Emergency Data Activation

EDA (Emergency Data Activation) is an application which give emergency data(internet) to its users for their usage for this users have to performs certain procedure embedded in our application

Disruption of smooth pursuit eye movements in cirrhosis: relationship to hepatic encephalopathy and its treatment.

Smooth pursuit eye movements (SPEM) are the conjugate movements used to track the smooth trajectory of small dots. Jerky or 'saccadic' ocular pursuit has been reported in patients with cirrhosis, but no formal assessment of SPEM has ever been undertaken. The aim of this study was to evaluate SPEM in patients with cirrhosis and varying degrees of hepatic encephalopathy. The patient population comprised 56 individuals (31 men, 25 women) of mean age 51.1 (range, 25-70) years, with biopsy-proven cirrhosis, classified, using clinical, electroencephalographic, and psychometric variables, as either neuropsychiatrically unimpaired or as having minimal or overt hepatic encephalopathy; patients were further categorized in relation to their treatment status. The reference population comprised 28 healthy volunteers (12 men, 16 women) of mean age 47.3 (range, 26-65) years. SPEM was assessed using an electro-oculographic technique. Visual inspection of the SPEM recordings showed clear disruption of smooth pursuit in the patients with minimal hepatic encephalopathy, and more pronounced disruption, if not complete loss, of smooth pursuit in patients with overt hepatic encephalopathy. The differences observed in quantifiable SPEM indices between the healthy volunteers/unimpaired patients and those with overt hepatic encephalopathy were significant (P < .05). In conclusion, SPEM performance is impaired in patients with hepatic encephalopathy in parallel with the degree of neuropsychiatric disturbance: the pathophysiology of these changes is unknown, but retinal, extrapyramidal, and attentional abnormalities are likely to play a role. Treatment status confounds the classification of neuropsychiatric status and should be taken into account when categorizing these patients

Response of dust on thermal emission spectra observed by Planetary Fourier3 Spectrometer (PFS) on-board Mars Express (MEX)

The thermal emission spectra have provided many useful insights about the Martian atmosphere and surface. The interpretation of the thermal emission spectra can give us information about atmospheric temperature, pressure, mineralogy and presence of atmospheric constituents including their isotopes. In the present work, we have analysed the thermal emission data for dust storm season on Mars. The signature of dust in the thermal emission spectra for Martian Year (MY) 28 confirms presence (Ls=280o and 300o) and absence (Ls=240o and 320o) of the dust storm at latitude range 0o-10oS, 10o-20oS and 20o-30oS. We have compared our results with earlier mission data with thermal emission measurements made by Planetary Fourier Spectrometer (PFS) on-board Mars Express (MEX) between wave numbers 250-1400 cm-1. We have observed features at wave numbers 600-750 cm-1 and 900-1200 cm-1 due to absorptions by CO2 and dust respectively. We have obtained brightness temperatures from thermal emission spectra by inverting the Planck function. The maximum brightness temperature ~280 K is measured at Ls=240o when Mars received a large amount of solar radiation at perihelion. The minimum brightness temperature ~ 220o K is observed at Ls=320o in the absence of dust storm. In presence of dust storm thermal emission spectra and brightness  temperatures are reduced by factors of ~ 3.0 and ~1.3 respectively between wave numbers 900-1200 cm-1 in comparison to that observed in absence of dust storm

Single Center Experience of Sirolimus Therapy in Head and Neck Low-flow Vascular Malformations

OBJECTIVE: Recently, studies have shown that sirolimus is clinically efficacious in the treatment of some low-flow vascular malformations (LFVM). This study aimed to assess the efficacy and safety of sirolimus in treating complex head and neck (H&N) LFVM that were challenging and/or refractory to standard treatment. METHODS: Each patient had baseline and 6-months assessments consisting of clinical history and examination, quality of life (QoL) questionnaires, laboratory investigations, MRI and medical photography. Patients were followed up 1-week and then 1-monthly for 6-months. Wilcoxon signed-rank test was used to compare pre-and 6-months treatment in all 8 domains of RAND 36-Item Short Form Health Survey (SF-36), hospital anxiety and depression scale (HADS), and visual analog score for pain (VAS-P). P < 0.05 was considered significant. RESULTS: Seven patients (median age 43 years, range 23-65 years) were recruited. Six patients completed the six-months course of therapy with 1 patient withdrawing due to intolerable side effects. All six patients reported reduction of swelling with and without other symptom improvement related to the vascular malformations while on treatment. However, at 1-month review after discontinuation of sirolimus, 5 patients reported return of initial symptoms. Overall, patients demonstrated an improvement in QoL six-months treatment but there was no statistical significance (P > 0.05) in all 8 domains of SF-36, HADS and VAS-P. Five patients demonstrated a minimum 10% decrease in lesion size six-months treatment (median 21%, range 13-40%). A Wilcoxon signed-rank test showed that sirolimus treatment did elicit a statistically significant change in lesion size in either direction (Z = -1.992, P = 0.046). The most common side effects found were dyslipidaemia (n-4) and mouth ulcers (n = 2). CONCLUSIONS: In our preliminary experience, sirolimus is effective and safe in treating patients with complex H&N LFVM. This provides an alternative treatment where standard treatment is challenging and/or refractory

Modeling infrared thermal emissions on Mars during dust storm of MY28: PFS/MEX observation

We have analysed thermal emission spectra obtained from Planetary Fourier Spectrometer (PFS) onboard Mars Express (MEX) for Martian Year (MY) 28 in presence and absence of dust storm at low latitude. A radiative transfer model for dusty atmosphere of Mars is developed to estimate the thermal emission spectra at latitude range 0-10oS, 10-20oS and 20-30oS. These calculations are made at Ls=240o, 280o, 300o, and 320o between wave numbers 250-1400 cm-1. We have also retrieved brightness temperatures from thermal emission spectra by inverting the Planck function. The model reproduces the observed features at wave numbers 600-750 cm-1 and 900-1200 cm-1 due to absorptions by CO2 and dust respectively. In presence of dust storm thermal emission spectra and brightness temperature are reduced by a factor of ~ 2 between wave numbers 900-1200 cm-1. The altitude profiles of dust concentration are also estimated for different aerosol particles of sizes 0.2 to 3 micron. The best fit to the PFS measurements is obtained in presence of aerosol particle of size 0.2 micron

Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain

VGF (non-acronymic) was first highlighted to have a role in energy homeostasis through experiments involving dietary manipulation in mice. Fasting increased VGF mRNA in the Arc and levels were subsequently reduced upon refeeding. This anabolic role for VGF was supported by observations in a VGF null (VGF-/-) mouse and in the diet-induced and gold-thioglucose obese mice. However, this anabolic role for VGF has not been supported by a number of subsequent studies investigating the physiological effects of VGF-derived peptides. Intracerebroventricular (ICV) infusion of TLQP-21 increased resting energy expenditure and rectal temperature in mice and protected against diet-induced obesity. Similarly, ICV infusion of TLQP-21 into Siberian hamsters significantly reduced body weight, but this was due to a decrease in food intake, with no effect on energy expenditure. Subsequently NERP-2 was shown to increase food intake in rats via the orexin system, suggesting opposing roles for these VGF-derived peptides. Thus to further elucidate the role of hypothalamic VGF in the regulation of energy homeostasis we utilised a recombinant adeno-associated viral vector to over-express VGF in adult male Siberian hamsters, thus avoiding any developmental effects or associated functional compensation. Initially, hypothalamic over-expression of VGF in adult Siberian hamsters produced no effect on metabolic parameters, but by 12 weeks post-infusion hamsters had increased oxygen consumption and a tendency to increased carbon dioxide production; this attenuated body weight gain, reduced interscapular white adipose tissue and resulted in a compensatory increase in food intake. These observed changes in energy expenditure and food intake were associated with an increase in the hypothalamic contents of the VGF-derived peptides AQEE, TLQP and NERP-2. The complex phenotype of the VGF-/- mice is a likely consequence of global ablation of the gene and its derived peptides during development, as well as in the adult