Chiral symmetry restoration in (2+1)-dimensional QEDQED with a Maxwell-Chern-Simons term at finite temperature

We study the role played by a Chern-Simons contribution to the action in the $QED_3$ formulation of a two-dimensional Heisenberg model of quantum spin systems with a strictly fixed site occupation at finite temperature. We show how this contribution affects the screening of the potential which acts between spinons and contributes to the restoration of chiral symmetry in the spinon sector. The constant which characterizes the Chern-Simons term can be related to the critical temperature $T_c$ above which the dynamical mass goes to zero.Comment: 8 pages, 4 figure

Synthesis of new derivants 11h-indeno[1,2-b] - quinoxaline as perspective inhibitors of JNK (C-Jun n-terminalnal kinase)

Various quinoxalines show biological activity and have such properties as antiviral, antibacterial, antimicrobial, anti-inflammatory, anticancer, antidepressant, vermicidal, and act as inhibitors of kinases [1]. JNK family enzymes (C-Jun N-terminal kinase) are involved in an embryonal heart development, a regulation of metabolism and normal functioning of a myocardium. Besides, they play an important role in the signaling pathways which lead to apoptosis and necrosis and, also, they regulate processes by which damage of brain neurons and cardiomyocytes during ischemia are depended on. In this regard, the development of specific inhibitors of JNK is a relevant objective of medical chemistry. Derivants with 11H-indeno[1,2-b]-quinoxaline system are described in literature, but there is not a lot of them. For example, it is known only 45 replaced (generally - methyl, nitro - alkoxy-, carboxyl groups) 11Hindeno[1,2-b]- quinoxaline-11-ones according to Reaxys base. For some of them provided data about inhibition of enzymes (glucosidase, SYK kinase) anticarcinogenic activity. Someone systematic researches on influence of the nature of the substituting group on activity and bioavailability of 11H-indeno [1,2-b]- quinoxalines are still unknown of carrying out. The expected results are urgent to from the fundamental and practical point of view. Methods of synthesis of new derivants of 11H-indeno[1,2-b] -quinoxaline will be developed, which will make a contribution to chemistry of the condensed heterocyclic systems. The obtained data will make a contribution to rational design of medicines for treatment of these diseases. Existence in synthesizable molecules of ionizable and biocompatible group does them by potentially more bioavailable and will give an opportunity for creation on their basis of pharmaceuticals

Testosterone causes both prosocial and antisocial status-enhancing behaviors in human males

Although popular discussion of testosterone’s influence on males often centers on aggression and antisocial behavior, contemporary theorists have proposed that it instead enhances behaviors involved in obtaining and maintaining a high social status. Two central distinguishing but untested predictions of this theory are that testosterone selectively increases status-relevant aggressive behaviors, such as responses to provocation, but that it also promotes nonaggressive behaviors, such as generosity toward others, when they are appropriate for increasing status. Here, we tested these hypotheses in healthy young males by injecting testosterone enanthate or a placebo in a double-blind, between-subjects, randomized design (n = 40). Participants played a version of the Ultimatum Game that was modified so that, having accepted or rejected an offer from the proposer, participants then had the opportunity to punish or reward the proposer at a proportionate cost to themselves. We found that participants treated with testosterone were more likely to punish the proposer and that higher testosterone levels were specifically associated with increased punishment of proposers who made unfair offers, indicating that testosterone indeed potentiates aggressive responses to provocation. Furthermore, when participants administered testosterone received large offers, they were more likely to reward the proposer and also chose rewards of greater magnitude. This increased generosity in the absence of provocation indicates that testosterone can also cause prosocial behaviors that are appropriate for increasing status. These findings are inconsistent with a simple relationship between testosterone and aggression and provide causal evidence for a more complex role for testosterone in driving status-enhancing behaviors in males

Исследование коррозионных свойств биосовместимых покрытий на основе титана, осажденных методом реактивного магнетронного распыления

В работе изучались свойства Ti-O-N покрытий, нанесенных на стальные подложки методом реактивного магнетронного напыления, такие как коррозионная стойкость, термическая устойчивость, а так же диффузионные процессы в физиологических растворах. Методами инфракрасной спектроскопии и атомно-эмиссионного анализа была установлена химическая инертность пленки, а так же потенциальная биологическая активность в виду обнаружения оксида азота в модельных растворах после контакта с покрытиями Ti-O-N.The properties of Ti-O-N coatings deposited on steel substrates by the method of reactive magnetron sputtering, such as corrosion resistance, thermal stability, as well as diffusion processes in physiological solutions were studied. By the methods of infrared spectroscopy and atomic emission analysis, the chemical inertness of the film was established, as well as the potential biological activity in the form of detection of nitrogen oxide in model solutions after contact with Ti-O-N coatings

Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1

Polyphenols are important immunonutrients which have been investigated in the context of inflammatory and autoimmune disease due to their significant immunosuppressive properties. However, the mechanism of action of many polyphenols is unclear, particularly in human immune cells. The emerging field of immunometabolism has highlighted the significance of metabolic function in the regulation of immune cell activity, yet the effects of polyphenols on immune cell metabolic signaling and function has not been explored. We have investigated the effects of two plant-derived polyphenols, carnosol and curcumin, on the metabolism of primary human dendritic cells (DC). We report that human DC display an increase in glycolysis and spare respiratory capacity in response to LPS stimulation, which was attenuated by both carnosol and curcumin treatment. The regulation of DC metabolism by these polyphenols appeared to be mediated by their activation of the cellular energy sensor, AMP-activated Protein Kinase (AMPK), which resulted in the inhibition of mTOR signaling in LPS-stimulated DC. Previously we have reported that both carnosol and curcumin can regulate the maturation and function of human DC through upregulation of the immunomodulatory enzyme, Heme Oxygenase-1 (HO-1). Here we also demonstrate that the induction of HO-1 by polyphenols in human DC is dependent on their activation of AMPK. Moreover, pharmacological inhibition of AMPK was found to reverse the observed reduction of DC maturation by carnosol and curcumin. This study therefore describes a novel relationship between metabolic signaling via AMPK and HO-1 induction by carnosol and curcumin in human DC, and characterizes the effects of these polyphenols on DC immunometabolism for the first time. These results expand our understanding of the mechanism of action of carnosol and curcumin in human immune cells, and suggest that polyphenol supplementation may be useful to regulate the metabolism and function of immune cells in inflammatory and metabolic disease

Primary care Identification and Referral to Improve Safety of women experiencing domestic violence (IRIS): protocol for a pragmatic cluster randomised controlled trial

BACKGROUND: Domestic violence, which may be psychological, physical, sexual, financial or emotional, is a major public health problem due to the long-term health consequences for women who have experienced it and for their children who witness it. In populations of women attending general practice, the prevalence of physical or sexual abuse in the past year from a partner or ex-partner ranges from 6 to 23%, and lifetime prevalence from 21 to 55%. Domestic violence is particularly important in general practice because women have many contacts with primary care clinicians and because women experiencing abuse identify doctors and nurses as professionals from whom they would like to get support. Yet health professionals rarely ask about domestic violence and have little or no training in how to respond to disclosure of abuse. METHODS/DESIGN: This protocol describes IRIS, a pragmatic cluster randomised controlled trial with the general practice as unit of randomisation. Our trial tests the effectiveness and cost-effectiveness of a training and support programme targeted at general practice teams. The primary outcome is referral of women to specialist domestic violence agencies. Forty-eight practices in two UK cities (Bristol and London) are randomly allocated, using minimisation, into intervention and control groups. The intervention, based on an adult learning model in an educational outreach framework, has been designed to address barriers to asking women about domestic violence and to encourage appropriate responses to disclosure and referral to specialist domestic violence agencies. Multidisciplinary training sessions are held with clinicians and administrative staff in each of the intervention practices, with periodic feedback of identification and referral data to practice teams. Intervention practices have a prompt to ask about abuse integrated in the electronic medical record system. Other components of the intervention include an IRIS champion in each practice and a direct referral pathway to a named domestic violence advocate. DISCUSSION: This is the first European randomised controlled trial of an intervention to improve the health care response to domestic violence. The findings will have the potential to inform training and service provision. TRIAL REGISTRATION: ISRCTN74012786

Variety of stylolites morphologies and statistical characterization of the amount of heterogeneities in the rock

The surface roughness of several stylolites in limestones was measured using high resolution laser profilometry. The 1D signals obtained were statistically analyzed to determine the scaling behavior and calculate a roughness exponent, also called Hurst exponent. Statistical methods based on the characterization of a single Hurst exponent imply strong assumptions on the mathematical characteristics of the signal: the derivative of the signal (or local increments) should be stationary and have finite variance. The analysis of the measured stylolites show that these properties are not always verified simultaneously. The stylolite profiles show persistence and jumps and several stylolites are not regular, with alternating regular and irregular portions. A new statistical method is proposed here, based on a non-stationary but Gaussian model, to estimate the roughness of the profiles and quantify the heterogeneity of stylolites. This statistical method is based on two parameters: the local roughness (H) which describes the local amplitude of the stylolite, and the amount of irregularities on the signal (\mu), which can be linked to the heterogeneities initially present in the rock before the stylolite formed. Using this technique, a classification of the stylolites in two families is proposed: those for which the morphology is homogeneous everywhere and those with alternating regular and irregular portions