TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients

<p>Abstract</p> <p>Background</p> <p><it>TNFRSF11B </it>computational development network construction and analysis of frontal cortex of HIV encephalitis (HIVE) is very useful to identify novel markers and potential targets for prognosis and therapy.</p> <p>Methods</p> <p>By integration of gene regulatory network infer (GRNInfer) and the database for annotation, visualization and integrated discovery (DAVID) we identified and constructed significant molecule <it>TNFRSF11B </it>development network from 12 frontal cortex of HIVE-control patients and 16 HIVE in the same GEO Dataset GDS1726.</p> <p>Results</p> <p>Our result verified <it>TNFRSF11B </it>developmental process only in the downstream of frontal cortex of HIVE-control patients (<it>BST2, DGKG, GAS1, PDCD4, TGFBR3, VEZF1 </it>inhibition), whereas in the upstream of frontal cortex of HIVE (<it>DGKG, PDCD4 </it>activation) and downstream (<it>CFDP1, DGKG, GAS1, PAX6 </it>activation; <it>BST2, PDCD4, TGFBR3, VEZF1 </it>inhibition). Importantly, we datamined that <it>TNFRSF11B </it>development cluster of HIVE is involved in T-cell mediated immunity, cell projection organization and cell motion (only in HIVE terms) without apoptosis, plasma membrane and kinase activity (only in HIVE-control patients terms), the condition is vital to inflammation, brain morphology and cognition impairment of HIVE. Our result demonstrated that common terms in both HIVE-control patients and HIVE include developmental process, signal transduction, negative regulation of cell proliferation, RNA-binding, zinc-finger, cell development, positive regulation of biological process and cell differentiation.</p> <p>Conclusions</p> <p>We deduced the stronger <it>TNFRSF11B </it>development network in HIVE consistent with our number computation. It would be necessary of the stronger <it>TNFRSF11B </it>development function to inflammation, brain morphology and cognition of HIVE.</p

Division of labor, skill complementarity, and heterophily in socioeconomic networks

Constituents of complex systems interact with each other and self-organize to form complex networks. Empirical results show that the link formation process of many real networks follows either the global principle of popularity or the local principle of similarity or a tradeoff between the two. In particular, it has been shown that in social networks individuals exhibit significant homophily when choosing their collaborators. We demonstrate, however, that in populations in which there is a division of labor, skill complementarity is an important factor in the formation of socioeconomic networks and an individual's choice of collaborators is strongly affected by heterophily. We analyze 124 evolving virtual worlds of a popular "massively multiplayer online role-playing game" (MMORPG) in which people belong to three different professions and are allowed to work and interact with each other in a somewhat realistic manner. We find evidence of heterophily in the formation of collaboration networks, where people prefer to forge social ties with people who have professions different from their own. We then construct an economic model to quantify the heterophily by assuming that individuals in socioeconomic systems choose collaborators that are of maximum utility. The results of model calibration confirm the presence of heterophily. Both empirical analysis and model calibration show that the heterophilous feature is persistent along the evolution of virtual worlds. We also find that the degree of complementarity in virtual societies is positively correlated with their economic output. Our work sheds new light on the scientific research utility of virtual worlds for studying human behaviors in complex socioeconomic systems.Comment: 14 Latex pages + 3 figure

An e-Business Logistic Model in Taiwan

The current article develops a framework for an e-business logistic model in Taiwan. The model includes e-marketplace, logistic, organization, and informational systems factors. Data used for this research come from a survey of business groups, including marine and air carriers, terminal warehousing, custom brokers, shipping centers, and marine information service providers. Our study reveals relationships between essential variables for e-business trading in the logistic industry. These include organizational advantage and information technology, strategy and vision, consumer-directed service and planning, lower cost and high quality customer service, quick merchandise delivery and low inventory, and long-term development plans. Specifically, we found that the logistic industry in Taiwan ignores the details of purchasing procedure in e-marketplace operation, focusing more on actual merchandise delivery, consumer satisfaction, and downstream consumer service. In addition, the logistical industry in Taiwan also involves employee adjustment to the new environment, support from upper management, training and, application of information technology

Tensor coupling effects on spin symmetry in anti-Lambda spectrum of hypernuclei

The effects of $\bar\Lambda\bar\Lambda\omega$-tensor coupling on the spin symmetry of $\bar{\Lambda}$ spectra in $\bar{\Lambda}$-nucleus systems have been studied with the relativistic mean-field theory. Taking $^{12}$C+$\bar{\Lambda}$ as an example, it is found that the tensor coupling enlarges the spin-orbit splittings of $\bar\Lambda$ by an order of magnitude although its effects on the wave functions of $\bar{\Lambda}$ are negligible. Similar conclusions has been observed in $\bar{\Lambda}$-nucleus of different mass regions, including $^{16}$O+$\bar{\Lambda}$, $^{40}$Ca+$\bar{\Lambda}$ and $^{208}$Pb+$\bar{\Lambda}$. It indicates that the spin symmetry in anti-lambda-nucleus systems is still good irrespective of the tensor coupling.Comment: 12 pages, 3 figures