8 research outputs found
A Competing Hydrogen Bonding Pattern to Yield Thermo-Thickening Supramolecular Polymer
International audienceIntroduction of competing interactions in the design of a supramolecular polymer (SP) creates pathway complexity. Esterâbisâureas contain both a strong bisâurea sticker that is responsible for the buildâup of long rodâlike objects by hydrogen bonding and ester groups that can interfere with this main pattern in a subtle way. Spectroscopic (FTIR and CD), calorimetric (DSC), and scattering (SANS) techniques show that such esterâbisâureas selfâassemble into three competing rodâlike SPs. The previously unreported lowâtemperature SP is stabilized by hydrogen bonds between the interfering ester groups and the urea moieties. It also features a weak macroscopic alignment of the rods. The other structures form isotropic dispersions of rods stabilized by the more classical ureaâurea hydrogen bonding pattern. The transition from the lowâtemperature structure to the next occurs reversibly by heating and is accompanied by an increase in viscosity, a rare feature for solutions in hydrocarbons
Musiques nomades : objets, réseaux, itinéraires
Ce numĂ©ro prĂ©sente des recherches inĂ©dites portant sur les formes de circulation du spectacle musical examinĂ© dans toute sa diversitĂ© (concert, musique sacrĂ©e, danse, opĂ©ra, cĂ©rĂ©monies princiĂšresâŠ), les acteurs sociaux qui y participent et les animent, leurs motivations et les effets de ces mobilitĂ©s artistiques, des prĂ©mices de lâĂąge baroque Ă lâĂšre romantique. Cette pĂ©riode coĂŻncide avec un ample processus de professionnalisation et de diversification du milieu musical, qui contribue au dĂ©veloppement dâun vĂ©ritable marchĂ© de la musique Ă lâĂ©chelle europĂ©enne, accentuant les concurrences et recomposant les hiĂ©rarchies internes Ă la sociĂ©tĂ© musicale. Les domaines dâinvestigation portent sur des objets variĂ©s : les instruments, les accessoires et tous les artefacts quâimpliquent une performance musicale ; les Ćuvres ; les artistes eux-mĂȘmes ; le rĂŽle des mĂ©diateurs culturels qui animent les rĂ©seaux structurant les itinĂ©raires des mobilitĂ©s artistiques ; les solidaritĂ©s multiples qui soutiennent les projets de mobilitĂ©, quâelles soient de nature professionnelle, religieuse, nationale ou liĂ©es Ă des formes de patronage ; lâimpact de ces circulations sur les transferts culturels et la fabrique du goĂ»t musical ; lâanalyse des contraintes matĂ©rielles et administratives qui peuvent peser sur les parcours, les calendriers et la densitĂ© des circulations. Ainsi sâagit-il dâarticuler les itinĂ©raires individuels des musiciens et musiciennes et les destins collectifs, dans le cadre de lâhistoriographie rĂ©cente des rĂ©seaux et des phĂ©nomĂšnes diasporiques. MĂ©lanie Traversier est maĂźtre de confĂ©rences en histoire moderne Ă Lille III, et membre de lâInstitut universitaire de France Ă compter du 1er octobre 2015. SpĂ©cialiste de lâhistoire sociale des pratiques musicales au XVIIIe siĂšcle, elle est lâauteure de plusieurs ouvrages et travaux sur les pratiques musicales et leur inscription dans le paysage urbain, le marchĂ© de la musique, et le milieu des professionnels de la scĂšne musicale dans lâEurope du siĂšcle des LumiĂšres. Elle a notamment codirigĂ© avec Laure Gauthier MĂ©lodies urbaines : la musique dans les villes dâEurope (XVIe-XIXe siĂšcle), PUPS, 2008
Efficacy and feasibility of sorafenib as a maintenance agent after allogeneic hematopoietic stem cell transplantation for Fms-like tyrosine kinase 3-mutated acute myeloid leukemia
International audienc
Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura
Preemptive rituximab infusions prevent relapses in immune thrombotic thrombocytopenic purpura (iTTP) by maintaining normal ADAMTS13 activity. However, the long-term outcome of these patients and the potential adverse events of this strategy need to be determined. We report the long-term outcome of 92 patients with iTTP in clinical remission who received preemptive rituximab after identification of severe ADAMTS13 deficiency (activity 1 iTTP episode, and the median cumulative relapse incidence before preemptive rituximab was 0.33 episode per year (interquartile range [IQR], 0.23-0.66). After preemptive rituximab, the median cumulative relapse incidence in the whole population decreased to 0 episodes per year (IQR, 0-1.32; P < .001). After preemptive rituximab, ADAMTS13 activity recovery was sustained in 34 patients (37%) during a follow-up of 31.5 months (IQR, 18-65), and severe ADAMTS13 deficiency recurred in 45 patients (49%) after the initial improvement. ADAMTS13 activity usually improved with additional courses of preemptive rituximab. In 13 patients (14%), ADAMTS13 activity remained undetectable after the first rituximab course, but retreatment was efficient in 6 of 10 cases. In total, 14 patients (15%) clinically relapsed, and 19 patients (20.7%) experienced benign adverse effects. Preemptive rituximab treatment was associated with a change in ADAMTS13 conformation in respondent patients. Finally, in the group of 23 historical patients with iTTP and persistently undetectable ADAMTS13 activity, 74% clinically relapsed after a 7-year follow-up (IQR, 5-11). In conclusion, persistently undetectable ADAMTS13 activity in iTTP during remission is associated with a higher relapse rate. Preemptive rituximab reduces clinical relapses by maintaining a detectable ADAMTS13 activity with an advantageous risk-benefit balance.status: publishe
Advancing environmental monitoring across the water continuum combining biomarker analysis in multiple sentinel species: A case study in the Seine-Normandie Basin (France)
International audienceNowadays, biomarkers are recognized as valuable tools to complement chemical and ecological assessments in biomonitoring programs. They provide insights into the effects of contaminant exposures on individuals and establish connections between environmental pressure and biological response at higher levels. In the last decade, strong improvements in the design of experimental protocols and the result interpretation facilitated the use of biomarker across wide geographical areas, including aquatic continua. Notably, the statistical establishment of reference values and thresholds enabled the discrimination of contamination effects in environmental conditions, allowed interspecies comparisons, and eliminated the need of a reference site.The aim of this work was to study freshwater-estuarine-coastal water continua by applying biomarker measurements in multi-species caged organisms. During two campaigns, eight sentinel species, encompassing fish, mollusks, and crustaceans, were deployed to cover 25 sites from rivers to the sea. As much as possible, a common methodology was employed for biomarker measurements (DNA damage and phagocytosis efficiency) and data interpretation based on guidelines established using reference values and induction/inhibition thresholds (establishment of three effect levels).The methodology was successfully implemented and allowed us to assess the environmental quality. Employing multiple species per site enhances confidence in observed trends. The results highlight the feasibility of integrating biomarker-based environmental monitoring programs across a continuum scale. Biomarker results align with Water Framework Directive indicators in cases of poor site quality. Additionally, when discrepancies arise between chemical and ecological statuses, biomarker findings offer a comprehensive perspective to elucidate the disparities. Presented as a pilot project, this work contributes to gain insights into current biomonitoring needs, providing new questions and perspectives
Advancing environmental monitoring across the water continuum combining biomarker analysis in multiple sentinel species: A case study in the Seine-Normandie Basin (France)
Nowadays, biomarkers are recognized as valuable tools to complement chemical and ecological assessments in biomonitoring programs. They provide insights into the effects of contaminant exposures on individuals and establish connections between environmental pressure and biological response at higher levels. In the last decade, strong improvements in the design of experimental protocols and the result interpretation facilitated the use of biomarker across wide geographical areas, including aquatic continua. Notably, the statistical establishment of reference values and thresholds enabled the discrimination of contamination effects in environmental conditions, allowed interspecies comparisons, and eliminated the need of a reference site. The aim of this work was to study freshwater -estuarine -coastal water continua by applying biomarker measurements in multi -species caged organisms. During two campaigns, eight sentinel species, encompassing fish, mollusks, and crustaceans, were deployed to cover 25 sites from rivers to the sea. As much as possible, a common methodology was employed for biomarker measurements (DNA damage and phagocytosis efficiency) and data interpretation based on guidelines established using reference values and induction/inhibition thresholds (establishment of three effect levels). The methodology was successfully implemented and allowed us to assess the environmental quality. Employing multiple species per site enhances confidence in observed trends. The results highlight the feasibility of integrating biomarker-based environmental monitoring programs across a continuum scale. Biomarker results align with Water Framework Directive indicators in cases of poor site quality. Additionally, when discrepancies arise between chemical and ecological statuses, biomarker findings offer a comprehensive perspective to elucidate the disparities. Presented as a pilot project, this work contributes to gain insights into current biomonitoring needs, providing new questions and perspectives