Tocopherols, Phycocyanin and Superoxide Dismutase from Microalgae: as Potential Food Antioxidants

 Background and Objective: Microalgae are photosynthetic organisms that are in contact with several reactive oxygen species, and under these conditions microalgae produce a wide variety of antioxidant compounds to protect from highly oxidant growth conditions, these facts can be used to optimize antioxidant production, however, firstly studies of antioxidant production by microalgae should be done. This work was focused to establish differences of antioxidants formation among microalgae species and elucidate some antioxidant properties of phycocyanin.Material and Methods: Superoxide dismutase activity was performed by using a commercial kit and determined by spectrophotometry. Phycocyanin and carotenoids were quantified by spectrophotometry and tocopherols were analysed by high pressure liquid chromatography with a fluorescence detector. Trolox equivalent antioxidant activity was determined by using 2,2´-azinobis (3-ethylbenzothiazoline-6-sulphonic) reagent, scavenging and synergic antioxidant activities were also ascertained.Results and Conclusion: The microalgae used in this study produces different amounts of superoxide dismutase, carotenoids, α, δ and γ-tocopherols, and phycocyanin. Trolox equivalent antioxidant activity varied according with the amount of antioxidants produced. Phycocyanin scavenge superoxide and hydrogen peroxide radicals work well to produce synergy with α-tocopherol, increasing protection of biomolecules against oxidation. One microalgae specie may be selected to produce one of the antioxidants mentioned above, but more detailed studies on growth phases are required to improve the antioxidant production. Microalgae has the potential to be considered as a natural antioxidants source.Conflict of interest: The authors declare no conflict of interest

Hernia incisional eviscerada: A propósito de un caso

Fundamento: La hernia incisional es una complicación frecuente de la cirugía abdominal, se presenta entre el 2 al 20 % de los pacientes laparotomizados. Entre sus complicaciones se describen la incarceración aguda, el atascamiento y la estrangulación. Objetivo: Describir el caso inusual de una paciente portadora de hernia incisional eviscerada. Reporte de caso: Anciana de 78 años, diabética tipo II, con vitíligo, hipertensión arterial controlada, presentó además hernia incisional voluminosa recidivada, la cual sufrió ruptura espontánea de pared y piel con evisceración. Fue tratada mediante hernioplastia con prótesis preperitoneal de polipropileno y cierre aponeurótico parcial. A los tres años de seguimiento posoperatorio los resultados fueron excelentes. Conclusiones: Es inusual esta complicación y se comparó con reportes similares que justifican y avalan la conducta asumida. La ruptura espontánea de la cubierta y piel de una hernia incisional recidivada y su evisceración a través del defecto es infrecuente, se le realizó hernioplastia protésica preperitoneal con favorables resultados posoperatorios. DeCS: HERNIA INCISIONAL; HERNIA ABDOMINAL/cirugía; EXENTERACIÓN PÉLVICA. Palabras clave: Hernia incisional; hernia abdominal y cirugía; exenteración pélvica; hernioplastia preperitoneal protésica. ABSTRACT Background: The incisional hernia is a frequent complication of the abdominal surgery; it is presented between the 2 to 20 % of the patients with laparotomy. Among their complications they are described: Incarcerated hernia, blockage or obstruction and strangulation. Objective: To describe the unusual case of a patient carrier with an incisional hernia with evisceration. Case report: A 78 years old, aged woman, type II diabetic, with vitiligo, controlled hypertension , carrier of incisional hernia too, voluminous, recurrent, which suffered spontaneous rupture of wall and skin, with evisceration. She was treated by hernioplasty with a polypropylene preperitoneal prosthesis and partial aponeurotic closure. At three years post-operative follow-up the results were excellent. Conclusions: It is an unusual complication that is compared with similar reports that justify and support the assumed behavior. The spontaneous rupture of the cover and skin of a recurrent incisional hernia and its evisceration through the defect are uncommon, preperitoneal hernioplasty prosthesis with favorable postoperative results was performed. DeCS: INCISIONAL HERNIA; HERNIA, ABDOMINAL/surgery; PELVIC EXENTERATION. Keywords: Incisional hernia; hernia, abdominal and surgery; pelvic exenteration; preperitoneal prosthesis hernioplasty

Hydrogenation of an iridium-coordinated imidazol-2-ylidene ligand fragment

An iridium complex featuring a metalated lutidine-derived CNP ligand reacts with KOt Bu to yield a dimeric species with the two metal centers bound to the opposite ligands through the CHN arms. Furthermore, reaction with H2 in the presence of KOt Bu of the same iridium derivative results in the hydrogenation of the –CHQCH– imidazolylidene moiety of the complex. NMR spectroscopy monitoring of the latter reaction supports the initial formation of a dihydride iridium complex containing an imidazolylidene ligand fragment that is hydrogenated after prolonged reaction time.Ministerio de Economía y Competitividad de España (MINECO) y fondos FEDER de la Unión Europea-CTQ2015-69568-P, CTQ2016-80814-R y CTQ2016- 81797-RED

RF Acquisition System Based on μTCA for Testing of High-Gradient Acceleration Cavities

The radio frequency (RF) laboratory hosted in the Corpuscular Physics Institute (IFIC) of the University of Valencia is designed to house a high-power and high-repetition-rate facility to test normal conduction RF accelerator cavities in the S-Band (2.9985 GHz) in order to perform R&D activities related to particle accelerator cavities. The system, which manages the entire process of RF signal generation, data acquisition and closed-loop control of the laboratory, is currently based on a modular and compact PXI platform system. This contribution details the development of a platform with similar features, but which is based on open architecture standards at both the hardware and software level. For this purpose, a complete system based on the μTCA platform has been developed. This new system must be able to work with accelerator cavities at other operating frequencies, such as 750 MHz, as well as to explore different options at firmware and software levels based on open-source codes

Construcción de un diccionario didáctico digital para la mejora del aprendizaje del latín y estudio preliminar de su extensión a otras lenguas

Los objetivos de este proyecto son la creación de una versión digital, disponible en línea y en abierto, de un diccionario basado en un modelo inédito lexicográfico y cognitivo y el estudio preliminar de su generalización a otras lenguas. La eficacia didáctica del modelo de diccionario ha sido probada en este curso académico experimentalmente para la enseñanza presencial del latín utilizando una versión en papel. La idea es construir una versión digital para que el alumno pueda utilizarlo tanto para el trabajo en el aula como para el trabajo personal y estudiar si es viable su aplicación general al estudio de otras lenguas, especialmente de las lenguas modernas. El diccionario en formato digital proporcionaría, frente al papel, tres ventajas significativas: (1) aumentar su accesibilidad lo que facilitaría su uso en cualquier momento y lugar, (2) ayudar al alumno con dificultades a nivelarse puesto que podría usarlo para repetir los ejercicios de aprendizaje tantas veces como lo necesite, y, (3), servir de base para llevar a cabo acciones educativas basadas en la autoformación en línea que faciliten y fomenten el aprendizaje del latín en particular y de otras lenguas si el resultado del estudio preliminar es positivo respecto a su generalización

Evaluación científica de la eficacia del nuevo método cognitivo-constructivista de iniciación al aprendizaje de nuevas lenguas. Implantación y difusión de resultados

El objetivo general del proyecto es evaluar, corregir, implantar y difundir un modelo de espacio autoformativo virtual dedicado al aprendizaje de nuevas lenguas. En concreto este modelo se ha implementado en dos espacios formativos para dos lenguas diferentes: latín y alemán. Dichos espacios están localizados en: - Curso de iniciación al aprendizaje de latín: https://cv4.ucm.es/moodle/course/view.php?id=115039 - Curso de iniciación al aprendizaje de alemán: https://cv4.ucm.es/moodle/course/view.php?id=115038 Ambos cursos tienen como soporte sendos diccionarios didácticos digitales desde los que también son accesibles los cursos: - Diccionario Didáctico Digital de latín: http://repositorios.fdi.ucm.es/DiccionarioDidacticoLatin - Diccionario Didáctico Digital de alemán: http://repositorios.fdi.ucm.es/DiccionarioDidacticoAlema

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Actas de las V Jornadas ScienCity 2022. Fomento de la Cultura Científica, Tecnológica y de Innovación en Ciudades Inteligentes

ScienCity es una actividad que viene siendo continuada desde 2018 con el objetivo de dar a conocer los conocimientos y tecnologías emergentes siendo investigados en las universidades, informar de experiencias, servicios e iniciativas puestas ya en marcha por instituciones y empresas, llegar hasta decisores políticos que podrían crear sinergias, incentivar la creación de ideas y posibilidades de desarrollo conjuntas, implicar y provocar la participación ciudadana, así como gestar una red internacional multidisciplinar de investigadores que garantice la continuación de futuras ediciones. En 2022 se recibieron un total de 48 trabajos repartidos en 25 ponencias y 24 pósteres pertenecientes a 98 autores de 14 instituciones distintas de España, Portugal, Polonia y Países Bajos.Fundación Española para la Ciencia y la Tecnología-Ministerio de Ciencia, Innovación y Universidades; Consejería de la Presidencia, Administración Pública e Interior de la Junta de Andalucía; Estrategia de Política de Investigación y Transferencia de la Universidad de Huelva; Cátedra de Innovación Social de Aguas de Huelva; Cátedra de la Provincia; Grupo de investigación TEP-192 de Control y Robótica; Centro de Investigación en Tecnología, Energía y Sostenibilidad (CITES