The organic chemistry in the innermost, infalling envelope of the Class 0 protostar L483

Context: The protostellar envelopes, outflow and large-scale chemistry of Class~0 and Class~I objects have been well-studied, but while previous works have hinted at or found a few Keplerian disks at the Class~0 stage, it remains to be seen if their presence in this early stage is the norm. Likewise, while complex organics have been detected toward some Class~0 objects, their distribution is unknown as they could reside in the hottest parts of the envelope, in the emerging disk itself or in other components of the protostellar system, such as shocked regions related to outflows. Aims: In this work, we aim to address two related issues regarding protostars: when rotationally supported disks form around deeply embedded protostars and where complex organic molecules reside in such objects. Methods: We observed the deeply embedded protostar, L483, using Atacama Large Millimeter/submillimeter Array (ALMA) Band~7 data from Cycles~1 and 3 with a high angular resolution down to $\sim$~0.1$^{\prime\prime}$ (20~au) scales. Results: We find that the kinematics of CS~$J=7$--$6$ and H$^{13}$CN~$J=4$--$3$ are best fitted by the velocity profile from infall under conservation of angular momentum and not by a Keplerian profile. The spatial extents of the observed complex organics are consistent with an estimated ice sublimation radius of the envelope at $\sim$~50~au, suggesting that the complex organics exist in the hot corino of L483. Conclusions: We find that L483 does not harbor a Keplerian disk down to at least $15$~au in radius. Instead, the innermost regions of L483 are undergoing a rotating collapse. This result highlights that some Class~0 objects contain only very small disks, or none at all, with the complex organic chemistry taking place on scales inside the hot corino of the envelope, in a region larger than the emerging disk.Comment: 19 pages, 11 figure

Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura

Publisher Copyright: © 2023, The Author(s).Migraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine subtypes, migraine with aura (MA) and migraine without aura (MO). We identified four new MA-associated variants (in PRRT2, PALMD, ABO and LRRK2) and classified 13 MO-associated variants. Rare variants with large effects highlight three genes. A rare frameshift variant in brain-expressed PRRT2 confers large risk of MA and epilepsy, but not MO. A burden test of rare loss-of-function variants in SCN11A, encoding a neuron-expressed sodium channel with a key role in pain sensation, shows strong protection against migraine. Finally, a rare variant with cis-regulatory effects on KCNK5 confers large protection against migraine and brain aneurysms. Our findings offer new insights with therapeutic potential into the complex biology of migraine and its subtypes.Peer reviewe

Morphologie et comportement mecanique d'aciers microcristallins extrudes

SIGLEINIST T 73769 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc