The Cellular Metabolism and Effects of Gold Complexes

Leads to the cellular effects of the anti-arthritic gold complexes may come from the determination of their metabolism by target cells and, possibly, cells in the immediate environment of the target cells. Polymorphonuclear leukocytes (PMN) and mononuclear cells (monocytes and lymphocytes) are present in inflamed joints of patients with rheumatoid arthritis and these cells have been widely used in pharmacological studies on the gold complexes. It is suggested that the cellular effects of the gold complexes are mediated by the production of aurocyanide. According to this hypothesis, PMN metabolize small quantities of thiocyanate to cyanide which, in turn, converts gold complexes, such as aurothiomalate, to aurocyanide (dicyanogold(I)) which inhibits the functions of PMN and other cells. There is now considerable evidence for this hypothesis from in vitro studies but there is little in vivo work to back up the hypothesis. One of the few in vivo studies which tested the hypothesis involved the examination of the activity of aurothiomalate in the treatment of polyarthritis in Hooded Wistar rats. Activity of aurothiomalate is only shown in animals which received thiocyanate. Hydrogen cyanide is a constituent of cigarette smoke and the aurocyanide formed by the interaction with gold complexes and inhaled hydrogen cyanide rapidly diffuses into red blood cells. Because of the metabolism of hydrogen cyanide to thiocyanate in the liver, there are higher plasma levels of thiocyanate in smokers than in non-smokers. Smokers may have a greater incidence of side effects than non-smokers but there appears to be little difference in therapeutic response, possibly because there is sufficient thiocyanate in extracellular fluid, even in non-smokers, to support the conversion of gold complexes to aurocyanide. The relationship between the metabolism and effects of the orally active gold complex, auranofin are less clear. Auranofin itself is taken up by cells with the loss of the ligands bound to gold while its inhibitory activity against the oxidative burst of PMN decreases with increasing cell density. For example, the lucigenin-dependent chemiluminescence of 106 PMN/ml is 46 percent of control at 0.5 μM auranofin but only 2.2 percent in 2.105 PMN/ml in the presence of the same concentration of auranofin. A potentially active gold complex is a plasma component which is taken up by red blood cells

3D-MHD simulations of an accretion disk with star-disk boundary layer

We present global 3D MHD simulations of geometrically thin but unstratified accretion disks in which a near Keplerian disk rotates between two bounding regions with initial rotation profiles that are stable to the MRI. The inner region models the boundary layer between the disk and an assumed more slowly rotating central, non magnetic star. We investigate the dynamical evolution of this system in response to initial vertical and toroidal fields imposed in a variety of domains contained within the near Keplerian disk. Cases with both non zero and zero net magnetic flux are considered and sustained dynamo activity found in runs for up to fifty orbital periods at the outer boundary of the near Keplerian disk. Simulations starting from fields with small radial scale and with zero net flux lead to the lowest levels of turbulence and smoothest variation of disk mean state variables. For our computational set up, average values of the Shakura & Sunyaev (1973) $\alpha$ parameter in the Keplerian disk are typically $0.004\pm 0.002.$ Magnetic field eventually always diffuses into the boundary layer resulting in the build up of toroidal field inward angular momentum transport and the accretion of disk material. The mean radial velocity, while exhibiting large temporal fluctuations is always subsonic. Simulations starting with net toroidal flux may yield an average $\alpha \sim 0.04.$ While being characterized by one order of magnitude larger average $\alpha$, simulations starting from vertical fields with large radial scale and net flux may lead to the formation of persistent non-homogeneous, non-axisymmetric magnetically dominated regions of very low density.Comment: Accepted for publication in Ap

The interaction of a giant planet with a disc with MHD turbulence I: The initial turbulent disc models

This is the first of a series of papers aimed at developing and interpreting simulations of protoplanets interacting with turbulent accretion discs. Here we study the disc models prior to the introduction of a protoplanet.We study models in which a Keplerian domain is unstable to the magnetorotational instability (MRI). Various models with B-fields having zero net flux are considered.We relate the properties of the models to classical viscous disc theory.All models attain a turbulent state with volume averaged stress parameter alpha ~ 0.005. At any particular time the vertically and azimuthally averaged value exhibited large fluctuations in radius. Time averaging over periods exceeding 3 orbital periods at the outer boundary of the disc resulted in a smoother quantity with radial variations within a factor of two or so. The vertically and azimuthally averaged radial velocity showed much larger spatial and temporal fluctuations, requiring additional time averaging for 7-8 orbital periods at the outer boundary to limit them. Comparison with the value derived from the averaged stress using viscous disc theory yielded schematic agreement for feasible averaging times but with some indication that the effects of residual fluctuations remained. The behaviour described above must be borne in mind when considering laminar disc simulations with anomalous Navier--Stokes viscosity. This is because the operation of a viscosity as in classical viscous disc theory with anomalous viscosity coefficient cannot apply to a turbulent disc undergoing rapid changes due to external perturbation. The classical theory can only be used to describe the time averaged behaviour of the parts of the disc that are in a statistically steady condition for long enough for appropriate averaging to be carried out.Comment: 10 pages, 23 figures, accepted for publication in MNRAS. A gzipped postscript version including high resolution figures is available at http://www.maths.qmul.ac.uk/~rp

Helicobacter pylori and cancer among adults in Uganda

Data from Africa on infection with Helicobacter pylori (H. pylori) are sparse. Therefore, as part of an epidemiological study of cancer in Uganda, we investigated the prevalence and determinants of antibodies against H. pylori among 854 people with different cancer types and benign tumours. Patients were recruited from hospitals in Kampala, Uganda, interviewed about various demographic and lifestyle factors and tested for antibodies against H. pylori. In all patients combined, excluding those with stomach cancer (which has been associated with H. pylori infection), the prevalence of antibodies was 87% (723/833) overall, but declined with increasing age (p = 0.02) and was lower among people who were HIV seropositive compared to seronegative (p <0.001). Otherwise, there were few consistent epidemiological associations. Among those with stomach cancer, 18/21 (86%) had anti-H. pylori antibodies (odds ratio 0.8, 95% confidence intervals 0.2–2.9, p = 0.7; estimated using all other patients as controls, with adjustment for age, sex and HIV serostatus). No other cancer site or type was significantly associated with anti-H. pylori antibodies. The prevalence of H. pylori reported here is broadly in accord with results from other developing countries, although the determinants of infection and its' role in the aetiology of gastric cancer in Uganda remain unclear

KELT-8b: A highly inflated transiting hot Jupiter and a new technique for extracting high-precision radial velocities from noisy spectra

We announce the discovery of a highly inflated transiting hot Jupiter discovered by the KELT-North survey. A global analysis including constraints from isochrones indicates that the V = 10.8 host star (HD 343246) is a mildly evolved, G dwarf with $T_{\rm eff} = 5754_{-55}^{+54}$ K, $\log{g} = 4.078_{-0.054}^{+0.049}$, $[Fe/H] = 0.272\pm0.038$, an inferred mass $M_{*}=1.211_{-0.066}^{+0.078}$ M$_{\odot}$, and radius $R_{*}=1.67_{-0.12}^{+0.14}$ R$_{\odot}$. The planetary companion has mass $M_P = 0.867_{-0.061}^{+0.065}$ $M_{J}$, radius $R_P = 1.86_{-0.16}^{+0.18}$ $R_{J}$, surface gravity $\log{g_{P}} = 2.793_{-0.075}^{+0.072}$, and density $\rho_P = 0.167_{-0.038}^{+0.047}$ g cm$^{-3}$. The planet is on a roughly circular orbit with semimajor axis $a = 0.04571_{-0.00084}^{+0.00096}$ AU and eccentricity $e = 0.035_{-0.025}^{+0.050}$. The best-fit linear ephemeris is $T_0 = 2456883.4803 \pm 0.0007$ BJD$_{\rm TDB}$ and $P = 3.24406 \pm 0.00016$ days. This planet is one of the most inflated of all known transiting exoplanets, making it one of the few members of a class of extremely low density, highly-irradiated gas giants. The low stellar $\log{g}$ and large implied radius are supported by stellar density constraints from follow-up light curves, plus an evolutionary and space motion analysis. We also develop a new technique to extract high precision radial velocities from noisy spectra that reduces the observing time needed to confirm transiting planet candidates. This planet boasts deep transits of a bright star, a large inferred atmospheric scale height, and a high equilibrium temperature of $T_{eq}=1675^{+61}_{-55}$ K, assuming zero albedo and perfect heat redistribution, making it one of the best targets for future atmospheric characterization studies.Comment: Submitted to ApJ, feedback is welcom

The Evolution of Early-type Red Galaxies with the GEMS Survey: Luminosity-size and Stellar Mass-size Relations Since z=1

We combine HST/ACS imaging from the GEMS survey with redshifts and rest-frame quantities from COMBO-17 to study the evolution of morphologically early-type galaxies with red colors since z=1. We use a new large sample of 728 galaxies with centrally-concentrated radial profiles (Sersic n>2.5) and rest-frame U-V colors on the red sequence. By appropriate comparison with the local relations from SDSS, we find that the luminosity-size (L-R) and stellar mass-size (M-R) relations evolve in a manner that is consistent with the passive aging of ancient stars. By itself, this result is consistent with a completely passive evolution of the red early-type galaxy population. If instead, as demonstrated by a number of recent surveys, the early-type galaxy population builds up in mass by a factor of 2 since z=1, our results imply that new additions to the early-type galaxy population follow similar L-R and M-R correlations, compared to the older subset of early-type galaxies. Adding early-type galaxies to the red sequence through disk fading appears to be consistent with the data. Through comparison with models, the role of dissipationless merging is limited to <1 major merger on average since z=1 for the most massive galaxies. Predictions from models of gas-rich mergers are not yet mature enough to allow a detailed comparison to our observations. We find tentative evidence that the amount of luminosity evolution depends on galaxy stellar mass, such that the least massive galaxies show stronger luminosity evolution compared to more massive early types. This could reflect a different origin of low-mass early-type galaxies and/or younger stellar populations; the present data is insufficient to discriminate between these possibilities. (abridged)Comment: Submitted to ApJ, 23 pages, Latex using emulateapj5.sty and onecolfloat.sty (included), 10 figures, version with full resolution figures at http://www.astro.umass.edu/~dmac/Papers/ETevol.hires.p

From Social Data Mining to Forecasting Socio-Economic Crisis

Socio-economic data mining has a great potential in terms of gaining a better understanding of problems that our economy and society are facing, such as financial instability, shortages of resources, or conflicts. Without large-scale data mining, progress in these areas seems hard or impossible. Therefore, a suitable, distributed data mining infrastructure and research centers should be built in Europe. It also appears appropriate to build a network of Crisis Observatories. They can be imagined as laboratories devoted to the gathering and processing of enormous volumes of data on both natural systems such as the Earth and its ecosystem, as well as on human techno-socio-economic systems, so as to gain early warnings of impending events. Reality mining provides the chance to adapt more quickly and more accurately to changing situations. Further opportunities arise by individually customized services, which however should be provided in a privacy-respecting way. This requires the development of novel ICT (such as a self- organizing Web), but most likely new legal regulations and suitable institutions as well. As long as such regulations are lacking on a world-wide scale, it is in the public interest that scientists explore what can be done with the huge data available. Big data do have the potential to change or even threaten democratic societies. The same applies to sudden and large-scale failures of ICT systems. Therefore, dealing with data must be done with a large degree of responsibility and care. Self-interests of individuals, companies or institutions have limits, where the public interest is affected, and public interest is not a sufficient justification to violate human rights of individuals. Privacy is a high good, as confidentiality is, and damaging it would have serious side effects for society.Comment: 65 pages, 1 figure, Visioneer White Paper, see http://www.visioneer.ethz.c

Assessing Coral Reef Fish Population and Community Changes in Response to Marine Reserves in the Dry Tortugas, Florida, USA

The efficacy of no-take marine reserves (NTMRs) to enhance and sustain regional coral reef fisheries was assessed in Dry Tortugas, Florida, through 9 annual fishery-independent research surveys spanning 2 years before and 10 years after NTMR implementation. A probabilistic sampling design produced precise estimates of population metrics of more than 250 exploited and non-target reef fishes. During the survey period more than 8100 research dives utilizing SCUBA Nitrox were optimally allocated using stratified random sampling. The survey domain covered 326 km2, comprised of eight reef habitats in four management areas that offered different levels of resource protection: the Tortugas North Ecological Reserve (a NTMR), Dry Tortugas National Park (recreational angling only), Dry Tortugas National Park Research Natural Area (a NTMR), and southern Tortugas Bank (open to all types of fishing). Surveys detected significant changes in population occupancy, density, and abundance within management zones for a suite of exploited and non-target species. Increases in size, adult abundance, and occupancy rates were detected for many principal exploited species in protected areas, which harbored a disproportionately greater number of adult spawning fishes. In contrast, density and occupancy rates for aquaria and non-target reef fishes fluctuated above and below baseline levels in each management zone. Observed decreases in density of exploited species below baseline levels only occurred at the Tortugas Bank area open to all fishing. Our findings indicate that these NTMRs, in conjunction with traditional fishery management control strategies, are helping to build sustainable fisheries while protecting the fundamental ecological dynamics of the Florida Keys coral-reef ecosystem