La iglesia parroquial de Santiago (San Clemente, Cuenca) : Nuevos datos para su estudio.

El artículo que a continuación proponemos estudia el proceso constructivo de la iglesia parroquial de San Clemente a partir del análisis de algunos textos ya publicados, la lectura de la documentación publicada por Diego Torrente Pérez y el análisis de documentación inédita aportada en el siguiente trabajo. Todo ello sumado a la observación directa de nuestro objeto de estudio nos permitirán trazar un recorrido cronológico para las obras de este magnífico templo parroquial, capaz de atraer en su construcción tanto el talento de diversos maestros locales como las ideas y consejos de maestros de primera fila a nivel peninsular en cuanto a la introducción de las formas renacentistas se refiere.The following study examines the construction process of the San Clemente parish church based on the analysis of previously published studies, reading the documentation published by Diego Torrente Pérez and the analysis of unpublished documentation provided in the following work. All this, combined with direct observation of our object of study, allows us to draw a chronological overview of the works of this magnificent parish church. A building which was able to attract the talent of several local master builders and the ideas and tips of the best master builders in a peninsular level, as introducers of its construction of the first Renaissance forms

El convento de carmelitas descalzos de San José de Uclés (1594-1611). Una obra inédita de Fray Alberto de la Madre de Dios

El convento de carmelitas descalzos de Uclés (Cuenca) ha pasado hasta ahora prácticamente inadvertido por la historiografía artística. El estado ruinoso que presenta desde el siglo XIX y la falta de documentación sobre el mismo ha impedido un análisis en profundidad sobre este interesante ejemplo conventual, cuyas obras se llevaron a cabo durante la llamada etapa de homogenización de los modos arquitectónicos carmelitanos. El presente artículo expone el proceso de fundación y patrocinio del convento por parte de la familia de los Velázquez desde Uclés y desde Nueva España. Además, aporta documentación inédita que constata la participación como trazadores del mismo de los monjes carmelitas fray Francisco de Jesús María y de fray Alberto de la Madre de Dios, siendo ésta hasta la fecha, la primera obra documentada de fray Alberto como tracista

The exhibition space as a place of encounter. The mediation processes in Bombas Gens Centre d’Art

El panorama general sobre el consumo de arte en nuestro país ha propiciado una profunda revisión crítica sobre el estatus del museo en la sociedad española. Dentro de la función educativa ampliamente extendida y asociada a estas instituciones, ha cobrado especial relevancia en los últimos tiempos el concepto de mediación. En el presente artículo, concretamos algunas de las ideas consensuadas sobre las estrategias de diálogo en los museos de arte a la par que exponemos la puesta en práctica de estas teorías en un ejemplo pionero en la ciudad de ValenciaThe current art scene in our country has led to a comprehensive, critical review of the status of art museums in Spanish society. Mediation has become particularly important in recent times within the educational role widely promoted by and associated with these institutions. In this article, we will summarise some of the predominant ideas regarding mediation strategies in art museums, and will show the results of implementing such pioneering strategies by using an art museum in Valencia as an example

Historia constructiva del Real Convento de Santiago de Uclés

Este trabajo tiene como objetivo el estudio histórico-artístico del Real Monasterio de Santiago de Uclés, a lo largo de la Edad Moderna y fundamentalmente a partir de 1529, cuando se da comienzo al proceso de remodelación total del entonces monasterio medieval hasta la conclusión del proyecto, a finales del siglo XVIII. El monasterio de los caballeros de Santiago de Uclés es un edificio que encapsula dentro de sus muros diferentes historias. Analizar su proceso constructivo nos ha permitido aproximarnos no solamente a las formas de construir de una época o a los estilos imperantes. Durante su dilatada construcción, a lo largo de más de doscientos años, entran en juego aspectos relacionados con la organización de la propia Orden Militar de Santiago en lo concerniente a la administración de las obras realizadas en sus territorios y muy especialmente al papel que jugó el propio rey como patrocinador del proyecto y administrador perpetuo de la orden. Este trabajo propone una cronología lo más completa posible hasta la fecha sobre el desarrollo constructivo del edificio. Ello ha permitido un mejor conocimiento de los artífices que en cada momento se vieron implicados en la construcción del monasterio y cual pudo ser su aportación real a las obras, confrontando los datos que se tenían hasta el momento con la nueva documentación dada a conocer en este trabajo. Además, este estudio tiene entre sus objetivos el estudio de la arquitectura desarrollada en el monasterio y en sus ámbitos de influencia teniendo en cuenta las “geografías históricas” en las que se produce, por lo que a lo largo del trabajo se establecen nexos entre la arquitectura del propio monasterio y la arquitectura del priorato de Uclés, así como de la arquitectura moderna de la península en general. Además, la realización de este trabajo ha evidenciado la importancia de entender los usos sociales y simbólicos de sus dependencias, ya que en este edificio entra en juego no solamente la práctica religiosa, función principal del conjunto monástico, sino que también se activan aspectos relacionados con la representación social de una clase noble privilegiada, unida y amparada por la pertenencia a un grupo relativamente exclusivo y corporativista. Por último, se incluyen aquí toda una serie de pequeñas biografías de artífices implicados en las obras del monasterio y su foco de influencia. En algunos casos, se documentan nuevos trabajos a personajes ya conocidos, mientras que en otros casos se trata de artífices desconocidos hasta la fecha. Pretendemos así contribuir al estudio de la arquitectura desarrollada durante la Edad Moderna en el área geográfica del priorato de Uclés y otras zonas conectadas artísticamente precisamente mediante el trasiego de estos artífices. En la actualidad no existe una monografía de estas características sobre el tema de estudio, por lo que la aportación de fuentes documentales inéditas, la ordenación de la información obtenida o la formulación de interrogantes e hipótesis, serán de gran provecho para el conocimiento de un edificio de singular importancia en el contexto peninsular de la Edad Moderna, y abrirá el camino de futuras investigaciones sobre el tema.The objective of this work is the art historical study of the Royal Monastery of Santiago de Uclés, throughout the Modern Age and specially from 1529, when the process of total remodeling of the medieval monastery began, until the end of the project at the end of the 18th century. The monastery of the knights of Santiago de Uclés is a building that involves different histories within its walls. The analysis of its constructive process has allowed us to approach not only the ways of building in a particular era but its domintant styles too. This study examines the different building campaigns, which stretched over a period of more than two hundred years. It focusses on aspects related to the organization of the Military Order of Santiago and its role in the administration of the works made in their territories, especially the importance of the king himself as sponsor of the project and as perpetual administrator of the order. This work provides a complete a chronology as possible for the constructive development of the building. That point allows for a better understanding of the architects who were involved in its construction and their effective contribution, comparing the data we already had with the new documentary evidence. In addition, this work tries to contextualize the architecture developed in the monastery and its areas of influence, taking into account the "historical geographies" by establishing links between the architecture of the monastery and the architecture in the Uclés priory, as well as the early modern architecture of the peninsula in general. Besides, this study shows the importance of understanding the social uses of its architectural spaces, taking into account that this building was developed not only for religious practice - the main function for the monastic community - but also for the social representation of a noble class, united and protected by the membership of the exclusive Military Order of Santiago. Finally, a series of short biographies of architects is included in this work, some already known from previous studies to which new data can be added. Other names included in this work were previously unknown. These biographies intend to contribute to the study of the architecture developed during the early modern period in the area of the priory of Uclés, as well as other areas connected artistically by the mobility of these architects. There exists no monograph about the Monastery of Uclés dedicated to these aspects, so the edition and analysis of previously unpublished documentary sources, as well as the formulation of questions and hypotheses will be of great benefit for the knowledge of a building with such an artistic importance in the peninsular context of the Modern Age, and will open the way for future research on the subject. The study includes the following chapters: The monastery of Uclés and its territory until our days. a historiographical review The order of santiago and the architecture in its territories The monastery of santiago de uclés in between the 15th and 16th centuries The initiation of the works of the new building of Santiago de Uclés (1528-1554) The church and the role of the major master builder (1567-1611) The 18th century in the Uclés monastery: the end of the project Working in the Uclés priorate in Modern Age. Biographical aspect

Recensiones (coord. José Martín Martínez y Felipe Jerez Moliner)

Recensione

Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice : A multicentre cohort study

Background: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Methods: Treatment-experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014-2018 and with more than 24 weeks of follow-up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or ≥ 50 copies/ml at the start of the regimen). Results: We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had ≥ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL ≥ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with baseline VL ≥ 50 copies/ml) changed due to virological failure. Conclusions: EVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment-experienced patients with undetectable viral load as a simplification strategy, allowing once-daily, two-pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads

How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort

CatedresBackground: To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods: Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results: Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions: Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women