Quantum field theory on a cosmological, quantum space-time

In loop quantum cosmology, Friedmann-LeMaitre-Robertson-Walker (FLRW) space-times arise as well-defined approximations to specific \emph{quantum} geometries. We initiate the development of a quantum theory of test scalar fields on these quantum geometries. Emphasis is on the new conceptual ingredients required in the transition from classical space-time backgrounds to quantum space-times. These include a `relational time' a la Leibnitz, the emergence of the Hamiltonian operator of the test field from the quantum constraint equation, and ramifications of the quantum fluctuations of the background geometry on the resulting dynamics. The familiar quantum field theory on classical FLRW models arises as a well-defined reduction of this more fundamental theory.Comment: 19 pages, no figures; A reference and footnote added, PACs and minor typos corrected; a significant technical clarification added to section IV.A; minor typos corrected; two references adde

A hunter-gatherer-farmer population model: Lie symmetries, exact solutions and their interpretation

The Lie symmetry classification of the known three-component reaction-diffusion system modelling the spread of an initially localized population of farmers into a region occupied by hunter-gatherers is derived. The Lie symmetries obtained for reducing the system in question to systems of ODEs and constructing exact solutions are applied. Several exact solutions of traveling front type are found, their properties are identified and biological interpretation is discussed

Interleukin-6 is not essential for bone turnover in hypothyroid mice.

Interleukin-6 (IL-6) has been shown to be involved in the pathogenesis of several bone diseases characterized by an imbalance between bone resorption and formation. The aim of the study was to estimate serum markers of bone turnover: osteoclast-derived tartrate-resistant acid phosphatase form 5a (TRACP 5b) and osteocalcin in IL-6-deficient mice to assess the role of IL-6 in bone metabolism in hypothyroidism in mice. C57BL/6J (wild-type; WT) and C57BL/6J(IL6-/-Kopf) (IL-6 knock-out; IL6KO) mice randomly divided into 4 groups with 10 in each one: 1/ WT mice in hypothyroidism (WT-ht), 2/ WT controls, 3/ IL6KO mice with hypothyroidism (IL6KO-ht) and 4/ IL6KO controls. Experimental model of hypothyroidism was induced by intraperitoneal injection of propylthiouracyl. The serum levels of TRACP 5b and osteocalcin were determined by ELISA. Serum concentrations of TRACP 5b (median and interquartile ranges) were significantly decreased in both groups of mice with hypothyroidism: WT (3.2 (2.5-4.7) U/l) and IL6KO (2.6 (1.8-3.5) U/l) as compared to the respective controls. Similarly, serum osteocalcin levels were significantly reduced in both groups of mice in experimental hypothyroidism: WT (25.8 (23.0-28.2) ng/ml) and IL6KO (21.5(19.0-24.6) ng/ml) in comparison to the respective controls. There were no significant differences in bone turnover markers between IL6KO and WT mice both in hypothyroid and control animals. The results of the present study suggest that IL-6 does not play an important role in bone turnover in both euthyroid and hypothyroid mice

Closed FRW model in Loop Quantum Cosmology

The basic idea of the LQC applies to every spatially homogeneous cosmological model, however only the spatially flat (so called $k=0$) case has been understood in detail in the literature thus far. In the closed (so called: k=1) case certain technical difficulties have been the obstacle that stopped the development. In this work the difficulties are overcome, and a new LQC model of the spatially closed, homogeneous, isotropic universe is constructed. The topology of the spacelike section of the universe is assumed to be that of SU(2) or SO(3). Surprisingly, according to the results achieved in this work, the two cases can be distinguished from each other just by the local properties of the quantum geometry of the universe. The quantum hamiltonian operator of the gravitational field takes the form of a difference operator, where the elementary step is the quantum of the 3-volume derived in the flat case by Ashtekar, Pawlowski and Singh. The mathematical properties of the operator are studied: it is essentially self-adjoint, bounded from above by 0, the 0 itself is not an eigenvalue, the eigenvectors form a basis. An estimate on the dimension of the spectral projection on any finite interval is provided.Comment: 19 pages, latex, no figures, high quality, nea

The status of Quantum Geometry in the dynamical sector of Loop Quantum Cosmology

This letter is motivated by the recent papers by Dittrich and Thiemann and, respectively, by Rovelli discussing the status of Quantum Geometry in the dynamical sector of Loop Quantum Gravity. Since the papers consider model examples, we also study the issue in the case of an example, namely on the Loop Quantum Cosmology model of space-isotropic universe. We derive the Rovelli-Thiemann-Ditrich partial observables corresponding to the quantum geometry operators of LQC in both Hilbert spaces: the kinematical one and, respectively, the physical Hilbert space of solutions to the quantum constraints. We find, that Quantum Geometry can be used to characterize the physical solutions, and the operators of quantum geometry preserve many of their kinematical properties.Comment: Latex, 12 page

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation