Confining massless Dirac particles in two-dimensional curved space

Dirac particles have been notoriously difficult to confine. Implementing a curved space Dirac equation solver based on the quantum Lattice Boltzmann method, we show that curvature in a 2-D space can confine a portion of a charged, mass-less Dirac fermion wave-packet. This is equivalent to a finite probability of confining the Dirac fermion within a curved space region. We propose a general power law expression for the probability of confinement with respect to average spatial curvature for the studied geometry.Comment: 10 pages 8 figure

The escape of Lyman photons from a young starburst: the case of Haro 11

(Abridged) Lyman-alpha (Lya) is a dominant probe of the galaxy population at high-z. However, interpretation of data drawn from Lya alone hinges on the Lya escape fraction which, due to the complex radiative transport, may vary greatly. Here we map the Lya emission from local starburst Haro 11, a Lya emitter and the only known candidate for low-z Lyman continuum emission (LyC). To aid in the interpretation we perform a detailed multi-wavelength analysis and model the stellar population, dust distribution, ionising photon budget, and star-cluster population. We use archival X-ray observations to further constrain properties of the starburst and estimate the HI column density. The Lya morphology is found to be strongly decoupled from stellar and nebular (H-alpha) morphologies. General surface photometry finds only very slight correlation between Lya and H-halpha, E(B-V), and stellar age. Only around the central Lya-bright cluster do we find the Lya/Ha ratio at values predicted by recombination theory. The total Lya escape fraction is found to be just 3%. We compute that ~90% of the Lya photons that escape do so after undergoing multiple resonance scattering events, masking their point of origin. This leads to a largely symmetric distribution and, by increasing the distance that photons must travel to escape, decreases the escape probability significantly. While dust must ultimately be responsible for the destruction of Lya, it plays little role in governing the observed morphology, which is regulated more by ISM kinematics and geometry. We find tentative evidence for local Lya equivalent width in the immediate vicinity of star-clusters being a function of cluster age, consistent with hydrodynamic studies. We estimate the ionising photon production and further constrain the escape fraction at 900 AA to <~9% .Comment: In press for MNRAS. 18 pages, 9 figures. Version with full resolution images to be found at http://www.astro.su.se/~matthew/english/papers/hayes_lya_haro11_hires.pd

Tuning the endocytosis mechanism of Zr-based metal−organic frameworks through linker functionalization

A critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us to design an effi-cient drug delivery system. In particular, naphthalene-2,6-dicarboxylic acid and 4,4'-biphenyldicarboxylic acid ligands promote entry through the caveolin-pathway, allowing the particles to avoid lysosomal degradation and be delivered into the cytosol, en-hancing their therapeutic activity when loaded with drugs

A Knowledge-Based Entrepreneurial Approach for Business Intelligence in Strategic Technologies: Bio-Mems

We propose a knowledge-based entrepreneurial (KBE) approach for business intelligence in strategic technologies at industrial sectors. The KBE approach is at the convergence of business intelligence and knowledge management and is used for advising users in business decisions and potential risks. Our approach comprises both a technology roadmap model as well as a knowledge-based entrepreneurial portal for various technologies. We use the Biological-Micro-Electrical-and- Mechanical-Systems industry (Bio-MEMS) to illustrate the approach. The technology roadmap model identifies the main actors, defines their roles and specifies the issues to be addressed. It handles information about main products, market trends, companies, research centers, application domains, products, standardization, and intellectual properties issues. The portal provides knowledge about the main actors through automation facilities based on digital libraries, searching and knowledge extraction from databases, data-ware houses and the Web. We explain how the KBE is helping Bio-MEMS users in business analysis

Clinicopathological classification of immune checkpoint inhibitor-associated myocarditis: Possible refinement by measuring macrophage abundance

BACKGROUND: Immune checkpoint inhibitor (ICI) myocarditis is associated with high morbidity and mortality. While endomyocardial biopsy (EMB) is considered a gold standard for diagnosis, the sensitivity of EMB is not well defined. Additionally, the pathological features that correlate with the clinical diagnosis of ICI-associated myocarditis remain incompletely understood. METHODS: We retrospectively identified and reviewed the clinicopathological features of 26 patients with suspected ICI-associated myocarditis based on institutional major and minor criteria. Seventeen of these patients underwent EMB, and the histopathological features were assessed by routine hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) staining for CD68, a macrophage marker. RESULTS: Only 2/17 EMBs obtained from patients with suspected ICI myocarditis satisfied the Dallas criteria. Supplemental IHC staining and quantification of CD68 CONCLUSIONS: While the Dallas criteria can identify a subset of ICI-associated myocarditis patients, quantification of macrophage abundance may expand the diagnostic role of EMB. Failure to meet the traditional Dallas Criteria should not exclude the diagnosis of myocarditis