Inclusive Policies Advance Dramatically in the States: Immigrants' Access to Driver's Licenses, Higher Education, Workers' Rights, and Community Policing

As Congress debated federal immigration reform this year, states led the way by adopting policies designed to integrate immigrants more fully in their communities. In the wake of the 2012 elections, with Latino and Asian voters participating in record numbers,1 the 2013 state legislative sessions witnessed a significant increase in pro-immigrant activity. Issues that had been dormant or had moved in a restrictive direction for years, such as expanding access to driver's licenses, gained considerable traction, along with measures improving access to education and workers' rights for immigrants.This report summarizes the activity on immigrant issues that took place during the states' 2013 legislative sessions, as well as efforts to improve access to services for immigrant youth

La crónica roja y su influencia en el comportamiento psicosocial de los pobladores del cantón La Libertad en el año 2010.

La relación entre medios de comunicación y la violencia es muy notoria en la actualidad. Las estrategias que los medios de masas utilizaron y que aun son utilizadas, son muy exitosas para las empresas comunicacionales que día a día se esfuerzan por innovar tácticas de enganche y que a la vez son entregadas a un público específico. El tema de la crónica roja, no es un tema totalmente desapercibido, su forma de redacción y la aceptación que mantiene en cada medio de comunicación, es totalmente preocupante; pues el consumo obsesivo por el tipo de información que relata acontecimientos sangrientos, y la presentación de imágenes que provocan impacto y asombro en el individuo, son factores que generan un grave problema sicológico y social en el individuo y en su medio. La presente investigación determina cuáles son esos factores que ocasionan un problema dentro de la información que maneja hechos sangrientos. En la Provincia de Santa Elena existe cierto tipo de preocupación por la forma en que se maneja la crónica roja por parte de los medios de comunicación y cómo a la vez ésta afecta en la cultura, intelecto e idiosincrasia de su medio. Los pobladores de la provincia, se encuentran muy preocupados e interesados por el perfeccionamiento de la información que implica respuestas negativas al ser receptores de crónica roja. Es por esta razón que la problemática informacional que maneja la crónica roja, conlleva a crear estrategias que junto a sondeos de opinión, y al desarrollo de unidades que explican los verdaderos formatos de crónicas que narran acontecimientos impactantes; garantizarán el desarrollo de una noticia preventiva y orientadora. La utilización de los instrumentos de la investigación como la encuesta, las entrevistas, y el análisis de cada una de ellas, fueron el complemento preciso para determinar y conformar un nuevo formato de crónica roja.UPS

Propuesta de intervención de enfermedades cardiovasculares del distrito de Turbo departamento de Antioquia

Figura 1 Localización del distrito de Turbo 2021, Figura 2 Tasa de mortalidad ajustada por sexo para las enfermedades del sistema circulatorio en hombres del distrito de Turbo, Figura 3 Tasa de mortalidad ajustada por sexo para las enfermedades del sistema circulatorio en mujeres del distrito de Turbo, Figura 4 Tasa de mortalidad ajustada para hombres en el distrito de Turbo 2005-2009, Figura 5 Tasa de mortalidad ajustad para mujeres en el distrito de Turbo 2005-2009, Figura 6 Banner principal, Figura 7 Banner prevención 1, Figura 8 Banner prevención 2, Figura 9 Banner prevención 3, Figura 10 Banner prevención 4, Figura 11 Banner prevención 5, Figura 12 Banner prevención 6, Figura 13 Banner prevención 7Las enfermedades cardiovasculares son un problema de salud pública por su impacto e incremento en la tasa de mortalidad y morbilidad en el distrito de Turbo departamento de Antioquia, perjudicando drásticamente el bienestar de dicha comunidad, por tal motivo nuestra propuesta de intervención va dirigido a la población más afectada que son los adultos de 25 a 59 años de edad hombre y mujeres del municipio. Nuestro enfoque y estrategia es en la promoción y prevención de las enfermedades cardiovasculares educando a la población, fomentando estilos de vida saludable, el autocuidado con EL lema “yo cuido mi corazón, si no me lo cuido quien me lo va a cuidar, con la finalidad de disminuir esta problemática en salud pública y así la comunidad pueda gozar de un mejor bienestar.Cardiovascular diseases are a public health problem due to their impact and increase in the mortality and morbidity rate in the district of Turbo, department of Antioquia, drastically damaging the well-being of the community. For this reason, our intervention proposal is aimed at the most affected population, which are adults between 25 and 59 years of age, men and women of the municipality. Our approach and strategy is in the promotion and prevention of cardiovascular diseases by educating the population, promoting healthy lifestyles, self-care with the slogan " I care for my heart, if i don't care for it who will care for it, in order to reduce this problem in public health and thus the community can enjoy a better welfare

Cistatina c y tasa de filtrado glomerular como biomarcador precoz de enfermedad renal

The use of cystatin C and glomerular filtration rate as an early biomarker in the detection of renal disease (CKD) has gained significant attention due to its ability to more accurately reflect renal function. The objective of this study was to evaluate the efficacy and relevance of cystatin C as an early biomarker of kidney disease or CKD. A bibliographic review investigation of type descritive was carried out, where recent studies were analyzed, highlighting the urgent need for more effective early diagnostic tools, research that evidenced the burden that kidney diseases represent for the health system was reviewed, data was collected from the investigations that showed an increase in cases of kidney disease in recent years. In addition to knowing the laboratory tests to measure the levels of the biomarker in ER patients. The results revealed that elevated cystatin C and glomerular filtration rate levels correlated with impaired kidney function early in the disease. In conclusion, the impact of this research lies in its potential to improve the quality of life of patients by offering an early diagnosis, as well as in the optimization of health resources by preventing the progression of the disease.El uso de la cistatina C y tasa de filtrado glomerular como biomarcador temprano en la detección de enfermedad renal (ER) ha ganado atención significativa debido a su capacidad para reflejar con mayor precisión la función renal. El objetivo de este estudio fue dar a conocer sobre la cistatina C y tasa de filtrado glomerular como biomarcador precoz de enfermedad renal. Se llevó a cabo una investigación de revisión bibliográfica de tipo descriptiva, donde analizaron estudios recientes, resaltando la necesidad urgente de herramientas de diagnóstico temprano más efectivas, se revisaron investigaciones que evidenciaron la carga que las enfermedades renales representan para el sistema de salud, se recolectaron datos de las investigaciones que mostraron un aumento de los casos de enfermedad renal en los últimos años. Además de conocer las pruebas de laboratorio para medir los niveles del biomarcador en pacientes ER. Los resultados revelaron que los niveles elevados de cistatina C y de la tasa de filtrado glomerular se correlacionaban con una función renal deteriorada en etapas tempranas de la enfermedad. En conclusión, el impacto de esta investigación radica en su potencial para mejorar la calidad de vida de los pacientes al ofrecer un diagnóstico temprano, así como en la optimización de los recursos de salud al prevenir el avance de la enfermedad

Consensus in Guidelines for Evaluation of DSD by the Texas Children's Hospital Multidisciplinary Gender Medicine Team

The Gender Medicine Team (GMT), comprised of members with expertise in endocrinology, ethics, genetics, gynecology, pediatric surgery, psychology, and urology, at Texas Children's Hospital and Baylor College of Medicine formed a task force to formulate a consensus statement on practice guidelines for managing disorders of sexual differentiation (DSD) and for making sex assignments. The GMT task force reviewed published evidence and incorporated findings from clinical experience. Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used to assess the quality of evidence presented in the literature for establishing evidence-based guidelines. The task force presents a consensus statement regarding specific diagnostic and therapeutic issues in the management of individuals who present with DSD. The consensus statement includes recommendations for (1) laboratory workup, (2) acute management, (3) sex assignment in an ethical framework that includes education and involvement of the parents, and (4) surgical management

Abortion decision-making trajectories and factors influencing such trajectories in low- and middle-income countries: a protocol for mixed-methods systematic review.

Introduction Globally, about half of all pregnancies are unintended and/or unwanted and three-fifths of these end in induced abortion. When faced with a choice to terminate pregnancy, women’s abortion decision-making processes are often complex and multiphasic and maybe amplified in low- and middle-income countries (LMICs) which bear the major burden of abortion-related morbidity and mortality. Our review aims to (1) describe abortion decision-making trajectories for women in LMICs and (2) investigate factors influencing the choice of abortion decision-making trajectories in LMICs. Methods and analysis We will search and retrieve published and unpublished qualitative, quantitative and mixed-methods, community and/or hospital-based studies conducted in LMICs from 1 January 2000 up to 16 February 2021. We will search Ovid Medline, Ovid EMBASE, Ovid PsycInfo, Ovid Global Health, Web of Science (including Social Science Citation Index), Scopus, IBSS, CINAHL via EBSCO, WHO Global Index Medicus, the Cochrane Library, WHO website, ProQuest and Google Scholar. We will search reference lists of eligible studies and contact experts for additional data/information, if required. We will extract all relevant data to answer our research questions and assess study quality using the appropriate appraisal tools. Depending on the extracted data, our analysis will use sequential or convergent synthesis methods proposed by Hong et al. For qualitative studies, we will synthesise evidence using thematic synthesis, meta-ethnography or ‘best-fit’ framework synthesis; and for quantitative findings, we will provide a narrative synthesis and/or meta-analysis. We will do sensitivity analyses and assess confidence in our findings using Grades of Recommendation, Assessment, and Evaluation –Confidence in Evidence from Reviews of Qualitative Research (GRADE-CERQUal) for qualitative findings and Grades of Recommednation, Assessment, and Evaluation (GRADE) for quantitative findings. Ethics and dissemination We did not require ethics approval for this systematic review. We will publish our findings in an open-access peer-reviewed journal with global and maternal health readership. We will also present our findings at national and international scientific conferences

Abortion decision-making process trajectories and determinants in low- and middle-income countries: A mixed-methods systematic review and meta-analysis.

Background: About 45.1% of all induced abortions are unsafe and 97% of these occur in low- and middle-income countries (LMICs). Women's abortion decisions may be complex and are influenced by various factors. We aimed to delineate women's abortion decision-making trajectories and their determinants in LMICs. Methods: We searched Medline, EMBASE, PsychInfo, Global Health, Web of Science, Scopus, IBSS, CINAHL, WHO Global Index Medicus, the Cochrane Library, WHO website, ProQuest, and Google Scholar for primary studies and reports published between January 1, 2000, and February 16, 2021 (updated on June 06, 2022), on induced abortion decision-making trajectories and/or their determinants in LMICs. We excluded studies on spontaneous abortion. Two independent reviewers extracted and assessed quality of each paper. We used "best fit" framework synthesis to synthesise abortion decision-making trajectories and thematic synthesis to synthesise their determinants. We analysed quantitative findings using random effects model. The study protocol is registered with PROSPERO number CRD42021224719. Findings: Of the 6960 articles identified, we included 79 in the systematic review and 14 in the meta-analysis. We identified nine abortion decision-making trajectories: pregnancy awareness, self-reflection, initial abortion decision, disclosure and seeking support, negotiations, final decision, access and information, abortion procedure, and post-abortion experience and care. Determinants of trajectories included three major themes of autonomy in decision-making, access and choice. A meta-analysis of data from 7737 women showed that the proportion of the overall women's involvement in abortion decision-making was 0.86 (95% CI:0.73-0.95, I2 = 99.5%) and overall partner involvement was 0.48 (95% CI:0.29-0.68, I2 = 99.6%). Interpretation: Policies and strategies should address women's perceptions of safe abortion socially, legally, and economically, and where appropriate, involvement of male partners in abortion decision-making processes to facilitate safe abortion. Clinical heterogeneity, in which various studies defined "the final decision-maker" differentially, was a limitation of our study. Funding: Nuffield Department of Population Health DPhil Scholarship for PL, University of Oxford, and the Medical Research Council Career Development Award for MN (Grant Ref: MR/P022030/1)

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production

Signal Transducer and Activator of Transcription 3 (STAT3) has been tied to various physiological and pathological functions, mainly as a transcription factor that translocates to the nucleus upon tyrosine phosphorylation induced by cytokine stimulation. In addition, a small pool of STAT3 resides in the mitochondria where it serves as a sensor for various metabolic stressors including reactive oxygen species (ROS). Mitochondrially-localized STAT3 largely exerts its effects through direct or indirect regulation of the activity of the electron transport chain (ETC). It has been assumed that STAT3 amounts in the mitochondria are static. We showed that various stimuli, including oxidative stress and cytokines, triggered a signaling cascade that resulted in a rapid loss of mitochondrially-localized STAT3. Recovery of the mitochondrial pool of STAT3 over time depended upon phosphorylation of Ser727 in STAT3 and new protein synthesis. Under these conditions, mitochondrially-localized STAT3 also became competent to bind to cyclophilin D (CypD). Binding of STAT3 to CypD was mediated by the N-terminus of STAT3, which was also important for reducing mitochondrial ROS production after oxidative stress. These results outline a role for mitochondrially-localized STAT3 in sensing and responding to external stimuli

Causas de la Infertilidad en Mujeres de la Clínica Santa Mónica Santo Domingo, Ecuador

Objective. the purpose of the research was to determine the most common causes and the main consequences that lead to infertility in women. Method. The research used a quantitative approach, descriptive and correlational in scope; and was developed with 384 meJunal histories of infertility patients from the Santa Monica Clinic, the results were analyzed through cross-data matrices and regression analysis, for which SPSS 27 was used.  Results. Through the ODDS ratios it was determined that the risk indexes that were most present in women with infertility problems were chronic diseases with an ODSS ratio of 2.31; followed by psychological problems with 2.16 and tubal, ovarian and uterine pathologies with 1.76, 1.61 and 1.53, respectively. Conclusions. The research showed that tubal obstruction, endometrioma and uterine myoma were the main gynecological pathologies present in women with infertility. On the other hand, it was possible to identify that the procedure most frequently used to identify the causes of infertility was hysterosonography and that the psychological consequences of infertility were depression and guilt.Objetivo. La investigación tuvo como finalidad determinar las causas más comunes y las principales consecuencias que conllevan a la presencia de infertilidad en las mujeres. Método. La investigación usó un enfoque cuantitativo, de alcance descriptivo y correlacional; y fue desarrollada con 384 historias méJunas de pacientes con infertilidad de la Clínica Santa Mónica, los resultados fueron analizados a través de matrices de datos cruzados y análisis de regresión, para lo cual se utilizó SPSS 27. Resultados. A través de las ratios ODDS se determinó que los ínJunes de riesgo que mayormente se presentaron en las mujeres con problemas de infertilidad fueron las enfermedades crónicas con un ODSS ratio de 2,31; seguido de los problemas psicológicos con 2,16 y las patologías tubáricas, ováricas y uterinas con el 1,76; 1,61 y 1,53, respectivamente.  Conclusiones. La investigación permitió evidenciar que la obstrucción de trompas, el endometrioma, y el mioma uterino; fueron las principales patologías ginecológicas presentes en las mujeres con infertilidad. Por otra parte, se pudo identificar que el procedimiento para identificar las causas de la infertilidad mayormente utilizado fue la histerosonografía y que las consecuencias psicológicas a las que conlleva la infertilidad fueron la depresión y el sentimiento de culpa

Multi-Messenger Astronomy with Extremely Large Telescopes

The field of time-domain astrophysics has entered the era of Multi-messenger Astronomy (MMA). One key science goal for the next decade (and beyond) will be to characterize gravitational wave (GW) and neutrino sources using the next generation of Extremely Large Telescopes (ELTs). These studies will have a broad impact across astrophysics, informing our knowledge of the production and enrichment history of the heaviest chemical elements, constrain the dense matter equation of state, provide independent constraints on cosmology, increase our understanding of particle acceleration in shocks and jets, and study the lives of black holes in the universe. Future GW detectors will greatly improve their sensitivity during the coming decade, as will near-infrared telescopes capable of independently finding kilonovae from neutron star mergers. However, the electromagnetic counterparts to high-frequency (LIGO/Virgo band) GW sources will be distant and faint and thus demand ELT capabilities for characterization. ELTs will be important and necessary contributors to an advanced and complete multi-messenger network.Comment: White paper submitted to the Astro2020 Decadal Surve