Resistance Thermometer for Heat Transfer Measurements in a Shock Tube

This report describes a method for the application of the well-known principle of the resistance thermometer to the problem of measuring surface temperatures and heat transfer rates under highly transient conditions, such as are experienced in a shock tube. By using a thin platinum film sputtered on glass, a resistance thermometer gage is obtained which has a response lag of less than 1 µ sec, a linear output of 2-3 mv/°c, repeatability and durability. The gage preparation, including the sputtering technique, calibration method, and response characteristics are discussed, and some measurements of surface temperatures and heat transfer rates on models in the shock tube are presented in order to illustrate the performance that can be expected from this instrument

Some Exploratory Photoelastic Studies in Stress Wave Propagation

During the last three years the Guggenheim Aeronautical Laboratory of the California Institute of Technology (GALCIT) has been conducting a photoelastic study of stress wave propagation in solids using a high speed framing camera. This paper presents a technical description of the camera, now operating at 100,000 35 mm frames per second at one tenth microsecond exposure time for an elapsed time of approximately two milliseconds. The design capability is expected to approach a half million frames per second. This equipment has been used to record dynamic photoelastic stress fringe patterns in various specimens under impact loadings. Typical experimental records of wave propagation in cracked plates, layered media, compressed bars and beams, and cross sections of rocket heads are included in this report

Resistance Thermometer for Transient High-Temperature Studies

Current interest in ultra-high-speed flight has stimulated the development of the shock tube as a device for simulating high stagnation temperatures in supersonic flow. The main difficulty in these tests is the extremely short duration of uniform flow, of the order of 100-500 µsec. This time interval dictates extremely fast response of any measuring instrument applied to shock tube research

Refining the ice flow chronology and subglacial dynamics across the migrating Labrador Divide of the Laurentide Ice Sheet with age constraints on deglaciation

The Laurentide Ice Sheet was characterized by a dynamic polythermal base. However, important data and knowledge gaps have led to contrasting reconstructions in areas such as the Labrador Ice Divide. In this study, detailed fieldwork was conducted at the southeastern edge of a major landform boundary to resolve the relative ice flow chronology and constrain the evolution of the subglacial dynamics, including the migration and collapse of the Labrador Ice Divide. Surficial mapping and analysis of 94 outcrop‐scale ice flow indicators were used to develop a relative ice flow chronology. 10Be exposure ages were used with optical ages to confine the timing of deglaciation within the study area. Four phases of ice flow were identified. Flow 1 was a northeasterly ice flow preserved under non‐erosive subglacial conditions associated with the development of an ice divide. Flow 2 was a northwest ice flow, which we correlate to the Ungava Bay Ice Stream and led to a westward migration of the ice divide, preserving Flow 2 features and resulting in Flow 3's eastward‐trending indicators. Flow 4 is limited to sparse fine striations within and around the regional uplands. The new optical ages and 10Be exposure ages add to the regional geochronology dataset, which further constrains the timing of ice margin retreat in the area to around 8.0 ka.Geological Survey of Canada's Geo‐Mapping for Energy and Minerals II (GEM2) Program (2013–2020)Polar Continental Support Program under the Core Zone Surficial Activity (Hudson–Ungava Project)Northern Scientific Training Program (NSTP)Ontario Graduate Scholarship (OGS) fundNatural Science and Engineering Research Council (NSERC) of Canada Discovery GrantNSERC Research Tools and Instruments GrantPeer-review status unspecifiedUpdate citation details during checkdate report - A

Anilinoquinoline based inhibitors of trypanosomatid proliferation.

We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent compounds against Trypanosoma brucei brucei (which causes human African trypanosomiasis), T. cruzi (the pathogen that causes Chagas disease), and Leishmania spp. (which cause leishmaniasis). In addition, sub-micromolar compounds were identified that inhibit proliferation of the parasites that cause African animal trypanosomiasis, T. congolense and T. vivax. We have found that this set of compounds display acceptable physicochemical properties and represent progress towards identification of lead compounds to combat several neglected tropical diseases

Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?

A kinase-targeting cell-based high-throughput screen (HTS) against Trypanosoma brucei was recently reported, and this screening set included the Published Kinase Inhibitor Set (PKIS). From the PKIS was identified 53 compounds with pEC(50) >= 6. Utilizing the published data available for the PKIS, a statistical analysis of these active antiparasitic compounds was performed, allowing identification of a set of human kinases having inhibitors that show a high likelihood for blocking T. brucei cellular proliferation in vitro. This observation was confirmed by testing other established inhibitors of these human kinases and by mining past screening campaigns at GlaxoSmithKline. Overall, although the parasite targets of action are not known, inhibitors of this set of human kinases displayed an enhanced hit rate relative to a random kinase-targeting HTS campaign, suggesting that repurposing efforts should focus primarily on inhibitors of these specific human kinases. We therefore term this statistical analysis-driven approach "preferred lead repurposing".We acknowledge funding from The Tres Cantos Open Lab Foundation (TC-007) and the National Institutes of Health (R01AI082577, R01AI114685).Peer reviewe

Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites

Human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis present a significant burden across the developing world. Existing therapeutics for these protozoal neglected tropical diseases suffer from severe side effects and toxicity. Previously, NEU-1045 (<b>3</b>) was identified as a promising lead with cross-pathogen activity, though it possessed poor physicochemical properties. We have designed a library of analogues with improved calculated physicochemical properties built on the quinoline scaffold of <b>3</b> incorporating small, polar aminoheterocycles in place of the 4-(3-fluorobenzyloxy)­aniline substituent. We report the biological activity of these inhibitors against <i>Trypanosoma brucei</i> (HAT), <i>T. cruzi</i> (Chagas disease), and <i>Leishmania major</i> (cutaneous leishmaniasis) and describe the identification of <i>N</i>-(5-chloropyrimidin-2-yl)-6-(4-(morpholinosulfonyl)­phenyl)­quinolin-4-amine (<b>13t</b>) as a promising inhibitor of <i>L. major</i> proliferation and 6-(4-(morpholinosulfonyl)­phenyl)-<i>N</i>-(pyrimidin-4-yl)­quinolin-4-amine (<b>13j</b>), a potent inhibitor of <i>T. brucei</i> proliferation with improved drug-like properties

neurostuff/NiMARE: 0.2.0rc3

What's Changed Exciting New Features Remove resample argument from IBMA estimators by @JulioAPeraza in https://github.com/neurostuff/NiMARE/pull/823 Add IBMAWorkflow by @JulioAPeraza in https://github.com/neurostuff/NiMARE/pull/817 Make torch optional by @JulioAPeraza in https://github.com/neurostuff/NiMARE/pull/836 ### Bug Fixes Addresses new RTD configuration file requirements by @JulioAPeraza in https://github.com/neurostuff/NiMARE/pull/829 ### Other Changes Fix the NeuroLibre badge by @tsalo in https://github.com/neurostuff/NiMARE/pull/824 [FIX] handle null values in metadata by @jdkent in https://github.com/neurostuff/NiMARE/pull/831 Add badges and citations for Aperture Neuro article by @tsalo in https://github.com/neurostuff/NiMARE/pull/834 Remove pytorch warning message by @yifan0330 in https://github.com/neurostuff/NiMARE/pull/828 [FIX] handle index errors by @jdkent in https://github.com/neurostuff/NiMARE/pull/839 Full Changelog: https://github.com/neurostuff/NiMARE/compare/0.2.0rc2...0.2.0rc