The Transition to Open Access: The State of the Market, Offsetting Deals, and a Demonstrated Model for Fair Open Access with the Open Library of Humanities

In this article, we explore the state of the OA market and the current situation with respect to offsetting deals in the Netherlands. We then offer a case study of the LingOA model for a transition to open access, backed by a consortial funding mechanism: the Open Library of Humanities (OLH). We also suggest how this approach can be extended into new disciplinary spaces (in particular, mathematics and psychology, where there is already some willingness from editors)

Zephyr bioharness in de praktijk

Een te hoge fysieke belasting bij (top)sporters en brandweerpersoneel kan op de lange termijn leiden tot overbelasting. In het revalidatie proces kan het de terugkeer naar het veld vertragen. Daarom is het nauwkeurig monitoren van de fysieke belasting erg belangrijk. Het Zephyr BioHarness lijkt hiervoor een geschikt instrument omdat het in staat is om verschillende fysiologische variabelen tegelijkertijd te meten. In dit rapport worden vier projecten besproken waarin de fysieke belasting gemeten is met het Zephyr BioHarness: (I) effect van veldgrootte op de belasting bij jonge talentvolle voetballers van FC Groningen, (II) overeenkomsten in belasting tussen oefeningen/sporten en uitrukken bij de professionele brandweer, (III) overeenkomsten tussen geplande belasting van fysiotherapeuten met daadwerkelijk belasting bij veldrevalidatie na een blessure (IV) validatie van Zensorium Tinké

Enantioselective Conjugate Addition of Diethylzinc to Chalcones Catalysed by Chiral Ni(II) Aminoalcohol Complexes

Conjugate addition of diethylzinc to chalcones is catalysed by complexes prepared in situ from Ni(acac)2 and cis-exo-N,N-dialkyl-3-aminoisoborneols or (+)-cis-endo-N,N-dimethyl-3-aminoborneol ((+)-DAB) (13b). The products are obtained with enantioselectivities up to 84 %. When scalemic (-)-cis-exo-N,N-dimethyl-3-aminoisoborneol ((-)-DAIB) (3c) was employed in the reaction a positive nonlinear relationship was found. Several factors which govern catalyst activity and enantioselectivity have been investigated

Ruthenium Complexes with PNN Pincer Ligands Based on (Chiral) Pyrrolidines:Synthesis, Structure, and Dynamic Stereochemistry

We report the synthesis of lutidine-based PNN type metal pincer complexes, using achiral (pyrrolidine) as well as chiral ((R,R)-2,5-dimethylpyrrolidine and (R)-2-methylpyrrolidine) substituents at the N side arm of the pincer ligand. With the six-coordinate saturated Ru pincers (PNN)Ru(H)(CO)(Cl), which have an aromatic pyridine ligand backbone, as the starting materials, treatment with strong base (KOtBu) generated the corresponding dearomatized pincer complexes (PNN′)Ru(H)(CO). Spectroscopic, crystallographic, and computational studies demonstrate that the C-centered chirality from the chiral pyrrolidine group exerts a small but non-negligible influence on the preferred stereochemistry at Ru (and N in the case of (R)-2-methylpyrrolidine) that is reflected in the equilibrium distribution of diastereomers of these Ru complexes in solution. Our data show that the N- and Ru-based stereogenic centers in this class of compounds are stereochemically labile and the mechanisms for epimerization are discussed. Inversion at the Ru center in the dearomatized complexes is proposed to occur via a rearomatized Ru(0) intermediate in which the Ru-bound hydride is transferred to the ligand. Support for this comes from the spectroscopic characterization of a closely related Ru(0) species that is obtained by reaction with CO. Testing these catalysts in enantioselective oxa-Michael addition or transfer hydrogenation led to racemic products, while a low ee (8%) was observed in the hydrogenation of 4-fluoroacetophenone. The lack of appreciable enantioinduction with these catalysts is ascribed to the kinetic lability of the Ru stereocenter, which results in the formation of equilibrium mixtures in which several diastereomers of the catalyst are present.</p

Entrepreneurship in the Netherlands; SMEs and International co-operation

This is the seventh edition of the series 'Entrepreneurship in the Netherlands'. The series started in 1997 and is a joint publication of the Netherlands Ministry of Economic Affairs and EIM Business & Policy Research. This edition deals with international cooperation of SMEs. The first Chapter by EIM describes characteristics of international cooperation: why, how and with what type of effects? Thereafter staff members of the Ministry sketch the aims and the ambition of policy instruments in the field. As practical illustrations three enterprises haven been portrayed. In addition to authors from EIM and the Ministry of Economic Affairs, three staff members working on internationalisation and entrepreneurship at the Nottingham University Business school in UK, reflect on the issues covered in this publication by presenting and commenting on ten myths that surround the internationalisation of smaller private firms.

Consistent paths towards a stable and resilient European economy

Management summary of the report 'Consistent paths towards a stable and resilient European economy'