Propuesta para el control del riesgo biologico en el manejo, almacenamiento y manipulacion de los residuos solidos peligrosos en el instituto Roosevelt - Bogotá.

Establecer mecanismos de control para la disminución del riesgo biológico producido por el manejo, almacenamiento, manipulación de los residuos sólidos peligrosos al interior del Instituto RooseveltDentro de las actividades realizadas en el instituto Roosevelt entidad prestadora de servicios de salud, se generan a diario grandes cantidades de residuos peligrosos, que se clasifican dentro de la Resolución 4741 de 2005, donde los residuos que en su mayoría se generan son de tipo biológico, los cuales representan un peligro dentro de los procesos de manipulación por los colaboradores de la institución

Propuesta para el control del riesgo biologico en el manejo, almacenamiento y manipulacion de los residuos solidos peligrosos en el instituto Roosevelt - Bogotá.

Establecer mecanismos de control para la disminución del riesgo biológico producido por el manejo, almacenamiento, manipulación de los residuos sólidos peligrosos al interior del Instituto RooseveltDentro de las actividades realizadas en el instituto Roosevelt entidad prestadora de servicios de salud, se generan a diario grandes cantidades de residuos peligrosos, que se clasifican dentro de la Resolución 4741 de 2005, donde los residuos que en su mayoría se generan son de tipo biológico, los cuales representan un peligro dentro de los procesos de manipulación por los colaboradores de la institución

Diseño de un plan de mejoramiento del clima organizacional, para la empresa Súper Drogas Crisan del municipio de La Plata Huila para el segundo semestre del año 2021.

El presente documento parte de la pregunta ¿Porque se está presentando un inadecuado clima organizacional dentro de la empresa Súper Drogas Crisan? La cual se resuelve con el objetivo el diseñar un plan de mejoramiento del clima organizacional para la empresa Súper Drogas Crisan del municipio de la Plata Huila. La investigación fue de carácter descriptivo y explicativo, para esto se realizaron actividades como un diagnóstico de la misma donde se obtuvo que la organización no cuenta debidamente con objetivos estructurados para con sus empleados, es decir el equipo no tiene definida las funciones y las tareas que cada uno tiene a desarrollar en su lugar de trabajo por lo que se presentan inconvenientes e ineficiencia a la hora de resolver problemas o a finalizar ciertas tareas; En segundo lugar se realizaron encuestas a una muestra de 12 personas para conocer cómo se sienten y que tan a gusto están con sus puestos de trabajo, en lo cual se concluyó que las personas a pesar de que las relaciones con sus compañeros y jefes son buenas, la empresa no les brinda oportunidades de mejora para lograr desarrollarse personal y profesionalmente.This document starts from the question, why is there an inappropriate organizational climate within the company Súper Drogas Crisan? Which is resolved with the objective of designing a plan to improve the organizational climate for the company Súper Drogas Crisan in the municipality of La Plata Huila. The research was descriptive and explanatory, for this, activities were carried out such as a diagnosis of the same where it was obtained that the organization does not have properly structured objectives for its employees, that is, the team does not have defined the functions and tasks that each one has to develop in their workplace so there are inconveniences and inefficiency when solving problems or completing certain tasks; Second, surveys were conducted on a sample of 12 people to find out how they feel and how comfortable they are with their jobs, in which it was concluded that people despite the fact that their relationships with their colleagues and bosses are good , the company does not offer them improvement opportunities to achieve personal and professional development

A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line

<p>Abstract</p> <p>Background</p> <p>Enhancement of tumor cell sensitivity may help facilitate a reduction in drug dosage using conventional chemotherapies. Consequently, it is worthwhile to search for adjuvants with the potential of increasing chemotherapeutic drug effectiveness and improving patient quality of life. Natural products are a very good source of such adjuvants.</p> <p>Methods</p> <p>The biological activity of a fraction enriched in hydrolysable polyphenols (P2Et) obtained from <it>Caesalpinia spinosa </it>was evaluated using the hematopoietic cell line K562. This fraction was tested alone or in combination with the conventional chemotherapeutic drugs doxorubicin, vincristine, etoposide, camptothecin and taxol. The parameters evaluated were mitochondrial depolarization, caspase 3 activation, chromatin condensation and clonogenic activity.</p> <p>Results</p> <p>We found that the P2Et fraction induced mitochondrial depolarization, activated caspase 3, induced chromatin condensation and decreased the clonogenic capacity of the K562 cell line. When the P2Et fraction was used in combination with chemotherapeutic drugs at sub-lethal concentrations, a fourfold reduction in doxorubicin inhibitory concentration 50 (IC₅₀) was seen in the K562 cell line. This finding suggested that P2Et fraction activity is specific for the molecular target of doxorubicin.</p> <p>Conclusions</p> <p>Our results suggest that a natural fraction extracted from <it>Caesalpinia spinosa </it>in combination with conventional chemotherapy in combination with natural products on leukemia cells may increase therapeutic effectiveness in relation to leukemia.</p

Brain health in diverse settings : How age, demographics and cognition shape brain function

Peer reviewe

Brain clocks capture diversity and disparities in aging and dementia

Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex and neurodegeneration) on the brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American and Caribbean countries (LAC) and 8 non-LAC countries). Based on higher-order interactions, we developed a brain-age gap deep learning architecture for functional magnetic resonance imaging (2,953) and electroencephalography (2,353). The datasets comprised healthy controls and individuals with mild cognitive impairment, Alzheimer disease and behavioral variant frontotemporal dementia. LAC models evidenced older brain ages (functional magnetic resonance imaging: mean directional error = 5.60, root mean square error (r.m.s.e.) = 11.91; electroencephalography: mean directional error = 5.34, r.m.s.e. = 9.82) associated with frontoposterior networks compared with non-LAC models. Structural socioeconomic inequality, pollution and health disparities were influential predictors of increased brain-age gaps, especially in LAC (R² = 0.37, F² = 0.59, r.m.s.e. = 6.9). An ascending brain-age gap from healthy controls to mild cognitive impairment to Alzheimer disease was found. In LAC, we observed larger brain-age gaps in females in control and Alzheimer disease groups compared with the respective males. The results were not explained by variations in signal quality, demographics or acquisition methods. These findings provide a quantitative framework capturing the diversity of accelerated brain aging.</p

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

Peer reviewe

XVI International Congress of Control Electronics and Telecommunications: "Techno-scientific considerations for a post-pandemic world intensive in knowledge, innovation and sustainable local development"

Este título, sugestivo por los impactos durante la situación de la Covid 19 en el mundo, y que en Colombia lastimosamente han sido muy críticos, permiten asumir la obligada superación de tensiones sociales, políticas, y económicas; pero sobre todo científicas y tecnológicas. Inicialmente, esto supone la existencia de una capacidad de la sociedad colombiana por recuperar su estado inicial después de que haya cesado la perturbación a la que fue sometida por la catastrófica pandemia, y superar ese anterior estado de cosas ya que se encontraban -y aún se encuentran- muchos problemas locales mal resueltos, medianamente resueltos, y muchos sin resolver: es decir, habrá que rediseñar y fortalecer una probada resiliencia social existente - producto del prolongado conflicto social colombiano superado parcialmente por un proceso de paz exitoso - desde la tecnociencia local; como lo indicaba Markus Brunnermeier - economista alemán y catedrático de economía de la Universidad de Princeton- en su libro The Resilient Society…La cuestión no es preveerlo todo sino poder reaccionar…aprender a recuperarse rápido.This title, suggestive of the impacts during the Covid 19 situation in the world, and which have unfortunately been very critical in Colombia, allows us to assume the obligatory overcoming of social, political, and economic tensions; but above all scientific and technological. Initially, this supposes the existence of a capacity of Colombian society to recover its initial state after the disturbance to which it was subjected by the catastrophic pandemic has ceased, and to overcome that previous state of affairs since it was found -and still is find - many local problems poorly resolved, moderately resolved, and many unresolved: that is, an existing social resilience test will have to be redesigned and strengthened - product of the prolonged Colombian social conflict partially overcome by a successful peace process - from local technoscience; As Markus Brunnermeier - German economist and professor of economics at Princeton University - indicates in his book The Resilient Society...The question is not to foresee everything but to be able to react...learn to recover quickly.Bogot

More than 10,000 pre-Columbian earthworks are still hidden throughout Amazonia

Indigenous societies are known to have occupied the Amazon basin for more than 12,000 years, but the scale of their influence on Amazonian forests remains uncertain. We report the discovery, using LIDAR (light detection and ranging) information from across the basin, of 24 previously undetected pre-Columbian earthworks beneath the forest canopy. Modeled distribution and abundance of large-scale archaeological sites across Amazonia suggest that between 10,272 and 23,648 sites remain to be discovered and that most will be found in the southwest. We also identified 53 domesticated tree species significantly associated with earthwork occurrence probability, likely suggesting past management practices. Closed-canopy forests across Amazonia are likely to contain thousands of undiscovered archaeological sites around which pre-Columbian societies actively modified forests, a discovery that opens opportunities for better understanding the magnitude of ancient human influence on Amazonia and its current state