Bioactivity of the specie Annona coriacea: A systematic review / Bioatividade da espécie Annona coriacea: Uma revisão sistemática

The araticum (Annona coriacea Mart.) is a tree of the Annonaceae family with great distribution in the northern Cerrados of the State of Piauí. Several species of this family have medicinal use and demonstrate some biological activities that have already been experimentally proven such as antihelmintic, antimalarial, antimicrobial, antinociceptive, antiprotozoal, insecticidal, parasiticidal and antioxidant activities due to the presence of acetogenins. The objective of this study was to carry out a scientific and technological prospection of the Annona coriacea plant related totickcidal activity. The scientific bases used were; PubMed, ScienceDirect and Web of Science and the technological databases include; EPO, WIPO, USPTO, DII, LATIPAT and INPI, with the following keywords: Annona coriacea, Annona coriacea and tickcidal, Annona coriacea and acaricide and Annona coriacea and biocide, all articles published in the last decade and without temporal cut for patent registration being counted. We found 156 articles and 17 patents, most of them dealing with medicinal use and chemical composition of the plant. The study showed that there is interest in the plant studied, but there is a wide field to carryout studies on technological innovation and development of new products, as in the area of tickcidal products

Educomunicação, Transformação Social e Desenvolvimento Sustentável

Esta publicação apresenta os principais trabalhos dos GTs do II Congresso Internacional de Comunicação e Educação nos temas Transformação social, com os artigos que abordam principalmente Educomunicação e/ou Mídia-Educação, no contexto de políticas de diversidade, inclusão e equidade; e, em Desenvolvimento Sustentável os artigos que abordam os avanços da relação comunicação/educação no contexto da educação ambiental e desenvolvimento sustentável

Notas de vocabulários indígenas do Niassa e da Zambézia (Moçambique)

É separata de: XIII Congresso Luso-espanhol para o Progresso das Ciéncias, t. V, 4ª Secção, Ciencias NaturaisÉ separata de: XIII Congresso Luso-espanhol para o Progresso das Ciéncias. 4ª Secção, Ciencias naturais. T. VDatas estimadas por outras separatas de Santos Júnior do mismo congres

Uma história de conceitos na saúde pública: integralidade, coordenação, descentralização, regionalização e universalidade A history of public health concepts: integrity, coordination, decentralization, regionalization, and universality

O Sistema Único de Saúde conferiu visibilidade a uma série de conceitos próprios da organização de sistemas de saúde. Entre eles a integralidade, que delimita fronteiras comuns com quase todos os demais princípios do Sistema, tem sido objeto de ampla literatura no Brasil. Com base em extensa revisão de fontes primárias e secundárias, este artigo apresenta uma recuperação histórica dos conceitos de integralidade, descentralização, regionalização e universalidade - ideias e conceitos que em grande parte se conformam e se interligam no ideário da organização dos serviços sanitários pelo modelo dos Centros de Saúde distritais.<br>Brazil's Unified Health System (Sistema Único de Saúde) has highlighted a series of concepts specific to the organization of healthcare systems. Among these, integrity - which shares boundaries with almost all other System principles - has been the object of much academic production in Brazil. Based on an extensive review of primary and secondary sources, the article offers a historical recovery of the concepts of integrity, decentralization, regionalization, and universality - ideas and concepts that in good measure are shaped by and interlinked with the set of ideals of the organization of sanitary services according to the district health centers model

Production and Characterization of a β-Cyclodextrin Inclusion Complex with <i>Platonia insignis</i> Seed Extract as a Proposal for a Gastroprotective System

Platonia insignis Mart, Clusiaceae, known as bacuri, is a species native to Brazil that, in studies with extract of the seed of its fruit, showed antioxidant activity against free radicals. Products with such properties may be of great importance in the treatment of peptic ulcers since this pathology may be associated with the inflammatory process caused by the action of free radicals. Cyclodextrins are molecules capable of forming inclusion complexes with other molecules, affecting their physicochemical properties and improving their pharmacokinetic characteristics. Thus, this work aimed to produce, characterize, and evaluate the gastroprotective effect of the inclusion complex of β-cyclodextrin (β-CD) with the bacuri seeds hexanic extract (BSHE). In the characterization of the inclusion complex, an apparent stability constant (Kc) of 416 mol/L was obtained in the solubility study; the BSHE:β-CD m/m (g) complexation ratios at 1:9, 2:8, and 3:7 were 5.51%, 21.46%, and 20.11%, respectively. The formation of the BSHE:β-CD inclusion complex was observed by FTIR technique, indicating the disappearance of bands characteristic of BSHE (2960 cm−1 and 1755 cm−1) when in the complex, compared to the spectra of pure BSHE or in physical mixture with β-CD, and by X-ray diffraction, which indicated a loss of crystallinity, typical signals of pure β-CD, and presentation of intense amorphization, characteristic of BSHE, incorporated in the β-CD pockets. In the evaluation of gastroprotective activity, through absolute ethanol-induced gastric lesions in mice, both BSHE and BSHE:β-CD reduced gastric lesions, with 100 mg/kg dose of the complex having the greatest gastroprotective effect. BSHE:β-CD was also able to reduce gastric lesions from ischemia and reperfusion, with the 50 mg/kg dose being the most effective. BSHE:β-CD, also at this dose, reduced the MDA levels of the gastric mucosa, indicating a possible antioxidant activity in its gastroprotective effect. Thus, it was concluded that inclusion complex formation between β-CD and BSHE is possible, and that this formulation enhanced the gastric protective activity