Peak acceleration scaling studies

An acceleration time history can be decomposed into a series of operations that transfers energy from each point on the fault to the recording station ACC(t) = S * R * E * Q where S is the source time function, R represents rupture over a finite fault, E is the elastic propagation through the earth, and Q is the path attenuation, assumed to be linear. If these operators were exactly known, a deterministic approach to predicting strong ground motions would be straightforward. For the current study, E was computed from a velocity model that incorporates a stiff sedimentary layer over a southern California crust. A range of realistic rupture velocities have been obtained by other investigators and is incorporated into the simulation. Assumptions of the path averaged attenuation, Q, can be tested by comparing with observational data, as a function of distance, the parameters peak acceleration, and computed M_L. This provides a check on both the high frequency (∼ 5 Hz) and long-period (∼ 1 sec) behavior of E^* Q. An average curstal shear wave Q_β of 300 is found to be compatible with observational data (M_L = 4.5 to 5.0). Assumptions of S can be avoided by using real sources derived from accelerograms recorded at small epicentral distances (epicentral distance/source depth < 1). Using these operators, accelerograms have been simulated for strike-slip faulting for four magnitudes: 4.5; 5.5; 6.5; and 7.0. The shapes of the derived average peak ground acceleration (PGA) versus distance curves are well described by the simple equation PGA α [R + C(M)]^(−1.75), where R is the closest distance to the fault surface and C(4.5) = 6, C(5.5) = 12, C(6.5) = 22, and C(7.0) = 36 km

Report of the Research Coordination Network RCN : OceanObsNetwork, facilitating open exchange of data and information

The OceanObsNetwork goals and objectives are to foster a broad, multi-disciplinary dialogue, enabling more effective use of sustained ocean observatories and observing systems. To achieve these, the activities for the RCN include a working group titled “Facilitating Open Exchange of Data and Information.” Within this area 3 task teams were created dealing with elements that impact on open exchange of data and information. This report examines the foundation of Open Data and its importance to the international community, science, innovation and jobs. While the goal may be similar, the paths to Open Data are varied and drawing together a pervasive approach will take time. There are however, near term steps, technical and social, that could have significant impacts. Stimulating interdisciplinary collaboration occurs through adoption of common standards for data exchange, creation of information brokering for improved discovery and access and working toward common or defined vocabularies. Simply finding other scientists’ data has been noted as a major barrier for research. Open Data impinges on existing reward systems and social interactions. Areas that need to be addressed are the academic reward system (in terms of promotion and resources), the peer review panels and grant selection processes (in terms of acknowledging the importance and challenge of data collection) and the needs for acceptable citation mechanisms. Intellectual property should not be abandoned in an Open Data environment and managing IPR is necessary. A sustainable Open Data Policy is essential and sustainability is a matter for all parties, government, private sector, academia and non-profit organizations. As full implementation of Open Data will involve a change in practices in a number of research and publication activities, an end-to-end perspective and strategy would most likely allow a long-term sustainable path to be pursued. Various business models are discussed in the paper that would not have been considered a decade ago. These range from cloud storage to publication of data with Digital Object Identifiers. These set a possible foundation for the future.National Science Foundation through Grant Award No. OCE-1143683

Facilitating open exchange of data and information

Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Earth Science Informatics 8 (2015): 721-739, doi:10.1007/s12145-014-0202-2.By broad consensus, Open Data presents great value. However, beyond that simple statement, there are a number of complex, and sometimes contentious, issues that the science community must address. In this review, we examine the current state of the core issues of Open Data with the unique perspective and use cases of the ocean science community: interoperability; discovery and access; quality and fitness for purpose; and sustainability. The topics of Governance and Data Publication are also examined in detail. Each of the areas covered are, by themselves, complex and the approaches to the issues under consideration are often at odds with each other. Any comprehensive policy on Open Data will require compromises that are best resolved by broad community input. In the final section of the review, we provide recommendations that serve as a starting point for these discussions.The authors acknowledge the support of the National Science Foundation through Grant Award No. OCE-1143683.2016-01-0

Laser-annealing Josephson junctions for yielding scaled-up superconducting quantum processors

As superconducting quantum circuits scale to larger sizes, the problem of frequency crowding proves a formidable task. Here we present a solution for this problem in fixed-frequency qubit architectures. By systematically adjusting qubit frequencies post-fabrication, we show a nearly ten-fold improvement in the precision of setting qubit frequencies. To assess scalability, we identify the types of 'frequency collisions' that will impair a transmon qubit and cross-resonance gate architecture. Using statistical modeling, we compute the probability of evading all such conditions, as a function of qubit frequency precision. We find that without post-fabrication tuning, the probability of finding a workable lattice quickly approaches 0. However with the demonstrated precisions it is possible to find collision-free lattices with favorable yield. These techniques and models are currently employed in available quantum systems and will be indispensable as systems continue to scale to larger sizes.Comment: 9 pages, 6 figures, Supplementary Information. Update to correct typo in author name and in text. Updated acknowledgements and corrected typo in acknowledgement

Asymmetric shallow mantle structure beneath the Hawaiian Swell—evidence from Rayleigh waves recorded by the PLUME network

Author Posting. © The Author(s), 2011. This article is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in Geophysical Journal International 187 (2011): 1725–1742, doi:10.1111/j.1365-246X.2011.05238.x.We present models of the 3-D shear velocity structure of the lithosphere and asthenosphere beneath the Hawaiian hotspot and surrounding region. The models are derived from long-period Rayleigh-wave phase velocities that were obtained from the analysis of seismic recordings collected during two year-long deployments for the Hawaiian Plume-Lithosphere Undersea Mantle Experiment. For this experiment, broad-band seismic sensors were deployed at nearly 70 seafloor sites as well as 10 sites on the Hawaiian Islands. Our seismic images result from a two-step inversion of path-averaged dispersion curves using the two-station method. The images reveal an asymmetry in shear velocity structure with respect to the island chain, most notably in the lower lithosphere at depths of 60 km and greater, and in the asthenosphere. An elongated, 100-km-wide and 300-km-long low-velocity anomaly reaches to depths of at least 140 km. At depths of 60 km and shallower, the lowest velocities are found near the northern end of the island of Hawaii. No major velocity anomalies are found to the south or southeast of Hawaii, at any depth. The low-velocity anomaly in the asthenosphere is consistent with an excess temperature of 200–250 °C and partial melt at the level of a few percent by volume, if we assume that compositional variations as a result of melt extraction play a minor role. We also image small-scale low-velocity anomalies within the lithosphere that may be associated with the volcanic fields surrounding the Hawaiian Islands.This research was financed by the National Science Foundation under grants OCE-00-02470 and OCE-00-02819. Markee was partly sponsored by a SIO graduate student fellowship

Phase 1 Study of Two Merozoite Surface Protein 1 (MSP1(42)) Vaccines for Plasmodium falciparum Malaria

OBJECTIVES: To assess the safety and immunogenicity of two vaccines, MSP1(42)-FVO/Alhydrogel and MSP1(42)-3D7/Alhydrogel, targeting blood-stage Plasmodium falciparum parasites. DESIGN: A Phase 1 open-label, dose-escalating study. SETTING: Quintiles Phase 1 Services, Lenexa, Kansas between July 2004 and November 2005. PARTICIPANTS: Sixty healthy malaria-naïve volunteers 18–48 y of age. INTERVENTIONS: The C-terminal 42-kDa region of merozoite surface protein 1 (MSP1(42)) corresponding to the two allelic forms present in FVO and 3D7 P. falciparum lines were expressed in Escherichia coli, refolded, purified, and formulated on Alhydrogel (aluminum hydroxide). For each vaccine, volunteers in each of three dose cohorts (5, 20, and 80 μg) were vaccinated at 0, 28, and 180 d. Volunteers were followed for 1 y. OUTCOME MEASURES: The safety of MSP1(42)-FVO/Alhydrogel and MSP1(42)-3D7/Alhydrogel was assessed. The antibody response to each vaccine was measured by reactivity to homologous and heterologous MSP1(42), MSP1(19), and MSP1(33) recombinant proteins and recognition of FVO and 3D7 parasites. RESULTS: Anti-MSP1(42) antibodies were detected by ELISA in 20/27 (74%) and 22/27 (81%) volunteers receiving three vaccinations of MSP1(42)-FVO/Alhydrogel or MSP1(42)-3D7/Alhydrogel, respectively. Regardless of the vaccine, the antibodies were cross-reactive to both MSP1(42)-FVO and MSP1(42)-3D7 proteins. The majority of the antibody response targeted the C-terminal 19-kDa domain of MSP1(42), although low-level antibodies to the N-terminal 33-kDa domain of MSP1(42) were also detected. Immunofluorescence microscopy of sera from the volunteers demonstrated reactivity with both FVO and 3D7 P. falciparum schizonts and free merozoites. Minimal in vitro growth inhibition of FVO or 3D7 parasites by purified IgG from the sera of the vaccinees was observed. CONCLUSIONS: The MSP1(42)/Alhydrogel vaccines were safe and well tolerated but not sufficiently immunogenic to generate a biologic effect in vitro. Addition of immunostimulants to the Alhydrogel formulation to elicit higher vaccine-induced responses in humans may be required for an effective vaccine

2. C. W. Holzwarth

Abstract: We have investigated the feasibility of multimode polysilicon waveguides to demonstrate the suitability of polysilicon as a candidate for multilayer photonic applications. Solid Phase Crystallization (SPC) with a maximum temperature of 1000°C is used to create polysilicon on thermally grown SiO 2 . We then measure the propagation losses for various waveguide widths on both polysilicon and crystalline silicon platforms. We find that as the width increases for polysilicon waveguides, the propagation loss decreases similar to crystalline silicon waveguides. At a waveguide width of 10µm, polysilicon and crystalline silicon waveguides have propagation losses of 0.56dB/cm and 0.31 dB/cm, respectively, indicating there is little bulk absorption from the polysilicon and is the lowest propagation loss for polysilicon demonstrated to date. In addition, the first 1x12 polysilicon MMI is demonstrated with a low insertion loss of −1.29dB and a high uniformity of 1.07dB. These results vindicate the use of polysilicon waveguides of varying widths in photonic integrated circuits

Epidemiologic heterogeneity of common mood and anxiety disorders over the lifecourse in the general population: a systematic review

Background Clinical evidence has long suggested there may be heterogeneity in the patterns and predictors of common mood and anxiety disorders; however, epidemiologic studies have generally treated these outcomes as homogenous entities. The objective of this study was to systematically review the epidemiologic evidence for potential patterns of heterogeneity of common mood and anxiety disorders over the lifecourse in the general population. Methods We reviewed epidemiologic studies examining heterogeneity in either the nature of symptoms experienced ( symptom syndromes ) or in patterns of symptoms over time ( symptom trajectories ). To be included, studies of syndromes were required to identify distinct symptom subtypes, and studies of trajectories were required to identify distinct longitudinal patterns of symptoms in at least three waves of follow-up. Studies based on clinical or patient populations were excluded. Results While research in this field is in its infancy, we found growing evidence that, not only can mood and anxiety disorders be differentiated by symptom syndromes and trajectories, but that the factors associated with these disorders may vary between these subtypes. Whether this reflects a causal pathway, where genetic or environmental factors influence the nature of the symptom or trajectory subtype experienced by an individual, or whether individuals with different subtypes differed in their susceptibility to different environmental factors, could not be determined. Few studies addressed issues of comorbidity or transitions in symptoms between common disorders. Conclusion Understanding the diversity of these conditions may help us identify preventable factors that are only associated with some subtypes of these common disorders