The contrasting physiological and subjective effects of chewing gum on social stress

Uncertainty exists with respect to the extent to which chewing gum may attenuate stress-induced rises in cortisol secretion (Scholey et al., 2009; Smith, 2010; Johnson et al., 2011). The present study used the Trier Social Stress Task (TSST: Kirschbaum et al., 1993), a task known to elevate cortisol secretion (Kudielka et al., 2004), in order to examine the moderating physiological and subjective effects of chewing gum on social stress. Forty participants completed the TSST either with or without chewing gum. As expected, completion of the TSST elevated both cortisol and subjective stress levels, whilst impairing mood. Although gum moderated the perception of stress, cortisol concentrations were higher following the chewing of gum. The findings are consistent with Smith (2010) who argued that elevations in cortisol following the chewing of gum reflect heightened arousal. The findings suggest that chewing gum only benefits subjective measures of stress. The mechanism remains unclear; however, this may reflect increased cerebral blood flow, cognitive distraction, and/or effects secondary to task facilitation

Flight test evaluation of a separate surface attitude command control system on a Beech 99 airplane

A joint NASA/university/industry program was conducted to flight evaluate a potentially low cost separate surface implementation of attitude command in a Beech 99 airplane. Saturation of the separate surfaces was the primary cause of many problems during development. Six experienced professional pilots who made simulated instrument flight evaluations experienced improvements in airplane handling qualities in the presence of turbulence and a reduction in pilot workload. For ride quality, quantitative data show that the attitude command control system results in all cases of airplane motion being removed from the uncomfortable ride region

Composition of secondary alcohols, ketones, alkanediols, and ketols in Arabidopsis thaliana cuticular waxes

Arabidopsis wax components containing secondary functional groups were examined (i) to test the biosynthetic relationship between secondary alcohols and ketols and (ii) to determine the regiospecificity and substrate preference of the enzyme involved in ketol biosynthesis. The stem wax of Arabidopsis wild type contained homologous series of C27 to C31 secondary alcohols (2.4 μg cm−2) and C28 to C30 ketones (6.0 μg cm−2) dominated by C29 homologues. In addition, compound classes containing two secondary functional groups were identified as C29 diols (∼0.05 μg cm−2) and ketols (∼0.16 μg cm−2). All four compound classes showed characteristic isomer distributions, with functional groups located between C-14 and C-16. In the mah1 mutant stem wax, diols and ketols could not be detected, while the amounts of secondary alcohols and ketones were drastically reduced. In two MAH1-overexpressing lines, equal amounts of C29 and C31 secondary alcohols were detected. Based on the comparison of homologue and isomer compositions between the different genotypes, it can be concluded that biosynthetic pathways lead from alkanes to secondary alcohols, and via ketones or diols to ketols. It seems plausible that MAH1 is the hydroxylase enzyme involved in all these conversions in Arabidopsis thaliana

Formation of a quasicrystalline Pb monolayer on the ten-fold surface of the decagonal Al-Ni-Co quasicrystal

Lead has been deposited on the ten-fold surface of decagonal Al72Ni11Co17 to form an epitaxial quasicrystalline single-element monolayer. The overlayer grows through nucleation of nanometer-sized irregular islands and the coverage saturates at 1 ML. The overlayer is well-ordered quasiperiodically as evidenced by LEED and Fourier transforms of STM images. Annealing the film to 600 K improves the structural quality, but causes the evaporation of some material such that the film develops pores. Electronic structure measurements using X-ray photoemission spectroscopy indicate that the chemical interaction of the Pb atoms with the substrate is weak.Comment: 12 pages, 5 figure

Belligerent Targeting and the Invalidity of a Least Harmful Means Rule

The law of armed conflict provides the authority to use lethal force as a first resort against identified enemy belligerent operatives. There is virtually no disagreement with the rule that once an enemy belligerent becomes hors de combat — what a soldier would recognizes as “combat ineffective” — this authority to employ deadly force terminates. Recently, however, some have forcefully asserted that the LOAC includes an obligation to capture in lieu of employing deadly force whenever doing so presents no meaningful risk to attacking forces, even when the enemy belligerent is neither physically disabled or manifesting surrender. Proponents of this obligation to capture rather than kill, or use the least harmful means to incapacitate enemy belligerents, do not contest the general authority to employ deadly force derived from belligerent status determinations. Instead, they insist that the conditions that rebut this presumptive attack authority are broader than the traditional understanding of the meaning of hors de combat embraced by military experts, and include any situation where an enemy belligerent who has yet to be rendered physically incapable of engaging in hostilities may be subdued without subjecting friendly forces to significant risk of harm. This essay offers our collective and — we hope — comprehensive rebuttal of this least harmful means LOAC interpretation. First, Section I reviews the fundamental principles of the LOAC that permit status-based attacks against enemy belligerents with combat power highly likely to cause death unless and until the enemy is rendered physically incapable of participating in hostilities. Section II thoroughly analyzes the affirmative prohibitions on the use of force that the LOAC — and specifically Additional Protocol I — does require, and also highlights what Additional Protocol I does not require. In particular, the fact that Additional Protocol I — by any account the most humanitarian-oriented LOAC treaty ever developed — did not impose any affirmative least harmful means obligation vis à vis belligerents undermines any assertion that such an obligation may be derived from the positive LOAC. Finally, and perhaps most importantly, Section III emphasizes how this least harmful means concept, especially when derived from an expanded interpretation of the meaning of the concept of hors de combat, is fundamentally inconsistent with the tactical, operational, and strategic objectives that dictate employment of military power. The LOAC must, as it has historically, remain rationally grounded in the realities of warfare. We are confident that anyone grappling with this issue understands that decisions related to the employment of combat power are not resolved in the quiet and safe confines of law libraries, academic conferences, or even courtrooms; they are resolved in the intensely demanding situations into which our nation thrusts our armed forces. The law must, as it always has, remain animated by the realities of warfare in the effort to strike a continuing credible balance between the authority to prevail on the battlefield and humanitarian objective of limiting unnecessary suffering. The clarity of the existing paradigm achieves that goal and does not include any legal obligation to use the least harmful means in targeting enemy belligerent personnel

Usability Study of an Online Tutorial for Volunteers at a Hospital Resource Library

An online tutorial for training volunteers at the Women's Health Information Center (WHIC) at the Women's Hospital at the University of North Carolina at Chapel Hill was created. It was intended to be understood by all adult age groups from any walk of life for such complex topics as the reference interview, ethics, and evaluating online health information. Usability testing was conducted using "think aloud" protocols and a questionnaire. This study identified specific aspects of the WHIC tutorial that can be improved, such as creating consistent links, clarifying terms and phrases, and adding more sample conversation dialogs. This study has implications for tutorial design generally, because certain aspects of this tutorial worked very well for learning, such as the sample conversation dialogs, and the lesson opening statements, summaries and exercise reviews

Cardiovascular disease biomarkers are associated with declining renal function in type 2 diabetes

Aims/hypothesis: We investigated whether biochemical cardiovascular risk factors and/or markers of subclinical cardiovascular disease were associated with the development of reduced renal function in people with type 2 diabetes. Methods: A cohort of 1066 Scottish men and women aged 60–74 years with type 2 diabetes from the Edinburgh Type 2 Diabetes Study were followed up for a median of 6.7 years. New-onset reduced renal function was defined as two eGFRs <60 ml−1 min−1 (1.73 m)−2 at least 3 months apart with a > 25% decline from baseline eGFR. Ankle brachial pressure index (ABI), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hsTnT) were measured at baseline. Pulse wave velocity (PWV) and carotid intima media thickness were measured 1 year into follow-up. Data were analysed using Cox proportional hazards models. Results: A total of 119 participants developed reduced renal function during follow-up. ABI, PWV, NT-proBNP and hsTnT were all associated with onset of decline in renal function following adjustment for age and sex. These associations were attenuated after adjustment for additional diabetes renal disease risk factors (systolic BP, baseline eGFR, albumin:creatinine ratio and smoking pack-years), with the exception of hsTnT which remained independently associated (HR 1.51 [95% CI 1.22, 1.87]). Inclusion of hsTnT in a predictive model improved the continuous net reclassification index by 0.165 (0.008, 0.286). Conclusions/interpretation: Our findings demonstrate an association between hsTnT, a marker of subclinical cardiac ischaemia, and subsequent renal function decline. Further research is required to establish the predictive value of hsTnT and response to intervention

The Carnian/Norian boundary succession at Berlin-Ichthyosaur State Park (Upper Triassic, central Nevada, USA)

The Upper Carnian-Lower Norian (Upper Triassic) Luning Formation at Berlin-Ichthyosaur State Park (BISP) in central NV (USA) has been sampled using for the first time the bed-by-bed approach for ammonoids, pelagic bivalves, and conodonts, more than 60 years after its first description by Silberling (U.S. Geological Survey Professional Paper 322: 1\u201363, 1959). BISP is historically important for the definition of the uppermost Carnian of the North American Triassic chronostratigraphic scale and is known worldwide as one of the most important ichthyosaur Fossil-Lagerst\ue4tte because of its extraordinary record of 37 articulated, large-sized specimens of Shonisaurus popularis. Nearly 190 ammonoids were collected from two stratigraphic sections, documenting all the latest Carnian to Early Norian ammonoid faunas previously described by Silberling. Halobiids were collected from five levels, and the first report of conodonts from BISP includes faunas from 13 levels. The ~340-m thick Brick Pile section, the most complete in the study area, includes the uppermost Carnian Macrolobatus Zone, which provides conodont faunas of the lower primitia zone and Halobia septentrionalis. The 200-m thick lowermost Norian Kerri Zone, which begins 52 m above the Macrolobatus Zone, yields conodonts of the upper primitia zone in its lower part, together with H. cf. beyrichi and H. cf. selwyni. The ichthyosaur-bearing interval, whose stratigraphic position has been interpreted quite differently by previous authors, is documented in the uppermost Carnian Macrolobatus Zone and is characterized by rich Tropites-dominated ammonoid faunas and by the onset of Halobia. All models proposed by various workers to explain the unusual ichthyosaur record are discussed and an additional explanation for the main ichthyosaur-bearing bed is proposed. The new hypothesis is that a harmful algal bloom (HAB) may have been the trigger for the mass mortality recorded in this level. Although the C/N boundary in the Brick Pile section lies within a 52 m interval that presently lacks paleontologic data, this succession is included in a small group of sections that are expected to contribute to the definition of the GSSP of the Norian stage. Correlation of the Brick Pile section with the best Carnian/Norian sections in northeastern British Columbia is discussed. Compared to the British Columbia Juvavites Cove and the GSSP candidate Black Bear Ridge sections, the Brick Pile section exhibits an ammonoid and Halobia record that is slightly more similar to that of the Tethyan sections. Correlation of the Brick Pile section with the second GSSP candidate Pizzo Mondello (Sicily, Italy) well demonstrates the significant problems encountered in calibration of the Tethyan and North American scales