Coronal and chromospheric physics

Achievements and completed results are discussed for investigations covering solar activity during the solar maximum mission and the solar maximum year; other studies of solar activity and variability; infrared and submillimeter photometry; solar-related atomic physics; coronal and transition region studies; prominence research; chromospheric research in quiet and active regions; solar dynamics; eclipse studies; and polarimetry and magnetic field measurements. Contributions were also made in defining the photometric filterograph instrument for the solar optical telescope, designing the combined filter spectrograph, and in expressing the scientific aims and implementation of the solar corona diagnostic mission

Scattering of the f-mode by small magnetic flux elements from observations and numerical simulations

The scattering of f-modes by magnetic tubes is analyzed using three-dimensional numerical simulations. An f-mode wave packet is propagated through a solar atmosphere embedded with three different flux tube models which differ in radius and total magnetic flux. A quiet Sun simulation without a tube present is also performed as a reference. Waves are excited inside the flux tube and propagate along the field lines, and jacket modes are generated in the surroundings of the flux tube, carrying 40% as much energy as the tube modes. The resulting scattered wave is mainly an f-mode composed of a mixture of m=0 and m=+/-1 modes. The amplitude of the scattered wave approximately scales with the magnetic flux. A small amount of power is scattered into the p_1-mode. We have evaluated the absorption and phase shift from a Fourier-Hankel decomposition of the photospheric vertical velocities. They are compared with the results obtained from the emsemble average of 3400 small magnetic elements observed in high-resolution MDI Doppler datacubes. The comparison shows that the observed dependence of the phase shift with wavenumber can be matched reasonably well with the simulated flux tube model. The observed variation of the phase-shifts with the azimuthal order $m$ appears to depend on details of the ensemble averaging, including possible motions of the magnetic elements and asymmetrically shaped elements.Comment: Accepted for publication in The Astrophysical Journa

Dendritic Cell Cross-Priming Is Essential for Immune Responses to Listeria monocytogenes

Cross-presentation is now recognized as a major mechanism for initiating CD8 T cell responses to virus and tumor antigens in vivo. It provides an elegant mechanism that allows relatively few Dendritic cells (DCs) to initiate primary immune responses while avoiding the consumptive nature of pathogenic infection. CD8 T cells play a major role in anti-bacterial immune responses; however, the contribution of cross-presentation for priming CD8 T cell responses to bacteria, in vivo, is not well established. Listeria monocytogenes (Listeria) is the causative agent of Listeriosis, an opportunistic food-borne bacterial infection that poses a significant public health risk. Here, we employ a transgenic mouse model in which cross-presentation is uniquely inactivated, to investigate cross-priming during primary Listeria infection. We show that cross-priming deficient mice are severely compromised in their ability to generate antigen-specific T cells to stimulate MHC I-restricted CTL responses following Listeria infection. The defect in generation of Listeria-elicited CD8 T cell responses is also apparent in vitro. However, in this setting, the endogenous route of processing Listeria-derived antigens is predominant. This reveals a new experimental dichotomy whereby functional sampling of Listeria-derived antigens in vivo but not in vitro is dependent on cross-presentation of exogenously derived antigen. Thus, under normal physiological circumstances, cross-presentation is demonstrated to play an essential role in priming CD8 T cell responses to bacteria

"Pre-semantic" cognition revisited: Critical differences between semantic aphasia and semantic dementia

Patients with semantic dementia show a specific pattern of impairment on both verbal and non-verbal “pre-semantic” tasks: e.g., reading aloud, past tense generation, spelling to dictation, lexical decision, object decision, colour decision and delayed picture copying. All seven tasks are characterised by poorer performance for items that are atypical of the domain and “regularisation errors” (irregular/atypical items are produced as if they were domain-typical). The emergence of this pattern across diverse tasks in the same patients indicates that semantic memory plays a key role in all of these types of “pre-semantic” processing. However, this claim remains controversial because semantically-impaired patients sometimes fail to show an influence of regularity. This study demonstrates that (a) the location of brain damage and (b) the underlying nature of the semantic deficit affect the likelihood of observing the expected relationship between poor comprehension and regularity effects. We compared the effect of multimodal semantic impairment in the context of semantic dementia and stroke aphasia on the seven “pre-semantic” tasks listed above. In all of these tasks, the semantic aphasia patients were less sensitive to typicality than the semantic dementia patients, even though the two groups obtained comparable scores on semantic tests. The semantic aphasia group also made fewer regularisation errors and many more unrelated and perseverative responses. We propose that these group differences reflect the different locus for the semantic impairment in the two conditions: patients with semantic dementia have degraded semantic representations, whereas semantic aphasia patients show deregulated semantic cognition with concomitant executive deficits. These findings suggest a reinterpretation of single case studies of comprehension-impaired aphasic patients who fail to show the expected effect of regularity on “pre-semantic” tasks. Consequently, such cases do not demonstrate the independence of these tasks from semantic memory

Treatment options for progression or recurrence of glioblastoma: a network meta-analysis

For treatment of first recurrence of GBM, among people previously treated with surgery and standard chemoradiotherapy, the combination treatments evaluated did not improve overall survival compared with LOM monotherapy and were often associated with a higher risk of severe adverse events. Limited evidence suggested that re‐operation with or without re‐irradiation and chemotherapy may be suitable for selected candidates. Evidence on second recurrence is sparse. Re‐irradiation with or without bevacizumab may be of value in selected individuals, but more evidence is needed

Superflares on Ordinary Solar-Type Stars

Short duration flares are well known to occur on cool main-sequence stars as well as on many types of `exotic' stars. Ordinary main-sequence stars are usually pictured as being static on time scales of millions or billions of years. Our sun has occasional flares involving up to $\sim 10^{31}$ ergs which produce optical brightenings too small in amplitude to be detected in disk-integrated brightness. However, we identify nine cases of superflares involving $10^{33}$ to $10^{38}$ ergs on normal solar-type stars. That is, these stars are on or near the main-sequence, are of spectral class from F8 to G8, are single (or in very wide binaries), are not rapid rotators, and are not exceedingly young in age. This class of stars includes many those recently discovered to have planets as well as our own Sun, and the consequences for any life on surrounding planets could be profound. For the case of the Sun, historical records suggest that no superflares have occurred in the last two millennia.Comment: 16 pages, accepted for publication in Ap

Treatment options for recurrent glioblastoma: a network meta-analysis

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:. To evaluate the effectiveness of further treatment/s for first and subsequent recurrence of glioblastoma multiforme (GBM) among people who have received the standard of care for primary treatment of the disease (chemoradiotherapy) or following development of GBM from a lower grade (radiotherapy with subsequent temozolomide at relapse); and to prepare a brief economic commentary on the available evidence

Solar Atmospheric Oscillations and the Chromospheric Magnetic Topology

We investigate the oscillatory properties of the quiet solar chromosphere in relation to the underlying photosphere, with particular regard to the effects of the magnetic topology. We perform a Fourier analysis on a sequence of line-of-sight velocities measured simultaneously in a photospheric (Fe I 709.0 nm) and a chromospheric line (Ca II 854.2 nm). The velocities were obtained from full spectroscopic data acquired at high spatial resolution with the Interferometric BIdimensional Spectrometer (IBIS). The field of view encompasses a full supergranular cell, allowing us to discriminate between areas with different magnetic characteristics. We show that waves with frequencies above the acoustic cut-off propagate from the photosphere to upper layers only in restricted areas of the quiet Sun. A large fraction of the quiet chromosphere is in fact occupied by ``magnetic shadows'', surrounding network regions, that we identify as originating from fibril-like structures observed in the core intensity of the Ca II line. We show that a large fraction of the chromospheric acoustic power at frequencies below the acoustic cut-off, residing in the proximity of the magnetic network elements, directly propagates from the underlying photosphere. This supports recent results arguing that network magnetic elements can channel low-frequency photospheric oscillations into the chromosphere, thus providing a way to input mechanical energy in the upper layers.Comment: 4 pages, 3 figure, A&A Letters in pres

Theory of Networked Minority Games based on Strategy Pattern Dynamics

We formulate a theory of agent-based models in which agents compete to be in a winning group. The agents may be part of a network or not, and the winning group may be a minority group or not. The novel feature of the present formalism is its focus on the dynamical pattern of strategy rankings, and its careful treatment of the strategy ties which arise during the system's temporal evolution. We apply it to the Minority Game (MG) with connected populations. Expressions for the mean success rate among the agents and for the mean success rate for agents with $k$ neighbors are derived. We also use the theory to estimate the value of connectivity $p$ above which the Binary-Agent-Resource system with high resource level goes into the high-connectivity state.Comment: 24 pages, 3 figures, submitted to PR