Is a gene-centric human proteome project the best way for proteomics to serve biology?

With the recent developments in proteomic technologies, a complete human proteome project (HPP) appears feasible for the first time. However, there is still debate as to how it should be designed and what it should encompass. In "proteomics speak", the debate revolves around the central question as to whether a gene-centric or a protein-centric proteomics approach is the most appropriate way forward. In this paper, we try to shed light on what these definitions mean, how large-scale proteomics such as a HPP can insert into the larger omics chorus, and what we can reasonably expect from a HPP in the way it has been proposed so far

"Seeing" Data Like an Expert: An Eye-Tracking Study Using Graphical Data Representations

Given the centrality of data visualizations in communicating scientific information, increased emphasis has been placed on the development of students’ graph literacy—the ability to generate and interpret data representations—to foster understanding of domain-specific knowledge and the successful navigation of everyday life. Despite prior literature that identifies student difficulties and methods to improve graphing competencies, there is little understanding as to how learners develop these skills. To gain a better resolution of the cognitive basis by which individuals “see” graphs, this study uses eye tracking (ET) to compare the strategies of non–science undergraduates (n = 9), early (n = 7) and advanced (n = 8) biology undergraduates, graduate students (n = 6), and science faculty (n = 6) in making sense of data displays. Results highlight variation in how individuals direct their attention (i.e., fixations and visual search patterns) when completing graph-based tasks as a function of science expertise. As research on the transition from novice to expert is crucially important in understanding how we might design curricula that help novices move toward more expert-like performance, this study has implications for the advancement of new strategies to aid the teaching and learning of data analysis skills

The Influence of Enhanced Side Impact Protection on Kinematics and Injury Measures of Far- or Center-Seated Children in Forward-Facing Child Restraints

<div><p><b>Objective:</b> To evaluate the influence of forward-facing child restraint systems’ (FFCRSs) side impact structure, such as side wings, on the head kinematics and response of a restrained, far- or center-seated 3-year-old anthropomorphic test device (ATD) in oblique sled tests.</p><p><b>Methods:</b> Sled tests were conducted utilizing an FFCRS with large side wings and with the side wings removed. The CRS were attached via LATCH on 2 different vehicle seat fixtures—a small SUV rear bench seat and minivan rear bucket seat—secured to the sled carriage at 20° from lateral. Four tests were conducted on each vehicle seat fixture, 2 for each FFCRS configuration. A Q3s dummy was positioned in FFCRS according to the CRS owner's manual and FMVSS 213 procedures. The tests were conducted using the proposed FMVSS 213 side impact pulse. Three-dimensional motion cameras collected head excursion data. Relevant data collected during testing included the ATD head excursions, head accelerations, LATCH belt loads, and neck loads.</p><p><b>Results:</b> Results indicate that side wings have little influence on head excursions and ATD response. The median lateral head excursion was 435 mm with side wings and 443 mm without side wings. The primary differences in head response were observed between the 2 vehicle seat fixtures due to the vehicle seat head restraint design. The bench seat integrated head restraint forced a tether routing path over the head restraint. Due to the lateral crash forces, the tether moved laterally off the head restraint reducing tension and increasing head excursion (477 mm median). In contrast, when the tether was routed through the bucket seat's adjustable head restraint, it maintained a tight attachment and helped control head excursion (393 mm median).</p><p><b>Conclusion:</b> This testing illustrated relevant side impact crash circumstances where side wings do not provide the desired head containment for a 3-year-old ATD seated far-side or center in FFCRS. The head appears to roll out of the FFCRS even in the presence of side wings, which may expose the occupant to potential head impact injuries. We postulate that in a center or far-side seating configuration, the absence of door structure immediately adjacent to the CRS facilitates the rotation and tipping of the FFCRS toward the impact side and the roll-out of the head around the side wing structure. Results suggest that other prevention measures, in the form of alternative side impact structure design, FFCRS vehicle attachment, or shared protection between the FFCRS and the vehicle, may be necessary to protect children in oblique side impact crashes.</p></div