71 research outputs found

    A SMASHing approach for developing staff and student digital capabilities within a community of practice

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    SMASH is a student-led partnership which considers how social media could be used to enhance learning and teaching. Mentored by their tutor, members of the team identified three key areas where social media may be utilised: within learning activities, as a means of organising learning and as a way of showcasing learning. The three strands of this framework have provided a focus to develop a range of resources and the foundation for a digital toolkit. This case study reflects upon not just the outputs developed thus far, but also on the experience, the learning gained and the sense of belonging and identify as a result of being part of this community of practice

    Selective schools: do they improve health?

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    Educated groups have better physical and mental health in later life. But is the type of school per se a cause of better later life health or it is simply that, for example, those attending “better” schools tend to come from a more advantaged background? This study looks at long term effects of education, specifically stratifying students based on their academic ability through selective schooling

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    Towards automated cancer screening: label-free classification of fixed cell samples using wavelength modulated Raman spectroscopy

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    This work was supported by the Engineering and Physical Sciences Research Council and Medical Research Council [EP/L016559/1, EP/P030017/1], and CRUK [A18075 Core Award].The ability to provide quantitative, objective and automated pathological analysis would provide enormous benefits for national cancer screening programmes, in terms of both resource reduction and improved patient wellbeing. The move towards molecular pathology through spectroscopic methods shows great promise, but has been restricted by spectral quality, acquisition times and lack of direct clinical application. In this paper, we present the application of wavelength modulated Raman spectroscopy for the automated label- and fluorescence-free classification of fixed squamous epithelial cells in suspension, such as those produced during a cervical smear test. Direct comparison with standard Raman spectroscopy shows marked improvement of sensitivity and specificity when considering both human papillomavirus (sensitivity +12.0%, specificity +5.3%) and transformation status (sensitivity +10.3%, specificity +11.1%). Studies on the impact of intracellular sampling location and storage effects suggest that wavelength modulated Raman spectroscopy is sufficiently robust to be used in fixed cell classification, but requires further investigations of potential sources of molecular variation in order to improve current clinical tools.Publisher PDFPeer reviewe
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