Médiation numérique : qu’est-ce que les bibliothèques peuvent apporter au Web ?

Mémoire de fin d\u27étude du diplôme de conservateur, promotion DCB19, portant sur les modalités d\u27implication des bibliothèques françaises sur Internet

Regional Convergence in Europe: A Dynamic Heterogeneous Panel Approach

This paper studies the effects of allowing for heterogeneous slope coefficients in the Mankiw, Romer and Weil (1992) model, based on panel data for 193 EU-15 regions from 1980 to 2005. We first estimate the model using conventional pooled panel data estimators, based on data at five-year intervals, allowing at most intercepts to differ across regions. Then we relax the restriction of homogeneous slope coefficients by estimating separate time-series models for each region based on annual data, using Pesaran and Smith's (1995) mean group estimator. To account for spatial dependence, we employ the common correlated effects approach of Pesaran (2006). Our empirical analysis indicates important differences across regions in the speed of adjustment to region-specific long-run paths for the level of income per capita. Allowing for heterogeneous coefficients doubles the speed of adjustment to 22% per year on average compared to the homogenous case, which suggests downward bias in the latter. We also find a positive and significant effect of the rate of investment, although the implied capital elasticity and the estimated long-run effect of investment are smaller than expected

Regional Convergence in Europe: A Dynamic Heterogeneous Panel Approach

This paper studies the effects of allowing for heterogeneous slope coefficients in the Mankiw, Romer and Weil (1992) model, based on panel data for 193 EU-15 regions from 1980 to 2005. We first estimate the model using conventional pooled panel data estimators, based on data at five-year intervals, allowing at most intercepts to differ across regions. Then we relax the restriction of homogeneous slope coefficients by estimating separate time-series models for each region based on annual data, using Pesaran and Smith's (1995) mean group estimator. To account for spatial dependence, we employ the common correlated effects approach of Pesaran (2006). Our empirical analysis indicates important differences across regions in the speed of adjustment to region-specific long-run paths for the level of income per capita. Allowing for heterogeneous coefficients doubles the speed of adjustment to 22% per year on average compared to the homogenous case, which suggests downward bias in the latter. We also find a positive and significant effect of the rate of investment, although the implied capital elasticity and the estimated long-run effect of investment are smaller than expected

Immer nur die zweitbeste Lösung? Protokolle als Dokumentationsmethode für qualitative Interviews

In der methodischen Literatur zu qualitativen Interviews wird als Standardverfahren oft die Aufzeichnung mit einem Aufnahmegerät und anschließende wortgetreue Verschriftlichung (Transkription) empfohlen. Protokolle werden als Mittel der Interviewdokumentation zumeist als zweitbeste Lösung für den Fall dargestellt, dass Mitschnitte nicht möglich sind. Diese Position stellen wir in diesem Beitrag aufgrund theoretischer Überlegungen und empirischer Erfahrungen infrage. Vor- und Nachteile der Dokumentationsformen "Audiomitschnitt + Transkription" und "Notizen + Protokollierung" werden systematisch gegenübergestellt. Anschließend wird anhand von zwei Studien exemplarisch verdeutlicht, dass die Protokollierung die beste Lösung zur Dokumentation der Interviewdaten sein kann. In beiden Studien wurden in Interviews sensible Themen behandelt und die Erhebung grundlegender Informationen über Prozesse und Routinen bezweckt.Grundsätzlich kann Protokollierung angezeigt sein, wenn weniger die Interpretation des Gesagten als vielmehr dessen Intention im Fokus der Forschung ist. Außerdem sollte eine Protokollierung erwogen werden, wenn eine Aufnahme besonders interessante InterviewpartnerInnen von der Teilnahme abhalten oder ein offenes Gespräch verhindern könnte.Mit diesem Beitrag wollen wir zu einer Auseinandersetzung darüber anregen, wann Protokollieren angemessen ist und wie es methodisch angelegt sein sollte.Qualitative interviews should be audio recorded and transcribed word by word. This is what most methodology texts recommend. Taking interview reports as a means of interview documentation is typically described as a second-best solution if audio recording is not possible. In this contribution, we question this position on the basis of theoretical considerations and research experiences.Advantages and disadvantages of "audio recording + transcription" versus "minute-taking + reporting" are systematically compared. Two studies are presented as exemplary cases in which interview reports have been chosen as the most suitable means of interview documentation. In both studies, interviews dealt with sensitive topics and aimed at reconstructing routines and procedures.Generally, reports can be adequate when researchers are less interested in the interpretation of what was exactly said and more interested in what interviewees intended to say. In addition, minute-taking should be considered if audio recording could prevent the participation of particularly interesting interviewees or if it could prevent an open conversation. With this contribution, we aim at stimulating further debate about when interview reports are appropriate and how they should be designed

Haploinsufficiency for BRCA1 is associated with normal levels of DNA nucleotide excision repair in breast tissue and blood lymphocytes

BACKGROUND: Screening mammography has had a positive impact on breast cancer mortality but cannot detect all breast tumors. In a small study, we confirmed that low power magnetic resonance imaging (MRI) could identify mammographically undetectable tumors by applying it to a high risk population. Tumors detected by this new technology could have unique etiologies and/or presentations, and may represent an increasing proportion of clinical practice as new screening methods are validated and applied A very important aspect of this etiology is genomic instability, which is associated with the loss of activity of the breast cancer-predisposing genes BRCA1 and BRCA2. In sporadic breast cancer, however, there is evidence for the involvement of a different pathway of DNA repair, nucleotide excision repair (NER), which remediates lesions that cause a distortion of the DNA helix, including DNA cross-links. CASE PRESENTATION: We describe a breast cancer patient with a mammographically undetectable stage I tumor identified in our MRI screening study. She was originally considered to be at high risk due to the familial occurrence of breast and other types of cancer, and after diagnosis was confirmed as a carrier of a Q1200X mutation in the BRCA1 gene. In vitro analysis of her normal breast tissue showed no differences in growth rate or differentiation potential from disease-free controls. Analysis of cultured blood lymphocyte and breast epithelial cell samples with the unscheduled DNA synthesis assay (UDS) revealed no deficiency in nucleotide excision repair (NER). CONCLUSION: As new breast cancer screening methods become available and cost effective, patients such as this one will constitute an increasing proportion of the incident population, so it is important to determine whether they differ from current patients in any clinically important ways. Despite her status as a BRCA1 mutation carrier, and her mammographically dense breast tissue, we did not find increased cell proliferation or deficient differentiation potential in her breast epithelial cells, which might have contributed to her cancer susceptibility. Although NER deficiency has been demonstrated repeatedly in blood samples from sporadic breast cancer patients, analysis of blood cultured lymphocytes and breast epithelial cells for this patient proves definitively that heterozygosity for inactivation of BRCA1 does not intrinsically confer this type of genetic instability. These data suggest that the mechanism of genomic instability driving the carcinogenic process may be fundamentally different in hereditary and sporadic breast cancer, resulting in different genotoxic susceptibilities, oncogene mutations, and a different molecular pathogenesis

Platelets drive fibronectin fibrillogenesis using integrin αIIbβ3

Platelets interact with multiple adhesion proteins during thrombogenesis, yet little is known about their ability to assemble fibronectin matrix. In vitro three-dimensional superresolution microscopy complemented by biophysical and biochemical methods revealed fundamental insights into how platelet contractility drives fibronectin fibrillogenesis. Platelets adhering to thrombus proteins (fibronectin and fibrin) versus basement membrane components (laminin and collagen IV) pull fibronectin fibrils along their apical membrane versus underneath their basal membrane, respectively. In contrast to other cell types, platelets assemble fibronectin nanofibrils using αIIbβ3 rather than α5β1 integrins. Apical fibrillogenesis correlated with a stronger activation of integrin-linked kinase, higher platelet traction forces, and a larger tension in fibrillar-like adhesions compared to basal fibrillogenesis. Our findings have potential implications for how mechanical thrombus integrity might be maintained during remodeling and vascular repair

Immune Regulatory 1 Cells: A Novel and Potent Subset of Human T Regulatory Cells

A subset of T regulatory cells (Tregs), identified by TIRC7 (T cell immune response cDNA 7) expression is designated as Immune Regulatory 1 Cells (IR1 cells). TIRC7 is an immune checkpoint inhibitor, co-localized with the T- cell receptor, HLA-DR and CTLA-4 during T-cell activation, which delivers regulatory signals via binding to its ligand, HLA-DR α2 domain. IR1 cells express FOXP3, and multiple other markers associated with immune suppression. They constitute as much as 10% of Tregs. IR1 cells strongly inhibit proliferation in mixed lymphocyte reactions, where they express high levels of IL-10. Ex vivo expansion of Tregs over 2 weeks in the presence of an agonist TIRC7 antibody disproportionately expands the IR1 Treg subset, while maintaining high expression of suppressive markers including CD39, IL-10, LAP and GARP. Ex vivo expanded IR1 cells are a potent, homogeneous, stable set of suppressor Tregs with the potential to modulate immune dysregulation. The characteristics of IR1 cells suggest a therapeutic advantage over polyclonal Tregs for therapeutic interventions. Early restoration of immune homeostasis using IR1 cells has the potential to fundamentally alter the natural history of conditions characterized by abnormalities in the T regulatory cell compartment

Sammanställning av artikelserien: Utemiljöns förvaltning och governance

Ämnesgruppen Landskapets governance och förvaltning är en del av SLU Landskap i Alnarp. Vi arbetar med att öka kunskapen om utemiljöförvaltning genom forskning, undervisning och samarbeten. Vår expertis berör till stor del professionell förvaltning av utemiljöer. Detta särtryck från artikelserien och boken det baseras på är resultatet av flera års strategiskt arbete för att stärka och lyfta kunskapen om utemiljöförvaltning inom forskning, utbildning och praktik. Artikelserien ger en överblick över den kunskap om förvaltning och governance av utemiljöer som vi utvecklar i gruppen