A Regional assessment on the influence of climate change on summer rainfall : an application to shallow landsliding in Wanzhou County, China

This study looks into the future of evolving triggering rainfall conditions in a changing climate, and aims to establish a link to tools in the present to assess shallow landslide susceptibility. Focus is given to the triggering rainfall conditions represented by extreme daily rainfall and mean seasonal rainfall. The study site selected in this research was Wanzhou County, China. This county lies in a region of China that receives 90% of its annual rainfall during the summer months. The effect of which is observed with 80% of shallow landslides occurring between June to August from 1995-2005. This research project delivered proof-of-concept for a methodological framework to derive shallow landslide triggering rainfall scenarios from climate model outputs. The presentation of the results and the identification of sources of uncertainties in this study demonstrated a viable link between for climate change projections to provide future rainfall scenarios as inputs for physically-based shallow landslide susceptibility models

HPG pore: an efficient and scalable framework for nanopore sequencing data.

BACKGROUND: The use of nanopore technologies is expected to spread in the future because they are portable and can sequence long fragments of DNA molecules without prior amplification. The first nanopore sequencer available, the MinION™ from Oxford Nanopore Technologies, is a USB-connected, portable device that allows real-time DNA analysis. In addition, other new instruments are expected to be released soon, which promise to outperform the current short-read technologies in terms of throughput. Despite the flood of data expected from this technology, the data analysis solutions currently available are only designed to manage small projects and are not scalable. RESULTS: Here we present HPG Pore, a toolkit for exploring and analysing nanopore sequencing data. HPG Pore can run on both individual computers and in the Hadoop distributed computing framework, which allows easy scale-up to manage the large amounts of data expected to result from extensive use of nanopore technologies in the future. CONCLUSIONS: HPG Pore allows for virtually unlimited sequencing data scalability, thus guaranteeing its continued management in near future scenarios. HPG Pore is available in GitHub at http://github.com/opencb/hpg-pore

De linguis orientalibus [Texto impreso] : deque re antiquitatis litteraria theses atque exercitationes

Sign. : []3, A-B4, C

Food Safety Management in a Global Environment: The Role of Risk Assessment Models

Quantitative risk assessment models are playing a minor role in the development of the new EU legal framework for food safety. There is a tendency of the EU institutions to apply the precautionary principle versus the predisposition of the USA institutions to rely on risk analysis. This paper provides a comparison of the role played by quantitative risk assessment models in the development of new policies on food safety in the EU and in the USA, focusing on a study case: the supply chain of shell eggs. We suggest that EU regulatory bodies should reconsider the role that quantitative risk assessment models have to play in order to design more effective food safety management systems.Food safety policy, food safety assurance, risk analysis, risk assessment, precautionary principle, Food Consumption/Nutrition/Food Safety,

Panegirico de la insigne Virgen Santa Catarina martir [Texto impreso] : predicado en su Real Parroquia de Valencia el día 25 de Noviembre de 1770

Índices: Partes del texto en latínSign. : A-C4, D3Viñeta xil. en port.Letra inicial decorada y friso tip. en p. 7Notas a pie de pág. y reclamo

Sistema de dirección monoplaza formula student

Treball final de Grau en Enginyeria Mecànica. Codi: EM1047. Curs acadèmic 2016/201

Cultivo de los microorganismos nativos en la reducción del contenido de bifenilos policlorados (PCBS) en el suelo de la subestación eléctrica de Puente Piedra

La investigación realizada tiene como objetivo principal reducir la concentración de Bifenilo policlorado (PCBs) en los suelos, mediante el uso de bacterias nativas en el tratamiento de biorremediacion del suelos, y así poder cumplir el Estándar de Calidad Ambiental. (ECA), para suelos agrícola. Para el desarrollo, se realizaron reactor Airlift A partir de botella de plástico de gaseosas de 3 L. se le hace un agujero de 1 cm de diámetro (en la base, a un costado) por este agujero ingresará una manguera de pecera para bombearle aire. De otro frasco se le cortara la base hasta una altura de 10 cm aproximadamente para asentar el birreactor sobre este. Luego se realiza el cultivo de las bacterias en el reactor utilizando dos tipos de suelos suelo agrícola y suelo contaminado con Bifenilo Policlorados (PCB), el siguiente paso es realizar una disolución sucesiva para poder caracterizar a las bacterias que se adecuan al Bifenilo Policlorados (PCB) para proceder a realizar la biorremediacion al suelo con las bacterias y poder analizar los reducción de Bifenilo Policlorados (PCB) La concentración inicial de Bifenilo policlorados (PCB) presente en el suelo de puente piedra (16.12 mg/Kg) con esto resultado excede los Estándares de Calidad Ambiental (ECA). Como resultado final se encontró que los microorganismos nativo degradan los bifenilo coliclorados (PCBs) en un 40.45 % siendo una alternativa viable y factible

Immunotherapies against HER2-Positive Breast Cancer

Immunotherapy; Resistance; VaccinesImmunoteràpia; Resistència; VacunesInmunoterapia; Resistencia; VacunasBreast cancer is the leading cause of cancer-related deaths among women worldwide. HER2-positive breast cancer, which represents 15–20% of all cases, is characterized by the overexpression of the HER2 receptor. Despite the variety of treatments available for HER2-positive breast cancer, both targeted and untargeted, many patients do not respond to therapy and relapse and eventually metastasize, with a poor prognosis. Immunotherapeutic approaches aim to enhance the antitumor immune response to prevent tumor relapse and metastasis. Several immunotherapies have been approved for solid tumors, but their utility for HER2-positive breast cancer has yet to be confirmed. In this review, we examine the different immunotherapeutic strategies being tested in HER2-positive breast cancer, from long-studied cancer vaccines to immune checkpoint blockade, which targets immune checkpoints in both T cells and tumor cells, as well as the promising adoptive cell therapy in various forms. We discuss how some of these new approaches may contribute to the prevention of tumor progression and be used after standard-of-care therapies for resistant HER2-positive breast tumors, highlighting the benefits and drawbacks of each. We conclude that immunotherapy holds great promise for the treatment of HER2-positive tumors, with the potential to completely eradicate tumor cells and prevent the progression of the disease.This research was funded by Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III

Corrigendum: Patrones psicofisiológicos relacionados con el éxito en un curso de selección de operaciones especiales

In the original article, the reference for “El-On et al., 2003” was incorrectly written as “El-On, J., Ben-Noun, L., Galitza, Z., and Ohana, N. (2003). Case report: clinical and serological evaluation of echinococcosis of the spine. Trans. R. Soc. Trop. Med. Hyg. 97, 567–569. doi: 10.1016/S0035-9203(03)80031-7.” It should be “Kato, T. (2012). Development of the coping flexibility scale: evidence for the coping flexibility hypothesis. J. Couns. Psychol. 59, 262–273. doi: 10.1037/a0027770.” The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. CopyrightEn el artículo original, la referencia a “El-On et al., 2003” estaba escrita incorrectamente como “El-On, J., Ben-Noun, L., Galitza, Z. y Ohana, N. (2003) . Reporte de caso: evaluación clínica y serológica de equinococosis de columna. Trans. R. Soc. Trop. Medicina. Hig. 97, 567–569. doi: 10.1016 / S0035-9203 (03) 80031-7 ”. Debería ser “Kato, T. (2012). Desarrollo de la escala de flexibilidad de afrontamiento: evidencia de la hipótesis de flexibilidad de afrontamiento. J. Couns. Psychol. 59, 262-273. doi: 10.1037 / a0027770 ". Los autores se disculpan por este error y afirman que esto no cambia las conclusiones científicas del artículo de ninguna manera. El artículo original ha sido actualizado. Derechos de auto