Managers’ understanding of agile in hardware development

The agile methodology is gaining attention among practitioners and researchers in hardware development. As a new methodology, it is a source of misunderstandings and misinterpretations. This is problematic at the managers' levels as they may hinder its adoption or lead to its impractical implementation and use. This study, therefore, aims to explore the manager's level of understanding of the agile methodology. The study identifies the similarities and differences between the fundamental elements of the agile methodology and the elements mentioned by managers in hardware development. The fundamental elements of the agile methodology are identified based on the elements presented in the Scrum method; the elements mentioned by managers are identified based on ten semi-structured interviews with managers in hardware development. The study shows that the understanding of the agile methodology varies largely among managers. The obtained detailed insights in the managers' level of understanding of the agile methodology could be used to develop appropriate support to facilitate its adoption and implementation

The Dark Halo - Spheroid Conspiracy and the Origin of Elliptical Galaxies

Dynamical modeling and strong lensing data indicate that the total density profiles of early-type galaxies are close to isothermal, i.e., rho_tot ~ r^gamma with gamma approx -2. To understand the origin of this universal slope we study a set of simulated spheroids formed in isolated binary mergers as well as the formation within the cosmological framework. The total stellar plus dark matter density profiles can always be described by a power law with an index of gamma approx -2.1 with a tendency toward steeper slopes for more compact, lower-mass ellipticals. In the binary mergers the amount of gas involved in the merger determines the precise steepness of the slope. This agrees with results from the cosmological simulations where ellipticals with steeper slopes have a higher fraction of stars formed in situ. Each gas-poor merger event evolves the slope toward gamma ~ -2, once this slope is reached further merger events do not change it anymore. All our ellipticals have flat intrinsic combined stellar and dark matter velocity dispersion profiles. We conclude that flat velocity dispersion profiles and total density distributions with a slope of gamma ~ -2 for the combined system of stars and dark matter act as a natural attractor. The variety of complex formation histories as present in cosmological simulations, including major as well as minor merger events, is essential to generate the full range of observed density slopes seen for present-day elliptical galaxies.Comment: Accepted by the Astrophysical Journal, 17 pages, 12 figure

Recent advances in the intellectual property landscape of filamentous fungi

For centuries, filamentous fungi have been used in the making of food and beverages, and for decades for the production of enzymes and pharmaceuticals. In the last decades, the intellectual property (IP) landscape for fungal technology has seen an ever increasing upward trend, introducing new and promising applications utilising fungi. In this review, we highlight fungi-related patent applications published during the last 5\ua0years (2015–2020), identify the key players in each field, and analyse future trends.\ua0New developments in the field of fungal technology include the increased use of filamentous fungi as a food source (mycoprotein), using fungi as biodegradable materials, in wastewater treatment, in integrated biorefineries and as biological pest agents. Biotechnology companies in Europe and the US are currently leading when it comes to the number of patents in these areas, but Asian companies and research institutes, in particular in China, are becoming increasingly important players, for example in pesticide formulation and agricultural practices

Lessons on Tumour Response: Imaging during Therapy with 177Lu-DOTA-octreotate. A Case Report on a Patient with a Large Volume of Poorly Differentiated Neuroendocrine Carcinoma

Favourable outcomes of peptide receptor radiotherapy (PRRT) of neuroendocrine tumours have been reported during the last years. Still, there are uncertainties on the radionuclides to be used, the treatment planning, and the indication in patients with a high proliferation rate

The co-evolution of total density profiles and central dark matter fractions in simulated early-type galaxies

We present evidence from cosmological hydrodynamical simulations for a co-evolution of the slope of the total (dark and stellar) mass density profile, gamma (tot), and the dark matter fraction within the half-mass radius, f(DM), in early-type galaxies. The relation can be described as gamma(tot) = A f(DM) + B for all systems at all redshifts. The trend is set by the decreasing importance of gas dissipation towards lower redshifts and for more massive systems. Early-type galaxies are smaller, more concentrated, have lower f(DM) and steeper gamma(tot) at high redshifts and at lower masses for a given redshift; f(DM) and gamma(tot) are good indicators for growth by 'dry' merging. The values for A and B change distinctively for different feedback models, and this relation can be used as a test for such models. A similar correlation exists between gamma(tot) and the stellar mass surface density Sigma(*). A model with weak stellar feedback and feedback from black holes is in best agreement with observations. All simulations, independent of the assumed feedback model, predict steeper gamma(tot) and lower f(DM) at higher redshifts. While the latter is in agreement with the observed trends, the former is in conflict with lensing observations, which indicate constant or decreasing gamma(tot). This discrepancy is shown to be artificial: the observed trends can be reproduced from the simulations using observational methodology to calculate the total density slopes.Peer reviewe

Zwischen Regulierung und Repression: Ein Beitrag zur Einordnung gesetzlicher Maßnahmen in Bezug auf die Auslandsfinanzierung von zivilgesellschaftlichen Organisationen

Gesetzliche Maßnahmen im Bereich der Auslandsfinanzierung von zivilgesellschaftlichen Organisationen werden inzwischen als zentraler Bestandteil von schrumpfenden zivilgesellschaftlichen Räumen angesehen. Allerdings existiert in der Literatur bisher kein Konsens über die Angemessenheit eines expliziten staatlichen Eingriffs in diesem Bereich. Der Artikel entwickelt deswegen einen konzeptionellen Rahmen, um den einschränkenden Charakter von staatlichen Eingriffen empirisch präziser als bisher bestimmen zu können. Wir plausibilisieren unser konzeptionelles Argument anhand von sechs kurzen Fallstudien zu Deutschland, Österreich, der Türkei, Ungarn, Uruguay und Venezuela. Damit tragen wir in dreifacher Art und Weise zur Debatte über schrumpfende zivilgesellschaftliche Räume bei. Wir zeigen erstens, dass gesetzliche Maßnahmen in Bezug auf die ausländische Finanzierung von Zivilgesellschaft nicht zwangsläufig als Teil eines weltweiten repressiven Trends anzusehen sind. Zweitens schlagen wir eine neue analytische Einordnung vor, die über das bisher dominante binäre Verständnis hinausgeht, welches gerade im Global Süden jeglicher Anpassung gesetzlicher Maßnahmen in diesem Bereich repressive Tendenzen unterstellt. Drittens versuchen wir eine Sicht der internationalen Menschenrechte zur Vereinigungsfreiheit mit einer auf nationalen verfassungsrechtlichen Normen fokussierten Perspektive in Verbindung zu bringen, um damit empirisch-analytisch präziser auf die in vielen Ländern existierenden rechtsnormativen Unterschiede zwischen diesen beiden Ebenen aufmerksam zu machen

Prognostic significance of VEGF after twenty-year follow-up in a randomized trial of fenretinide in non-muscle-invasive bladder cancer

Non-muscle-invasive bladder cancer (NMIBC) may progress to muscle-invasive disease, but no effective preventive treatments are available. In addition, no reliable prognostic biomarkers have been identified. We assessed the long-term effect of the oral retinoid fenretinide and the prognostic value of circulating VEGF levels. We updated through the Tumor Registry the vital status of 99 patients with resected Ta/T1 bladder tumors who were recruited in a randomized trial of 2 years of fenretinide or no treatment in 1993-1994. Serum VEGF levels measured at baseline and 12 months were available in a subgroup of 62 patients. After a median of 20.5 years, 54 subjects died, 35 of any cancer and 14 of bladder cancer. Neither overall survival (OS), nor cancer survival (CS) or bladder cancer survival (BCS) was affected by fenretinide (log-rank P 65 0.2). DNA aneuploidy in bladder washing was associated with shorter OS (P =0.02), CS (P =0.05), and BCS (P = 0.09). Subjects with baseline VEGF levels in the top quintile ( 65350 pg/mL) had a significantly shorter OS (P =0.01), CS (P = 0.02), and BCS (P= 0.008). The trend across quintiles of VEGF was significant for BCS (P =0.007). Multivariate analyses showed that, in addition to smoking status, VEGF level in the top quintile was an independent prognostic factor for OS (HR =2.7; 95% CI, 1.1-6.5), CS (HR = 3.3; 95% CI, 1.1-9.4) and BCS (HR =8.9; 95% CI,1.3-61). Fenretinide did not affect the long-term outcome of patients with NMIBC. High serum VEGF level was a significant predictor of overall and cancer death and may help to identify high-risk subjects who may benefit from a preventive therapy. Cancer Prev Res; 9(6); 437-44

Pollution trace gas distributions and their transport in the Asian monsoon upper troposphere and lowermost stratosphere during the StratoClim campaign 2017

We present the first high-resolution measurements of pollutant trace gases in the Asian summer monsoon upper troposphere and lowermost stratosphere (UTLS) from the Gimballed Limb Observer for Radiance Imaging of the Atmosphere (GLORIA) during the StratoClim (Stratospheric and upper tropospheric processes for better climate predictions) campaign based in Kathmandu, Nepal, 2017. Measurements of peroxyacetyl nitrate (PAN), acetylene (C$_2$H$_2$), and formic acid (HCOOH) show strong local enhancements up to altitudes of 16\,km. More than 500\,pptv of PAN, more than 200\,pptv of C$_2$H$_2$, and more than 200\,pptv of HCOOH are observed. Air masses with increased volume mixing ratios of PAN and C$_2$H$_2$ at altitudes up to 18\,km, reaching to the lowermost stratosphere, were present at these altitudes for more than 10\,d, as indicated by trajectory analysis. A local minimum of HCOOH is correlated with a previously reported maximum of ammonia (NH$_3$), which suggests different washout efficiencies of these species in the same air masses. A backward trajectory analysis based on the models Alfred Wegener InsTitute LAgrangian Chemistry/Transport System (ATLAS) and TRACZILLA, using advanced techniques for detection of convective events, and starting at geolocations of GLORIA measurements with enhanced pollution trace gas concentrations, has been performed. The analysis shows that convective events along trajectories leading to GLORIA measurements with enhanced pollutants are located close to regions where satellite measurements by the Ozone Monitoring Instrument (OMI) indicate enhanced tropospheric columns of nitrogen dioxide (NO$_2$) in the days prior to the observation. A comparison to the global atmospheric models Copernicus Atmosphere Monitoring Service (CAMS) and ECHAM/MESSy Atmospheric Chemistry (EMAC) has been performed. It is shown that these models are able to reproduce large-scale structures of the pollution trace gas distributions for one part of the flight, while the other part of the flight reveals large discrepancies between models and measurement. These discrepancies possibly result from convective events that are not resolved or parameterized in the models, uncertainties in the emissions of source gases, and uncertainties in the rate constants of chemical reactions