Pirates and Librarians: Big Media, Technology, and the Role of Liberal Education

The widespread appearance of computers in libraries during the early 1990s elicited a debate among those who welcomed new technologies and those who perceived such changes as a threat to the traditional role of academic libraries and the values of liberal education. At the same time, increasing consolidation of major media channels—including sources of scholarly communication—has allowed a small number of corporations to control distribution and access to the materials libraries offer, through tools such as licensing fees, copyright restrictions, and digital rights management. In response to these barriers, librarians and educators have embraced open access publishing and Creative Commons licensing as viable alternatives. Some go further in their struggle to separate content from its proprietors, through channels such as torrent sites that undermine conventional notions of ownership. This paper will argue that restricting information and denying access to resources without addressing the systemic failure of affordable access weakens critical thinking and threatens the mission of liberal education. By pursuing new models for scholarly communication and resource sharing, libraries can both reassert control over their collections and help support the mission of libera

Critical Information Literacy and the Technology of Control: The Case of Armenia

As direct providers of information literacy, librarians can help patrons analyze the social and economic forces involved in the creation and use of information. This chapter will discuss why critical information literacy and critical pedagogy are especially important in the Armenian context, with its unique historical, cultural, and geopolitical concerns. The authors will document how the Armenian government has used cutting-edge Internet controls to block online content or misdirect users. We will also examine how Armenians perceive the independence of their available media and explore current efforts by telecom, publishing, and governmental concerns to restrict Internet freedom. The authors suggest ways for users to regain control over restricted media and argue that an open online culture cannot exist without local self-determination and a basic human right to produce and share information

Use and Awareness of Library Services among Faculty at Two Armenian Universities

This study surveyed instructional faculty at two Armenian universities to determine use and awareness of academic library services or resources including reference, interlibrary loan, subscription databases, subject liaisons, and more. A minority of respondents reported making frequent use of the services investigated, with usage varying according to such factors as academic rank, length of employment, and full- or part-time status. Many participants also had suggestions for services not available at their libraries. These results help illuminate user preferences among faculty at these universities and could help librarians at similar institutions identify underutilized resources to promote or new services to offer

Adaptive versus non-adaptive strategies for quantum channel discrimination

We provide a simple example that illustrates the advantage of adaptive over non-adaptive strategies for quantum channel discrimination. In particular, we give a pair of entanglement-breaking channels that can be perfectly discriminated by means of an adaptive strategy that requires just two channel evaluations, but for which no non-adaptive strategy can give a perfect discrimination using any finite number of channel evaluations.Comment: 11 page

Collection Development at Two Armenian University Libraries: A Conversation with Librarians and Faculty

In the summer of 2016 two Hunter College librarians, working with a colleague in the Republic of Armenia, conducted an IRB-approved focus group at the American University of Armenia in Yerevan, Armenia. This group drew participants from the libraries and other academic departments of the American University of Armenia as well as Yerevan State University, a large public institution. The discussion attempted to ascertain whether these libraries have devised effective strategies to acquire materials and build collections in the face of the challenges they face (budgetary, linguistic, and sometimes political) and whether faculty at these institutions feel their library’s collection meets their teaching and research needs. Together with results from an online survey, the responses gathered help illuminate the challenges that scholars and librarians face in the unique context of the South Caucasus, as Armenia and other countries in the region continue to develop post-Soviet models of higher education and transition to more democratic forms of government

Development of a Coherent Doppler Lidar for Precision Maneuvering and Landing of Space Vehicles

A coherent Doppler lidar has been developed to address NASAs need for a high-performance, compact, and cost-effective velocity and altitude sensor onboard its landing vehicles. Future robotic and manned missions to planetary bodies require precise ground-relative velocity vector and altitude data to execute complex descent maneuvers and safe, soft landing at a pre-designated site. This lidar sensor, referred to as a Navigation Doppler Lidar, meets the required performance of landing missions while complying with vehicle size, mass, and power constraints. Operating from over five kilometers altitude, the lidar obtains velocity and range precision measurements with 2 cm/sec and 2 meters, respectively, dominated by the vehicle motion. After a series of flight tests onboard helicopters and rocket-powered free-flyer vehicles, the Navigation Doppler Lidar is now being ruggedized for future missions to various destinations in the solar system

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells.

Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood. We used patient-derived GBM cultures to identify GSC subtypes with differential activation of Notch signaling, which co-exist in tumors but occupy distinct niches and match their metabolism accordingly. Multipotent GSCs with Notch pathway activation reside in perivascular niches, and are unable to entrain anaerobic glycolysis during hypoxia. In contrast, most CD133-expressing GSCs do not depend on canonical Notch signaling, populate tumors regardless of local vascularity and selectively utilize anaerobic glycolysis to expand in hypoxia. Ectopic activation of Notch signaling in CD133-expressing GSCs is sufficient to suppress anaerobic glycolysis and resistance to hypoxia. These findings demonstrate a novel role for Notch signaling in regulating GSC metabolism and suggest intratumoral GSC heterogeneity ensures metabolic adaptations to support tumor growth in diverse tumor microenvironments

The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles

Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensatory proliferation, morphology and cell migration. How caspases are activated under non-apoptotic conditions and process a selective set of substrates without killing the cell remain enigmatic. Here we find that the Drosophila unconventional myosin CRINKLED (CK) selectively interacts with the initiator caspase DRONC and regulates some of its non-apoptotic functions. Loss of CK in the arista, border cells or proneural clusters of the wing imaginal discs affects DRONC-dependent patterning. Our data indicate that CK acts as substrate adaptor, recruiting SHAGGY46/GSK3-β to DRONC, thereby facilitating caspase-mediated cleavage and localized modulation of kinase activity. Similarly, the mammalian CK counterpart, MYO7A, binds to and impinges on CASPASE-8, revealing a new regulatory axis affecting receptor interacting protein kinase-1 (RIPK1)>CASPASE-8 signalling. Together, our results expose a conserved role for unconventional myosins in transducing caspase-dependent regulation of kinases, allowing them to take part in specific signalling events

Dose-escalation study of a second-generation non-ansamycin HSP90 inhibitor, onalespib (AT13387), in combination with imatinib in patients with metastatic gastrointestinal stromal tumour

AbstractBackgroundGastrointestinal stromal tumours (GIST) treated with the tyrosine kinase inhibitor (TKI) imatinib can become resistant when additional mutations in the receptor tyrosine kinases KIT or PDGFRA block imatinib activity. Mutated KIT requires the molecular chaperone heat-shock protein 90 (HSP90) to maintain stability and activity. Onalespib (AT13387) is a potent non-ansamycin HSP90 inhibitor. We hypothesised that the combination of onalespib and imatinib may be safe and effective in managing TKI-resistant GIST.Patients and methodsIn this dose-escalation study, we evaluated the safety and efficacy of combination once-weekly intravenous onalespib for 3 weeks and daily oral imatinib in 28-d cycles. Twenty-six patients with TKI-resistant GIST were enrolled into four sequential dose cohorts of onalespib (dose range, 150–220 mg/m2) and imatinib 400 mg. The relationship between tumour mutational status (KIT/PDGFRA) and efficacy of treatment was explored.ResultsCommon onalespib-related adverse events were diarrhoea (58%), nausea (50%), injection site events (46%), vomiting (39%), fatigue (27%), and muscle spasms (23%). Overall, 81% of patients reported more than one onalespib-related gastrointestinal disorder. Nine patients (35%) had a best response of stable disease, including two patients who had KIT mutations known to be associated with resistance to imatinib and sunitinib. Disease control at 4 months was achieved in five patients (19%), and median progression-free survival was 112 d (95% confidence interval 43–165). One patient with PDGFRA-mutant GIST had a partial response for more than 376 d.ConclusionThe combination of onalespib plus imatinib was well tolerated but exhibited limited antitumour activity as dosed in this TKI-resistant GIST patient population.Trial registration ID: clinicaltrials.gov: NCT0129420