Lorentz-Invariant Interactions in Honeycomb Lattice with Hubbard Interaction

We derive Lorentz-invariant four-fermion interactions, including Nambu-Jona-Lasinio type (NJL) and superconducting type, which are widely studied in high-energy physics, from the Honeycomb lattice Hamiltonian with Hubbard interaction. We investigate the phase transitions induced by these two interactions and consider the effects of the chemical potential and magnetic flux (Haldane mass term) on these phase transitions. We find that the chiral excitation and superconductivity generated by the attractive interactions are mainly controlled by the chemical potential, while the magnetic flux delimits the domain of phase transition. Our analysis underscores the influence of the initial topological state on the phase transitions, a facet largely overlooked in prior studies. We present experimental protocols using cold atoms to verify our theoretical results

Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth

Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacological inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity and other diseases. Here we report a previously unknown mechanism of FASN regulation involving its acetylation by KAT8 and its deacetylation by HDAC3. FASN acetylation promoted its degradation via the ubiquitin-proteasome pathway. FASN acetylation enhanced its association with the E3 ubiquitin-ligase TRIM21. Acetylation destabilized FASN and resulted in decreased de novo lipogenesis and tumor cell growth. FASN acetylation was frequently reduced in human hepatocellular carcinoma samples, which correlated with increased HDAC3 expression and FASN protein levels. Our results suggest opportunities to target FASN acetylation as an anticancer strategy

بررسی حیطه‌های موجود در فرم‌های ارزشیابی از دیدگاه دانشجویان در دانشگاه علوم پزشکی زنجان در سال تحصیلی 86- 87

زمینه و هدف: ارزشیابی استادان متداول‌ترین روش جهت سنجش کیفیت آموزش می‌باشد. دانشجویان بیش از دست‌اندرکاران در جریان روند آموزش قرار‌دارند بنابراین با نظرخواهی از آنان دیدگاه کاملی برای مسئولین در مورد نقاط قوت و ضعف استادان به‌دست می‌آید. هدف از این پژوهش بررسی حیطه‌های موجود در فرم‌های ارزشیابی از دیدگاه دانشجویان در دانشکده‌های پزشکی، پیراپزشکی و پرستاری و مامایی می‌باشد. روش بررسی: این تحقیق به صورت توصیفی انجام گرفت. 1683 برگ ارزشیابی دانشجویان از استادان هیأت علمی (73 نفر) مربوط به دانشکده‌های پزشکی، پیراپزشکی و پرستاری- مامایی بررسی شد. پرسش‌نامه‌ی دانشجویان پزشکی حاوی 15 سؤوال و دانشجویان پیراپزشکی و پرستاری مامایی 21 سؤوال بود که بر اساس مقیاس لیکرات از حیطه‌های مختلف مقرراتی، علمی و آموزشی، نظارتی و نگرشی تشکیل شده بود. نمرات سؤوالات از نمره‌ی 100 محاسبه شد، نمرات بالاتر بیانگر عملکرد مطلوب‌تراستادان می‌باشد. تجزیه و تحلیل داده‌ها به‌صورت آمار توصیفی با نرم‌افزار SPSS انجام شد. یافته‌ها: نتایج نشان داد مقایسه در سطوح کلی بین دانشکده‌ها، دانشکده‌ی پیراپزشکی با میانگین کل و انحراف معیار 61/3 ±50/85 نسبت به سایر دانشکده‌ها برتری دارد. دانشکده‌ی پیراپزشکی در حیطه‌ی مقرراتی با میانگین و انحراف معیار 89/3±01/91، دانشکده‌ی پزشکی در حیطه‌ی نگرشی با میانگین و انحراف معیار 45/5±48/90 و دانشکده‌ی پرستاری مامایی در حیطه‌ی مقرراتی با میانگین و انحراف معیار 25/4±34/88 بیشترین امتیاز را داشتند. نتیجه‌نهایی نشان می‌دهد، حیطه‌ی علمی و آموزشی نسبت به سایر حیطه‌ها در سطح پایین‌تر می‌باشد. نتایج حیطه‌ها (علمی و آموزشی، نظارتی و نگرشی) بین دانشکده‌ها معنی‌دار می‌باشد (0001/0=P). نتیجه‌گیری: به نظر می‌رسد با برنامه‌ریزی جهت برگزاری کارگاه‌های آموزشی، روش تدریس و تحقیق جهت ارتقای آموزش استادان، اعطا‌ی فرصت مطالعاتی و تشویق انجام کارهای تحقیقاتی و پژوهشی گام مؤثری جهت ارتقای سطح علمی و بالاخره عملکرد بالای استادان خواهد بود

Present situation and benefit analysis of the straw recycling in Southwest of China

Currently, Chinese sustainable agricultural development is facing some big challenges that how to promote the present developing pattern, lengthen material transformation chain, increase the utilization rate of material and energy in agricultural system and form a healthy agriculture ecological circulatory system. China is the major country in producing crops as well as in straw. Both high-efficient utilizing pattern of straw and technological system are needed urgently. We point out the status of straw utilization and the main recycling patterns in typical farming area in Sichuan China through the literature review and data collection, combined with field survey. Based on the statistical analysis, with the economic, environmental and social benefits of each utilization way analyzed, this paper proposes the methods and measures to promote recycling utilization of the straw in Sichuan farming area, where is under the theoretically guide on energy-saving, food safety, and pollution control

Present situation and benefit analysis of the straw recycling in Southwest of China

Currently, Chinese sustainable agricultural development is facing some big challenges that how to promote the present developing pattern, lengthen material transformation chain, increase the utilization rate of material and energy in agricultural system and form a healthy agriculture ecological circulatory system. China is the major country in producing crops as well as in straw. Both high-efficient utilizing pattern of straw and technological system are needed urgently. We point out the status of straw utilization and the main recycling patterns in typical farming area in Sichuan China through the literature review and data collection, combined with field survey. Based on the statistical analysis, with the economic, environmental and social benefits of each utilization way analyzed, this paper proposes the methods and measures to promote recycling utilization of the straw in Sichuan farming area, where is under the theoretically guide on energy-saving, food safety, and pollution control.Straw utilization, Benefit, Sichuan, China, Agribusiness, Present situation,

Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications

Although some studies have shown that some static magnetic fields (SMFs) can promote wound healing in diabetic mice, it is not clear whether the other diabetes complications, such as liver disease and diabetic nephropathy, can also be alleviated. Here, we constructed two simple magnetic plates using neodymium permanent magnets to examine the comprehensive effects of moderate SMFs on genetically obese leptin receptor-deficient db/db diabetic mice. We found that although the blood glucose was not obviously reduced by these two SMF settings, both of the glycated serum protein (GSP) and malondialdehyde (MDA) levels were significantly decreased (Cohen’s d = 2.57–3.04). Moreover, the wound healing, liver lipid accumulation, and renal defects were all significantly improved by SMF treatment (Cohen’s d = 0.91–2.05). Wound tissue examination showed obvious nuclear factor erythroid 2-related factor 2 (NRF2) level decrease (Cohen’s d = 2.49–5.40) and Ki-67 level increase (Cohen’s d = 2.30–3.40), indicating decreased oxidative stress and increased cell proliferation. In vitro cellular studies with fibroblast NIH3T3 cells showed that SMFs could reduce high glucose-induced NRF2 nucleus translocation (Cohen’s d = 0.87–1.15) and cellular reactive oxygen species (ROS) elevation (Cohen’s d = 0.92), indicating decreased oxidative stress. Consequently, high glucose-induced impairments in cell vitality, proliferation, and migration were all improved by SMF treatment. Therefore, our results demonstrate that these simple SMF devices could effectively reduce oxidative stress in diabetic mice and may provide a cost-effective physical therapy strategy to alleviate multiple diabetic complications in the future

Targeting the Raft-Associated Akt Signaling in Hepatocellular Carcinoma

Caveolin-1 and flotillin-1 are considered as markers of lipid rafts which can be regarded as sorting platforms for targeted transport of transmembrane proteins and are involved in fundamental cellular events such as signal transduction, cell adhesion, lipid/protein sorting, and human cancer. We addressed caveolin-1 and flotillin-1 expression in 90 human hepatocellular carcinoma (HCC) and adjacent noncancerous tissues (ANT) samples by SDS-PAGE and immunoblotting with specific antibodies. Significant caveolin-1 and flotillin-1 overexpression was found in HCC tissues compared to ANT and was confirmed by immunohistochemistry. Raft-associated Akt signaling pathway components involved in the regulation of cell survival were altered by western blotting in HCC microdomain-enriched subcellular fractions purified from paired HCC and ANT samples. Our results demonstrated that the activity of raft-associated but not total membrane Akt determines its cellular functions. Lipid rafts differ in different types of tissues, which allows for the possibility of tissue-type-specific targeting for cell survival

Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth.

Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacologic inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity, and other diseases. Here, we report a previously unknown mechanism of FASN regulation involving its acetylation by KAT8 and its deacetylation by HDAC3. FASN acetylation promoted its degradation via the ubiquitin-proteasome pathway. FASN acetylation enhanced its association with the E3 ubiquitin ligase TRIM21. Acetylation destabilized FASN and resulted in decreased de novo lipogenesis and tumor cell growth. FASN acetylation was frequently reduced in human hepatocellular carcinoma samples, which correlated with increased HDAC3 expression and FASN protein levels. Our results suggest opportunities to target FASN acetylation as an anticancer strategy. Cancer Res; 76(23); 6924-36. ©2016 AACR