Seeding affect-mediations as close-making. : A designerly response to the problematic depiction of the CEE being in distance/ distant by proposing digitally induced disruptions.

The climate and ecological emergency (CEE) is depicted as far in space and time to the (yet) unaffected human through politics not acting according to it as well as media not doing the topic justice. No experiences or experiences only through media depiction are created which the human bases its reality on. This is not only problematic but also mediates a distorted reality of not being and feeling affected by the CEE. (Climate) activism can be seen as a counter-perspective of politics. Extinction Rebellion (XR) – a decentralized movement – mostly aims for polarization, actions in the physical space, and disruptions. Decentral XR groups practice close-making of the CEE through different strategies and affect-mediations in the public space. Nevertheless, like most climate activist actions, it also deals with the dilemma of media depictions. The reach of the action within the public space as an affect-mediation is lesser than the reach through the media translation. If most humans are negatively affected through the media reach, what happens if affect-mediations are executed in the coded infrastructure(s) that surrounds the humans? As human entanglements with the coded infrastructure(s) can be seen as a body-mind-life extension, I aim with this work to intervene in it. By proposing to seed digitally induced disruptions as affect-mediations in the human entanglements with coded infrastructures(s) surrounding them, the work is aiming to practice close-making and enhance the notion of feeling affected. The approach was explored by mapping out the coded infrastructure(s) of the author, making it public through two workshops as well as setting up affect-mediation prototypes. By empowering local (XR) activist groups to explore and generate disruptive ideas based on my proposal, the research question emerged: How can local activist (Extinction Rebellion) groups be empowered to create affect-mediations and therefore affecting bodily experiences with the CEE through executing digitally induced disruptions to support their local demands? While conceptualizing a platform for XR as the Design Project – incorporating and digitally translating the workshop as well as other elements – the concept aims to host a collective pool of digitally induced disruption actions and approaches. 

Finanční analýza Wikov MGI, a.s.

Metodologická část: úloha finanční analýzy, její uživatelé, zdroje informací pro sestavení finanční analýzy, postup a metody - absolutní ukazatele, poměrové ukazatele, pyramidový rozklad DuPont, souhrnné indexy, hodnotové ukazatele výkonnosti (EVA, MVA), mezipodnikové srovnání. Praktická část: popis a historie společnosti, charakteristika odvětví, SWOT analýza, výpočet absolutních a poměrových ukazazelů, pyramidový rozklad DuPont, souhrnné indexy (Altmanův index, Index důvěryhodnosti, Kralickův test), výpočet hodnotové výkonnosti EVA, metoda srovnání poměrových ukazatelů s odvětvovými průměry (Spider analýza)

Seeding affect-mediations as close-making. : A designerly response to the problematic depiction of the CEE being in distance/ distant by proposing digitally induced disruptions.

The climate and ecological emergency (CEE) is depicted as far in space and time to the (yet) unaffected human through politics not acting according to it as well as media not doing the topic justice. No experiences or experiences only through media depiction are created which the human bases its reality on. This is not only problematic but also mediates a distorted reality of not being and feeling affected by the CEE. (Climate) activism can be seen as a counter-perspective of politics. Extinction Rebellion (XR) – a decentralized movement – mostly aims for polarization, actions in the physical space, and disruptions. Decentral XR groups practice close-making of the CEE through different strategies and affect-mediations in the public space. Nevertheless, like most climate activist actions, it also deals with the dilemma of media depictions. The reach of the action within the public space as an affect-mediation is lesser than the reach through the media translation. If most humans are negatively affected through the media reach, what happens if affect-mediations are executed in the coded infrastructure(s) that surrounds the humans? As human entanglements with the coded infrastructure(s) can be seen as a body-mind-life extension, I aim with this work to intervene in it. By proposing to seed digitally induced disruptions as affect-mediations in the human entanglements with coded infrastructures(s) surrounding them, the work is aiming to practice close-making and enhance the notion of feeling affected. The approach was explored by mapping out the coded infrastructure(s) of the author, making it public through two workshops as well as setting up affect-mediation prototypes. By empowering local (XR) activist groups to explore and generate disruptive ideas based on my proposal, the research question emerged: How can local activist (Extinction Rebellion) groups be empowered to create affect-mediations and therefore affecting bodily experiences with the CEE through executing digitally induced disruptions to support their local demands? While conceptualizing a platform for XR as the Design Project – incorporating and digitally translating the workshop as well as other elements – the concept aims to host a collective pool of digitally induced disruption actions and approaches. 

Elektronisch steuerbarer Praezisionsabschwaecher Abschlussbericht

SIGLEAvailable from TIB Hannover: F00B954 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung und Forschung (BMBF), Bonn (Germany)DEGerman

Strabismic suppression is mediated by inhibitory interactions in the primary visual cortex

Most strabismic observers do not suffer from double vision because of suppression from conscious perception of 1 of the 2 eyes’ conflicting views. Direct evidence for the site and neural substrate of strabismic suppression has not been available so far, although psychophysical data suggest a cortical origin. On the other hand, cross-orientation suppression among conflicting stimuli presented monocularly has recently been shown to have a strong thalamic component. Here we present evidence, using both visual stimulation and pharmacological techniques, that strabismic suppression occurs in the primary visual cortex and involves g-amino butyric acid (GABA)--mediated inhibition. We show that its dependency on the drift rate of the suppressing stimulus is consistent with a cortical origin; unlike monocular cross-orientation suppression, it cannot be evoked by very fast--moving stimuli. Furthermore, strabismic suppression is greatly reduced when GABAergic inhibition is locally blocked by the GABAA antagonist bicuculline

A Nanomolar Multivalent Ligand as Entry Inhibitor of the Hemagglutinin of Avian Influenza

Influenza virus attaches itself to sialic acids on the surface of epithelial cells of the upper respiratory tract of the host using its own protein hemagglutinin. Species specificity of influenza virus is determined by the linkages of the sialic acids. Birds and humans have α2–3 and α2–6 linked sialic acids, respectively. Viral hemagglutinin is a homotrimeric receptor, and thus, tri- or oligovalent ligands should have a high binding affinity. We describe the <i>in silico</i> design, chemical synthesis and binding analysis of a trivalent glycopeptide mimetic. This compound binds to hemagglutinin H5 of avian influenza with a dissociation constant of <i>K</i>_D = 446 nM and an inhibitory constant of <i>K</i>_I = 15 μM. <i>In silico</i> modeling shows that the ligand should also bind to hemagglutinin H7 of the virus that causes the current influenza outbreak in China. The trivalent glycopeptide mimetic and analogues have the potential to block many different influenza viruses

A Nanomolar Multivalent Ligand as Entry Inhibitor of the Hemagglutinin of Avian Influenza

Influenza virus attaches itself to sialic acids on the surface of epithelial cells of the upper respiratory tract of the host using its own protein hemagglutinin. Species specificity of influenza virus is determined by the linkages of the sialic acids. Birds and humans have α2–3 and α2–6 linked sialic acids, respectively. Viral hemagglutinin is a homotrimeric receptor, and thus, tri- or oligovalent ligands should have a high binding affinity. We describe the <i>in silico</i> design, chemical synthesis and binding analysis of a trivalent glycopeptide mimetic. This compound binds to hemagglutinin H5 of avian influenza with a dissociation constant of <i>K</i>_D = 446 nM and an inhibitory constant of <i>K</i>_I = 15 μM. <i>In silico</i> modeling shows that the ligand should also bind to hemagglutinin H7 of the virus that causes the current influenza outbreak in China. The trivalent glycopeptide mimetic and analogues have the potential to block many different influenza viruses