The use of arc-erosion as a patterning technique for transparent conductive materials

Within the framework of cost-effective patterning processes a novel technique that saves photolithographic processing steps, easily scalable to wide area production, is proposed. It consists of a tip-probe, which is biased with respect to a conductive substrate and slides on it, keeping contact with the material. The sliding tip leaves an insulating path (which currently is as narrow as 30 μm) across the material, which enables the drawing of tracks and pads electrically insulated from the surroundings. This ablation method, called arc-erosion, requires an experimental set up that had to be customized for this purpose and is described. Upon instrumental monitoring, a brief proposal of the physics below this process is also presented. As a result an optimal control of the patterning process has been acquired. The system has been used on different substrates, including indium tin oxide either on glass or on polyethylene terephtalate, as well as alloys like Au/Cr, and Al. The influence of conditions such as tip speed and applied voltage is discusse

Gravitational shocks as a key ingredient of Gamma-Ray Bursts

We identify a novel physical mechanism that may be responsible for energy release in $\gamma$-ray bursts. Radial perturbations in the neutron core, induced by its collision with collapsing outer layers during the early stages of supernova explosions, can trigger a gravitational shock, which can readily eject a small but significant fraction of the collapsing material at ultra-relativistic speeds. The development of such shocks is a strong-field effect arising in near-critical collapse in General Relativity and has been observed in numerical simulations in various contexts, including in particular radially perturbed neutron star collapse, albeit for a tiny range of initial conditions. Therefore, this effect can be easily missed in numerical simulations if the relevant parameter space is not exhaustively investigated. In the proposed picture, the observed rarity of $\gamma$-ray bursts would be explained if the relevant conditions for this mechanism appear in only about one in every $10^4-10^5$ core collapse supernovae. We also mention the possibility that near-critical collapse could play a role in powering the central engines of Active Galactic Nuclei.Comment: 9 pages, 3 figure

Background, Systematic Review, Challenges and Outlook

Publisher Copyright: © 2013 IEEE. This research is supported by the Digital Manufacturing and Design Training Network (DiManD) project funded by the European Union through the Marie Skłodowska-Curie Innovative Training Networks (H2020-MSCA-ITN-2018) under grant agreement no. 814078The concept of smart manufacturing has attracted huge attention in the last years as an answer to the increasing complexity, heterogeneity, and dynamism of manufacturing ecosystems. This vision embraces the notion of autonomous and self-organized elements, capable of self-management and self-decision-making under a context-aware and intelligent infrastructure. While dealing with dynamic and uncertain environments, these solutions are also contributing to generating social impact and introducing sustainability into the industrial equation thanks to the development of task-specific resources that can be easily adapted, re-used, and shared. A lot of research under the context of self-organization in smart manufacturing has been produced in the last decade considering different methodologies and developed under different contexts. Most of these works are still in the conceptual or experimental stage and have been developed under different application scenarios. Thus, it is necessary to evaluate their design principles and potentiate their results. The objective of this paper is threefold. First, to introduce the main ideas behind self-organization in smart manufacturing. Then, through a systematic literature review, describe the current status in terms of technological and implementation details, mechanisms used, and some of the potential future research directions. Finally, the presentation of an outlook that summarizes the main results of this work and their interrelation to facilitate the development of self-organized manufacturing solutions. By providing a holistic overview of the field, we expect that this work can be used by academics and practitioners as a guide to generate awareness of possible requirements, industrial challenges, and opportunities that future self-organizing solutions can have towards a smart manufacturing transition.publishersversionpublishe

Document management practices in SMEs: An information management capability-based approach

Purpose: This research studied the current document management (DM) practices in small and medium-sized enterprises (SMEs) of a road freight transport sector in a South American city with the aim to determine strengths and challenges for improving information management. Design/methodology/approach: The study was conducted using a survey approach based on measuring information management capabilities (IMC) through the following main dimensions: perception about DM practices, DM policies and tools, IT usage, organizational climate, and problems related to document management. Findings: The main results from the work stated the challenges for these companies in adopting electronic document management systems (EDMS) and handling information effectively even though the business experience. Also, the study highlighted the top management commitment in terms of investments for IMC development. Nevertheless, this economic support tends to be not enough to afford the EDMS implementation. Originality/value: Regarding the importance of information in road freight transport sector, this paper explored DM practices in a field in which no previous studies related to DM had been conducted and set the basis to make decisions to improve information management performance

Exploring the Concept of the Digital Educator During COVID-19

T In many machine learning classification problems, datasets are usually of high dimensionality and therefore require efficient and effective methods for identifying the relative importance of their attributes, eliminating the redundant and irrelevant ones. Due to the huge size of the search space of the possible solutions, the attribute subset evaluation feature selection methods are not very suitable, so in these scenarios feature ranking methods are used. Most of the feature ranking methods described in the literature are univariate methods, which do not detect interactions between factors. In this paper, we propose two new multivariate feature ranking methods based on pairwise correlation and pairwise consistency, which have been applied for cancer gene expression and genotype-tissue expression classification tasks using public datasets. We statistically proved that the proposed methods outperform the state-of-the-art feature ranking methods Clustering Variation, Chi Squared, Correlation, Information Gain, ReliefF and Significance, as well as other feature selection methods for attribute subset evaluation based on correlation and consistency with the multi-objective evolutionary search strategy, and with the embedded feature selection methods C4.5 and LASSO. The proposed methods have been implemented on the WEKA platform for public use, making all the results reported in this paper repeatable and replicabl

A DNA aptamer for binding and inhibition of DNA methyltransferase 1.

DNA methyltransferases (DNMTs) are enzymes responsible for establishing and maintaining DNA methylation in cells. DNMT inhibition is actively pursued in cancer treatment, dominantly through the formation of irreversible covalent complexes between small molecular compounds and DNMTs that suffers from low efficacy and high cytotoxicity, as well as no selectivity towards different DNMTs. Herein, we discover aptamers against the maintenance DNA methyltransferase, DNMT1, by coupling Asymmetrical Flow Field-Flow Fractionation (AF4) with Systematic Evolution of Ligands by EXponential enrichment (SELEX). One of the identified aptamers, Apt. #9, contains a stem-loop structure, and can displace the hemi-methylated DNA duplex, the native substrate of DNMT1, off the protein on sub-micromolar scale, leading for effective enzymatic inhibition. Apt. #9 shows no inhibition nor binding activity towards two de novo DNMTs, DNMT3A and DNMT3B. Intriguingly, it can enter cancer cells with over-expression of DNMT1, colocalize with DNMT1 inside the nuclei, and inhibit the activity of DNMT1 in cells. This study opens the possibility of exploring the aptameric DNMT inhibitors being a new cancer therapeutic approach, by modulating DNMT activity selectively through reversible interaction. The aptamers could also be valuable tools for study of the functions of DNMTs and the related epigenetic mechanisms

Manual técnico: el cultivo de la yuca manihot esculenta crantz; para producción forrajera y su utilización en alimentación de bovinos

Análisis y conocimiento de los sistemas de producción ganaderos con el propósito de identificar y formular programas, planes y proyectos de Desarrollo tecnológico que permitan contribuir a mantener y mejorar la productividad, competitividad (viabilidad económica) , sostenibilidad agroecológica y la equidad social. Entre los factores que afectan principalmente la productividad de los sistemas de producción ganadera en Colombia y los países ubicados en la franja tropical, es la baja capacidad de sostenimiento animal por unidad de área, debido a la baja cantidad y calidad de las pasturas en diferentes épocas del año, principalmente en las épocas secas, Es en estas circunstancias es cuando se requiere tener o encontrar alternativas tecnológicas que permitan mantener las cantidades mínimas de forrajes requeridas para la alimentación de ganado. Con base en lo anterior, se propuso indagar e investigar sobre el potencial del cultivo de la yuca Manihot esculenta crantz como una alternativa importante para la producción forrajera, por el alto potencial de producción de biomasa de su parte aérea (en base fresca o base seca), y su alto valor nutricional pues sus hojas son ricas en proteínas, (entre 25-30%, de proteína, comparables con los de alfalfa y otras leguminosas forrajeras utilizadas en la alimentación de rumiantes.), carotenos, vitaminas B 1, B2, C y minerales

Reaction flash sintering for producing high quality functional ceramics within seconds

For ceramic materials, it has been recently shown in literature that applying a small electric field and a small DC current through a sample produces sudden sintering (within seconds) at relatively low temperatures. This method is known as Flash Sintering and it has been applied to number of materials. In this work it is shown that both chemical reaction and sintering can be combined into a single flash sintering experiments. This new approach is known as Reaction Flash Sintering. To demonstrate the feasibility of this method, a multiferroic material, BiFeO3, is prepared from a stoichiometric mixture of Bi2O3 and Fe2O3 oxides. Thus, in a single process, dense nanostructured BiFeO3 ceramics are obtained by applying an electric field of 50 V cm-1 and with a current limit of 35 mA mm-2 within seconds at a furnace temperature of about 625 °C. The resulting materials were pure-phase perovskites without any evidence of secondary phases, sillenite or mullite, that are commonly present in materials prepared by conventional procedures. Moreover, samples were electrically insulating, as measured by complex impedance spectroscopy. It is shown here that the synthesis of pure single-phase ceramics of complex oxides from stoichiometric mixtures of single oxides is possible by reaction flash sintering, even for materials difficult to prepare by conventional procedures. This discovery is a breakthrough in materials preparation

Adrenomedullin and proadrenomedullin N-terminal 20 peptide in the normal prostate and in prostate carcinoma

There is increasing evidence for the important role played by regulatory peptides in the physiology of the normal and neoplastic prostate. Adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP) are recently discovered regulatory peptides widely expressed in the normal prostate and in prostate carcinoma. AM is produced in secretory, stroma, and endothelial cells and in neurons of the prostate ganglia. PAMP is only produced by neuroendocrine cells. The expression of AM mRNA is regulated by androgens in the rat prostate. The number of neuroendocrine cells expressing PAMP is increased in prostate carcinoma after androgen deprivation, which shows that this peptide could regulate androgen-independent prostate tumor growth. However, the roles of AM and PAMP in the normal prostate and in prostate carcinoma are yet to be elucidated