The Holocene history of the North American Monsoon: 'known knowns' and 'known unknowns' in understanding its spatial and temporal complexity

Evidence for climatic change across the North American Monsoon (NAM) and adjacent areas is reviewed, drawing on continental and marine records and the application of climate models. Patterns of change at 12,000, 9000, 6000 and 4000 cal yr BP are presented to capture the nature of change from the Younger Dryas (YD) and through the mid-Holocene. At the YD, conditions were cooler overall, wetter in the north and drier in the south, while moving into the Holocene wetter conditions became established in the south and then spread north as the NAM strengthened. Until c. 8,000 cal yr BP, the Laurentide Ice Sheet influenced precipitation in the north by pushing the Bermuda High further south. The peak extent of the NAM seems to have occurred around 6000 cal yr BP. 4000 cal yr BP marks the start of important changes across the NAM region, with drying in the north and the establishment of the clear differences between the summer-rain dominated south and central areas and the north, where winter rain is more important. This differentiation between south and north is crucial to understanding many climate responses across the NAM. This increasing variability is coincident with the declining influence of orbital forcing. 4000 cal yr BP also marks the onset of significant anthropogenic activity in many areas. For the last 2000 years, the focus is on higher temporal resolution change, with strong variations across the region. The Medieval Climate Anomaly (MCA) is characterised by centennial scale ‘megadrought’ across the southwest USA, associated with cooler tropical Pacific SSTs and persistent La Niña type conditions. Proxy data from southern Mexico, Central America and the Caribbean reveal generally wetter conditions, whereas records from the highlands of central Mexico and much of the Yucatan are typified by long -term drought. The Little Ice Age (LIA), in the north, was characterised by cooler, wetter winter conditions that have been linked with increased frequency of El Niño’s. Proxy records in the central and southern regions reveal generally dry LIA conditions, consistent with cooler SSTs in the Caribbean and Gulf of Mexico. This synthesis demonstrates that in some periods, one major forcing can dominate across the whole area (e.g. insolation in the early-mid Holocene), but at other times there is strong variability in patterns of change due to the differential impact of forcings such as the Pacific Decadal Oscillation (PDO) and the Atlantic Multidecadal Oscillation (AMO) on precipitation seasonality

Repeated Acceleration Activity in Competitive Youth Soccer

Soccer match-play is increasingly characterised by short, high-speed bursts reliant on the ability to accelerate. Performance is impaired after peak acceleration activity and during the second half and may compromise a player’s effectiveness. To date, information about repeated acceleration sequences is lacking but would provide further insight into high-speed activity during competition. This study examined repeated acceleration ability (RAA) using GPS (5 Hz) and accelerometer (100 Hz), during 14 competitive youth soccer matches from the 2014–2015 season. Results showed that RAA profiles were relatively homogeneous, and there were no significant differences between playing positions. RAA activity was also relatively stable between playing halves and only the activity of forwards declined significantly. In summary, this study suggests that RAA is a generic requirement of match-play at this level but presents a specific focus for conditioning regimens

Systematic hybrid analog/digital signal coding

Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.Includes bibliographical references (p. 201-206).This thesis develops low-latency, low-complexity signal processing solutions for systematic source coding, or source coding with side information at the decoder. We consider an analog source signal transmitted through a hybrid channel that is the composition of two channels: a noisy analog channel through which the source is sent unprocessed and a secondary rate-constrained digital channel; the source is processed prior to transmission through the digital channel. The challenge is to design a digital encoder and decoder that provide a minimum-distortion reconstruction of the source at the decoder, which has observations of analog and digital channel outputs. The methods described in this thesis have importance to a wide array of applications. For example, in the case of in-band on-channel (IBOC) digital audio broadcast (DAB), an existing noisy analog communications infrastructure may be augmented by a low-bandwidth digital side channel for improved fidelity, while compatibility with existing analog receivers is preserved. Another application is a source coding scheme which devotes a fraction of available bandwidth to the analog source and the rest of the bandwidth to a digital representation. This scheme is applicable in a wireless communications environment (or any environment with unknown SNR), where analog transmission has the advantage of a gentle roll-off of fidelity with SNR. A very general paradigm for low-latency, low-complexity source coding is composed of three basic cascaded elements: 1) a space rotation, or transformation, 2) quantization, and 3) lossless bitstream coding. The paradigm has been applied with great success to conventional source coding, and it applies equally well to systematic source coding. Focusing on the case involving a Gaussian source, Gaussian channel and mean-squared distortion, we determine optimal or near-optimal components for each of the three elements, each of which has analogous components in conventional source coding. The space rotation can take many forms such as linear block transforms, lapped transforms, or subband decomposition, all for which we derive conditions of optimality. For a very general case we develop algorithms for the design of locally optimal quantizers. For the Gaussian case, we describe a low-complexity scalar quantizer, the nested lattice scalar quantizer, that has performance very near that of the optimal systematic scalar quantizer. Analogous to entropy coding for conventional source coding, Slepian-Wolf coding is shown to be an effective lossless bitstream coding stage for systematic source coding.by Richard J. Barron.Ph.D

17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors

Clinical observations imply that female cocaine addicts experience enhanced relapse vulnerability compared with males, an effect tied to elevated estrogen phases of the ovarian hormone cycle. Although estrogens can enhance drug-seeking behavior, they do not directly induce reinstatement on their own. To model this phenomenon, we tested whether an estrogen could augment drug-seeking behavior in response to an ordinarily subthreshold reinstatement trigger. Following cocaine self-administration and extinction, female rats were ovariectomized to isolate estrogen effects on reinstatement. Although neither peak proestrus levels of the primary estrogen 17β-estradiol (E2; 10 μg/kg, i.p., 1-h pretreatment) nor a subthreshold cocaine dose (1.25 mg/kg, i.p.) alone were sufficient to reinstate drug-seeking behavior, pretreatment with E2 potentiated reinstatement to the ordinarily subthreshold cocaine dose. Furthermore, E2 microinfusions revealed that E2 (5 μg/0.3 μl, 15-min pretreatment) acts directly within the prelimbic prefrontal cortex (PrL-PFC) to potentiate reinstatement. As E2 has been implicated in endocannabinoid mobilization, which can disinhibit PrL-PFC projection neurons, we investigated whether cannabinoid type-1 receptor (CB1R) activation is necessary for E2 to potentiate reinstatement. The CB1R antagonist AM251 (1 or 3 mg/kg, i.p., 30-min pretreatment) administered prior to E2 and cocaine suppressed reinstatement in a dose-dependent manner. Finally, PrL-PFC AM251 microinfusions (300 ng/side, 15-min pretreatment) also suppressed E2-potentiated reinstatement. Together, these results suggest that E2 can augment reactivity to an ordinarily subthreshold relapse trigger in a PrL-PFC CB1R activation-dependent manner

Channel equalization for self-synchronizing chaotic systems

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.Includes bibliographical references (p. 75-77).by Richard J. Barron.M.S

The association between diabetes related medical costs and glycemic control: A retrospective analysis

BACKGROUND: The objective of this research is to quantify the association between direct medical costs attributable to type 2 diabetes and level of glycemic control. METHODS: A longitudinal analysis using a large health plan administrative database was performed. The index date was defined as the first date of diabetes diagnosis and individuals had to have at least two HbA1c values post index date in order to be included in the analyses. A total of 10,780 individuals were included in the analyses. Individuals were stratified into groups of good (N = 6,069), fair (N = 3,586), and poor (N = 1,125) glycemic control based upon mean HbA1c values across the study period. Differences between HbA1c groups were analyzed using a generalized linear model (GLM), with differences between groups tested by utilizing z-statistics. The analyses allowed a wide range of factors to affect costs. RESULTS: 42.1% of those treated only with oral agents, 66.1% of those treated with oral agents and insulin, and 57.2% of those treated with insulin alone were found to have suboptimal control (defined as fair or poor) throughout the study period (average duration of follow-up was 2.95 years). Results show that direct medical costs attributable to type 2 diabetes were 16% lower for individuals with good glycemic control than for those with fair control ($1,505 vs.$1,801, p < 0.05), and 20% lower for those with good glycemic control than for those with poor control ($1,505 vs.$1,871, p < 0.05). Prescription drug costs were also significantly lower for individuals with good glycemic control compared to those with fair ($377 vs.$465, p < 0.05) or poor control ($377 vs.$423, p < 0.05). CONCLUSION: Almost half (44%) of all patients diagnosed with type 2 diabetes are at sub-optimal glycemic control. Evidence from this analysis indicates that the direct medical costs of treating type 2 diabetes are significantly higher for individuals who have fair or poor glycemic control than for those who have good glycemic control. Patients under fair control account for a greater proportion of the cost burden associated with antidiabetic prescription drugs

A Comparison of GPS Workload Demands in Match Play and Small-Sided Games by the Positional Role in Youth Soccer

The external demands of small-sided games (SSGs) according to the positional role are currently unknown. Using a Catapult Minimax X3 5 Hz GPS, with a 100 Hz tri-axial accelerometer, we compared the accumulated tri-axial player workload per min (PLacc·min(-1)) during friendly youth match play (MP) (11 vs. 11) and SSGs (2 vs. 2, 3 vs. 3, and 4 vs. 4). Significant differences existed between all SSGs and MP for PLacc·min(-1) (F = 21.91, p < 0.001, η2 = 0.38), and individual X (F = 27.40, p < 0.001, η2 = 0.43), Y (F = 14.50, p < 0.001, η2 = 0.29) and Z (F = 19.28, p < 0.001, η2 = 0.35) axis loads. Across all conditions, mean PLacc·min(-1) was greater for midfielders (p = 0.004, CI: 0.68, 4.56) and forwards (p = 0.037, CI: 0.08, 3.97) than central defenders. In all conditions, greater Y axis values existed for wide defenders (p = 0.024, CI: 0.67, 1.38), midfielders (p = 0.006, CI: 0.18, 1.50) and forwards (p = 0.007, CI: 0.17, 0.15) compared to central defenders. Midfielders reported greater Z axis values compared to central defenders (p = 0.002, CI: 0.40, 2.23). We concluded that SSGs elicited greater external loads than MP, and previous studies may have underestimated the demands of SSGs

‘Getting Back Into the Swing of Things’: A Qualitative Study Into Barriers and Facilitators to Golf Participation for Stroke Survivors

This paper draws on interviews with four stroke survivors (age range = 52–68 years), who participated in a six week ‘Get-into-Golf’ program and four coaches with experiences of delivering disability golf sessions, to examine the barriers and facilitators to golf participation. Findings indicate a positive response from participants, who referred to the social and physical benefits of the program that was perceived to promote independence. The results also highlight that considerations in regards to format, equipment, cost, access and overall awareness should be borne in mind for golf programs among people with disabilities. Golf clubs could employ this framework to help facilitate the participation of people with physical limitations. It is argued that opportunities to promote golf as a lifelong physical activity among people with disabilities may be missed in clubs where personnel are unsure of the barriers and facilitators to participation outlined here

Report of the panel on the land surface: Process of change, section 5

The panel defined three main areas of study that are central to the Solid Earth Science (SES) program: climate interactions with the Earth's surface, tectonism as it affects the Earth's surface and climate, and human activities that modify the Earth's surface. Four foci of research are envisioned: process studies with an emphasis on modern processes in transitional areas; integrated studies with an emphasis on long term continental climate change; climate-tectonic interactions; and studies of human activities that modify the Earth's surface, with an emphasis on soil degradation. The panel concluded that there is a clear requirement for global coverage by high resolution stereoscopic images and a pressing need for global topographic data in support of studies of the land surface