5 research outputs found
Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates
- Author
- Akdim
- Braasch
- Christoph Rosenbohm
- Crooke
- Elayadi
- Ellen Marie Straarup
- Elmen
- Fluiter
- Frieden
- Frieden
- Frieden
- Gao
- Greeve
- GrĂŒnweller
- GrĂŒnweller
- Hansson
- Henrik Frydenlund Hansen
- Henrik Ărum
- Jens B. Rode Hansen
- Jepsen
- Kastelein
- Koch
- Koch
- Krzystanek
- Kurreck
- Leblanc
- Lennox
- Maj HedtjÀrn
- Marie W. Lindholm
- Moewis
- Mong
- Niels Fisker
- Nishina
- Olofsson
- Schonfeld
- Seth
- SimĂ”es-WĂŒst
- Soutschek
- Stein
- Swayze
- Troels Koch
- Ullberg
- Ullberg
- Vibeke Aarup
- Watanabe
- Yu
- Yu
- Zimmermann
- Zon
- Publication venue
- Oxford University Press
- Publication date
- 01/01/2010
- Field of study
The potency and specificity of locked nucleic acid (LNA) antisense oligonucleotides was investigated as a function of length and affinity. The oligonucleotides were designed to target apolipoprotein B (apoB) and were investigated both in vitro and in vivo. The high affinity of LNA enabled the design of short antisense oligonucleotides (12- to 13-mers) that possessed high affinity and increased potency both in vitro and in vivo compared to longer oligonucleotides. The short LNA oligonucleotides were more target specific, and they exhibited the same biodistribution and tissue half-life as longer oligonucleotides. Pharmacology studies in both mice and non-human primates were conducted with a 13-mer LNA oligonucleotide against apoB, and the data showed that repeated dosing of the 13-mer at 1â2âmg/kg/week was sufficient to provide a significant and long lasting lowering of non-high-density lipoprotein (non-HDL) cholesterol without increasing serum liver toxicity markers. The data presented here show that oligonucleotide length as a parameter needs to be considered in the design of antisense oligonucleotide and that potent short oligonucleotides with sufficient target affinity can be generated using the LNA chemistry. Conclusively, we present a 13-mer LNA oligonucleotide with therapeutic potential that produce beneficial cholesterol lowering effect in non-human primates
Bibliographie
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- Field of study
Inclusive and multiplicity dependent production of electrons from heavy-flavour hadron decays in pp and p-Pb collisions
- Author
- Abranches De Carvalho Leopoldo
- Acharya Shreyasi
- Adamova Dagmar
- Adler Alexander
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahmad Shakeel
- Ahn Sang Un
- Ahuja Ishaan
- Akindinov Alexander
- Al-turany Mohammad
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfanda Haidar Mas'ud
- Alfaro Molina Jose Ruben
- Ali Bushra
- ALICE Collaboration
- Alici Andrea
- Alizadehvandchali Negin
- Alkin Anton
- Alme Johan
- Alocco Giacomo
- Alt Torsten
- Altsybeev Igor
- Alvarado Garcia Jesus Ricardo
- Amatriain Carballo Aitor
- Anaam Mustafa
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Antinori Federico
- Antonioli Pietro
- Apadula Nicole
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Arata Carolina
- Arcelli Silvia
- Aresti Mauro
- Arnaldi Roberta
- Arsene Ionut Cristian
- Arslandok Mesut
- Arteche Diaz Raul
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Badala Angela
- Badaro Saramela Thiago
- Bae Joonsuk
- Baek Yongwook
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- Glassel Peter
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- Goh Daniel Jia Qin
- Gonzalez Sebastian Victor Luis
- Gorbunov Sergey
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- Goswami Kangkan
- Gotovac Sven
- Grabski Varlen
- Graczykowski Lukasz Kamil
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- Taghavi Seyed Farid
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- Tapus Nicolae
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- Tkacik Tomas
- Toia Alberica
- Tokumoto Ryoka
- Toledo Matuoka Paula Fernanda
- Topilskaya Nataliya
- Toppi Marco
- Tork Theraa M. A.
- Torres Ramos Arianna Grisel
- Trifiro Antonio
- Triolo Andrea Sofia
- Tripathy Sushanta
- Tripathy Tulika
- Trogolo Stefano
- Tropp Klaudia
- Trubnikov Victor
- Trzaska Wladyslaw Henryk
- Trzcinski Tomasz Piotr
- Tumkin Alexandr
- Turrisi Rosario
- Tveter Trine Spedstad
- Ullaland Kjetil
- Ulukutlu Berkin
- Uras Antonio
- Urioni Marta
- Usai Gianluca
- Vala Martin
- Valle Nicolo
- Van Doremalen Lennart
- Van Leeuwen Marco
- Van Veen Casper Arie
- Van Weelden Roelof Jan Gijs
- Vande Vyvre Pierre
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- Varga Zoltan
- Vasileiou Maria
- Vasiliev Andrey
- Vazquez Doce Oton
- Vazquez Rueda Omar
- Vechernin Vladimir
- Vercellin Ermanno
- Vergara Limon Sergio
- Vermunt Lucas Anne
- Vertesi Robert
- Verweij Marta
- Vickovic Linda
- Vilakazi Zabulon
- Villalobos Baillie Orlando
- Villani Anna
- Vino Gioacchino
- Vinogradov Alexander
- Viqueira Rodriguez Manuel
- Virgili Tiziano
- Virta Maxim Mikael Olavi
- Vislavicius Vytautas
- Vodopyanov Alexander
- Voelkel Benedikt
- Volkl Martin Andreas
- Voloshin Kirill
- Voloshin Sergey
- Volpe Giacomo
- Von Haller Barthelemy
- Vorobyev Ivan
- Vozniuk Nikita
- Vrlakova Janka
- Wan Jie
- Wang Chunzheng
- Wang Dongfang
- Wang Yuanzhe
- Wegrzynek Adam Tadeusz
- Weiglhofer Felix Thomas
- Wenzel Sandro Christian
- Wessels Johannes Peter
- Weyhmiller Sierra Lisa
- Wiechula Jens
- Wikne Jon
- Wilk Grzegorz Andrzej
- Wilkinson Jeremy John
- Willems Guido Alexander
- Windelband Bernd Stefan
- Winn Michael Andreas
- Wright Josephina Rae
- Wu Wenya
- Wu Yitao
- Xu Ran
- Yadav Ankur
- Yadav Arun Kumar
- Yalcin Kuzu Serpil
- Yamaguchi Yorito
- Yang Shiming
- Yano Satoshi
- Yin Zhongbao
- Yoo In Kwon
- Yoon Jin Hee
- Yoval Pozos Irandheny
- Yu Hyeonjin
- Yu Zhi
- Yuan Shiming
- Yuncu Alperen
- Zaccolo Valentina
- Zampolli Chiara
- Zanone Federica
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zhalov Mikhail
- Zhang Biao
- Zhang Liuyao
- Zhang Song
- Zhang Xiaoming
- Zhang Yifei
- Zhang Zhen
- Zhao Mingrui
- Zherebchevskii Vladimir
- Zhou Daicui
- Zhou You
- Zhu Jianhui
- Zhu Ya
- Zugravel Stefan Cristi
- Zurlo Nicola
- Publication venue
- SISSA
- Publication date
- 01/01/2023
- Field of study
Inclusive and multiplicity dependent production of electrons from heavy-flavour hadron decays in pp and pâPb collisions
- Author
- Abranches De Carvalho Leopoldo
- Acharya Shreyasi
- Adamova Dagmar
- Adler Alexander
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahmad Shakeel
- Ahn Sang Un
- Ahuja Ishaan
- Akindinov Alexander
- Al-turany Mohammad
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfanda Haidar Mas'ud
- Alfaro Molina Jose Ruben
- Ali Bushra
- Alici Andrea
- Alizadehvandchali Negin
- Alkin Anton
- Alme Johan
- Alocco Giacomo
- Alt Torsten
- Altsybeev Igor
- Alvarado Garcia Jesus Ricardo
- Amatriain Carballo Aitor
- Anaam Mustafa
- Anastasia Berdnikova
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Antinori Federico
- Antonioli Pietro
- Apadula Nicole
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Arata Carolina
- Arcelli Silvia
- Aresti Mauro
- Arnaldi Roberta
- Arsene Ionut Cristian
- Arslandok Mesut
- Arteche Diaz Raul
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Badala Angela
- Badaro Saramela Thiago
- Bae Joonsuk
- Baek Yongwook
- Bai Xiaozhi
- Bailhache Raphaelle Marie
- Bailung Yoshini
- Balbino Alessandro
- Baldisseri Alberto
- Balis Bartosz
- Banerjee Debjani
- Banoo Zarina
- Barbera Roberto
- Barile Francesco
- Barioglio Luca
- Barlou Maria
- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Barreto De Oliveira Campos Leonardo
- Bartels Clara
- Barth Klaus
- Bartsch Esther
- Bastid Nicole
- Basu Sumit
- Batigne Guillaume
- Battistini Daniel
- Batyunya Boris
- Bauri Dibakar
- Bazo Alba Jose Luis
- Bearden Ian Gardner
- Beattie Caitlin
- Becht Pascal
- Behera Debadatta
- Belikov Iouri
- Bell Hechavarria A.D. C.
- Bellini Francesca
- Bellwied Rene
- Belokurova Svetlana
- Bencedi Gyula
- Beole Stefania Maria
- Bercuci Alexandru
- Berdnikov Yaroslav
- Bergmann Luisa
- Bertran Ferrer Marta
- Besoiu Mihaela Gabriela
- Betev Latchezar
- Bhaduri Partha Pratim
- Bhasin Anju
- Bhat Mohammad Asif
- Bhattacharjee Buddhadeb
- Bianchi Livio
- Bianchi Nicola
- Bielcik Jaroslav
- Bielcikova Jana
- Biernat Jacek Bogumil
- Bigot Alexandre Patrick
- Bilandzic Ante
- Biro Gabor
- Biswas Saikat
- Bize Nicolas Luc
- Blair Justin Thomas
- Blau Dmitry
- Blidaru Mihail Bogdan
- Bluhme Nora
- Blume Christoph
- Boca Gianluigi
- Bock Friederike
- Bodova Tea
- Bogdanov Alexey
- Boi Stefano
- Bok Jeongsu
- Boldizsar Laszlo
- Bombara Marek
- Bond Peter Matthew
- Bonomi Germano
- Borel Herve
- Borissov Alexander
- Borquez Carcamo Andres Gerardo
- Bossi Hannah
- Botta Elena
- Bratrud Lars
- Braun-munzinger Peter
- Bregant Marco
- Broz Michal
- Bruno Giuseppe Eugenio
- Buckland Matthew Daniel
- Budnikov Dmitry
- Buesching Henner
- Bufalino Stefania
- Buhler Paul Alois
- Buthelezi Edith Zinhle
- Bylinkin Aleksandr
- Bysiak Sebastian Adam
- Cai Mengke
- Caines Helen Louise
- Caliva Alberto
- Calvo Villar Ernesto
- Camerini Paolo
- Carabas Mihai
- Carnesecchi Francesca
- Caron Robin Albert Andre
- Castillo Castellanos Javier Ernesto
- Catalano Fabio
- Ceballos Sanchez Cesar
- Chakaberia Irakli
- Chakraborty Pritam
- Chandra Sinjini
- Chapeland Sylvain
- Chartier Marielle
- Chattopadhyay Subhasis
- Chattopadhyay Sukalyan
- Cheng Tiantian
- Cheshkov Cvetan Valeriev
- Cheynis Brigitte
- Chibante Barroso Vasco Miguel
- Chizzali Emma Sophia
- Cho Jaeyoon
- Cho Soyeon
- Chochula Peter
- Christakoglou Panagiotis
- Christensen Christian Holm
- Christiansen Peter
- Chujo Tatsuya
- Ciacco Mario
- Cicalo Corrado
- Cindolo Federico
- Ciupek Michael Rudolf
- Clai Giulia
- Colamaria Fabio Filippo
- Colburn Jonathan Samuel
- Colella Domenico
- Colocci Manuel
- Conesa Balbastre Gustavo
- Conesa Del Valle Zaida
- Contin Giacomo
- Contreras Nuno Jesus Guillermo
- Coquet Maurice Louis
- Cormier Thomas Michael
- Cortese Pietro
- Cosentino Mauro Rogerio
- Costa Filippo
- Costanza Susanna
- Cot Corentin
- Crkovska Jana
- Crochet Philippe
- Cruz Torres Reynier
- Cui Pengyao
- Czeslaw Miskowiec Dariusz
- Dainese Andrea
- Danisch Meike Charlotte
- Danu Andrea
- Das Prottay
- Das Prottoy
- Das Supriya
- Dash Archita Rani
- Dash Sadhana
- De Caro Annalisa
- De Cataldo Giacinto
- De Cuveland Jan
- De Falco Alessandro
- De Gruttola Daniele
- De Leone Gay Maria Beatriz
- De Marco Nora
- De Martin Chiara
- De Moraes Canedo Fabio
- De Pasquale Salvatore
- Deb Rohaan
- Deb Suman
- Deja Kamil Rafal
- Del Grande Raffaele
- Dello Stritto Luigi
- Demmich Katharina
- Deng Wenjing
- Dhankher Preeti
- Di Bari Domenico
- Di Mauro Antonio
- Diab Batoul
- Dietel Thomas
- Ding Yanchun
- Divia Roberto
- Dixit Dhruv Utpalkumar
- Djuvsland Oeystein
- Dmitrieva Uliana
- Dobrigkeit Chinellato David
- Dobrin Alexandru Florin
- Dominguez Rosas Edgar
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- Voloshin Sergey
- Volpe Giacomo
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- Vorobyev Ivan
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- Wang Dongfang
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- Wegrzynek Adam Tadeusz
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- Wiechula Jens
- Wikne Jon
- Wilk Grzegorz Andrzej
- Wilkinson Jeremy John
- Willems Guido Alexander
- Windelband Bernd Stefan
- Winn Michael Andreas
- Wright Josephina Rae
- Wu Wenya
- Wu Yitao
- Xu Ran
- Yadav Ankur
- Yadav Arun Kumar
- Yalcin Kuzu Serpil
- Yamaguchi Yorito
- Yang Shiming
- Yano Satoshi
- Yin Zhongbao
- Yoo In Kwon
- Yoon Jin Hee
- Yoval Pozos Irandheny
- Yu Hyeonjin
- Yu Zhi
- Yuan Shiming
- Yuncu Alperen
- Zaccolo Valentina
- Zampolli Chiara
- Zanone Federica
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zhalov Mikhail
- Zhang Biao
- Zhang Liuyao
- Zhang Song
- Zhang Xiaoming
- Zhang Yifei
- Zhang Zhen
- Zhao Mingrui
- Zherebchevskii Vladimir
- Zhou Daicui
- Zhou You
- Zhu Jianhui
- Zhu Ya
- Zugravel Stefan Cristi
- Zurlo Nicola
- Publication venue
- HAL CCSD
- Publication date
- 01/01/2023
- Field of study
International audienceMeasurements of the production of electrons from heavy-flavour hadron decays in pp collisions at sâ=13 TeV at midrapidity with the ALICE detector are presented down to a transverse momentum (pTâ) of 0.2 GeV/c and up to pTâ=35 GeV/c, which is the largest momentum range probed for inclusive electron measurements in ALICE. In pâPb collisions, the production cross section and the nuclear modification factor of electrons from heavy-flavour hadron decays are measured in the pTâ range 0.5<pTâ<26 GeV/c at sNNââ=8.16 TeV. The nuclear modification factor is found to be consistent with unity within the statistical and systematic uncertainties. In both collision systems, first measurements of the yields of electrons from heavy-flavour hadron decays in different multiplicity intervals normalised to the multiplicity-integrated yield (self-normalised yield) at midrapidity are reported as a function of the self-normalised charged-particle multiplicity estimated at midrapidity. The self-normalised yields in pp and pâPb collisions grow faster than linear with the self-normalised multiplicity. A strong pTâ dependence is observed in pp collisions, where the yield of high-pTâ electrons increases faster as a function of multiplicity than the one of low-pTâ electrons. The measurement in pâPb collisions shows no pTâ dependence within uncertainties. The self-normalised yields in pp and pâPb collisions are compared with measurements of other heavy-flavour, light-flavour, and strange particles, and with Monte Carlo simulations
Inclusive and multiplicity dependent production of electrons from heavy-flavour hadron decays in pp and pâPb collisions
- Author
- Abranches De Carvalho Leopoldo
- Acharya Shreyasi
- AdamovĂĄ Dagmar
- Adler Alexander
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahmad Shakeel
- Ahn Sang Un
- Ahuja Ishaan
- Akindinov Alexander
- Al-Turany Mohammad
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfanda Haidar Masâud
- Alfaro Molina Jose Ruben
- Ali Bushra
- Alici Andrea
- Alizadehvandchali Negin
- Alkin Anton
- Alme Johan
- Alocco Giacomo
- Alt Torsten
- Altsybeev Igor
- Alvarado Garcia JesĂșs Ricardo
- Amatriain Carballo Aitor
- Anaam Mustafa Naji
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Antinori Federico
- Antonioli Pietro
- Apadula Nicole
- Aphecetche Laurent Bernard
- AppelshÀuser Harald
- Arata Carolina
- Arcelli Silvia
- Aresti Mauro
- Arnaldi Roberta
- Arneiro Jhoao Gabriel Martins Campos Almeida
- Arsene Ionut Cristian
- Arslandok Mesut
- Arteche Diaz Raul
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- BadalĂ Angela
- Bae Joonsuk
- Baek Yong Wook
- Bai Xiaozhi
- Bailhache Raphaëlle
- Bailung Yoshini
- Balbino Alessandro
- Baldisseri Alberto
- Balis Bartosz
- Banerjee Debjani
- Banoo Zarina
- Barbera Roberto
- Barile Francesco
- Barioglio Luca
- Barlou Maria
- Barnaföldi Gergely Gåbor
- Barnby Lee Stuart
- Barreto De Oliveira Campos Leonardo
- Bartels Clara
- Barth Klaus
- Bartsch Esther
- Bastid Nicole
- Basu Sumit
- Batigne Guillaume
- Battistini Daniel
- Batyunya Boris
- Bauri Dibakar
- Bazo Alba José Luis
- Bearden Ian Gardner
- Beattie Caitlin
- Becht Pascal
- Behera Debadatta
- Belikov Iouri
- Bell Hechavarria Ailec de la Caridad
- Bellini Francesca
- Bellwied Rene
- Belokurova Svetlana
- Bencédi Gyula
- BeolĂš Stefania
- Bercuci Alexandru
- Berdnikov Yaroslav
- Berdnikova Anastasia
- Bergmann Luisa
- Bertran Ferrer Marta
- Besoiu Mihaela Gabriela
- Betev Latchezar
- Bhaduri Partha Pratim
- Bhasin Anju
- Bhat Mohammad Asif
- Bhattacharjee Buddhadeb
- Bianchi Livio
- Bianchi Nicola
- BielÄĂk Jaroslav
- BielÄĂkovĂĄ Jana
- Biernat Jacek
- Bigot Alexandre Patrick
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- ZĂĄvada Petr
- Ănnerstad Anna
- Ć afaĆĂk Karel
- Ć erkĆĄnytÄ Laura
- Ć uljiÄ Miljenko
- Publication venue
- Publication date
- 23/03/2023
- Field of study
Measurements of the production of electrons from heavy-flavour hadron decays in pp collisions at sâ=13 TeV at midrapidity with the ALICE detector are presented down to a transverse momentum (pT) of 0.2 GeV/c and up to pT=35 GeV/c, which is the largest momentum range probed for inclusive electron measurements in ALICE. In pâPb collisions, the production cross section and the nuclear modification factor of electrons from heavy-flavour hadron decays are measured in the pT range 0.5<pT<26 GeV/c at sNNââââ=8.16 TeV. The nuclear modification factor is found to be consistent with unity within the statistical and systematic uncertainties. In both collision systems, first measurements of the yields of electrons from heavy-flavour hadron decays in different multiplicity intervals normalised to the multiplicity-integrated yield (self-normalised yield) at midrapidity are reported as a function of the self-normalised charged-particle multiplicity estimated at midrapidity. The self-normalised yields in pp and pâPb collisions grow faster than linear with the self-normalised multiplicity. A strong pT dependence is observed in pp collisions, where the yield of high-pT electrons increases faster as a function of multiplicity than the one of low-pT electrons. The measurement in pâPb collisions shows no pT dependence within uncertainties. The self-normalised yields in pp and pâPb collisions are compared with measurements of other heavy-flavour, light-flavour, and strange particles, and with Monte Carlo simulations