Cognitive Multihop Wireless Sensor Networks over Nakagami-m Fading Channels

This work is supported by the National Science Foundation of China (NSFC) under Grant 61372114, by the National 973 Program of China under Grant 2012CB316005, by the Joint Funds of NSFC-Guangdong under Grant U1035001, and by Beijing Higher Education Young Elite Teacher Project (no. YETP0434)

Tim-3 Negatively Regulates IL-12 Expression by Monocytes in HCV Infection

T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is a newly identified negative immunomodulator that is up-regulated on dysfunctional T cells during viral infections. The expression and function of Tim-3 on human innate immune responses during HCV infection, however, remains poorly characterized. In this study, we report that Tim-3 is constitutively expressed on human resting CD14+ monocyte/macrophages (M/MØ) and functions as a cap to block IL-12, a key pro-inflammatory cytokine linking innate and adaptive immune responses. Tim-3 expression is significantly reduced and IL-12 expression increased upon stimulation with Toll-like receptor 4 (TLR4) ligand - lipopolysaccharide (LPS) and TLR7/8 ligand - R848. Notably, Tim-3 is over-expressed on un-stimulated as well as TLR-stimulated M/MØ, which is inversely associated with the diminished IL-12 expression in chronically HCV-infected individuals when compared to healthy subjects. Up-regulation of Tim-3 and inhibition of IL-12 are also observed in M/MØ incubated with HCV-expressing hepatocytes, as well as in primary M/MØ or monocytic THP-1 cells incubated with HCV core protein, an effect that mimics the function of complement C1q and is reversible by blocking the HCV core/gC1qR interaction. Importantly, blockade of Tim-3 signaling significantly rescues HCV-mediated inhibition of IL-12, which is primarily expressed by Tim-3 negative M/MØ. Tim-3 blockade reduces HCV core-mediated expression of the negative immunoregulators PD-1 and SOCS-1 and increases STAT-1 phosphorylation. Conversely, blocking PD-1 or silencing SOCS-1 gene expression also decreases Tim-3 expression and enhances IL-12 secretion and STAT-1 phosphorylation. These findings suggest that Tim-3 plays a crucial role in negative regulation of innate immune responses, through crosstalk with PD-1 and SOCS-1 and limiting STAT-1 phosphorylation, and may be a novel target for immunotherapy to HCV infection

Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis

Background: Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been conventionally considered as clinical neurological signs without localized brain regions. However, recent brain imaging studies suggest that NSS are partly localizable and may be associated with deficits in specific brain areas. Method: We conducted an activation likelihood estimation meta-analysis to quantitatively review structural and functional imaging studies that evaluated the brain correlates of NSS in patients with schizophrenia and other psychotic disorders. Six structural magnetic resonance imaging (sMRI) and 15 functional magnetic -resonance imaging (fMRI) studies were included. Results: The results from meta-analysis of the sMRI studies-indicated that NSS were associated with atrophy of the precentral gyrus, the cerebellum, the inferior frontal gyrus, and the thalamus. The results from meta-analysis of the fMRI studies demonstrated that the NSS-related task was significantly associated with altered brain activation in the inferior frontal gyrus, bilateral putamen, the cerebellum, and the superior temporal gyrus. Conclusions: Ourfindings from both sMRI and fMRI meta-analyses further support the conceptualization of NSS as a manifestation of the "cerebello-thalamo-prefrontal" brain network model of schizophrenia and related psychotic disorders

Analysis of the triply heavy baryon states with QCD sum rules

In this article, we study the ${1\over 2}^{\pm}$ and ${3\over 2}^{\pm}$ triply heavy baryon states in an systematic way by subtracting the contributions from the corresponding ${1\over 2}^{\mp}$ and ${3\over 2}^{\mp}$ triply heavy baryon states with the QCD sum rules, and make reasonable predictions for their masses.Comment: 14 pages, 25 figures, revised versio

The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity

Presenilin mutations are responsible for most cases of autosomal dominant inherited forms of early onset Alzheimer disease. Presenilins play an important role in amyloid beta-precursor processing, NOTCH receptor signaling, and apoptosis. However, the molecular mechanisms by which presenilins regulate apoptosis are not fully understood. Here, we report that presenilin-1 (PS1) regulates the proteolytic activity of the serine protease Omi/HtrA2 through direct interaction with its regulatory PDZ domain. We show that a peptide corresponding to the cytoplasmic C-terminal tail of PS1 dramatically increases the proteolytic activity of Omi/HtrA2 toward the inhibitor of apoptosis proteins and beta-casein and induces cell death in an Omi/HtrA2-dependent manner. Consistent with these results, ectopic expression of full-length PS1, but not PS1 lacking the C-terminal PDZ binding motif, potentiated Omi/HtrA2-induced cell death. Our results suggest that the C terminus of PS1 is an activation peptide ligand for the PDZ domain of Omi/HtrA2 and may regulate the protease activity of Omi/HtrA2 after its release from the mitochondria during apoptosis. This mechanism of Omi/HtrA2 activation is similar to the mechanism of activation of the related bacterial DegS protease by the outer-membrane porins

Social network market: Storytelling on a web 2.0 original literature site

This article looks at a Chinese Web 2.0 original literature site, Qidian, in order to show the coevolution of market and non-market initiatives. The analytic framework of social network markets (Potts et al., 2008) is employed to analyse the motivations of publishing original literature works online and to understand the support mechanisms of the site, which encourage readers’ willingness to pay for user-generated content. The co-existence of socio-cultural and commercial economies and their impact on the successful business model of the site are illustrated in this case. This article extends the concept of social network markets by proposing the existence of a ripple effect of social network markets through convergence between PC and mobile internet, traditional and internet publishing, and between publishing and other cultural industries. It also examines the side effects of social network markets, and the role of market and non-market strategies in addressing the issues

Microwave Integrated Circuits Design with Relational Induction Neural Network

The automation design of microwave integrated circuits (MWIC) has long been viewed as a fundamental challenge for artificial intelligence owing to its larger solution space and structural complexity than Go. Here, we developed a novel artificial agent, termed Relational Induction Neural Network, that can lead to an automotive design of MWIC and avoid brute-force computing to examine every possible solution, which is a significant breakthrough in the field of electronics. Through the experiments on microwave transmission line circuit, filter circuit and antenna circuit design tasks, strongly competitive results are obtained respectively. Compared with the traditional reinforcement learning method, the learning curve shows that the proposed architecture is able to quickly converge to the pre-designed MWIC model and the convergence rate is up to four orders of magnitude. This is the first study which has been shown that an agent through training or learning to automatically induct the relationship between MWIC's structures without incorporating any of the additional prior knowledge. Notably, the relationship can be explained in terms of the MWIC theory and electromagnetic field distribution. Our work bridges the divide between artificial intelligence and MWIC and can extend to mechanical wave, mechanics and other related fields

Angular dependence of resistivity in the superconducting state of NdFeAsO0.82_{0.82}F0.18_{0.18} single crystals

We report the results of angle dependent resistivity of NdFeAsO$_{0.82}$F$_{0.18}$ single crystals in the superconducting state. By doing the scaling of resistivity within the frame of the anisotropic Ginzburg-Landau theory, it is found that the angle dependent resistivity measured under different magnetic fields at a certain temperature can be collapsed onto one curve. As a scaling parameter, the anisotropy $\Gamma$ can be determined for different temperatures. It is found that $\Gamma(T)$ increases slowly with decreasing temperature, varying from $\Gamma \simeq$ 5.48 at T=50 K to $\Gamma \simeq$ 6.24 at T=44 K. This temperature dependence can be understood within the picture of multi-band superconductivity.Comment: 7 pages, 4 figure

Study on the One-Proton Halo Structure in 23^{23}Al

The Glauber theory has been used to investigate the reaction cross section of proton-rich nucleus $^{23}$Al. A core plus a proton structure is assumed for $^{23}$Al. HO-type density distribution is used for the core while the density distribution for the valence proton is calculated by solving the eigenvalue problem of Woods-Saxon potential. The transparency function in an analytical expression is obtained adopting multi-Gaussian expansion for the density distribution. Coulomb correction and finite-range interaction are introduced. This modified Glauber model is apt for halo nuclei. A dominate s-wave is suggested for the last proton in $^{23}$Al from our analysis which is possible in the RMF calculation.Comment: 4 pages, 4 figure