19 research outputs found
The organic chemistry in the innermost, infalling envelope of the Class 0 protostar L483
Context: The protostellar envelopes, outflow and large-scale chemistry of
Class~0 and Class~I objects have been well-studied, but while previous works
have hinted at or found a few Keplerian disks at the Class~0 stage, it remains
to be seen if their presence in this early stage is the norm. Likewise, while
complex organics have been detected toward some Class~0 objects, their
distribution is unknown as they could reside in the hottest parts of the
envelope, in the emerging disk itself or in other components of the
protostellar system, such as shocked regions related to outflows.
Aims: In this work, we aim to address two related issues regarding
protostars: when rotationally supported disks form around deeply embedded
protostars and where complex organic molecules reside in such objects.
Methods: We observed the deeply embedded protostar, L483, using Atacama Large
Millimeter/submillimeter Array (ALMA) Band~7 data from Cycles~1 and 3 with a
high angular resolution down to ~0.1 (20~au) scales.
Results: We find that the kinematics of CS~-- and
HCN~-- are best fitted by the velocity profile from infall under
conservation of angular momentum and not by a Keplerian profile. The spatial
extents of the observed complex organics are consistent with an estimated ice
sublimation radius of the envelope at ~50~au, suggesting that the complex
organics exist in the hot corino of L483.
Conclusions: We find that L483 does not harbor a Keplerian disk down to at
least ~au in radius. Instead, the innermost regions of L483 are undergoing
a rotating collapse. This result highlights that some Class~0 objects contain
only very small disks, or none at all, with the complex organic chemistry
taking place on scales inside the hot corino of the envelope, in a region
larger than the emerging disk.Comment: 19 pages, 11 figure
Automated microfluidic sample-preparation platform for high-throughput structural investigation of proteins by small-angle X-ray scattering
Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura
Publisher Copyright: © 2023, The Author(s).Migraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine subtypes, migraine with aura (MA) and migraine without aura (MO). We identified four new MA-associated variants (in PRRT2, PALMD, ABO and LRRK2) and classified 13 MO-associated variants. Rare variants with large effects highlight three genes. A rare frameshift variant in brain-expressed PRRT2 confers large risk of MA and epilepsy, but not MO. A burden test of rare loss-of-function variants in SCN11A, encoding a neuron-expressed sodium channel with a key role in pain sensation, shows strong protection against migraine. Finally, a rare variant with cis-regulatory effects on KCNK5 confers large protection against migraine and brain aneurysms. Our findings offer new insights with therapeutic potential into the complex biology of migraine and its subtypes.Peer reviewe
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Self-association of long-acting insulin analogues studied by size exclusion chromatography coupled to multi-angle light scattering
The Phosphodiesterase 5 Inhibitor Sildenafil Has No Effect on Cerebral Blood Flow or Blood Velocity, but Nevertheless Induces Headache in Healthy Subjects
Morphologie et comportement mecanique d'aciers microcristallins extrudes
SIGLEINIST T 73769 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc