Dirac Cosmology and the Acceleration of the Contemporary Universe

A model is suggested to unify the Einstein GR and Dirac Cosmology. There is one adjusted parameter $b_2$ in our model. After adjusting the parameter $b_2$ in the model by using the supernova data, we have calculated the gravitational constant $\bar G$ and the physical quantities of $a(t)$, $q(t)$ and $\rho_r(t)/ \rho_b(t)$ by using the present day quantities as the initial conditions and found that the equation of state parameter $w_{\theta}$ equals to -0.83, the ratio of the density of the addition creation $\Omega_{\Lambda}=0.8$ and the ratio of the density of the matter including multiplication creation, radiation and normal matter $\Omega_m =0.2$ at present. The results are self-consistent and in good agreement with present knowledge in cosmology. These results suggest that the addition creation and multiplication creation in Dirac cosmology play the role of the dark energy and dark matter.Comment: 13 pages, 8 figure

OLR anomalies of the Dezhou MS5.5 earthquake in Shandong Province based on FY-3E satellite data

Based on the periodic variation of tidal forces, outgoing longwave radiation (OLR) data from the FY-3E satellite were used to analyze the daily variations of OLR from June 30 to August 30 in 2023 over a large area (17°N～55°N, 73°E～136°E) of the Chinese mainland. In addition, correlations between tidal forces, OLR, and the MS5.5 earthquake that occurred in Pingyuan County, Dezhou on August 6, 2023 were discussed. Analysis of OLR changes and the synchronous tidal force cycle revealed that: ① During the periods without earthquake tidal force changes (cycles A and B before the earthquake and D after the earthquake), OLR exhibited no significant variations near the epicenter, whereas continuous OLR anomalies were observed during the earthquake period (cycle C), accompanied by continuous variation in tidal force from trough to peak to trough. OLR anomalies show the stage characteristics of initial warming, strengthening, peak attenuation, and gradual calming, which are synchronous in time. ② OLR anomalies were closely distributed around the Liaocheng-lankou fault, indicating that seismic tectonic movement was the main cause of OLR anomalies associated with the earthquake, and the evolution of OLR anomalies during the earthquake represent the radiation of seismic tectonic stress changes. ③ The earthquake occurred near the peak phase point of cycle C, synchronous with the enhanced characteristics of the OLR anomalies. Therefore, when accumulated seismic tectonic stress exceeded the critical state of rock fracture and sliding, the sudden change in the size and direction of the tidal force promoted the instability of the Liaocheng-lankou fault and induced the earthquake. These results also show that the OLR products of the FY-3E satellite are useful for identifying seismic infrared anomalies

Dietary selenium supplementation: its impact on growth, microbiota, antioxidant capacity, and immunity in Inner Mongolian cashmere goats

Selenium (Se) is an essential trace element in the animal body that plays a crucial role in regulating antioxidant defense, immune response, and reproductive performance, contributing significantly to overall animal health. This study aimed to investigate the effects of dietary yeast selenium added to the feed on growth performance, antioxidant capacity, immune response, and rumen microbes of Inner Mongolian cashmere goats. A total of 18 male Inner Mongolian cashmere goats (47.1 ± 1.1 kg, 24 months of age) were selected and randomly divided into two groups, the normal feeding group (CON group) and the yeast selenium supplementation group (0.4 mg/d, Se group) (n = 9 in each group) for 30 days of the experiment. The results showed that the average daily weight gain in the Se group was significantly higher than that in the CON group (p < 0.05). In addition, the levels of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), immunoglobulin IgA, and IgG in the blood and semen in the Se group were significantly higher than those in the CON group (p < 0.05). Dietary supplementation with yeast selenium mainly increased the abundance of Bacteroidales_RF16_group, p-251-o5, UCG-004, and UCG-010 in the rumen (p < 0.05). Spearman’s correlation analysis showed that Bacteroidales_RF16_group, Bacteroidales_RCG-004, and Bacteroidales_RCG-010 significantly affected the rumen microbiota and fermentation parameters and significantly increased the antioxidant and immune capacity of plasma and seminal plasma (p < 0.05). This study provides data to support the use of supplemental yeast selenium for the healthy breeding of cashmere goats

Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation

Background The Epstein-Barr virus (EBV)-encoded EBNA1 protein is expressed in all EBV-associated tumours, including undifferentiated nasopharyngeal carcinoma (NPC), where it is indispensable for viral replication, genome maintenance and viral gene expression. EBNA1's transcription factor-like functions also extend to influencing the expression of cellular genes involved in pathways commonly dysregulated during oncogenesis, including elevation of AP-1 activity in NPC cell lines resulting in enhancement of angiogenesis in vitro. In this study we sought to extend these observations by examining the role of EBNA1 upon another pathway commonly deregulated during carcinogenesis; namely NF-κB. Results In this report we demonstrate that EBNA1 inhibits the canonical NF-κB pathway in carcinoma lines by inhibiting the phosphorylation of IKKα/β. In agreement with this observation we find a reduction in the phosphorylation of IκBα and reduced phosphorylation and nuclear translocation of p65, resulting in a reduction in the amount of p65 in nuclear NF-κB complexes. Similar effects were also found in carcinoma lines infected with recombinant EBV and in the EBV-positive NPC-derived cell line C666-1. Inhibition of NF-κB was dependent upon regions of EBNA1 essential for gene transactivation whilst the interaction with the deubiquitinating enzyme, USP7, was entirely dispensable. Furthermore, in agreement with EBNA1 inhibiting p65 NF-κB we demonstrate that p65 was exclusively cytoplasmic in 11 out of 11 NPC tumours studied. Conclusions Inhibition of p65 NF-κB in murine and human epidermis results in tissue hyperplasia and the development of squamous cell carcinoma. In line with this, p65 knockout fibroblasts have a transformed phenotype. Inhibition of p65 NF-κB by EBNA1 may therefore contribute to the development of NPC by inducing tissue hyperplasia. Furthermore, inhibition of NF-κB is employed by viruses as an immune evasion strategy which is also closely linked to oncogenesis during persistent viral infection. Our findings therefore further implicate EBNA1 in playing an important role in the pathogenesis of NPC

Case report: Identification of atypical mantle cell lymphoma with CCND3 rearrangement by next-generation sequencing

The t(11;14) (q13;q32) translocation resulting in overexpression of cyclin D1 is the major oncogenic mechanism in mantle cell lymphoma (MCL). Most MCLs can be diagnosed based on morphological features, cyclin D1 expression, and IGH/CCND1 rearrangement. However, in some atypical cases where conventional FISH studies fail to detect IGH/CCND1 rearrangement or immunohistochemistry for cyclin D1 is negative, the diagnosis of the disease can be difficult. Hence, next-generation sequencing (NGS) may allow the identification of molecular alterations and assist in the diagnosis of atypical MCL. In this study, we reported a case of a patient diagnosed as asymptomatic MCL who presented with lymphadenopathy during the initial assessment. A lymph node biopsy was performed and the results revealed a high Ki67 index. However, initial diagnosis of aggressive MCL was difficult since the IGH/CCND1 rearrangement result was negative. Ultimately, by the aid of NGS we identified a rare CCND3 rearrangement in the patient, which lead to overexpression of cyclin D3, thereby facilitating the diagnosis of MCL

Decitabine for Treatment of Myelodysplastic Syndromes in Chinese Patients: An Open-Label, Phase-3b Study

The objective of this study was to evaluate the efficacy and safety of decitabine in Chinese patients with myelodysplastic syndrome (MDS). Patients (a parts per thousand yen18 years) who had a de novo or secondary MDS diagnosis according to French-American-British classification and an International Prognostic Scoring System score a parts per thousand yen0.5 were enrolled and randomized (1:1) to one of two decitabine regimens: 3-day treatment (3-h intravenous infusion of 15 mg/m(2) given every 8 h for three consecutive days/cycle/6 weeks) or 5-day treatment (1-h intravenous infusion of 20 mg/m(2) once daily on days 1-5/cycle/4 weeks). After a minimum of 30 patients were assigned to 3-day schedule, the remaining were assigned to the 5-day schedule. The primary efficacy endpoint was the overall response rate (ORR). Secondary outcome measures included hematologic improvement (HI), cytogenetic response rate, the time to acute myeloid leukemia (AML) progression, and overall survival (OS). In total, 132 of 135 enrolled patients (3-day treatment, n = 36; 5-day treatment, n = 99) discontinued treatment (major reasons included patient withdrawal/lack of efficacy, n = 48; adverse events, n = 23; and disease progression, n = 22). During the study, 35 of 132 (26.5%) patients from the intent-to-treat (ITT) group achieved significant (P < 0.001) ORR [3-day group (n = 10, 29.4%), P = 0.003; 5-day group (n = 25, 25.5%), P < 0.001]. The HI rate was similar between the 3-day (47.1%) and 5-day groups (48.0%). Cytogenetic response was achieved in 20 of the 30 (66.7%) patients who had a baseline cytogenetic abnormality. Fifty-three (40.2%) AML transformations or deaths occurred and the median AML-free survival time was 23.8 months for all patients from the ITT set; 24-month OS rate was 48.9%. Adverse events of myelosuppression-related disorders (85.6%) and infections (43.2%) were commonly reported. Decitabine treatment was efficacious in Chinese patients with MDS with its safety profile comparable to the global studies of decitabine conducted to date. Xian-Janssen Pharmaceutical Ltd. China (a company of Johnson & Johnson). ClinicalTrials.gov identifier, NCT01751867.Xian-Janssen Pharmaceutical Ltd. China; Xian-Janssen Pharmaceutical Ltd. China (a company of Johnson Johnson)SCI(E)[email protected]

Gas Sensors Based on Electrospun Nanofibers

Nanofibers fabricated via electrospinning have specific surface approximately one to two orders of the magnitude larger than flat films, making them excellent candidates for potential applications in sensors. This review is an attempt to give an overview on gas sensors using electrospun nanofibers comprising polyelectrolytes, conducting polymer composites, and semiconductors based on various sensing techniques such as acoustic wave, resistive, photoelectric, and optical techniques. The results of sensing experiments indicate that the nanofiber-based sensors showed much higher sensitivity and quicker responses to target gases, compared with sensors based on flat films

Study on the Deformation Induced by Vertical Two-Layer Large Diameter Pipe-Jacking in the Soil-Rock Composite Stratum

Aiming at the features of deformation caused by large diameter vertical two-layer pipe jacking in the soil-rock composite stratum, on-site monitoring and numerical analysis has been done based on an electric power tunnel project constructed with the pipe jacking method, in which the upper tunnel is located in the soil layer and the lower tunnel is partially located in the rock layer. The research shows that: (1) During upper pipe jacking construction, the maximum transverse and longitudinal ground settlements are about three times those of the lower pipe jacking construction, and the maximum horizontal lateral displacement is about 3.3 times the lower pipe jacking construction. (2) Total ground settlement increases rapidly with the reduction of vertical clear spacing of the upper and lower pipe, and the superimposed effect should be taken into consideration during the vertical arranged pipe-jacking construction. (3) The Peck formula, which is used to estimate lateral surface subsidence distribution, is modified to make it more applicable in the soil–rock composite stratum to calculate the ground settlement induced by the construction of pipe-jacking

Study on the Deformation Induced by Vertical Two-Layer Large Diameter Pipe-Jacking in the Soil-Rock Composite Stratum

Aiming at the features of deformation caused by large diameter vertical two-layer pipe jacking in the soil-rock composite stratum, on-site monitoring and numerical analysis has been done based on an electric power tunnel project constructed with the pipe jacking method, in which the upper tunnel is located in the soil layer and the lower tunnel is partially located in the rock layer. The research shows that: (1) During upper pipe jacking construction, the maximum transverse and longitudinal ground settlements are about three times those of the lower pipe jacking construction, and the maximum horizontal lateral displacement is about 3.3 times the lower pipe jacking construction. (2) Total ground settlement increases rapidly with the reduction of vertical clear spacing of the upper and lower pipe, and the superimposed effect should be taken into consideration during the vertical arranged pipe-jacking construction. (3) The Peck formula, which is used to estimate lateral surface subsidence distribution, is modified to make it more applicable in the soil–rock composite stratum to calculate the ground settlement induced by the construction of pipe-jacking