PPM Reduction on Embedded Memories in System on Chip

This paper summarizes advanced test patterns designed to target dynamic and time-related faults caused by new defect mechanisms in deep-submicron memory technologies. Such tests are industrially evaluated together with the traditional tests at "Design of Systems on Silicon (DS2)" in Spain in order to (a) validate the used fault models and (b) investigate the added value of the new tests and their impact on the PPM level. The preliminary silicon results are presented and analyzed. They validate some of the new dynamic fault models and show the importance of considering dynamic faults for high outgoing product quality.Electrical Engineering, Mathematics and Computer Scienc

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Impact of dynamic coupling between relative orbit and attitude on the estimation of relative dynamics of spacecraft

In this work the extent to which orbit and attitude sensors may cross-support each other in a joint processing to reduce estimation errors of the relative orbital and attitude dynamics is investigated. In order to do this, an engineering dynamic model taking into account the coupling effects between orbit and attitude dynamics is exploited for estimation purposes. A simple yet common configuration of two spacecraft in an along-track formation flying in low Earth Orbit (LEO) is used as case study, where the atmospheric drag perturbation constitutes the source of coupling. An extended Kalman Filter considering the dynamic coupling between orbital and attitude dynamics is used to estimate the absolute and relative dynamics of the system. It is shown that the coupling leads to higher accuracy estimation results.Space Systems EgineeringSpace Engineerin

Flexible framework for the development of versatile MAV systems for multi-disciplinary applications

MAV (Micro Aerial Vehicle) systems have proven useful in multiple applications (e.g. aerial photogrammetry, aerial inspections,...). For each application different sensors and even different airframes are often needed. Having a flexible UAS (Unmanned Aircraft System) devices (specifically an autopilot, a payload manager and a ground control station) that can be seamlessly used with different platforms is of great interest as it reduces the development time and effort (and hence cost). This flexibility must apply to the hardware, software and design methodologies so the system can be rapidly adapted to meet the requirements of other applications. This paper introduces a flexible system developed by CATEC consisting of an autopilot, Ground Control Station (GCS) and a payload manager for MAVs. This system has already been tested in real experiments for different applications that are also presented in this paper

Cell-free biogenesis of bacterial division proto-rings that can constrict liposomes

A major challenge towards the realization of an autonomous synthetic cell resides in the encoding of a division machinery in a genetic programme. In the bacterial cell cycle, the assembly of cytoskeletal proteins into a ring defines the division site. At the onset of the formation of the Escherichia coli divisome, a proto-ring consisting of FtsZ and its membrane-recruiting proteins takes place. Here, we show that FtsA-FtsZ ring-like structures driven by cell-free gene expression can be reconstituted on planar membranes and inside liposome compartments. Such cytoskeletal structures are found to constrict the liposome, generating elongated membrane necks and budding vesicles. Additional expression of the FtsZ cross-linker protein ZapA yields more rigid FtsZ bundles that attach to the membrane but fail to produce budding spots or necks in liposomes. These results demonstrate that gene-directed protein synthesis and assembly of membrane-constricting FtsZ-rings can be combined in a liposome-based artificial cell.BN/Christophe Danelon LabEducation and Student AffairsBN/Technici en Analiste

Towards covariance realism in batch least-squares orbit determination

Regular products within the field of Space Surveillance and Tracking (SST) and Space Traffic Management (STM), such as high-risk collisions, upcoming re-entries or fragmentations, rely both on the estimated state and associated uncertainty of detectable resident space objects (RSOs). Classical orbit determination (OD) algorithms provide the required estimations, assuming that the uncertainty in the state of the object is properly characterized by its state vector covariance and assuming Gaussian processes. However, a common problem of classical orbit determination processes is the misrepresentation of the RSOs uncertainty through the estimated covariance. Ultimately, this causes a great impact in the quality and accuracy of SST products as the estimated covariance is overly optimistic (too small) and the true uncertainty of the object is not captured. One of the causes for the unrealism of the estimated covariance is found in the classical OD approaches, as they fail to consider, or properly characterize, the uncertainty of the dynamical models used to describe the motion of the objects, such as the atmospheric drag force or the solar radiation pressure acting on the orbiting RSOs. Because these models provide a deterministic solution to a stochastic phenomenon, an inherent associated uncertainty should be regarded when used during an orbit determination. The aim of this work is to devise a methodology to improve the covariance realism of common OD processes through the classical theory of consider parameters of batch least squares methods. The methodology uses the classical theory of consider parameter to add to the estimated covariance the contribution coming from the uncertainty of the consider parameters. To do so, the variances of the consider parameters are estimated through another least squares process, with which the propagated covariance best fits a so-called observed covariance, previously derived, in a process named covariance determination. The influence of the main sources of dynamic model uncertainty can be evaluated by examining the resulting covariance correction for each uncertainty source (e.g. atmospheric drag force modelling, sensor calibration parameters or solar radiation prediction). This publication focus on studying the effect of the atmospheric drag force and range bias modelling uncertainty in the correction of an estimated covariance. The proposed methodology has been applied to a simulated realistic scenario of measurements and objects to evaluate the consistency of the corrected covariance via Monte Carlo analysis. Thorough analyses are presented to illustrate the effect of dynamic model errors on covariance realism. Copyright © 2019 by the International Astronautical Federation (IAF). All rights reserved.Astrodynamics & Space Mission

High-resolution X-ray diffraction investigation on the evolution of the substructure of individual austenite grains in TRIP steels during tensile deformation

The martensitic transformation behaviour of the metastable austenite phase in low-alloyed transformation-induced plasticity (TRIP) steels has been studied in situ using high-energy X-ray diffraction during deformation. The austenite stability during tensile deformation has been evaluated at different length scales. A powder diffraction analysis has been performed to correlate the macroscopic behaviour of the material to the observed changes in the volume phase fraction. Moreover, the austenite deformation response has been studied at the length scale of individual grains, where an in-depth characterization of four selected grains has been performed, including grain volume, local carbon concentration and grain orientation. For the first time, a high-resolution far-field detector was used to study the initial and evolving structure of individual austenite grains during uniaxial tensile deformation. It was found that the austenite subgrain size does not change significantly during tensile deformation. Most austenite grains show a complete martensitic transformation in a single loading step.Delft University of Technolog

Practical Indicators for Risk of Airborne Transmission in Shared Indoor Environments and Their Application to COVID-19 Outbreaks

Some infectious diseases, including COVID-19, can undergo airborne transmission. This may happen at close proximity, but as time indoors increases, infections can occur in shared room air despite distancing. We propose two indicators of infection risk for this situation, that is, relative risk parameter (Hr) and risk parameter (H). They combine the key factors that control airborne disease transmission indoors: virus-containing aerosol generation rate, breathing flow rate, masking and its quality, ventilation and aerosol-removal rates, number of occupants, and duration of exposure. COVID-19 outbreaks show a clear trend that is consistent with airborne infection and enable recommendations to minimize transmission risk. Transmission in typical prepandemic indoor spaces is highly sensitive to mitigation efforts. Previous outbreaks of measles, influenza, and tuberculosis were also assessed. Measles outbreaks occur at much lower risk parameter values than COVID-19, while tuberculosis outbreaks are observed at higher risk parameter values. Because both diseases are accepted as airborne, the fact that COVID-19 is less contagious than measles does not rule out airborne transmission. It is important that future outbreak reports include information on masking, ventilation and aerosol-removal rates, number of occupants, and duration of exposure, to investigate airborne transmission.Support AE+

The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer

Candidate immune biomarkers have been proposed for predicting response to immunotherapy in urothelial cancer (UC). Yet, these biomarkers are imperfect and lack predictive power. A comprehensive overview of the tumor immune contexture, including Tertiary Lymphoid structures (TLS), is needed to better understand the immunotherapy response in UC. We analyzed tumor sections by quantitative multiplex immunofluorescence to characterize immune cell subsets in various tumor compartments in tumors without pretreatment and tumors exposed to preoperative anti-PD1/CTLA-4 checkpoint inhibitors (NABUCCO trial). Pronounced immune cell presence was found in UC invasive margins compared to tumor and stroma regions. CD8+PD1+ T-cells were present in UC, particularly following immunotherapy. The cellular composition of TLS was assessed by multiplex immunofluorescence (CD3, CD8, FoxP3, CD68, CD20, PanCK, DAPI) to explore specific TLS clusters based on varying immune subset densities. Using a k-means clustering algorithm, we found five distinct cellular composition clusters. Tumors unresponsive to anti-PD-1/CTLA-4 immunotherapy showed enrichment of a FoxP3+ T-cell-low TLS cluster after treatment. Additionally, cluster 5 (macrophage low) TLS were significantly higher after pre-operative immunotherapy, compared to untreated tumors. We also compared the immune cell composition and maturation stages between superficial (submucosal) and deeper TLS, revealing that superficial TLS had more pronounced T-helper cells and enrichment of early TLS than TLS located in deeper tissue. Furthermore, superficial TLS displayed a lower fraction of secondary follicle like TLS than deeper TLS. Taken together, our results provide a detailed quantitative overview of the tumor immune landscape in UC, which can provide a basis for further studies.Pattern Recognition and Bioinformatic

Corrigendum to “Assessment of Predictive Genomic Biomarkers for Response to Cisplatin-based Neoadjuvant Chemotherapy in Bladder Cancer” [Eur Urol 2023;83:313–17] (European Urology (2023) 83(4) (313–317), (S0302283822025386), (10.1016/j.eururo.2022.07.023))

The authors regret that the following statement regarding author contributions was missed: Kristan van der Vos is currently a Scientific Editor for Cell Reports Medicine, which is published by Elsevier. Dr van der Vos was not involved in the peer-review process or editorial discussions about this manuscript. The authors would like to apologise for any inconvenience caused.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Pattern Recognition and Bioinformatic