Pygmalion: A Pappus Word Game

The theorem of Pappus is a result from projective geometry about nine points and nine lines. It can be used as a basis for a word game similar to the game of David Silvermann using the word stockpile ARMY CHAT FISH GIRL HORN KNIT SOUP SWAN VOTE (A. Ross Eckler, Word Recreations (Dover Publications, 1979), p. 113)

A SYSTEM AND METHOD FOR TARGETED UPDATING OF SOFTWARE ON DEVICES

The present disclosure relates to a method for updating target devices (104). The method comprises transmitting change message to the target devices (104). The change message comprises address data and condition change data associated with updating a condition of the target devices (104). Further, the method comprises receiving an update message from the target devices (104). The update message comprises update data associated with a status of updating the condition. Furthermore, the method comprises determining whether the condition of the target devices (104) is updated. Moreover, the method comprises transmitting a validation test message to the target devices (104). The validation test message comprises validation inquiry data associated with determining whether the condition of the target devices (104) is valid. Thereafter, the method comprises receiving a validation response message comprising validation response data, where the validation response data is indicative of validation of the condition of the target devices (104)

A Proposed Meta-Reality Immersive Development Pipeline: Generative AI Models and Extended Reality (XR) Content for the Metaverse

The realization of an interoperable and scalable virtual platform, currently known as the “metaverse,” is inevitable, but many technological challenges need to be overcome first. With the metaverse still in a nascent phase, research currently indicates that building a new 3D social environment capable of interoperable avatars and digital transactions will represent most of the initial investment in time and capital. The return on investment, however, is worth the financial risk for firms like Meta, Google, and Apple. While the current virtual space of the metaverse is worth $6.30 billion, that is expected to grow to$84.09 billion by the end of 2028. But the creation of an entire alternate virtual universe of 3D avatars, objects, and otherworldly cityscapes calls for a new development pipeline and workflow. Existing 3D modeling and digital twin processes, already well-established in industry and gaming, will be ported to support the need to architect and furnish this new digital world. The current development pipeline, however, is cumbersome, expensive and limited in output capacity. This paper proposes a new and innovative immersive development pipeline leveraging the recent advances in artificial intelligence (AI) for 3D model creation and optimization. The previous reliance on 3D modeling software to create assets and then import into a game engine can be replaced with nearly instantaneous content creation with AI. While AI art generators like DALL-E 2 and DeepAI have been used for 2D asset creation, when combined with game engine technology, such as Unreal Engine 5 and virtualized geometry systems like Nanite, a new process for creating nearly unlimited content for immersive reality is possible. New processes and workflows, such as those proposed here, will revolutionize content creation and pave the way for Web 3.0, the metaverse and a truly 3D social environment

Spatiotemporal modelling of flood-related impacts on daily population movement

This paper presents research combining spatiotemporal population flow data, flood modelling and network analysis to examine the effect of time of flood onset and flood magnitude on travel across a city for commuters and primary school children. Findings quantify that flood onset time has an effect on the disruption to travel comparable to flood event magnitud

Key Topics on End-of-Life Care for African Americans

Racial classifications of human populations are politically and socially determined. There is no biological or genetic basis for these racial classifications. Health behaviors may be influenced by culture and poverty. Disparities in health outcomes, sometimes resulting in higher mortality rates for African-Americans appear to influence end of life decision-making attitudes and behaviors. To improve the quality of end of life care in African-American communities, health care professionals must better understand and work to eliminate disparities in health care, increase their own skills, knowledge and confidence in palliative and hospice care, and improve awareness of the benefits and values of hospice and palliative care in their patients and families

The Systems Biology Research Tool: evolvable open-source software

BACKGROUND: Research in the field of systems biology requires software for a variety of purposes. Software must be used to store, retrieve, analyze, and sometimes even to collect the data obtained from system-level (often high-throughput) experiments. Software must also be used to implement mathematical models and algorithms required for simulation and theoretical predictions on the system-level. RESULTS: We introduce a free, easy-to-use, open-source, integrated software platform called the Systems Biology Research Tool (SBRT) to facilitate the computational aspects of systems biology. The SBRT currently performs 35 methods for analyzing stoichiometric networks and 16 methods from fields such as graph theory, geometry, algebra, and combinatorics. New computational techniques can be added to the SBRT via process plug-ins, providing a high degree of evolvability and a unifying framework for software development in systems biology. CONCLUSION: The Systems Biology Research Tool represents a technological advance for systems biology. This software can be used to make sophisticated computational techniques accessible to everyone (including those with no programming ability), to facilitate cooperation among researchers, and to expedite progress in the field of systems biology

Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.

BACKGROUND: Observational research suggests that combined therapy with Vitamin C, thiamine and hydrocortisone may reduce mortality in patients with septic shock. METHODS AND DESIGN: The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) trial is a multicenter, double-blind, adaptive sample size, randomized, placebo-controlled trial designed to test the efficacy of combination therapy with vitamin C (1.5 g), thiamine (100 mg), and hydrocortisone (50 mg) given every 6 h for up to 16 doses in patients with respiratory or circulatory dysfunction (or both) resulting from sepsis. The primary outcome is ventilator- and vasopressor-free days with mortality as the key secondary outcome. Recruitment began in August 2018 and is ongoing; 501 participants have been enrolled to date, with a planned maximum sample size of 2000. The Data and Safety Monitoring Board reviewed interim results at N = 200, 300, 400 and 500, and has recommended continuing recruitment. The next interim analysis will occur when N = 1000. This update presents the statistical analysis plan. Specifically, we provide definitions for key treatment and outcome variables, and for intent-to-treat, per-protocol, and safety analysis datasets. We describe the planned descriptive analyses, the main analysis of the primary end point, our approach to secondary and exploratory analyses, and handling of missing data. Our goal is to provide enough detail that our approach could be replicated by an independent study group, thereby enhancing the transparency of the study. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03509350. Registered on 26 April 2018

Simulations of the Microwave Sky

We create realistic, full-sky, half-arcminute resolution simulations of the microwave sky matched to the most recent astrophysical observations. The primary purpose of these simulations is to test the data reduction pipeline for the Atacama Cosmology Telescope (ACT) experiment; however, we have widened the frequency coverage beyond the ACT bands to make these simulations applicable to other microwave background experiments. Some of the novel features of these simulations are that the radio and infrared galaxy populations are correlated with the galaxy cluster populations, the CMB is lensed by the dark matter structure in the simulation via a ray-tracing code, the contribution to the thermal and kinetic Sunyaev-Zel'dovich (SZ) signals from galaxy clusters, groups, and the IGM has been included, and the gas prescription to model the SZ signals matches the most recent X-ray observations. Regarding the contamination of cluster SZ flux by radio galaxies, we find for 148 GHz (90 GHz) only 3% (4%) of halos have their SZ decrements contaminated at a level of 20% or more. We find the contamination levels higher for infrared galaxies. However, at 90 GHz, less than 20% of clusters with M_{200} > 2.5 x 10^{14} Msun and z<1.2 have their SZ decrements filled in at a level of 20% or more. At 148 GHz, less than 20% of clusters with M_{200} > 2.5 x 10^{14} Msun and z<0.8 have their SZ decrements filled in at a level of 50% or larger. Our models also suggest that a population of very high flux infrared galaxies, which are likely lensed sources, contribute most to the SZ contamination of very massive clusters at 90 and 148 GHz. These simulations are publicly available and should serve as a useful tool for microwave surveys to cross-check SZ cluster detection, power spectrum, and cross-correlation analyses.Comment: Sims are now public at http://lambda.gsfc.nasa.gov/toolbox/tb_cmbsim_ov.cfm; Expanded discussion of N-body sim and IGM; Version accepted by Ap