Professional Opinions of Effective Interventions for Adults with Psychotic Disorders Who Experienced Childhood Trauma

This is a qualitative research study that examined professionals’ perceptions of effective interventions for adults with psychotic disorders who have experienced childhood trauma. The participants of the study were obtained through a snowball technique. The first participant’s information was given to the researcher through the research committee. The researcher then asked every participant to provide the contact information of another professional who fit the research criteria. In total, there were six professionals who were either clinical social workers, clinical psychologists or licensed marriage and family therapists. The data was obtained through structured, in person interviews with each of these professionals. The overall finding of the research was that there is no difference in the effectiveness of interventions for adults with psychotic disorders who have experienced childhood trauma versus those who have not. However, there were many themes found from the research study regarding working with adults who have psychotic disorders including: there is a relationship between childhood trauma and psychosis, there are some interventions that are more effective than others, there are some interventions that are less effective, antipsychotics are helpful, psychoeducation is necessary, normalization and stigma recognition are important and cognitive remediation therapy is great, but unavailable. Additionally, implications for the social work profession and social work education are discussed including the need for more education about psychosis, etc

Combinatorial Effects of Double Cardiomyopathy Mutant Alleles in Rodent Myocytes: A Predictive Cellular Model of Myofilament Dysregulation in Disease

Inherited cardiomyopathy (CM) represents a diverse group of cardiac muscle diseases that present with a broad spectrum of symptoms ranging from benign to highly malignant. Contributing to this genetic complexity and clinical heterogeneity is the emergence of a cohort of patients that are double or compound heterozygotes who have inherited two different CM mutant alleles in the same or different sarcomeric gene. These patients typically have early disease onset with worse clinical outcomes. Little experimental attention has been directed towards elucidating the physiologic basis of double CM mutations at the cellular-molecular level. Here, dual gene transfer to isolated adult rat cardiac myocytes was used to determine the primary effects of co-expressing two different CM-linked mutant proteins on intact cardiac myocyte contractile physiology. Dual expression of two CM mutants, that alone moderately increase myofilament activation, tropomyosin mutant A63V and cardiac troponin mutant R146G, were shown to additively slow myocyte relaxation beyond either mutant studied in isolation. These results were qualitatively similar to a combination of moderate and strong activating CM mutant alleles αTmA63V and cTnI R193H, which approached a functional threshold. Interestingly, a combination of a CM myofilament deactivating mutant, troponin C G159D, together with an activating mutant, cTnIR193H, produced a hybrid phenotype that blunted the strong activating phenotype of cTnIR193H alone. This is evidence of neutralizing effects of activating/deactivating mutant alleles in combination. Taken together, this combinatorial mutant allele functional analysis lends molecular insight into disease severity and forms the foundation for a predictive model to deconstruct the myriad of possible CM double mutations in presenting patients

Genetic Engineering and Therapy for Inherited and Acquired Cardiomyopathies

The cardiac myofilaments consist of a highly ordered assembly of proteins that collectively generate force in a calcium-dependent manner. Defects in myofilament function and its regulation have been implicated in various forms of acquired and inherited human heart disease. For example, during cardiac ischemia, cardiac myocyte contractile performance is dramatically downregulated due in part to a reduced sensitivity of the myofilaments to calcium under acidic pH conditions. Over the last several years, the thin filament regulatory protein, troponin I, has been identified as an important mediator of this response. Mutations in troponin I and other sarcomere genes are also linked to several distinct inherited cardiomyopathic phenotypes, including hypertrophic, dilated, and restrictive cardiomyopathies. With the cardiac sarcomere emerging as a central player for such a diverse array of human heart diseases, genetic-based strategies that target the myofilament will likely have broad therapeutic potential. The development of safe vector systems for efficient gene delivery will be a critical hurdle to overcome before these types of therapies can be successfully applied. Nonetheless, studies focusing on the principles of acute genetic engineering of the sarcomere hold value as they lay the essential foundation on which to build potential gene-based therapies for heart disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72315/1/annals.1380.033.pd

Tax Abatement in Saint Louis: Reforms Could Foster Equitable Development

Across the United States, municipal governments use tax abatement in various ways to incentivize development and revitalize urban areas. In Saint Louis, historical housing trends related to deindustrialization, redlining, and “white flight” led to the City’s depopulation, creating the current need to incentivize development. However, in certain neighborhoods, development now occurs without tax abatement, and some homeowners and developers receive tax abatement despite being able to afford paying taxes. This points to a need to understand where and when tax abatement is necessary, and whether it is being used effectively. In this brief, we ask the following questions: (1) Does Saint Louis use this policy differently than other cities, and (2) What is the most effective use of tax abatement when considering equitable development of blighted areas

Variability in Short Gamma-ray Bursts: Gravitationally Unstable Tidal Tails

Short gamma-ray bursts are thought to result from the mergers of two neutron stars or a neutron star and stellar mass black hole. The final stages of the merger are generally accompanied by the production of one or more tidal "tails" of ejecta, which fall back onto the remnant-disc system at late times. Using the results of a linear stability analysis, we show that if the material comprising these tails is modeled as adiabatic and the effective adiabatic index satisfies $\gamma \ge 5/3$, then the tails are gravitationally unstable and collapse to form small-scale knots. We analytically estimate the properties of these knots, including their spacing along the tidal tail and the total number produced, and their effect on the mass return rate to the merger remnant. We perform hydrodynamical simulations of the disruption of a polytropic (with the polytropic and adiabatic indices $\gamma$ equal), $\gamma =2$ neutron star by a black hole, and find agreement between the predictions of the linear stability analysis and the distribution of knots that collapse out of the instability. The return of these knots to the black hole induces variability in the fallback rate, which can manifest as variability in the lightcurve of the GRB and -- depending on how rapidly the instability operates -- the prompt emission. The late-time variability induced by the return of these knots is also consistent with the extended emission observed in some GRBs.Comment: Small corrections, additional references included to reflect ApJL published versio

Light emission intensities of luminescent Y2O3:Eu and Gd2O3:Eu particles of various sizes

There is great technological interest in elucidating the effect of particle size on the luminescence efficiency of doped rare earth oxides. This study demonstrates unambiguously that there is a size effect and that it is not dependent on the calcination temperature. The Y2O3:Eu and Gd2O3:Eu particles used in this study were synthesized using wet chemistry to produce particles ranging in size between 7 nm and 326 nm and a commercially available phosphor. These particles were characterized using three excitation methods: UV light at 250 nm wavelength, electron beam at 10 kV, and X-rays generated at 100 kV. Regardless of the excitation source, it was found that with increasing particle diameter there is an increase in emitted light. Furthermore, dense particles emit more light than porous particles. These results can be explained by considering the larger surface area to volume ratio of the smallest particles and increased internal surface area of the pores found in the large particles. For the small particles, the additional surface area hosts adsorbates that lead to non-radiative recombination, and in the porous particles, the pore walls can quench fluorescence. This trend is valid across calcination temperatures and is evident when comparing particles from the same calcination temperature

A Detailed Observational Analysis of V1324 Sco, the Most Gamma-Ray Luminous Classical Nova to Date

It has recently been discovered that some, if not all, classical novae emit GeV gamma rays during outburst, but the mechanisms involved in the production of the gamma rays are still not well understood. We present here a comprehensive multi-wavelength dataset---from radio to X-rays---for the most gamma-ray luminous classical nova to-date, V1324 Sco. Using this dataset, we show that V1324 Sco is a canonical dusty Fe-II type nova, with a maximum ejecta velocity of 2600 km s$^{-1}$ and an ejecta mass of few $\times 10^{-5}$ M$_{\odot}$. There is also evidence for complex shock interactions, including a double-peaked radio light curve which shows high brightness temperatures at early times. To explore why V1324~Sco was so gamma-ray luminous, we present a model of the nova ejecta featuring strong internal shocks, and find that higher gamma-ray luminosities result from higher ejecta velocities and/or mass-loss rates. Comparison of V1324~Sco with other gamma-ray detected novae does not show clear signatures of either, and we conclude that a larger sample of similarly well-observed novae is needed to understand the origin and variation of gamma rays in novae.Comment: 26 pages, 13 figure

Temperature distribution in a gas-solid fixed bed probed by rapid magnetic resonance imaging

Controlling the temperature distribution inside catalytic fixed bed reactors is crucial for yield optimization and process stability. Yet, in situ temperature measurements with spatial and temporal resolution are still challenging. In this work, we perform temperature measurements in a cylindrical fixed bed reactor by combining the capabilities of real-time magnetic resonance imaging (MRI) with the temperature-dependent proton resonance frequency (PRF) shift of water. Three-dimensional (3D) temperature maps are acquired while heating the bed from room temperature to 60~$^{\circ}$C using hot air. The obtained results show a clear temperature gradient along the axial and radial dimensions and agree with optical temperature probe measurements with an average error of $\pm$ 1.5~$^{\circ}$C. We believe that the MR thermometry methodology presented here opens new perspectives for the fundamental study of mass and heat transfer in gas-solid fixed beds and in the future might be extended to the study of reactive gas-solid systems