The political career of Henry, third Earl Grey ( 1826 - 52 )

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Optimizing the Delivery of a GFP Gene via a Biocompatible Nanocarrier in Daphnia and a Chironomid

Current pest control methods impose risks including pest resistance to insecticides, bioaccumulation of the insecticide, and ecosystem impact. There is a need for a better and more sustainable method of pest control in order to protect the environment and the populations reliant on it. Currently, an alternative method of pest control uses RNA interference (RNAi), that exploits heterologous protein expression to disable the insect pest, delivered by the use of nanoparticles. Nanocarriers show great promise in this method of use, but concerns of cytotoxicity, biodegradability, and transfer to off target organisms require careful consideration. This study focuses on optimizing a biocompatible nanoparticle-mediated gene delivery system in a chironomid species and Daphnia spp. (Daphnia) to induce transient GFP expression. A weak GFP expression was detected in the head and thoracic regions of Daphnia, but additional trials with a few changes in protocol are expected to yield more conclusive results. The successful expression of GFP would provide insight on the molecular mechanisms and interactions involved in nanoparticle-mediated gene delivery, as well as broaden understanding of a biocompatible nanocarrier’s use with insect

Cost comparison of asthma treatments in 12-week study : caution about matching and short observational follow-up

This review was funded by Observational and Pragmatic Research Institute Pte Ltd.Peer reviewedPublisher PD

Adapting vat dye as an alternate dyeing agent for vegetable tanned leather

The research explores the use of vat dye, a selected dye that is available locally in the Ghanaian market in large quantities, with varied colour ranges to identify their suitability as effective colourants on vegetable tanned leather. Four different experiments were performed with vat dye, and two others were tried with suede dye. In the first experiment, a more familiar technique ofapplying vat dye on fabric was used; this resulted in the burning of the exposed areas of the leather. For the second experiment, a new formula was composed and applied. This experiment was subdivided into three parts where various techniques for applying dyes were used. It proved successful, thus indicating that, with proper formulation, vat dye and its accompanying agents could perform effectively on protein fibre in leatherwork, just as it does on cellulose fibre in textiles

Rework causes classification model with liable parties of the contract in construction projects

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Bringing Salary Transparency to the World: Computing Robust Compensation Insights via LinkedIn Salary

The recently launched LinkedIn Salary product has been designed with the goal of providing compensation insights to the world's professionals and thereby helping them optimize their earning potential. We describe the overall design and architecture of the statistical modeling system underlying this product. We focus on the unique data mining challenges while designing and implementing the system, and describe the modeling components such as Bayesian hierarchical smoothing that help to compute and present robust compensation insights to users. We report on extensive evaluation with nearly one year of de-identified compensation data collected from over one million LinkedIn users, thereby demonstrating the efficacy of the statistical models. We also highlight the lessons learned through the deployment of our system at LinkedIn.Comment: Conference information: ACM International Conference on Information and Knowledge Management (CIKM 2017

Moving beyond a limited follow-up in cost-effectiveness analyses of behavioral interventions

Background Cost-effectiveness analyses of behavioral interventions typically use a dichotomous outcome criterion. However, achieving behavioral change is a complex process involving several steps towards a change in behavior. Delayed effects may occur after an intervention period ends, which can lead to underestimation of these interventions. To account for such delayed effects, intermediate outcomes of behavioral change may be used in cost-effectiveness analyses. The aim of this study is to model cognitive parameters of behavioral change into a cost-effectiveness model of a behavioral intervention. Methods The cost-effectiveness analysis (CEA) of an existing dataset from an RCT in which an high-intensity smoking cessation intervention was compared with a medium-intensity intervention, was re-analyzed by modeling the stages of change of the Transtheoretical Model of behavioral change. Probabilities were obtained from the dataset and literature and a sensitivity analysis was performed. Results In the original CEA over the first 12 months, the high-intensity intervention dominated in approximately 58% of the cases. After modeling the cognitive parameters to a future 2nd year of follow-up, this was the case in approximately 79%. Conclusion This study showed that modeling of future behavioral change in CEA of a behavioral intervention further strengthened the results of the standard CEA. Ultimately, modeling future behavioral change could have important consequences for health policy development in general and the adoption of behavioral interventions in particular

Growth, Structural and Micro hardness studies of KSbF4 and K2SbF5 crystals

Interest in Potassium Fluoro Antimonate crystals has been increased for the last four decades due its superionic conduction and its unusual electro-optic properties. Potassium tetra fluoro antimonate (KSbF4) and Potassium penta fluoro antimonite (K2SbF5) crystals have been grown by slow evaporation method. KSbF4 crystallizes into orthorhombic structure with a space group Pmmn. K2SbF5 belongs to orthorhombic crystal system with a space group Cmcm.nbsp Micro indentation analysis on these crystals indicates that they are moderately softer substances. Both crystals revealed reverse indentation size effect (RISE). Variation of stiffness constant with load has been discussed. Yield strength for KSbF4 and K2SbF5 crystals have been found out as 16.72 and 16.941 MPa respectively.nbs