Ischemic postconditioning fails to reduce infarct size in pig models of intermediate and prolonged ischemia

This study was funded by the Spanish Ministry of Science and Innovation (“RETOS 2019” grant No PID2019-107332RB-I00 to B.I). B.I is funded by the European Commission (ERC-CoG grant No 819775, and H2020-HEALTH grant No 945118). J.N. is recipient of a predoctoral grant (Jordi Soler Soler) through CIBERCV. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministry of Science and Innovation and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (CEX2020-001041-S).S

Study protocol of a randomized controlled trial to assess safety of teleconsultation compared with face-to-face consultation: the ECASeT study

BackgroundThe use of remote consultation modalities has exponentially grown in the past few years, particularly since the onset of the COVID-19 pandemic. Although a huge body of the literature has described the use of phone (tele) and video consultations, very few of the studies correspond to randomized controlled trials, and none of them has assessed the safety of these consultation modalities as the primary objective. The primary objective of this trial was to assess the safety of remote consultations (both video and teleconsultation) in the follow-up of patients in the hospital setting.MethodsMulticenter, randomized controlled trial being conducted in four centers of an administrative healthcare area in Catalonia (North-East Spain). Participants will be screened from all individuals, irrespective of age and sex, who require follow-up in outpatient consultations of any of the departments involved in the study. Eligibility criteria have been established based on the local guidelines for screening patients for remote consultation. Participants will be randomly allocated into one of the two study arms: conventional face-to-face consultation (control) and remote consultation, either teleconsultation or video consultation (intervention). Routine follow-up visits will be scheduled at a frequency determined by the physician based on the diagnostic and therapy of the baseline disease (the one triggering enrollment). The primary outcome will be the number of adverse reactions and complications related to the baseline disease. Secondary outcomes will include non-scheduled visits and hospitalizations, as well as usability features of remote consultations. All data will either be recorded in an electronic clinical report form or retrieved from local electronic health records. Based on the complications and adverse reaction rates reported in the literature, we established a target sample size of 1068 participants per arm. Recruitment started in May 2022 and is expected to end in May 2024.DiscussionThe scarcity of precedents on the assessment of remote consultation modalities using randomized controlled designs challenges making design decisions, including recruitment, selection criteria, and outcome definition, which are discussed in the manuscript.Trial registrationNCT05094180. The items of the WHO checklist for trial registration are available in Additional file 1. Registered on 24 November 2021

ESQUEMA PARA LA INSTRUCCIÓN Y EVALUACIÓN DEL RAZONAMIENTO EN ESTADÍSTICA INFERENCIAL ELEMENTAL

El principal objetivo de este trabajo es descrilrir un esquema para caracterizar y evaluar el aprendizaje de la inferencia estadística elemental. La inferencia estadística ha sido recientemente incluida en los currículos españoles para la enseñanza secundaria y esto lia planteado nuevas necesidades tanto de tipo teórico como didáctico. El esquema que describimos es nuestra contribución teórica al conocimiento en el dominio del razonamiento estadístico y para planificar la enseñanza del tema

Esquema para la instrucción y evaluación del razonamiento en estadística inferencial elemental

El principal objetivo de este trabajo es describir un esquema para caracterizar y evaluar el aprendizaje de la inferencia estadística elemental. La inferencia estadística ha sido recientemente incluida en los currículos españoles para la enseñanza secundaria y esto ha planteado nuevas necesidades tanto de tipo teórico como didáctico. El esquema que describimos es nuestra contribución teórica al conocimiento en el dominio del razonamiento estadístico y para planificar la enseñanza del tema

Paciente de 60 años con diabetes, obesidad y psoriasis

IX Reunión de Diabetes y Obesidad (30-31 de enero de 2015, Sevilla). Grupo de Diabetes y Obesidad de la Fundación Española de Medicina Interna.Mujer de 60 años con antecedentes personales de diabetes, obesidad y psoriasis que fue derivada desde Atención Primaria por mal control glucémico (Hb glicada: 7,3%). Se inició tratamiento con metformina 850 mg/12h y liraglutide 1,2 mg/sc/d, manteniéndose el mismo tratamiento que venía realizando para la psoriasis con corticoides tópicos y metrotexate. Tres meses tras el cambio de tratamiento se revisó en consultas objetivándose un óptimo control glucémico (Hb glicada 6,1%), reducción de 8,5 Kg de peso y mejoría de las lesiones cutáneas.N