1,244 research outputs found
On the Catalysis of the Electroweak Vacuum Decay by Black Holes at High Temperature
We study the effect of primordial black holes on the classical rate of
nucleation of AdS regions within the standard electroweak vacuum at high
temperature. We find that the energy barrier for transitions to the new vacuum,
which determines the exponential suppression of the nucleation rate, can be
reduced significantly, or even eliminated completely, in the black-hole
background if the Standard Model Higgs is coupled to gravity through the
renormalizable term .Comment: LaTeX file, 15 pages, 5 figure
The chloroplast import receptor Toc34 functions as preprotein-regulated GTPase
Toc34 is a protein of the chloroplast outer envelope membrane that acts as receptor for preproteins containing a transit sequence. The recognition of preproteins by Toc34 is regulated by GTP binding and phosphorylation. The phosphorylation site of Toc34 is located at serine 113, close to the postulated triphosphate binding site. This can explain the down-regulation of Toc34 by phosphorylation, resulting in the loss of GTP binding. Vice versa, GTP but not GDP binding of Toc34 influences the phosphorylation. The nucleotide specificity of Toc34 is not only determined by the classical nucleotide binding domains but by a non-typical region at the N-terminus of the protein. As a result, the GTP binding properties are unusual, since the triphosphate moiety of GTP is bound with higher affinity than the purine base. Purified Toc34 hydrolyses GTP at a low rate, which could regulate the receptor function. The rate of hydrolysis is greatly stimulated by a precursor protein
ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of malignant glioma
The double well potential in quantum mechanics: a simple, numerically exact formulation
The double well potential is arguably one of the most important potentials in
quantum mechanics, because the solution contains the notion of a state as a
linear superposition of `classical' states, a concept which has become very
important in quantum information theory. It is therefore desirable to have
solutions to simple double well potentials that are accessible to the
undergraduate student. We describe a method for obtaining the numerically exact
eigenenergies and eigenstates for such a model, along with the energies
obtained through the Wentzel-Kramers-Brillouin (WKB) approximation. The exact
solution is accessible with elementary mathematics, though numerical solutions
are required. We also find that the WKB approximation is remarkably accurate,
not just for the ground state, but for the excited states as well.Comment: 10 pages, 4 figures; suitable for undergraduate courses in quantum
mechanic
ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of malignant glioma.
Wide-field LOFAR-LBA power-spectra analyses: Impact of calibration, polarization leakage and ionosphere
Contamination due to foregrounds (Galactic and Extra-galactic), calibration
errors and ionospheric effects pose major challenges in detection of the cosmic
21 cm signal in various Epoch of Reionization (EoR) experiments. We present the
results of a pilot study of a field centered on 3C196 using LOFAR Low Band
(56-70 MHz) observations, where we quantify various wide field and calibration
effects such as gain errors, polarized foregrounds, and ionospheric effects. We
observe a `pitchfork' structure in the 2D power spectrum of the polarized
intensity in delay-baseline space, which leaks into the modes beyond the
instrumental horizon (EoR/CD window). We show that this structure largely
arises due to strong instrumental polarization leakage () towards
{Cas\,A} ( kJy at 81 MHz, brightest source in northern sky), which is
far away from primary field of view. We measure an extremely small ionospheric
diffractive scale ( m at 60 MHz) towards {Cas\,A}
resembling pure Kolmogorov turbulence compared to
km towards zenith at 150 MHz for typical ionospheric conditions. This is one of
the smallest diffractive scales ever measured at these frequencies. Our work
provides insights in understanding the nature of aforementioned effects and
mitigating them in future Cosmic Dawn observations (e.g. with SKA-low and HERA)
in the same frequency window.Comment: 20 pages, 11 figures, accepted for publication in MNRA
Matrix metalloproteinase-2 (MMP-2) and-9 (MMP-9) gene variants and microvascular complications in type 2 diabetes patients
AbstractVascular complications are the leading cause of increased morbidity and mortality of diabetic patients. It has been postulated that matrix metalloproteinases MMP-2 and MMP-9, zinc-dependent endopeptidases through remodeling of the extracellular matrix, can contribute to the onset and progression of diabetic vascular complications. The aim of our study was to assess whether there is a major difference in single nucleotide polymorphisms in the MMP-2 (at position -1306C˃T) and MMP-9 (at position -1562C˃T) gene in type 2 diabetic patients and healthy controls and to determine whether there is an association of these gene variants with the presence of microvascular complications in diabetic patients. Our study included 102 type 2 diabetes patients and a control group which was comprised of 56 healthy controls. All diabetic patients were screened for microvascular diabetes complications. Genotypes were detected by polymerase chain reactions followed by restriction analyses with specific endonucleases and their frequencies were determined. The MMP-2 variant -1306C>T showed a negative correlation with type 2 diabetes (p=0.028). It was also shown that the presence of the -1306C allele increases the probability of developing type 2 diabetes. This was a 2.2 fold increase and that the -1306 T allele has a protective role in regards t
Prospects for detecting the 21cm forest from the diffuse intergalactic medium with LOFAR
We discuss the feasibility of the detection of the 21cm forest in the diffuse
IGM with the radio telescope LOFAR. The optical depth to the 21cm line has been
derived using simulations of reionization which include detailed radiative
transfer of ionizing photons. We find that the spectra from reionization models
with similar total comoving hydrogen ionizing emissivity but different
frequency distribution look remarkably similar. Thus, unless the reionization
histories are very different from each other (e.g. a predominance of UV vs.
x-ray heating) we do not expect to distinguish them by means of observations of
the 21cm forest. Because the presence of a strong x-ray background would make
the detection of 21cm line absorption impossible, the lack of absorption could
be used as a probe of the presence/intensity of the x-ray background and the
thermal history of the universe. Along a random line of sight LOFAR could
detect a global suppression of the spectrum from z>12, when the IGM is still
mostly neutral and cold, in contrast with the more well-defined, albeit broad,
absorption features visible at lower redshift. Sharp, strong absorption
features associated with rare, high density pockets of gas could be detected
also at z~7 along preferential lines of sight.Comment: 12 pages, 13 figures. MNRAS, in pres
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Review of experience of family medicine in Europe and Central Asia : Executive summary
This report summarizes the findings of four case studies that review the experience of family medicine in Europe and Central Asia (ECA) Region. It is part of a study comprising five volumes that review the experience of family medicine in four countries in ECA--Armenia, Bosnia and Herzegovina, Kyrgyz Republic and Moldova. The report reviews the experience, draws lessons, and establishes an evidence base for detailed analysis. The study presents best practices for policy dialogue and future investments by the World Bank and other financial institutions. The detailed case studies compare these countries and draw common themes and issues. Comparisons are made with best-developed or existing models in the OECD and other countries in the Europe and Central Asia Region that have already undertaken family medicine reform
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