13 research outputs found
1-(2-Hydroxy-5-methylphenyl)-3-(2-methylphenyl)prop-2-en-1-one
In the title compound, C17H16O2, the dihedral angle between the aromatic rings is 5.12 (13)° and an intramolecular O—H⋯O hydrogen bond generates an S(6) ring
1-(2-Hydroxy-5-methylphenyl)-3-(3-methylthiophen-2-yl)prop-2-en-1-one
In the structure of the title compound, C15H14O2S, the benzene ring is nearly coplanar with the thiophene ring. The hydroxy group substituted at C2 position is in an antiperiplanar conformation with respect to the phenyl ring. The crystal structure exhibits weak intramolecular O—H⋯O hydrogen bonding
1-(2-Hydroxy-4-methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one
The molecule of the title compound, C17H16O3, exists in the E conformation with respect to the central C=C bond, is almost planar(r.m.s. deviation = 0.003 Å) and has an intramolecular O—H⋯O hydrogen bond, which generates an S(6) ring. In the crystal, molecules are linked by C—H⋯O interactions
Genotype-phenotype relationship of F7 R353Q polymorphism and plasma factor VII coagulant activity in Asian Indian families predisposed to coronary artery disease
Corrigendum to “Insights into high pressure gas adsorption properties of ZIF-67: Experimental and theoretical studies” [Microporous Mesoporous Mater. 294 (1) (2020) 109867]
A de novo matrix for macroscopic living materials from bacteria.
Engineered living materials (ELMs) embed living cells in a biopolymer matrix to create materials with tailored functions. While bottom-up assembly of macroscopic ELMs with a de novo matrix would offer the greatest control over material properties, we lack the ability to genetically encode a protein matrix that leads to collective self-organization. Here we report growth of ELMs from Caulobacter crescentus cells that display and secrete a self-interacting protein. This protein formed a de novo matrix and assembled cells into centimeter-scale ELMs. Discovery of design and assembly principles allowed us to tune the composition, mechanical properties, and catalytic function of these ELMs. This work provides genetic tools, design and assembly rules, and a platform for growing ELMs with control over both matrix and cellular structure and function
Identification and Characterization of Potential Impurities of Dronedarone Hydrochloride
Six
potential process related impurities were detected during the
impurity profile study of an antiarrhythmic drug substance, Dronedarone
(<b>1</b>). Simple high performance liquid chromatography and
liquid chromatography–mass spectrometry methods were used for
the detection of these process impurities. Based on the synthesis
and spectral data (MS, IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR,
and DEPT), the structures of these impurities were characterized as
5-amino-3-[4-(3-di-<i>n</i>-butylaminopropoxy)benzoyl]-2-<i>n</i>-butylbenzofuran (impurity I); <i>N</i>-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)-<i>N</i>-(methylsulfonyl)methanesulfonamide (impurity II); <i>N</i>-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)-1-chloromethanesulfonamide
(impurity III); <i>N</i>-{2-propyl-3-[4-(3-dibutylaminopropoxy)benzoyl]benzofuran-5-yl}methanesulfonamide
(impurity IV); <i>N</i>-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)formamide
(impurity V); and (2-butyl-5-((3-(dibutylamino)propyl)amino)benzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone
(impurity VI). The synthesis and characterization of these impurities
are discussed in detail