Retroperitoneal Inflammatory Pseudotumor Presenting as a Pancreatic Mass

Context The inflammatory pseudotumor is a rare chronic inflammatory disease not considered as a real tumor but with a similar locally aggressive behavior. Although usually located in the lungs it may be found in other organs. Case report We present the clinical case of a 66-year-old woman diagnosed with inflammatory pseudotumor after undergoing an exploratory laparotomy due to a large non resectable abdominal mass. Preoperative abdominal CT revealed a large solid polylobulated mass involving the pancreas, duodenum, hepatic hilum and superior mesenteric artery. Percutaneous fine needle aspiration and tru-cut biopsies ruled out lymphoma but did not achieve a definitive diagnosis. CD68 antibody positivity of the surgical biopsy specimen confirmed the histiocytary origin. Ki67 antibody expression was 10%. The final diagnosis was inflammatory pseudotumor rather than malignant fibrohistiocytoma based on the features and the severity of the inflammatory component. Chemotherapy was ineffective and the patient died 25 months later because of local progression and infection of the tumoral necrotic tissue. Conclusion Although inflammatory pseudotumor is not considered to be a real tumor, its aggressive local growth is similar to that of malignant soft tissue sarcomas. The only curative option is the complete surgical resection, albeit frequent recurrence

Fairy tale anime adaptation as a tool of Japanization: the case of Belle

[EN] The adaptation of fairy tales allows stories to be kept alive over time. Nowadays, it can also be a tool of Japanization by allowing elements of Japanese culture to be introduced into originally Western stories. This research explores that use of fairy tale adaptation through an analysis of the anime Belle, based on the classic story Beauty and the Beast. Through a comparative analysis with Disney's popular animated version, the most relevant divergences between the two works have been identified. Thus, it has been shown how Belle introduces specific concepts and ideas that allow us to approach a specific imaginary about Japan and its culture.[ES] La adaptación de cuentos de hadas permite mantener vivas las historias a lo largo del tiempo. En la actualidad también puede servir como una herramienta de japonización al permitir introducir elementos propios de la cultura nipona en historias originariamente occidentales. Esta investigación explora ese uso de la adaptación de los cuentos de hadas a través del análisis del anime Belle, basado en la clásica historia de La Bella y la Bestia. Mediante un análisis comparativo con la popular versión animada de Disney, se han identificado las divergencias más relevantes entre las dos obras. De esta manera, se ha comprobado cómo Belle introduce conceptos e ideas concretos que permiten acercar un imaginario concreto sobre Japón y su cultura.Vicent-Ibáñez, M.; Antona-Jimeno, T.; Bonaut-Iriarte, J. (2024). La adaptación al anime de los cuentos de hadas como herramienta de japonización: el caso de Belle. Con A de animación. (18):48-65. https://doi.org/10.4995/caa.2024.1977448651

Rectal Aberrant Crypt Foci in Humans Are Not Surrogate Markers for Colorectal Cancer Risk

NTRODUCTION: Over the past 20 years, aberrant crypt foci (ACF) have emerged as potential precursors and biomarkers for colorectal cancer (CRC). However, data regarding their molecular pathogenesis, as well as their endoscopic and histological identification, remain inconsistent. METHODS: A wide cohort of ACF from 100 control subjects and 100 case patients, including patients with adenoma and CRC, were characterized for endoscopic, morphologic, and molecular features. RESULTS: We observed that among all the endoscopic features evaluated, only the number of large ACF correlated with CRC risk (P = 0.003), whereas the histological classification, as assessed by 2 different pathologists, was inconsistent and did not differ between control and case patients. Moreover, only a few APC and BRAF mutations and no microsatellite instability were detected in our samples. KRAS mutations were detected in 16.3% of ACF samples, which also exhibited increased MGMT hypermethylation. However, none of those events were found to be predictive of CRC risk. DISCUSSION: Although ACF might be preneoplastic lesions of the colon, they are not suitable biomarkers for assessing CRC progression

Aberrant Gene Promoter Methylation Associated with Sporadic Multiple Colorectal Cancer

BACKGROUND: Colorectal cancer (CRC) multiplicity has been mainly related to polyposis and non-polyposis hereditary syndromes. In sporadic CRC, aberrant gene promoter methylation has been shown to play a key role in carcinogenesis, although little is known about its involvement in multiplicity. To assess the effect of methylation in tumor multiplicity in sporadic CRC, hypermethylation of key tumor suppressor genes was evaluated in patients with both multiple and solitary tumors, as a proof-of-concept of an underlying epigenetic defect. METHODOLOGY/PRINCIPAL FINDINGS: We examined a total of 47 synchronous/metachronous primary CRC from 41 patients, and 41 gender, age (5-year intervals) and tumor location-paired patients with solitary tumors. Exclusion criteria were polyposis syndromes, Lynch syndrome and inflammatory bowel disease. DNA methylation at the promoter region of the MGMT, CDKN2A, SFRP1, TMEFF2, HS3ST2 (3OST2), RASSF1A and GATA4 genes was evaluated by quantitative methylation specific PCR in both tumor and corresponding normal appearing colorectal mucosa samples. Overall, patients with multiple lesions exhibited a higher degree of methylation in tumor samples than those with solitary tumors regarding all evaluated genes. After adjusting for age and gender, binomial logistic regression analysis identified methylation of MGMT2 (OR, 1.48; 95% CI, 1.10 to 1.97; p = 0.008) and RASSF1A (OR, 2.04; 95% CI, 1.01 to 4.13; p = 0.047) as variables independently associated with tumor multiplicity, being the risk related to methylation of any of these two genes 4.57 (95% CI, 1.53 to 13.61; p = 0.006). Moreover, in six patients in whom both tumors were available, we found a correlation in the methylation levels of MGMT2 (r = 0.64, p = 0.17), SFRP1 (r = 0.83, 0.06), HPP1 (r = 0.64, p = 0.17), 3OST2 (r = 0.83, p = 0.06) and GATA4 (r = 0.6, p = 0.24). Methylation in normal appearing colorectal mucosa from patients with multiple and solitary CRC showed no relevant difference in any evaluated gene. CONCLUSIONS: These results provide a proof-of-concept that gene promoter methylation is associated with tumor multiplicity. This underlying epigenetic defect may have noteworthy implications in the prevention of patients with sporadic CRC

Differentially Deregulated MicroRNAs as Novel Biomarkers for Neoplastic Progression in Ulcerative Colitis.

INTRODUCTION: Colorectal cancer (CRC) is a potentially life-threatening complication of long-standing ulcerative colitis (UC). MicroRNAs (miRNA) are epigenetic regulators that have been involved in the development of UC-associated CRC. However, their role as potential mucosal biomarkers of neoplastic progression has not been adequately studied. METHODS: In this study, we analyzed the expression of 96 preselected miRNAs in human formalin-fixed and paraffin-embedded tissue of 52 case biopsies (20 normal mucosa, 20 dysplasia, and 12 UC-associated CRCs) and 50 control biopsies (10 normal mucosa, 21 sporadic adenomas, and 19 sporadic CRCs) by using Custom TaqMan Array Cards. For validation of deregulated miRNAs, we performed individual quantitative real-time polymerase chain reaction in an independent cohort of 50 cases (13 normal mucosa, 25 dysplasia, and 12 UC-associated CRCs) and 46 controls (7 normal mucosa, 19 sporadic adenomas, and 20 sporadic CRCs). RESULTS: Sixty-four miRNAs were found to be differentially deregulated in the UC-associated CRC sequence. Eight of these miRNAs were chosen for further validation. We confirmed miR-31, -106a, and -135b to be significantly deregulated between normal mucosa and dysplasia, as well as across the UC-associated CRC sequence (all P < 0.01). Notably, these miRNAs also confirmed to have a significant differential expression compared with sporadic CRC (all P < 0.05). DISCUSSION: UC-associated and sporadic CRCs have distinct miRNA expression patterns, and some miRNAs indicate early neoplastic progression.This work was funded by grants from the Instituto de Salud Carlos III (PI12/01481; PI19/01050). Project PI19/ 01050 is funded by Instituto de Salud Carlos III (ISCIII) and co funded by the European Union. CIBEREHD is funded by the Insti tuto de Salud Carlos III and Beca Marató de TV3 (201932-30). Parts of this work were also supported by the Xarxa de Bancs de Tumors de Catalunya sponsored by Pla Director d’Oncología de Catalunya (XBTC) and by the Hospital Clínics Premi Fi de Residència (G.J). None of the funding parties has been involved in collection, analysis, and interpretation of the data

Differentially Deregulated MicroRNAs as Novel Biomarkers for Neoplastic Progression in Ulcerative Colitis

Introduction: Colorectal cancer (CRC) is a potentially life-threatening complication of long-standing ulcerative colitis (UC). MicroRNAs (miRNA) are epigenetic regulators that have been involved in the development of UC-associated CRC. However, their role as potential mucosal biomarkers of neoplastic progression has not been adequately studied. Methods: In this study, we analyzed the expression of 96 preselected miRNAs in human formalin-fixed and paraffin-embedded tissue of 52 case biopsies (20 normal mucosa, 20 dysplasia, and 12 UC-associated CRCs) and 50 control biopsies (10 normal mucosa, 21 sporadic adenomas, and 19 sporadic CRCs) by using Custom TaqMan Array Cards. For validation of deregulated miRNAs, we performed individual quantitative real-time polymerase chain reaction in an independent cohort of 50 cases (13 normal mucosa, 25 dysplasia, and 12 UC-associated CRCs) and 46 controls (7 normal mucosa, 19 sporadic adenomas, and 20 sporadic CRCs). Results: Sixty-four miRNAs were found to be differentially deregulated in the UC-associated CRC sequence. Eight of these miRNAs were chosen for further validation. We confirmed miR-31, -106a, and -135b to be significantly deregulated between normal mucosa and dysplasia, as well as across the UC-associated CRC sequence (all P < 0.01). Notably, these miRNAs also confirmed to have a significant differential expression compared with sporadic CRC (all P < 0.05). Discussion: UC-associated and sporadic CRCs have distinct miRNA expression patterns, and some miRNAs indicate early neoplastic progression

Literature on Franco’s television: literary adaptations and the promotion of reading in franco’s programming (1958-1975)

El objetivo es evaluar en qué medida la literatura estaba presente en la programación de TVE durante la etapa franquista. Para ello se abordará la presencia de las letras en los programas emitidos entre el 1 de enero de 1958 y el 20 de noviembre de 1975. Se analizarán dos tipos de programas: por un lado, las emisiones de corte cultural, que tenían como objetivo la divulgación de las novedades literarias y el fomento de la lectura entre los espectadores; y, por otro, las adaptaciones o representaciones de obras literarias. En el primer caso, se realizará una aproximación exhaustiva mediante el análisis de los contenidos de cada programa. En cuanto a los programas que convertían los clásicos literarios en entretenimiento televisivo se realizará un estudio de los mismos desde el punto de vista de la programación, centrado en qué momento del día se programaban, a qué público iban dirigidos y el peso real en parrilla. La conclusión principal de este análisis es que la literatura fue uno de los pilares de la divulgación culturalThe aim is to assess the extent to which literature was present in TVE’s programming during the Franco era. To this end, the presence of literature in the programmes broadcast between 1 January 1958 and 20 November 1975 will be examined. Two types of programmes will be analysed: on the one hand, cultural programmes, which were aimed at disseminating literary novelties and promoting reading among viewers; and, on the other hand, adaptations or representations of literary works. In the first case, an exhaustive approach will be made by analysing the contents of each programme. As for the programmes that turned literary classics into television entertainment, a study will be made of them from the point of view of programming, focusing on the time of day they were scheduled, the audience they were aimed at and their real weight in the grills. The main conclusion of this analysis is that literature was one of the pillars of cultural disseminationDepto. de Periodismo y Comunicación GlobalFac. de Ciencias de la InformaciónTRUEpu

Literature on Franco’s television: literary adaptations and the promotion of reading in Franco’s programming (1958-1975)

El objetivo es evaluar en qué medida la literatura estaba presente en la programación de TVE durante la etapa franquista. Para ello se abordará la presencia de las letras en los programas emitidos entre el 1 de enero de 1958 y el 20 de noviembre de 1975. Se analizarán dos tipos de programas: por un lado, las emisiones de corte cultural, que tenían como objetivo la divulgación de las novedades literarias y el fomento de la lectura entre los espectadores; y, por otro, las adaptaciones o representaciones de obras literarias. En el primer caso, se realizará una aproximación exhaustiva mediante el análisis de los contenidos de cada programa. En cuanto a los programas que convertían los clásicos literarios en entretenimiento televisivo se realizará un estudio de los mismos desde el punto de vista de la programación, centrado en qué momento del día se programaban, a qué público iban dirigidos y el peso real en parrilla. La conclusión principal de este análisis es que la literatura fue uno de los pilares de la divulgación cultural.The aim is to assess the extent to which literature was present in TVE’s programming during the Franco era. To this end, the presence of literature in the programmes broadcast between 1 January 1958 and 20 November 1975 will be examined. Two types of programmes will be analysed: on the one hand, cultural programmes, which were aimed at disseminating literary novelties and promoting reading among viewers; and, on the other hand, adaptations or representations of literary works. In the first case, an exhaustive approach will be made by analysing the contents of each programme. As for the programmes that turned literary classics into television entertainment, a study will be made of them from the point of view of programming, focusing on the time of day they were scheduled, the audience they were aimed at and their real weight in the grills. The main conclusion of this analysis is that literature was one of the pillars of cultural dissemination

Research on News Sharing. A Proposal of bibliometric analysis

This study seeks to establish whether news sharing in social media is a mature field of research by using bibliometrics as a tool. The Web of Science database was searched for articles that contained the term ‘news sharing’ in titles, keywords, and abstracts. A total of 133 articles was obtained, which enabled us to address the question of whether there are well-established journals and authors that cover the subject. The results show a certain ambiguity, which could explain why the chosen subject matter is often studied in fields outside of Communication Studies; however, while studies on news sharing are conducted by researchers from heterogeneous fields, this has not translated into greater interdisciplinarity.Esta investigación utiliza la bibliometría como herramienta para averiguar si la difusión de noticias en redes sociales conforma un campo de investigación maduro. Mediante la consulta de la base de datos Web of Science, a través de la búsqueda del término ‘news sharing’ en títulos, palabras clave y resúmenes, se obtiene un universo de 133 artículos que permiten enfrentar la pregunta sobre si existen revistas y autores consolidados. Los resultados obtenidos revelan cierta ambigüedad que explicaría por qué la temática escogida se estudia a menudo desde ámbitos ajenos a la comunicación, sin que la presencia heterogénea de investigadores se traduzca en una mayor interdisciplinariedad

Fairy tale anime adaptation as a tool of japanization: the case of Belle

La adaptación de cuentos de hadas permite mantener vivas las historias a lo largo del tiempo. En la actualidad también puede servir como una herramienta de japonización al permitir introducir elementos propios de la cultura nipona en historias originariamente occidentales. Esta investigación explora ese uso de la adaptación de los cuentos de hadas a través del análisis del anime Belle, basado en la clásica historia de La Bella y la Bestia. Mediante un análisis comparativo con la popular versión animada de Disney, se han identificado las divergencias más relevantes entre las dos obras. De esta manera, se ha comprobado cómo Belle introduce conceptos e ideas concretos que permiten acercar un imaginario concreto sobre Japón y su cultura.The adaptation of fairy tales allows sto-ries to be kept alive over time. Nowadays, it can also be a tool of Japanization by allowing elements of Japanese culture to be introduced into originally Western stories. This research explores that use of fairy tale adaptation through an analysis of the animeBelle, based on the classic story Beauty and the Beast. Through a compara-tive analysis with Disney’s popular anima-ted version, the most relevant divergences between the two works have been identi-fied. Thus, it has been shown how Belle in-troduces specific concepts and ideas that allow us to approach a specific imaginary about Japan and its cultureMinisterio de UniversidadesUnión Europea-Next Generation EUDepto. de Periodismo y Comunicación GlobalFac. de Ciencias de la InformaciónTRUEpu