Development of an instrument for early detection of dementia in people with Down syndrome

The successful detection of early signs of dementia in people with Down syndrome could form a basis for useful early support and for drug treatment. This report describes the development and preliminary application of an interview and test instrument for the assessment of dementia among people with intellectual disability, as well as a framework for diagnosis that combines the findings of an interview and a test with the diagnostic criteria of ICD-10, DSM-IV and NINCDS-ADRDA. From among the number of tests and interview questions developed, those showing the most significant differences between participants in three groups of differing levels of intellectual disability and estimated dementia were kept. Reported are the assumptions for the items used, descriptions of the process and items used, and the associations of test items with predicting the presence of dementia. The authors conclude that a protocol combining testing and interview has promise and potential for detecting early signs of dementia in this population and could prove feasible for use in practice

Psychometric testing of a Swedish version of the Apathy Evaluation Scale

Background: Apathy, a prevalent and clinically relevant symptom in neurodegenerative disease, is often evaluated by the instrument Apathy Evaluation Scale (AES). However, this instrument has not been translated into Swedish, halting clinical and research efforts. Furthermore, previous studies lack analyses of some basic properties, such as the legitimacy of a total score, or have analysed dimensionality by questionable methods.Aim: To translate and psychometrically evaluate a Swedish version of the AES.Method: The AES was translated, and its psychometric properties were tested in the Swedish BioFINDER study, including cognitively well elderly, and subjects with mild cognitive or parkinsonian symptoms. Psychometric analyses were conducted according to classical test theory (CTT) and aimed to resemble those performed in the English original study by Marin et al. in 1991. Dimensionality was additionally analysed on a matrix of polychoric correlations and parallel analyses.Results: Data indicate that the Swedish AES performs satisfactorily regarding data completeness, scaling assumptions, targeting, and reliability. Principal component analyses (with parallel analysis) of polychoric correlation matrices identified a single component. Convergent and discriminative validity correlations accorded with a priori expectations.Conclusions: The study provides initial support that this Swedish AES performs similarly to the English original, and exhibits acceptable psychometric properties according to CTT, including supported unidimensionality, and may be adopted for use in clinical and research settings.Keywords: Apathy, Apathy Evaluation Scale (AES), neurodegenerative disease, neuropsychiatric assessment, psychometric

GOTRIS - Göta Älv River Information Services Final report - Swedish

GOTRI

Sustainable Development and Sustainability: Landscape Approach as a Practical Interpretation of Principles and Implementation Concepts

The situation for governors and managers of natural resources has increased in complexity. Previously it was enough to sustain the yields of wood, food and energy. Today, maintenance of ecosystem services, conservation of biodiversity, rural development and human wellbeing are new additional objectives. At the same time there are new risks and uncertainties linked to climate change, economic globalisation, energy security and water supply. Consequently, adaptive and holistic research, governance and management are needed. Landscape is a concept and framework that can be used as an approach to enhance implementation of policies about sustainable development as a societal process and sustainability as outcomes on the ground. For our analysis to define the landscape approach we used a hierarchical framework consisting of principles, concepts and initiatives; and included three principles defining SD and sustainability and five international concepts to analyze its implementation for our analysis to define landscape approach. We propose a practical operationalization that consists of five core attributes, (1) a sufficiently large area that matches management requirements and challenges to deliver desired goods, services and values, (2) multi-level and multi-sector stakeholder collaboration that promotes sustainable development as a social process, (3) commitment to and understanding of sustainability as an aim among stakeholders, (4) integrative knowledge production, and (5) sharing of experience, results and information, to develop local or tacit to general or explicit knowledge. Finally, we discuss the need for integrative research to study landscape approach concepts and what local initiatives using different concepts deliver on the ground

Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1

AbstractAquaporins are water channel proteins that facilitate the movement of water and other small solutes across biological membranes. Plants usually have large aquaporin families, providing them with many ways to regulate the water transport. Some aquaporins are regulated post-translationally by phosphorylation. We have previously shown that the water channel activity of SoPIP2;1, an aquaporin in the plasma membrane of spinach leaves, was enhanced by phosphorylation at Ser115 and Ser274. These two serine residues are highly conserved in all plasma membrane aquaporins of the PIP2 subgroup. In this study we have purified and characterized two protein kinases phosphorylating Ser115 and Ser274 in SoPIP2;1. By anion exchange chromatography, the Ser115 kinase was purified from the soluble protein fraction isolated from spinach leaves. The Ca2+-dependent Ser274 kinase was purified by peptide affinity chromatography using plasma membranes isolated from spinach leaves. When characterized, the Ser115 kinase was Mg2+-dependent, Ca2+-independent and had a pH-optimum at 6.5. In accordance with previous studies using the oocyte expression system, site-directed mutagenesis and kinase and phosphatase inhibitors, the phosphorylation of Ser274, but not of Ser115, was increased in the presence of phosphatase inhibitors while kinase inhibitors decreased the phosphorylation of both Ser274 and Ser115. The molecular weight of the Ser274 kinase was approximately 50 kDa. The identification and characterization of these two protein kinases is an important step towards elucidating the signal transduction pathway for gating of the aquaporin SoPIP2;1

The outcome of an automated assessment of trabecular pattern in intraoral radiographs as a fracture risk predictor

Objectives: This study aims to investigate if automated analyses of the trabecular pattern in intraoral radiographs independently contribute to fracture risk assessment when other risk factors incorporated in the Fracture Risk Assessment Tool (FRAX) are taken into account. A secondary aim is to explore the correlation between the automated trabecular pattern assessment in intraoral radiographs and Trabecular Bone Score (TBS). Methods: A total of 567 intraoral radiographs from older females participating in a large population-based study (SUPERB) based in Gothenburg, Sweden, were selected to analyse trabecular pattern using semi-automated and fully automated software. Associations between trabecular pattern analysis and incident fractures were studied using Cox proportional hazard model, unadjusted and adjusted for FRAX risk factors (previous fracture, family history of hip fracture, smoking, corticosteroids, rheumatoid arthritis, without and with bone mineral density (BMD) of the femoral neck). In addition, the correlation between trabecular pattern analysis and TBS of the lumbar spine was investigated using Pearson correlation analysis. Results: Neither the unadjusted nor the adjusted trabecular pattern analysis in intraoral radiographs was significantly associated with any fracture or major osteoporotic fracture (MOF). A weak correlation was found between semi-automated trabecular pattern analysis and TBS. No correlation was found between the fully automated trabecular pattern analysis and TBS. Conclusions: The present study shows that semi-automated and fully automated digital analyses of the trabecular pattern in intraoral radiographs do not contribute to fracture risk prediction. Furthermore, the study shows a weak correlation between semi-automated trabecular pattern analysis and TBS

Measurements and simulations of single-event upsets in a 28-nm FPGA

Single-event upsets in the configuration memory of the 28-nm Xilinx Kintex-7 FPGA, used in the PANDA electromagnetic calorimeter, have been studied. Results from neutron and proton irradiations at energies up to 184 MeV are presented and compared with previous experimental results. In order to gain information about the energy-dependence of the single-event upset cross section, a GEANT4-based Monte Carlo simulation of upset mechanisms in nanometric silicon volumes has been developed. The results from this model are shown to agree with the experimental data for both neutrons and protons. Knowledge about the energy dependence of the cross section and of the particle flux at the location of the front-end modules in PANDA enables better estimates of the mean time between failures in the electromagnetic calorimeter. At PANDA, a total neutron flux of 1·102 cm− 2 s− 1 at the location of the front-end modules is expected at the lowest antipro-ton beam momentum and a luminosity of 1·1031 cm− 2 s− 1, leading to a predicted Mean Time Between Failures of 47±10 hours per FPGA in the electromagnetic calorimeter

Proton-and Neutron-Induced Single-Event Upsets in FPGAs for the PANDA Experiment

Single-event upsets (SEUs) affecting the configuration memory of a 28-nm field-programmable gate array (FPGA) have been studied through experiments and Monte Carlo modeling. This FPGA will be used in the front-end electronics of the electromagnetic calorimeter in PANDA (Antiproton Annihilation at Darmstadt), an upcoming hadron-physics experiment. Results from proton and neutron irradiations of the FPGA are presented and shown to be in agreement with previous experimental results. To estimate the mean time between SEUs during operation of PANDA, a Geant4-based Monte Carlo model of the phenomenon has been used. This model describes the energy deposition by particles in a silicon volume, the subsequent drift and diffusion of charges in the FPGA memory cell, and the eventual collection of charges in the sensitive regions of the cell. The values of the two free parameters of the model, the sensitive volume side d = 87 nm and the critical charge Qcrit = 0.23 fC, were determined by fitting the model to the experimental data. The results of the model agree well with both the proton and neutron data and are also shown to correctly predict the cross sections for upsets induced by other particles. The model-predicted energy dependence of the cross section for neutron-induced upsets has been used to estimate the rate of SEUs during initial operation of PANDA. At a luminosity of 1&amp;cdot; 1031 cm-2s-1, the predicted mean time between upsets (MTBU) is between 120 and 170 h per FPGA, depending on the beam momentum.</p

Multiple factors shape the interaction of people with urban greenspace: Sweden as a case study

This study identifies and analyses multiple factors that impact people's interactions with urban greenspace in Sweden. An unrestricted, self-selected online survey was used to collect the data. The survey questions were related to individual characteristics of respondents, including socio-demographic characteristics, self-reported nature connectedness, and self-reported constraints to greenspace usage; perceived characteristics of urban greenspace, including its availability, quality, and accessibility, and benefits and problems; and preferences of respondents regarding types of urban greenspace and activities. Additionally, several spatially explicit variables were included in the analysis. A total of 2806 respondents from 208 (of 290) municipalities completed the survey. Our findings indicate that greenspace users are highly heterogeneous and utilise diverse green spaces along the urban-peri-urban gradient for various benefits. The statistical analyses identified 61 explanatory variables that affect the frequency of interactions with urban greenspace. In addition, we identify key factors that shape critical differences between frequent and infrequent urban users, such as nature connectedness, perceptions of urban greenspace functions, and their perceived accessibility. Our results highlight the complex challenge facing urban planners and managers of green spaces, who have to consider and integrate a vast array of factors influencing the willingness of increasingly diverse urban populations to interact with greenspace