The PPy films showed excellent resistance to acidic Cr(VI) solutions and remained adherent after continuous exposure to the solutions. In order to optimise the remediation process a number of experimental parameters were investigated, including the thickness of the PPy coating, the reduction potential used in pre-treatment of the PPy and the degree of solution agitation. The durability of the materials on exposure to the Cr(VI) test solutions made them suitable for repeated remediation experiments. Following several test-runs, the cleanup efficiency of the material was found to decrease slightly, however, increasing the exposure/experiment time resulted in significantly improved cleanup ability

Efficient depletion of host DNA contamination in malaria clinical sequencing.

The cost of whole-genome sequencing (WGS) is decreasing rapidly as next-generation sequencing technology continues to advance, and the prospect of making WGS available for public health applications is becoming a reality. So far, a number of studies have demonstrated the use of WGS as an epidemiological tool for typing and controlling outbreaks of microbial pathogens. Success of these applications is hugely dependent on efficient generation of clean genetic material that is free from host DNA contamination for rapid preparation of sequencing libraries. The presence of large amounts of host DNA severely affects the efficiency of characterizing pathogens using WGS and is therefore a serious impediment to clinical and epidemiological sequencing for health care and public health applications. We have developed a simple enzymatic treatment method that takes advantage of the methylation of human DNA to selectively deplete host contamination from clinical samples prior to sequencing. Using malaria clinical samples with over 80% human host DNA contamination, we show that the enzymatic treatment enriches Plasmodium falciparum DNA up to ∼9-fold and generates high-quality, nonbiased sequence reads covering >98% of 86,158 catalogued typeable single-nucleotide polymorphism loci

Models of OH Maser Variations in U Her

Arecibo spectra of the mainline OH maser emission from U Her over more than a decade show variations of the OH emission over these time scales. These observations are combined with high spatial resolution VLBA maps to investigate the causes of the variations in the velocities of the maser components. Global properties of the dust shell, such as accelerations, variations in the pump and shell-wide magnetic field changes are examined as possibilities, and eliminated. A possible solution to the problem involving plasma turbulence and the local magnetic field is introduced, and the relevant time scales of the turbulence are calculated. The turbulent velocity field yields time scales of the turbulence are calculated. The turbulent velocity field yields time scales that are too long (of order centuries), while the turbulent magnetic field produces variations on appropriate time scales of a few years. A line-of-sight model of the turbulence is developed and investigated. The complete exploration of this solution requires extensive theoretical and observational work. Possible avenues of investigation of the plasma turbulence model are presented.Comment: 23 pages, 17 figures, ApJ: accepted Sept, 199

Safety and tolerability of adjunct non-invasive vagus nerve stimulation in people with parkinson’s:a study protocol

Abstract Background Parkinson’s disease (PD) is the fastest growing neurological condition worldwide. Recent theories suggest that symptoms of PD may arise due to spread of Lewy-body pathology where the process begins in the gut and propagate transynaptically via the vagus nerve to the central nervous system. In PD, gait impairments are common motor manifestations that are progressive and can appear early in the disease course. As therapies to mitigate gait impairments are limited, novel interventions targeting these and their consequences, i.e., reducing the risk of falls, are urgently needed. Non-invasive vagus nerve stimulation (nVNS) is a neuromodulation technique targeting the vagus nerve. We recently showed in a small pilot trial that a single dose of nVNS improved (decreased) discrete gait variability characteristics in those receiving active stimulation relative to those receiving sham stimulation. Further multi-dose, multi-session studies are needed to assess the safety and tolerability of the stimulation and if improvement in gait is sustained over time. Design This will be an investigator-initiated, single-site, proof-of-concept, double-blind sham-controlled randomised pilot trial in 40 people with PD. Participants will be randomly assigned on a 1:1 ratio to receive either active or sham transcutaneous cervical VNS. All participants will undergo comprehensive cognitive, autonomic and gait assessments during three sessions over 24 weeks, in addition to remote monitoring of ambulatory activity and falls, and exploratory analyses of cholinergic peripheral plasma markers. The primary outcome measure is the safety and tolerability of multi-dose nVNS in PD. Secondary outcomes include improvements in gait, cognition and autonomic function that will be summarised using descriptive statistics. Discussion This study will report on the proportion of eligible and enrolled patients, rates of eligibility and reasons for ineligibility. Adverse events will be recorded informing on the safety and device tolerability in PD. This study will additionally provide us with information for sample size calculations for future studies and evidence whether improvement in gait control is enhanced when nVNS is delivered repeatedly and sustained over time. Trial registration This trial is prospectively registered at www.isrctn.com/ISRCTN19394828 . Registered August 23, 2021

Further empirical evidence for the non-linearity of the period-luminosity relations as seen in the Large Magellanic Cloud Cepheids

(abridged) Recent studies, using OGLE data for LMC Cepheids in the optical, strongly suggest that the period-luminosity (PL) relation for the Large Magellanic Cloud (LMC) Cepheids shows a break or non-linearity at a period of 10 days. In this paper we apply statistical tests, the chi-square test and the F-test, to the Cepheid data from the MACHO project to test for a non-linearity of the V- and R-band PL relations at 10 days, and extend these tests to the near infrared (JHK-band) PL relations with 2MASS data. We correct the extinction for these data by applying an extinction map towards the LMC. The statistical test we use, the F-test, is able to take account of small numbers of data points and the nature of that data on either side of the period cut at 10 days. With our data, the results we obtained imply that the VRJH-band PL relations are non-linear around a period of 10 days, while the K-band PL relation is (marginally) consistent with a single-line regression. The choice of a period of 10 days, around which this non-linearity occurs, is consistent with the results obtained when this "break" period is estimated from the data. Long period Cepheids are supplemented from the literature to increase our sample size. The photometry of these long period Cepheids is compared with our data and no trend with period is found. Our main results remain unchanged when we supplement our dataset with these long period Cepheids. By examining our data at maximum light, we also suggest arguments why errors in reddening are unlikely to be responsible for our results. The non-linearity of the mean V-band PL relation as seen in both of the OGLE and MACHO data, using different extinction maps, suggests that this non-linearity is real.Comment: 18 pages, 10 tables, 7 figures. MNRAS accepte

Status of the atomic fountain clock at the National Research Council of Canada

Despite the rapid advances in optical frequency standards, caesium fountain clocks retain a critical role as the most accurate primary frequency standards available. At the National Research Council Canada, we are working to develop a second generation caesium fountain clock. Work is currently underway to improve several systems of FCs1, such as the laser system and microwave local oscillator, which will be incorporated into its refurbished version, FCs2. In addition, we have added an optical pumping stage which has increased the detected atom number by over a factor of six. In collaboration with the National Physical Laboratory (NPL), we are planning on replacing the physics package of FCs1. We will report on several recent improvements to FCs1, along with our progress in the development of FCs2