Study on Spatial Variation of Shear Mechanical Properties of Soil-rock Mixture

The soil-rock mixture (SRM) is a kind of special engineering geological material, which has been exposed to the field for a long time and is affected by rainwater seepage, geological force, slope sliding force and human activities, resulting in the spatial variability of its mechanical properties. Taking the SRM distributed on a slope of the Three Gorges Reservoir area as the research object, four test locations were selected along and transverse the slope. First, in-situ large-scale direct shear test was carried out, and then the laboratory large-scale direct shear test, particle sieving test, and water content test were carried out in the undisturbed sample to study the variation of shear mechanical properties of SRM distributed in different spatial locations. The results show that: (1) Under the same normal stress, the peak strength of the SRM decreases at a similar rate along the slope direction and the transverse slope direction. (2) The cohesion of the SRM is continuously strengthened, and the friction angle is continuously deteriorated along the slope from high to low, the cohesion and friction angle are almost no variability along the transverse slope. (3) The mechanism of the above-mentioned variation in the shear mechanics parameters of SRM is that the lower the elevation along the slope, the more fragmented the rock, the lower the rock content. (4) Spatial variability models of cohesion and friction angle of SRM were established, which can provide references for related engineering applications

Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation.

Congenital pulmonary airway malformation (CPAM) is the most common congenital lesion detected in the neonatal lung, which may lead to respiratory distress, infection, and pneumothorax. CPAM is thought to result from abnormal branching morphogenesis during fetal lung development, arising from different locations within the developing respiratory tract. However, the pathogenic mechanisms are unknown, and previous studies have focused on abnormalities in airway epithelial cells. We have analyzed 13 excised lung specimens from infants (age < 1 year) with a confirmed diagnosis of type 2 CPAM, which is supposed to be derived from abnormal growth of intrapulmonary distal airways. By examining the mesenchymal components including smooth muscle cells, laminin, and elastin in airway and cystic walls using immunofluorescence staining, we found that the thickness and area of the smooth muscle layer underlining the airway cysts in these CPAM tissue sections were significantly decreased compared with those in bronchiolar walls of normal controls. Extracellular elastin fibers were also visually reduced or absent in airway cystic walls. In particular, a layer of elastin fibers seen in normal lung between airway epithelia and underlying smooth muscle cells was missing in type 2 CPAM samples. Thus, our data demonstrate for the first time that airway cystic lesions in type 2 CPAM occur not only in airway epithelial cells, but also in adjacent mesenchymal tissues, including airway smooth muscle cells and their extracellular protein products. This provides a new direction to study the molecular and cellular mechanisms of CPAM pathogenesis in human

BcBIM: A Blockchain-Based Big Data Model for BIM Modification Audit and Provenance in Mobile Cloud

Building Information Modeling (BIM) is envisioned as an indispensable opportunity in the architecture, engineering, and construction (AEC) industries as a revolutionary technology and process. Smart construction relies on BIM for manipulating information flow, data flow, and management flow. Currently, BIM model has been explored mainly for information construction and utilization, but rare works pay efforts to information security, e.g., critical model audit and sensitive model exposure. Moreover, few BIM systems are proposed to chase after upcoming computing paradigms, such as mobile cloud computing, big data, blockchain, and Internet of Things. In this paper, we make the first attempt to propose a novel BIM system model called bcBIM to tackle information security in mobile cloud architectures. More specifically, bcBIM is proposed to facilitate BIM data audit for historical modifications by blockchain in mobile cloud with big data sharing. The proposed bcBIM model can guide the architecture design for further BIM information management system, especially for integrating BIM cloud as a service for further big data sharing. We propose a method of BIM data organization based on blockchains and discuss it based on private and public blockchain. It guarantees to trace, authenticate, and prevent tampering with BIM historical data. At the same time, it can generate a unified format to support future open sharing, data audit, and data provenance

Hybrid grating in reduced-diameter fiber for temperature-calibrated high-sensitivity refractive index sensing

We propose and experimentally demonstrate a hybrid grating, in which an excessively tilted fiber grating (Ex-TFG) and a fiber Bragg grating (FBG) were co-inscribed in a reduced-diameter fiber (RDF). The hybrid grating showed strong resonances due to coupling among core mode and a set of polarization-dependent cladding modes. This coupling showed enhanced evanescent fields by the reduced cladding size, thus allowing stronger interaction with the surrounding medium. Moreover, the FBG's Bragg resonance confined by the thick cladding was exempt from the change of the surrounding medium's refractive index (RI), and then the FBG can work as a temperature compensator. As a result, the Ex-TFG in RDF promised a highly sensitive RI measurement, with a sensitivity up to ~1224 nm/RIU near the RI of 1.38. Through simultaneous measurement of temperature and RI, the temperature dependence of water's RI is then determined. Therefore, the proposed hybrid grating with a spectrum of multi-peaks embedded with a sharp Bragg resonance is a promising alternative for the simultaneous measurement of multi-parameters for many RI-based sensing applications

Temperature-calibrated high-precision refractometer using a tilted fiber Bragg grating

We present a refractometer with main- and vernier-scale to measure the refractive index (RI) of liquids with high precision by using the fine spectrum structure of a tilted fiber Bragg grating (TFBG). The absolute RI values are determined by the accurate wavelength of cut-off mode resonances. The main- and vernier-scale are calibrated by measuring large groups of fine spectra at different cut-off mode resonances in a small RI range, and the use of vernier-scale certainly reduces the RI measurement uncertainty resulted from the discrete cladding mode resonances. The performance of the TFBG-based vernier refractometer is experimentally verified by exploring the temperature dependence of RI of anhydrous ethanol in a near infrared region, showing an enhanced accuracy to the order of 10−4, high repeatability and temperature self-calibration capability

Study on the Time-lag Failure of Sandstone With Different Degrees of Unloading Damage

The unloading effect of rock mass excavation is an inevitable practice, and it’s often characterized by a relatively large-scale engineering hazard with a noticeable time lag.A set of unloading triaxial tests were conducted on a sandstone rock to establish the deformation law and the threshold time. Based on the renormalization group theory, the unloading sandstone model was developed by considering the interaction between particles. Similarly, a logistic model was used to predict the unloading damage of sandstone. The unloading time lag damage of sandstone rock was predicted by using the damage threshold. The research shows that: (1) The higher the degree of unloading, the shorter the time-lag failure. (2) The damage range of critical values was optimized. (3) The error between the predicted value and the experimental value of the time threshold was almost less than 5 %, the prediction result was found to be good, and the employed logistic evolution model was reasonable. The findings of this research provide a prediction method and precise information about the mechanism of unloading time lag deformation. Therefore, it can be used as a reference for excavation-support design of underground structures

STATISTICAL ANALYSIS OF 70-MER OLIGONUCLEOTIDE MICROARRAY DATA FROM POLYPLOID EXPERIMENTS USING REPEATED DYE-SWAPS

Polyploidy plays an important role in plant evolution. A series of Arabidopsis autopolyploids and allopolyploids have been developed, and their transcript abundance compared using a 70-mer oligonucleotide microarray consisting of 26,090 annotated genes in Arabidopsis thaliana. The experimental design included repeated dye-swaps, and analysis of variance (ANOVA) was employed to detect significant gene expression changes among and between the diploid, autopolyploid, and allopolyploid populations. Here, we discuss the statistical issues (replication, normalization, transformation, per-gene variance estimate, and the pooled estimate of variation) involved in analyzing these data, as well as the statistical findings of these analyses