The Artist\u27s Dilemma; A Philosophical Analysis of “Selling Out” and Its Impacts on Well-Being In the Music Industry

Beginning with a discussion of a concept referred to as “The Artist’s Dilemma,” my thesis discusses the common criticism of artists in the music industry that they can “sell out” by changing their sound, appearance, and jeopardizing their artistic integrity in exchange for financial or celebrity gain. Furthermore, it attempts to search for a universal guide by which artists in the music industry could circumnavigate this “artist’s dilemma” in order to ensure a meaningful career without over-playing their role as a celebrity, nor under-playing their role as a musician. In order to evaluate this topic, I consider multiple “real world” examples of both artists who have been traditionally labeled as “sellouts,” and those that have managed to maintain artistic integrity throughout their career. Next I move to acknowledging philosophical perspectives on the topic of well-being (e.g. Hedonistic, Desire-Satisfaction, and Objective List theories) in attempts to gain outside perspectives on what constitutes a meaningful life for an individual, and how it can be achieved. Then I attempt to evaluate the “artist’s dilemma” through the lens of each previously mentioned philosophical perspective on well-being. My thesis concludes that, more often than not, “selling out” in the music industry will not result in an increase to overall well-being across the course of a career or lifetime. However, this conclusion is provided under the stipulation that determinations on this matter are ultimately subject to preferences and desires of the individual artist, and by which of the three philosophical perspectives of well-being they find themselves most compelled

Fall Calving in the Intermountain West

Fall calving has been practiced by beef producers for many years, although in small numbers relative to spring calving. The spring calf crop has been a traditional event for most beef producers and probably will continue to be. There are distinct advantages, however, to fall calving which producers could take advantage of. The potential for higher conception and weaning rates, price premiums and the elimination of calf scours are among the reasons some beef producers have switched from spring calving their herd to fall calving

Notes--\u3ci\u3eNebraska Bird Review\u3c/i\u3e (March 1982)

Notes contain stories of Cattle Egrets viewed on Prairie Dog Waterfowl Production Area near Axtell; Wood Duck broods on Carter Lake in Omaha; a first-year Thayer’s Gull on Lake North near Columbus; a variety of birds (Swamp Sparrow, Great Horned Owl, Cliff Swallows, Savannah Sparrows, Grasshopper Sparrows, Purple Martins, Carolina Wren, Great Blue Heron, Western Kingbird, Prairie Chicken, Sprague’s Pipits, and more) seen in and around the Minden area; and a Scissor-tailed Flycatcher at Verdon Lake in Richardson County

Insecticide Sensitivity of Native Chloride and Sodium Channels in a Mosquito Cell Line

The aim of this study was to investigate the utility of cultured Anopheles gambiae Sua1B cells for insecticide screening applications without genetic engineering or other treatments. Sua1B cells were exposed to the known insecticidal compounds lindane and DIDS, which inhibited cell growth at micromolar concentrations. In patch clamp studies, DIDS produced partial inhibition (69%) of chloride current amplitudes, and an IC50 of 5.1 μM was determined for Sua1B cells. A sub-set of chloride currents showed no response to DIDS; however, inhibition (64%) of these currents was achieved using a low chloride saline solution, confirming their identity as chloride channels. In contrast, lindane increased chloride current amplitude (EC50 = 116 nM), which was reversed when cells were bathed in calcium-free extracellular solution. Voltage-sensitive chloride channels were also inhibited by the presence of fenvalerate, a type 2 pyrethroid, but not significantly blocked by type 1 allethrin, an effect not previously shown in insects. Although no evidence of fast inward currents typical of sodium channels was observed, studies with fenvalerate in combination with veratridine, a sodium channel activator, revealed complete inhibition of cell growth that was best fit by a two-site binding model. The high potency effect was completely inhibited in the presence of tetrodotoxin, a specific sodium channel blocker, suggesting the presence of some type of sodium channel. Thus, Sua1B cells express native insect ion channels with potential utility for insecticide screening

The Eyes Have It: Measuring Spatial Orientation in Virtual Worlds to Explain Gender Differences in Real Ones

Here, we explore how 3D, networked virtual worlds - in particular Second Life, which enables users to create and modify their own environments - can act as a kind of \u27virtual\u27 laboratory for studying gender difference. By tracking users\u27 eye movements as they navigate a virtual rendition of the Morris Water Maze (the \u27gold standard\u27 for measuring gender difference in spatial orientation, navigation and mobility), this work constitutes an empirical basis for claims that we have attempted to make in the context of ethnographic work with female and male video game players, both novice and expert: that mastery of, and the ability to competently navigate through space, both real and virtual, is as much (if not more) learned and acquired, as it inheres in the bodies and brains of differently-sexed subjects

One in four die from acute infectious illness in an emergency department in Eastern Cape Province, South Africa

Background. Despite the breadth of data supporting evidence-based practice for sepsis care in high-resource settings, there are relatively few data to guide the management of sepsis in low-resource settings, particularly in areas where HIV and tuberculosis (TB) are prevalent. Furthermore, few studies had broadened sepsis parameters to include all patients with acute infectious illness or followed patients up after hospital discharge. Understanding the epidemiology and outcomes of acute infections in a local context is the critical first step to developing locally informed targeted management strategies.Objectives. To quantify and describe the incidence of and risk factors for mortality in a cohort of patients with undifferentiated acute infectious illnesses who presented to an emergency department (ED) in the Eastern Cape region of South Africa (SA).Methods. In this prospective cohort study, patients with suspected acute infectious illness were enrolled at a district casualty ward in Mthatha, SA, between 1 July and 1 September 2017. Demographic data, interventions, diagnostic studies and disposition were prospectively collected during the initial encounter and during the hospital stay. Follow-up was conducted both in hospital and via phone interviews 30 days after the index visit.Results. A total of 301 patients presented to the ED with acute infectious illness during the study period, of whom 54.8% had complete 30-day follow-up. Of the study population, only 5.7% had a complete set of vital signs (heart rate, respiratory rate, blood pressure and temperature) documented. Of the cohort, 51.8% had HIV and 32.9% active or treated TB; 25.2% of patients died within 30 days. Accounting for medical history, diagnosis and ED interventions, risk of mortality was independently associated with age (odds ratio (OR) 1.03; 95% confidence interval (CI) 1.00 - 1.06), HIV-positive status (OR 4.10; 95% CI 1.44 - 11.67) and Quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score (OR 1.90; 95% CI 1.14 - 3.19) in an adjusted model. No ED interventions were protective for mortality, with intravenous fluid administration associated with increased 30-day mortality in this cohort (OR 3.65; 95% CI 1.38 - 9.62).Conclusions. Among adults with suspected acute infectious illness in Mthatha, SA, 30-day mortality was concerningly high. Mortality was highest in patients with concomitant HIV infection. In particular, vital sign assessment to identify possible sepsis in this cohort is crucial, as it affects mortality to a meaningful extent, yet is often unavailable. Future research is needed on the management of sepsis in low-resource settings, particularly in HIV-positive individuals

The physicAl aCtivity Counselling for young adult cancEr SurvivorS (ACCESS) trial: a protocol for a parallel, two-arm pilot randomized controlled trial

BackgroundYoung adults aged 18–39 years commonly experience persistent side effects following cancer treatment that can impair their quality of life. Physical activity (PA) holds promise as a behavioral intervention to mitigate persistent side effects and improve quality of life. Yet, few young adults are active enough to incur these benefits and efforts to promote PA after cancer treatment ends are lacking. Therefore, we developed a novel theory-driven behavior change intervention to promote PA via videoconferencing technology in young adults who have completed cancer treatment, and are undertaking a pilot randomized controlled trial (RCT) to gather evidence to inform the design of a large, full-scale RCT. The specific aims of this parallel, two-arm pilot RCT are to: (1) assess intervention and trial protocol feasibility and acceptability; and (2) generate data on PA behavior. To promote transparency, improve reproducibility, and serve as a reference for forthcoming publication of results, we present the study protocol for this pilot RCT (version 7) within this paper.MethodsYoung adults who have completed cancer treatment are being recruited from across Canada. After informed consent is obtained and baseline assessments are completed, participants are randomized to the intervention group (i.e., a 12-week behavior change intervention delivered via videoconferencing technology by trained PA counsellors) or usual care group (i.e., no intervention). Several feasibility outcomes covering enrollment, allocation, follow-up, and analysis are tracked by study staff. Acceptability is assessed through interviews exploring participants’ experiences, thoughts, and perspectives of the trial protocol (i.e., intervention and usual care groups), as well as participants’ views of the intervention and its mode of delivery (i.e., intervention group only) and PA counsellors’ experiences delivering the intervention. PA behavior is measured using accelerometers at baseline (pre-randomization), post-intervention, and at follow-up (24 weeks post-baseline).DiscussionThere are growing calls to develop interventions to support young adults’ motivation to engage in PA and adopt an active lifestyle to improve their quality of life after cancer treatment ends. Real-time videoconferencing shows promise for disseminating behavior change interventions to young adults and addressing participation barriers. Considering the importance of establishing intervention and trial protocol feasibility and acceptability prior to evaluating intervention efficacy (or effectiveness), this pilot RCT is critical to understand how participants embrace, engage with, and complete the intervention and trial protocol. Indeed, these data will help to determine which refinements, if any, are required to the intervention and trial protocol (e.g., implementation approach, evaluation methods) prior to a large, full-scale RCT aiming to test the effects of the intervention on PA behavior. Additionally, the PA behavior data collected will be useful to inform the sample size calculation for a large, full-scale RCT.Trial registrationThe trial was registered with the ClinicalTrials.gov database (ID: NCT04163042) on November 14, 2019, prior to the start of the trial in February, 2021

Finding the Magnetic Center of a Quadrupole to High Resolution

In a companion pro, collposal it is proposed to align quadrupoles of a transport line to within transverse tolerances of 5 to 10 micrometers. Such a proposal is meaningful only if the effective magnetic center of such lenses can in fact be repeatably located with respect to some external mechanical tooling to comparable accuracy. It is the purpose of this note to describe some new methods and procedures that will accomplish this aim. It will be shown that these methods are capable of yielding greater sensitivity than the more traditional methods used in the past. The notion of the ''nodal'' point is exploited