{Ba[Au(SCN)2]2}n: a three-dimensional net comprised of monomeric and trimeric gold(I) units

The noteworthy structural feature of the title complex, poly[acetonitrile­tetra-μ2-thio­cyanato-barium(II)digold(I)], {[Au2Ba(SCN)4(CH3CN)]}n, is that the bis­(thio­cyanato)­aurate(I) anion adopts both monomeric and trimeric motifs. The trimer unit has an Au⋯Au distance of 3.1687 (3) Å. In both the monomeric and trimeric units, the AuI atoms are also bonded to two S atoms. Within the trimeric unit, the AuI atoms exist in differing environments; one Au atom has a T-shaped three-coordinate geometry while the other has a square-planar four-coordinate geometry. The AuI atom of the monomer adopts a linear two-coordinate geometry. The extended structure can be described as a three-dimensional coordination polymer consisting of chains of Ba atoms bridged by thio­cyanate N atoms. These chains are cross-linked via the gold monomeric and trimeric units

Grandpa Bulbrook

A series of platinum­(II) complexes with the formulas Pt­(diimine)­(pip₂NCNH₂)­(L)²⁺ [pip₂NCNH₂⁺ = 2,6-bis­(piperidiniummethyl)­phenyl cation; L = Cl, Br, I, NCS, OCN, and NO₂; diimine = 1,10-phenanthroline (phen), 5-nitro-1,10-phenanthroline (NO₂phen), and 5,5′-ditrifluoromethyl-2,2′-bipyridine (dtfmbpy)] were prepared by the treatment of Pt­(pip₂NCN)­Cl with a silver­(I) salt followed by the addition of the diimine and halide/pseudohalide under acidic conditions. Crystallographic data as well as ¹H NMR spectra establish that the metal center is bonded to a bidentate phenanthroline and a monodentate halide/pseudohalide. The pip₂NCNH₂⁺ ligand with protonated piperidyl groups is monodentate and bonded to the platinum through the phenyl ring. Structural and spectroscopic data indicate that the halide/pseudohalide group (L^–) and the metal center in Pt­(phen)­(pip₂NCNH₂)­(L)²⁺ behave as Brønsted bases, forming intramolecular NH···L/NH···Pt interactions involving the piperidinium groups. A close examination of the 10 structures reported here reveals linear correlations between N–H···Pt/L angles and H···Pt/L distances. In most cases, the N–H bond is directed toward the Pt–L bond, thereby giving the appearance that the proton bridges the Pt and L groups. In contrast to observations for Pt­(tpy)­(pip₂NCN)⁺ (tpy = 2,2′;6′,2″-terpyridine), the electrochemical oxidation of deprotonated adducts, Pt­(diimine)­(L)­(pip₂NCN), is chemically and electrochemically irreversible

trans-K3[TcO2(CN)4]

The structure of the title compound, tripotassium trans-tetra­cyanidodioxidotechnetate(V), is isotypic with its Re analogue. The [TcO2(CN)4]3− trans-tetra­cyanido­dioxido­technetate anion has a slightly distorted octa­hedral configuration. The Tc atom is located on a center of inversion and is bound to two O atoms in axial and to four cyanide ligands in equatorial positions. The Tc—O distance is consistent with a double-bond character. The two potassium cations, one located on a center of inversion and one in a general position, reside in octa­hedral or tetra­hedral environments, respectively. K⋯O and K⋯N inter­actions occur in the 2.7877 (19)–2.8598 (15) Å range

Hierarchical Corannulene‐Based Materials: Energy Transfer and Solid‐State Photophysics

We report the first example of a donor–acceptor corannulene-containing hybrid material with rapid ligand-to-ligand energy transfer (ET). Additionally, we provide the first time-resolved photoluminescence (PL) data for any corannulene-based compounds in the solid state. Comprehensive analysis of PL data in combination with theoretical calculations of donor–acceptor exciton coupling was employed to estimate ET rate and efficiency in the prepared material. The ligand-to-ligand ET rate calculated using two models is comparable with that observed in fullerene-containing materials, which are generally considered for molecular electronics development. Thus, the presented studies not only demonstrate the possibility of merging the intrinsic properties of π-bowls, specifically corannulene derivatives, with the versatility of crystalline hybrid scaffolds, but could also foreshadow the engineering of a novel class of hierarchical corannulene-based hybrid materials for optoelectronic devices

Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads

© 2019 A total of 44 bis-aryl-monocyclic polyamines, monoaryl-monocyclic polyamines and their transition metal complexes were prepared, chemically characterized, and screened in vitro against the Leishmania donovani promastigotes, axenic amastigotes and intracellular amastigotes in THP1 cells. The IC 50 and/or IC 90 values showed that 10 compounds were similarly active at about 2-fold less potent than known drug pentamidine against promastigotes. The most potent compound had an IC 50 of 2.82 µM (compared to 2.93 µM for pentamidine). Nine compounds were 1.1–13.6-fold more potent than pentamidine against axenic amastigotes, the most potent one being about 2-fold less potent than amphotericin B. Fourteen compounds were about 2–10 fold more potent than pentamidine, the most potent one is about 2-fold less potent than amphotericin B against intracellular amastigotes in THP1 cells. The 2 most promising compounds (FeL7Cl 2 and MnL7Cl 2 ), with strong activity against both promastigotes and amastigotes and no observable toxicity against the THP1 cells are the Fe 2+ - and Mn 2+ -complexes of a dibenzyl cyclen derivative. Only 2 of the 44 compounds showed observable cytotoxicity against THP1 cells. Tetraazamacrocyclic monocyclic polyamines represent a new class of antileishmanial lead structures that warrant follow up studies

The role of facemasks and hand hygiene in the prevention of influenza transmission in households: results from a cluster randomised trial; Berlin, Germany, 2009-2011

Background: Previous controlled studies on the effect of non-pharmaceutical interventions (NPI) - namely the use of facemasks and intensified hand hygiene - in preventing household transmission of influenza have not produced definitive results. We aimed to investigate efficacy, acceptability, and tolerability of NPI in households with influenza index patients. Methods: We conducted a cluster randomized controlled trial during the pandemic season 2009/10 and the ensuing influenza season 2010/11. We included households with an influenza positive index case in the absence of further respiratory illness within the preceding 14 days. Study arms were wearing a facemask and practicing intensified hand hygiene (MH group), wearing facemasks only (M group) and none of the two (control group). Main outcome measure was laboratory confirmed influenza infection in a household contact. We used daily questionnaires to examine adherence and tolerability of the interventions. Results: We recruited 84 households (30 control, 26 M and 28 MH households) with 82, 69 and 67 household contacts, respectively. In 2009/10 all 41 index cases had a influenza A (H1N1) pdm09 infection, in 2010/11 24 had an A (H1N1) pdm09 and 20 had a B infection. The total secondary attack rate was 16% (35/218). In intention-totreat analysis there was no statistically significant effect of the M and MH interventions on secondary infections. When analysing only households where intervention was implemented within 36 h after symptom onset of the index case, secondary infection in the pooled M and MH groups was significantly lower compared to the control group (adjusted odds ratio 0.16, 95% CI, 0.03-0.92). In a per-protocol analysis odds ratios were significantly reduced among participants of the M group (adjusted odds ratio, 0.30, 95% CI, 0.10-0.94). With the exception of MH index cases in 2010/11 adherence was good for adults and children, contacts and index cases. Conclusions: Results suggest that household transmission of influenza can be reduced by the use of NPI, such as facemasks and intensified hand hygiene, when implemented early and used diligently. Concerns about acceptability and tolerability of the interventions should not be a reason against their recommendation

POCOP-type cobalt and nickel pincer complexes bearing an appended phosphinite group

The reaction of 1,3,5-(iPr2PO)3C6H3 with Co2(CO)8 leads to the isolation of a POCOP-type mononuclear pincer complex {κP,κC,κP-2,4,6-(iPr2PO)3C6H2}Co(CO)2 (1) or a tetranuclear species {κP-{κP,κC,κP-2,4,6-(iPr2PO)3C6H2}Co(CO)2}2Co2(CO)6 (2), depending on the ligand to cobalt ratio employed. The latter compound can be an impurity during the synthesis of {2,6-(iPr2PO)2-4-Me2N-C6H2}Co(CO)2, when the ligand precursor 5-(dimethylamino)resorcinol is contaminated with phloroglucinol due to incomplete monoamination. Similarly, the reaction of 1,3,5-(iPr2PO)3C6H3 with NiCl2 in the presence of 4-dimethylaminopyridine provides {κP,κC,κP-2,4,6-(iPr2PO)3C6H2}NiCl (3) bearing an appended phosphinite group. Structures 1–3 have been studied by X-ray crystallography.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author