Herbex-kid Inhibits Immediate Hypersensitivity Reactions in Mice and Rats

Herbex-kid (HK), a polyherbal formulation was evaluated in various experimental allergic models of Type I hypersensitivity reactions. Compound 48/80 (C 48/80) has been shown to induce rat mesentery mast cell degranulation and HK (1.07, 10.75 and 107.5 mg ml−1) inhibited the mast cell degranulation in a dose dependent manner. HK (1.07, 10.75 and 107.5 mg kg−1; p.o.) showed dose-dependent protection against C 48/80 induced systemic anaphylaxis in male Balb/C mice. In active anaphylaxis model, male Wistar rats orally administered with 10.75 and 107.5 mg kg−1 of HK showed significant (P < 0.01) protection against mast cell degranulation, while in passive anaphylaxis model, only at 107.5 mg kg−1 showed significant (P < 0.01) reduction in mast cell degranulation. HK at all dose levels was able to significantly decrease the time spent in nasal rubbing in Wistar rats sensitized to ovalbumin, while only at 107.5 mg kg−1 it showed significant (P < 0.01) reduction in number of sneezes. In C 48/80-induced skin itch model, all dose levels of HK significantly (P < 0.001) decreased the time spent in itching and the number of itches. HK did not produce any significant inhibition in histamine induced contraction in guinea pig ileum. From the above findings we conclude that the HK possesses antiallergic activity mediated by reducing of the release mediators from mast cells and also by 5-HT antagonism without the involvement of histamine (H1) receptors

Ages and metallicities of circumnuclear star formation regions from Gemini IFU observations

Aims: We derive the age and metallicity of circumnuclear star formation regions (CNSFRs) located in the spiral galaxies NGC6951 and NGC1097, and investigate the cause of the very low equivalent widths of emission lines found for these regions. Methods: We used optical two-dimensional spectroscopic data obtained with Gemini GMOS-IFUs and a grid of photoionization models to derive the the metallicities and ages of CNSFRs. Results: We find star formation rates in the range 0.002-0.14 Msun/yr and oxygen abundance of 12+log(O/H)~8.8 dex, similar to those of most metal-rich nebulae located in the inner region of galactic disks. Conclusions: We conclude that the very low emission-line equivalent widths observed in CNSFRs are caused by the ``contamination'' of the continuum by (1) contribution of the underlying bulge continuum combined with (2) contribution from previous episodes of star formation at the CNSFRs.Comment: Accepted for publication in Astronomy and Astrophysic