John Carruth to John D. Reinhardt, 11 April 1854

https://egrove.olemiss.edu/aldrichcorr_c/1086/thumbnail.jp

Valuation of estate of Robert A. Reinhardt, 1854

https://egrove.olemiss.edu/aldrichcorr_c/1088/thumbnail.jp

Valuation of estate of Robert A. Reinhardt, 1854

https://egrove.olemiss.edu/aldrichcorr_c/1089/thumbnail.jp

Pan troglodytes (errata version published in 2018)

Assessment Information: Although Pan troglodytes is the most abundant and widespread of the great apes, and many populations exist in protected areas, the declines that have occurred are expected to continue, satisfying the criteria for an Endangered listing (Oates 2006). Due to high levels of poaching, infectious diseases, and loss of habitat and habitat quality caused by expanding human activities, this species is estimated to have experienced a significant population reduction in the past 20–30 years and it is suspected that this reduction will continue for the next 30–40 years. Due to their slow life history and a generation time estimated to be 25 years, Chimpanzee populations cannot sustain high levels of mortality, whether disease-induced or caused by poaching. The maximum population reduction over a three-generation (75 year) period from 1975 to 2050 is suspected to exceed 50%, hence qualifying this taxon as Endangered under criterion A. Although conservation efforts directed at Chimpanzees and other wildlife have increased significantly in recent years, the assumption that population reductions will continue is a precautionary approach based on the rapid growth of human populations in sub-Saharan Africa, continuing poaching for bushmeat, the commercial bushmeat trade, the arrival of industrial agriculture (which requires clearcutting of forest), corruption and lack of law enforcement, lack of capacity and resources, and political instability in some range states. At the same time, zoonosis and disease outbreaks present significant risks; there is, for example, evidence that Ebolavirus will continue to spreadin some parts of the Chimpanzee's geographic range(Walshet al.2005)

Sensitive Flow Cytometric Analysis Reveals a Novel Type of Parent-of-Origin Effect in the Mouse Genome

AbstractThe discovery of classic parental imprinting came, at least in part, from the analysis of transgene expression in mice [1]. It was noticed that some transgenes were only expressed following paternal transmission [2–4] and that others sometimes showed differential patterns of methylation depending on the parent of origin [5, 6]. Here, we present evidence of a novel and more subtle form of parental imprinting by taking advantage of the highly sensitive detection of murine transgene expression afforded by flow cytometry. We have produced nine lines of transgenic mice carrying a GFP reporter linked to the human α-globin promoter and enhancer elements, which direct expression to erythroid cells. A high proportion of transgenic lines, four of the nine, display significantly lower levels of expression following maternal transmission. Both the percentage of expressing cells and the mean fluorescence in expressing cells are between 10% and 30% lower following maternal transmission. These effects are reversible upon passage through the opposite germline. This finding raises the possibility that differences in the epigenetic state of the maternal and paternal chromosomes in adult somatic cells are more widespread than was previously thought

Molecular Beams

Contains research objectives, summary of research and reports on eight research projects.Joint Services Electronics Programs (U. S. Army, U. S. Navy, and U. S. Air Force) under Contract DAAB07-71-C-030

Triamterene Enhances the Blood Pressure Lowering Effect of Hydrochlorothiazide in Patients with Hypertension

BACKGROUND: Triamterene, because of its potassium-sparing properties, is frequently used in combination with hydrochlorothiazide (HCTZ) to treat patients with hypertension. By inhibiting the epithelial sodium channel (ENaC) in the cortical collecting duct, triamterene reduces potassium secretion, thus reducing the risk of hypokalemia. Whether triamterene has an independent effect on blood pressure (BP) has not been well studied. OBJECTIVE: To determine if triamterene provides an effect to further lower BP in patients treated with HCTZ. DESIGN: We conducted an observational study using electronic medical record data from the Indiana Network for Patient Care. Participants were 17,291 patients with the diagnosis of hypertension between 2004 and 2012. MAIN MEASURES: BP was the primary outcome. We compared the BP between patients who were taking HCTZ, with and without triamterene, either alone or in combination with other antihypertensive medications, by using a propensity score analysis. For each medication combination, we estimated the propensity score (i.e., probability) of a patient receiving triamterene using a logistic regression model. Patients with similar propensity scores were stratified into subclasses and BP was compared between those taking triamterene or not within each subclass; the effect of triamterene was then assessed by combining BP differences estimated from all subclasses. KEY RESULTS: The mean systolic BP in the triamterene + HCTZ group was 3.8 mmHg lower than in the HCTZ only group (p < 0.0001); systolic BP was similarly lower for patients taking triamterene with other medication combinations. Systolic BP reduction was consistently observed for different medication combinations. The range of systolic BP reduction was between 1 and 4 mm Hg, depending on the concurrently used medications. CONCLUSIONS: In the present study, triamterene was found to enhance the effect of HCTZ to lower BP. In addition to its potassium-sparing action, triamterene's ability to lower BP should also be considered

Determination of the pharmacokinetics and oral bioavailability of salicylamine, a potent γ-ketoaldehyde scavenger, by LC/MS/MS

Levels of reactive γ-ketoaldehydes derived from arachidonate increase in diseases associated with inflammation and oxidative injury. To assess the biological importance of these γ-ketoaldehydes, we previously identified salicylamine as an effective γ-ketoaldehyde scavenger in vitro and in cells. To determine if salicylamine could be administered in vivo, we developed an LC/MS/MS assay to measure salicylamine in plasma and tissues. In mice, half-life (t1/2) was 62 minutes. Drinking water supplementation (1-10 g/L) generated tissue concentrations (10-500 μM) within the range previously shown to inhibit γ-ketoaldehydes in cells. Therefore, oral administration of salicylamine can be used to assess the contribution of γ-ketoaldehydes in animal models of disease. © 2010 by the authors licensee Molecular Diversity Preservation International, Basel, Switzerland

Transcultural adaptation to the Brazilian Portuguese of the Postpartum Bonding Questionnaire for assessing the postpartum bond between mother and baby

The establishment of the bond between mother and baby in the postpartum period is important for ensuring the physical and psychological health of both. This short communication reports the first phase of the cross-cultural translation and adaptation to the Brazilian context of the Postpartum Bonding Questionnaire (PBQ). Four aspects of equivalence between the original scale and the Portuguese version were evaluated: the conceptual, semantic, operational and item equivalences. Literature review, the study of PBQ history, translation, expert evaluation, back-translation and pretests involving 30 mothers with children aging up to 7 months using a primary healthcare unit were conducted. Each step demonstrated the need for adjustments, which were made during the adaptation process. At the end of the study, a version of PBQ in Brazilian Portuguese equivalent to the original one was obtained, offering promise for national studies on the mother-baby bond, and its influence on health, and for use in health services

Regional Action Plan for the Conservation of the Cross River Gorilla (Gorilla gorilla diehli)

From Executive Summary: This document represents the consensus of experts who met at a workshop in April 2006 in Calabar, Cross River State, Nigeria, to formulate a set of priority actions that would increase the survival prospects for the Cross River gorilla (Gorilla gorilla diehli). The Cross River gorilla is recognized by IUCN as Critically Endangered, and is the most threatened taxon of ape in Africa. It is the most westerly and northerly form of gorilla, and occurs only in a limited area around the mountainous headwaters of the Cross River, straddling the border between Cameroon and Nigeria. Participants at the 2006 workshop, which built upon the outcomes of previous meetings in Calabar in 2001 and Limbe, Cameroon, in 2003, included representatives of forestry and wildlife conservation agencies from the two range countries, of local and international nongovernmental conservation and development organizations, and of university-based researchers