Charge solitons and their dynamical mass in 1-D arrays of Josephson junctions

We investigate the charge transport in one-dimensional arrays of Josephson junctions. In the interesting regime of "small charge solitons" (polarons), the charge dynamics is strongly influenced by the polaronic effects, i.e., by dressing of a Cooper pair by charge dipoles. In particular, the soliton's mass in this regime scales approximately as inverse square of the Josephson energy. We employ two theoretical techniques: the many body tight-binding approach and the mean-field approach. Results of the two approaches agree in the regime of "small charge solitons".Comment: 10 pages, 10 figure

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy

Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and non-dividing cells. A broad variety of natural products exists that are known to interfere with the microtubule network, by either stabilizing or de-stabilizing these rope-like polymers. Among those tubulysins represent a new and potent class of cytostatic tetrapeptides originating from myxobacteria. Early studies suggested that tubulysins interact with the eukaryotic cytoskeleton by inhibition of tubulin polymerization with EC50 values in the picomolar range. Recently, pretubulysins have been described to retain the high tubulindegradation activity of their more complex tubulysin relatives and represent an easier synthetic target with an efficient synthesis already in place. Although tubulin has been suggested as the dedicated target of tubulysin a comprehensive molecular target analysis of pretubulysin in the context of the whole proteome has not been carried out so far. Here we utilize synthetic chemistry to develop two pretubulysin photoaffinity probes which were applied in cellular activity-based protein profiling and imaging studies in order to unravel and visualize dedicated targets. Our results clearly show a remarkable selectivity of pretubulysin for beta-tubulin which we independently confirmed by a mass-spectrometry based proteomic profiling platform as well as by tubulin antibody based co-staining on intact cells

Picoradian deflection measurement with an interferometric quasi-autocollimator using weak value amplification

We present an "interferometric quasi-autocollimator" that employs weak value amplification to measure angular deflections of a target mirror. The device has been designed to be insensitive to all translations of the target. We present a conceptual explanation of the amplification effect used by the device. An implementation of the device demonstrates sensitivities better than 10 picoradians per root hertz between 10 and 200 hertz.Comment: To be published in Optics Letter

Improvement in the decadal prediction skill of the North Atlantic extratropical winter circulation through increased model resolution

In this study the latest version of the MiKlip decadal hindcast system is analyzed, and the effect of an increased horizontal and vertical resolution on the prediction skill of the extratropical winter circulation is assessed. Four different metrics – the storm track, blocking, cyclone and windstorm frequencies – are analyzed in the North Atlantic and European region. The model bias and the deterministic decadal hindcast skill are evaluated in ensembles of five members in a lower-resolution version (LR, atm: T63L47, ocean: 1.5∘ L40) and a higher-resolution version (HR, atm: T127L95, ocean: 0.4∘ L40) of the MiKlip system based on the Max Planck Institute Earth System model (MPI-ESM). The skill is assessed for the lead winters 2–5 in terms of the anomaly correlation of the quantities' winter averages using initializations between 1978 and 2012. The deterministic predictions are considered skillful if the anomaly correlation is positive and statistically significant. While the LR version shows common shortcomings of lower-resolution climate models, e.g., a storm track that is too zonal and southward displaced as well as a negative bias of blocking frequencies over the eastern North Atlantic and Europe, the HR version counteracts these biases. Cyclones, i.e., their frequencies and characteristics like strength and lifetime, are particularly better represented in HR. As a result, a chain of significantly improved decadal prediction skill between all four metrics is found with the increase in the spatial resolution. While the skill of the storm track is significantly improved primarily over the main source region of synoptic activity – the North Atlantic Current – the other extratropical quantities experience a significant improvement primarily downstream thereof, i.e., in regions where the synoptic systems typically intensify. Thus, the skill of the cyclone frequencies is significantly improved over the central North Atlantic and northern Europe, the skill of the blocking frequencies is significantly improved over the Mediterranean, Scandinavia and eastern Europe, and the skill of the windstorms is significantly improved over Newfoundland and central Europe. Not only is the skill improved with the increase in resolution, but the HR system itself also exhibits significant skill over large areas of the North Atlantic and European sector for all four circulation metrics. These results are particularly promising regarding the high socioeconomic impact of European winter windstorms and blocking situations

Attosecond Streaking in the Water Window: A New Regime of Attosecond Pulse Characterization

We report on the first streaking measurement of water-window attosecond pulses generated via high harmonic generation, driven by sub-2-cycle, CEP-stable, 1850 nm laser pulses. Both the central photon energy and the energy bandwidth far exceed what has been demonstrated thus far, warranting the investigation of the attosecond streaking technique for the soft X-ray regime and the limits of the FROGCRAB retrieval algorithm under such conditions. We also discuss the problem of attochirp compensation and issues regarding much lower photo-ionization cross sections compared with the XUV in addition to the fact that several shells of target gases are accessed simultaneously. Based on our investigation, we caution that the vastly different conditions in the soft X-ray regime warrant a diligent examination of the fidelity of the measurement and the retrieval procedure.Comment: 14 Pages, 12 figure

Interferometric Quasi-Autocollimator

Systems and method are disclosed for measuring small angular deflections of a target using weak value amplification. A system includes a beam source, a beam splitter, a target reflecting surface, a photodetector, and a processor. The beam source generates an input beam that is split into first and second beams by the beam splitter. The first and second beams are propagated to the target reflecting surface, at least partially superimposed at the target reflecting surface, and incident to the target reflecting surface normal to the target reflecting surface. The first beam is reflected an additional even number of times during propagation to the photodetector. The second beam is reflected an additional odd number of times during propagation to the photodetector. The first and second beams interfere at the photodetector so as to produce interference patterns. The interference patterns are interpreted to measure angular deflections of the target reflecting surface

Pattern of Activated Pathways and Quality of Collateral Status in Patients with Symptomatic Internal Carotid Artery Occlusion

Background: Internal carotid artery occlusion (ICAO) is an important risk factor for stroke. Cerebral hemodynamics in patients with ICAO depends on the individual capacity to activate sufficient collateral pathways. Therefore, the assessment of intracranial collaterals is essential for the acute and long-term management of these patients and accurate estimation of further stroke risk. Methods: Acute stroke patients with unilateral ICAO were prospectively enrolled. We assessed the following collaterals by transcranial color-coded sonography (TCCS): the anterior and posterior communicating artery (ACoA, PCoA), the ophthalmic artery (OA), and leptomeningeal collaterals of the posterior cerebral artery (LMC). We subdivided the flow pattern of the Doppler spectrum in the middle cerebral artery (MCA) into 3 categories: (1) good, (2) moderate, and (3) bad according to the hemodynamic effects on the ipsilateral MCA flow. Finally, we compared the individual TCCS results with the stroke pattern detected on CT or MRI scan. Results: One hundred thirteen patients (age 66 +/- 12 years; female 24) were included. The collateral status was good, moderate, and bad in 59 (52%), 37 (33%), and 17 (15%) patients, respectively. The ACoA collateral was most frequently activated (81%), followed by the OA (63%), the PCoA (53%), and the LMC (22%). The quality of the collateral status was determined by the type (p = 0.0003) but not by the number (p = 0.19) of activated collateral pathways. Good collateral function was highly associated with primary collaterals (ACoA > PCoA). Best parameter for a good collateral status was an antegrade flow in the OA, indicating a high blood supply via the communicating arteries. Conclusions: TCCS allows the assessment of intracranial collaterals and their hemodynamic capacity. Prevalence of collateral sufficiency in ICAO seems to be higher than previously reported. ACoA cross flow is essential for the optimal hemodynamic compensation of ICAO. Antegrade OA flow indicates good collateral status