1-(2-Hy­droxy-5-methyl­phen­yl)-3-(2-methyl­phen­yl)prop-2-en-1-one

In the title compound, C17H16O2, the dihedral angle between the aromatic rings is 5.12 (13)° and an intra­molecular O—H⋯O hydrogen bond generates an S(6) ring

1-(2-Hydr­oxy-5-methyl­phen­yl)-3-(3-methylthiophen-2-yl)prop-2-en-1-one

In the structure of the title compound, C15H14O2S, the benzene ring is nearly coplanar with the thio­phene ring. The hydroxy group substituted at C2 position is in an antiperi­planar conformation with respect to the phenyl ring. The crystal structure exhibits weak intramolecular O—H⋯O hydrogen bonding

1-(2-Hy­droxy-4-meth­oxy­phen­yl)-3-(4-methyl­phen­yl)prop-2-en-1-one

The mol­ecule of the title compound, C17H16O3, exists in the E conformation with respect to the central C=C bond, is almost planar(r.m.s. deviation = 0.003 Å) and has an intra­molecular O—H⋯O hydrogen bond, which generates an S(6) ring. In the crystal, mol­ecules are linked by C—H⋯O inter­actions

A de novo matrix for macroscopic living materials from bacteria.

Engineered living materials (ELMs) embed living cells in a biopolymer matrix to create materials with tailored functions. While bottom-up assembly of macroscopic ELMs with a de novo matrix would offer the greatest control over material properties, we lack the ability to genetically encode a protein matrix that leads to collective self-organization. Here we report growth of ELMs from Caulobacter crescentus cells that display and secrete a self-interacting protein. This protein formed a de novo matrix and assembled cells into centimeter-scale ELMs. Discovery of design and assembly principles allowed us to tune the composition, mechanical properties, and catalytic function of these ELMs. This work provides genetic tools, design and assembly rules, and a platform for growing ELMs with control over both matrix and cellular structure and function

Identification and Characterization of Potential Impurities of Dronedarone Hydrochloride

Six potential process related impurities were detected during the impurity profile study of an antiarrhythmic drug substance, Dronedarone (<b>1</b>). Simple high performance liquid chromatography and liquid chromatography–mass spectrometry methods were used for the detection of these process impurities. Based on the synthesis and spectral data (MS, IR, ¹H NMR, ¹³C NMR, and DEPT), the structures of these impurities were characterized as 5-amino-3-[4-(3-di-<i>n</i>-butylaminopropoxy)­benzoyl]-2-<i>n</i>-butylbenzofuran (impurity I); <i>N</i>-(2-butyl-3-(4-(3-(dibutylamino)­propoxy)­benzoyl)­benzofuran-5-yl)-<i>N</i>-(methylsulfonyl)­methanesulfonamide (impurity II); <i>N</i>-(2-butyl-3-(4-(3-(dibutylamino)­propoxy)­benzoyl)­benzofuran-5-yl)-1-chloromethanesulfonamide (impurity III); <i>N</i>-{2-propyl-3-[4-(3-dibutylaminopropoxy)­benzoyl]­benzofuran-5-yl}­methanesulfonamide (impurity IV); <i>N</i>-(2-butyl-3-(4-(3-(dibutylamino)­propoxy)­benzoyl)­benzofuran-5-yl)­formamide (impurity V); and (2-butyl-5-((3-(dibutylamino)­propyl)­amino)­benzofuran-3-yl)­(4-(3-(dibutylamino)­propoxy)­phenyl)­methanone (impurity VI). The synthesis and characterization of these impurities are discussed in detail