The Swiss Approach - feasibility of a national low-dose CT lung cancer screening program.

BACKGROUND Lung cancer is the leading cause of cancer-related deaths in Switzerland. Despite this, there is no lung cancer screening program in the country. In the United States, low-dose computed tomography (LDCT) lung cancer screening is partially established and endorsed by guidelines. Moreover, evidence is growing that screening reduces lung cancer-related mortality and this was recently shown in a large European randomized controlled trial. Implementation of a lung cancer screening program, however, is challenging and depends on many country-specific factors. The goal of this article is to outline a potential Swiss lung cancer screening program. FRAMEWORK An exhaustive literature review on international screening models as well as interviews and site visits with international experts were initiated. Furthermore, workshops and interviews with national experts and stakeholders were conducted to share experiences and to establish the basis for a national Swiss lung cancer screening program. SCREENING APPROACH General practitioners, pulmonologists and the media should be part of the recruitment process. Decentralisation of the screening might lead to a higher adherence rate. To reduce stigmatisation, the screening should be integrated in a "lung health check". Standardisation and a common quality level are mandatory. The PLCOm2012 risk calculation model with a threshold of 1.5% risk for developing cancer in the next six years should be used in addition to established inclusion criteria. Biennial screening is preferred. LUNG RADS and NELSON+ are applied as classification models for lung nodules. CONCLUSION Based on data from recent studies, literature research, a health technology assessment, the information gained from this project and a pilot study the Swiss Interest Group for lung cancer screening (CH-LSIG) recommends the timely introduction of a systematic lung cancer screening program in Switzerland. The final decision is for the Swiss Cancer Screening Committee to make

The Swiss Approach - feasibility of a national low-dose CT lung cancer screening program

BACKGROUND Lung cancer is the leading cause of cancer-related deaths in Switzerland. Despite this, there is no lung cancer screening program in the country. In the United States, low-dose computed tomography (LDCT) lung cancer screening is partially established and endorsed by guidelines. Moreover, evidence is growing that screening reduces lung cancer-related mortality and this was recently shown in a large European randomized controlled trial. Implementation of a lung cancer screening program, however, is challenging and depends on many country-specific factors. The goal of this article is to outline a potential Swiss lung cancer screening program. FRAMEWORK An exhaustive literature review on international screening models as well as interviews and site visits with international experts were initiated. Furthermore, workshops and interviews with national experts and stakeholders were conducted to share experiences and to establish the basis for a national Swiss lung cancer screening program. SCREENING APPROACH General practitioners, pulmonologists and the media should be part of the recruitment process. Decentralisation of the screening might lead to a higher adherence rate. To reduce stigmatisation, the screening should be integrated in a "lung health check". Standardisation and a common quality level are mandatory. The PLCOm2012 risk calculation model with a threshold of 1.5% risk for developing cancer in the next six years should be used in addition to established inclusion criteria. Biennial screening is preferred. LUNG RADS and NELSON+ are applied as classification models for lung nodules. CONCLUSION Based on data from recent studies, literature research, a health technology assessment, the information gained from this project and a pilot study the Swiss Interest Group for lung cancer screening (CH-LSIG) recommends the timely introduction of a systematic lung cancer screening program in Switzerland. The final decision is for the Swiss Cancer Screening Committee to make

Climate change and possible challenges for crop protection – Yesterday, today, tomorrow

Das Klima und die Witterung sind prägende Faktoren für den Pflanzenschutz. Bereits vor 100 Jahren haben sich Wissenschaftler im Nachrichtenblatt für den Deutschen Pflanzenschutzdienst dieser Thematik gewidmet. Die Auswirkungen des Klimawandels sind ambivalent und es wird insgesamt zu einer Veränderung des Schaderregerspektrums kommen. Tendenziell werden Schäden durch Insekten, Krankheitserreger und wärmetolerante Unkräu­ter begünstigt. Das Risiko der Etablierung invasiver Arten nimmt zu. Ebenso kann die Wirksamkeit des biologischen Pflanzenschutzes beeinträchtigt und neue Verfahren erforderlich werden. Beim chemischen Pflanzenschutz wird sich das Wirkstoffspektrum verschieben und die Anforderungen an Applikationstechnik und -termin steigen. Starkregen kann das Risiko des Austrags von Pflanzenschutzmitteln in die Umwelt steigern. Auch in Mitteleuropa kann es verstärkt zu Befall mit Vorratsschädlingen bereits im Feld kommen und die Qualität und Lagerstabilität der Ernteprodukte abnehmen. Ins­gesamt wird die Bedeutung präventiver Pflanzenschutzmaßnahmen zunehmen. Die Folgen des Klimawandels erhöhen die betriebs- und volkswirtschaftlichen Risiken und stellen alle Akteursebenen vor erhebliche Heraus­forderungen.Climate and weather are decisive factors for plant protection. Already 100 years ago, scientists dedicated themselves to this topic in the newsletter of the German Plant Protection Service. The effects of climate change are ambi­valent and there will be an overall change in the pest spectrum. Damage caused by insects, pathogens and heat-tolerant weeds will tend to be favoured. The risk of invasive species becoming established increases. Simi­larly, the effectiveness of biological crop protection may be compromised and new methods may be required. In the case of chemical pesticides, the spectrum of active substances will shift and the demands on application technology and timing will increase. Heavy rains can increase the risk of pesticide run-off into the environment. There may be increased infestation with storage pests already in the field in Central Europe too, and the quality and storage stability of harvested products may decline. Overall, the importance of preventive plant protection measures will increase. The consequences of climate change increase operational and economic risks and pose considerable challenges for all levels of stakeholders

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10−5. We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10−17; including ADGC data, meta P = 5.0 × 10−21) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10−14; including ADGC data, meta P = 1.2 × 10−16) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10−4; including ADGC data, meta P = 8.6 × 10−9), CD33 (GERAD+, P = 2.2 × 10−4; including ADGC data, meta P = 1.6 × 10−9) and EPHA1 (GERAD+, P = 3.4 × 10−4; including ADGC data, meta P = 6.0 × 10−10)

Beiträge zum 28. Darmstädter Geotechnik-Kolloquium am 09. März 2022

Themenschwerpunkte: 1. Modell- und Feldversuche 2. Digitalisierung und künstliche Intelligenz in der Geotechnik 3. Nationale und internationale Großprojekte 4. Normung und Rechtliche

Industry-Scale Duplicate Detection

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Integrative Scenario Assessment as a Tool to Support Decisions in Energy Transition

Energy scenarios represent a prominent tool to support energy system transitions towards sustainability. In order to better fulfil this role, two elements are widely missing in previous work on designing, analyzing, and using scenarios: First, a more systematic integration of social and socio-technical characteristics of energy systems in scenario design, and, second, a method to apply an accordingly enhanced set of indicators in scenario assessment. In this article, an integrative scenario assessment methodology is introduced that combines these two requirements. It consists of: (i) A model-based scenario analysis using techno-economic and ecological indicators; (ii) a non-model-based analysis using socio-technical indicators; (iii) an assessment of scenario performances with respect to pre-determined indicator targets; (iv) a normalization method to make the two types of results (model-based and non-model-based) comparable; (v) an approach to classify results to facilitate structured interpretation. The combination of these elements represents the added-value of this methodology. It is illustrated for selected indicators, and exemplary results are presented. Methodological challenges and remaining questions, e.g., regarding the analysis of non-model-based indicators, resource requirements, or the robustness of the methodology are pointed out and discussed. We consider this integrative methodology being a substantial improvement of previous scenario assessment methodologies

Context scenarios and their usage for the construction of socio-technical energy scenarios

Model-based energy scenarios are a widely used tool for supporting economic and political decision makers. The results of energy modeling and the conclusions deduced therefrom, however, depend on the model input data derived from framework assumptions about future developments in the embedding society, which are deeply uncertain in the long term. The challenge to deal with this ‘context uncertainty’ in a systematic and comprehensive manner has only recently started to attract intensified attention in energy research; the search for appropriate methods is ongoing. This paper proposes a new concept for the construction of socio-technical energy scenarios, which combines familiar environmental modeling approaches with new developments in qualitative scenario methodology, and demonstrates the possible application of the concept in model-based energy scenario construction