Providers choices in web-medical records: An analysis of trade-offs made by physicians in San Bernardino County

This thesis concluded that offering physicians an appropriate Web-based transcription service should be well received and improve their medical record management and patient care

The Design and Synthesis of β-Keto Vinyl Sultams and Macrocyclic β-Keto Vinyl Sultams: Novel Analogs of Tetramic Acids

Sulfur (S)-containing heterocyclic compounds possessing R1R2N–SO2R3 functionality have been recognized as important due to their innate physical properties that affect biological systems marking them as attractive targets for probing biological pathways. Specifically, sulfonamides and sultams represent two significant compound classes, which exhibit broad ranges of biological activities. Similarly, natural products possessing the tetramic acid core structural motif have emerged as a rich chemotype due to their potent and broad biological activities. Several bioactive tetramic acid-containing compounds have been reported with a variety of activities, including antibacterial, anticancer and anti-inflammatory activities, as well as unique biological profiles in different cell assays. Tetramic acid analogs are also known to modulate protein-protein interactions. In light of the biological significance of the tetramic acid subunit, and the notable physical properties of sulfur containing compounds, we have become interested in the generation of S-analogs of tetramic acids in order to screen for biological activity, and to serve as new probes in Chemical Biology studies with our collaborators. One such class is β-keto sultams, and their unsaturated analogs, both of which represent relatively unexplored chemical space. While there are several reports in the literature for the synthesis of tetramic acid-containing compounds, there are a relatively limited number of examples of the corresponding β-keto sultam analogs. Moreover, their unsaturated analogs are even more limited. It is the purpose of this thesis to start our investigations to explore the substitution of the β-keto sultam group for the iv β-keto lactam subunit in drug-like tetramic acid-containing molecules, which ultimately has the potential to modulate biological activity as well as ADME profiles of the resulting analogs compounds. This thesis will describe the design and synthesis of β-keto sultam analogs of tetramic acids and their corresponding unsaturated and macrocyclic derivatives as novel electrophilic probes that can be modulated electronically, sterically, and stereochemicall

Solving N-queen Problem Using Genetic Algorithm by Advance Mutation Operator

N-queen problem represents a class of constraint problems. It belongs to set of NP-Hard problems. It is applicable in many areas of science and engineering. In this paper N-queen problem is solved using genetic algorithm. A new genetic algoerithm is proposed which uses greedy mutation operator. This new mutation operator solves the N-queen problem very quickly. The proposed algorithm is applied on some instances of N-queen problem and results outperforms the previous findings

Database-centric Development of Menus andGraphic User Interfaces

The database-centric approach to graphic user interface (GUI) development, quickly andeasily manages standardisation and modification of labels and look and feel of controls bykeeping various control-creation data into the database. The runtime generation of controlsprovides the flexibility to control their creation and modification issues. This method freezes theapplication code once the development is over. The process of recompilation is eliminated whencreation or modification of controls is done. Dynamic controls such as menus, label, text box,button, combo box, list box, group box, check box, radio button, tab control, spin button, treecontrol can be easily formed and controlled using this approach

A plant growth promoting rhizospheric Pseudomonas aeruginosa strain inhibits seed germination in Triticum aestivum (L) and Zea mays (L)

Various rhizobacteria strains are isolated and tested worldwide for their plant growth promoting activities. A strain is said to be a plant growth promoter if it has the ability to influence plant growth directly or indirectly. Though the main focus has always been to realize the plant growth promoting traits of rhizobacteria and use them as biofertilizers, but the disadvantages or deleterious effects of such plant growth promoting rhizobacteria (PGPR) if any have also been ignored to a greater extent. The present study deals with the characterization of both promoting as well as deleterious activities of an isolated strain of Pseudomonas aeruginosa on plants. The bacterium was isolated from the soil of the college campus of Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh and was characterized as P. aeruginosa by various positive biochemical tests such as oxidase, catalase, citrate tests and confirmed by MALDI-TOF-MS. Its growth as well as IAA producing ability at different salt (NaCl) concentrations was tested. Tests examining HCN, Ammonia and siderophore production, flocculation ability, phosphate and zinc solubilization by the strain were carried out. Its anti-microbial property was tested against three phytopathogenic fungi: Fusarium solani, Aspergillus niger and Curvularia lunata and two bacterial strains - Klebsiella pneumoniae and E. coli. Its effect over seed germination of Triticum aestivum and Zea mays was inspected in plates as well as in pots. The strain showed a great potential as a plant growth promoter growing up to 10% NaCl concentration and producing considerable amount of IAA upto 8% NaCl concentration. It showed antagonistic nature against the three phytopathogenic fungi, solubilized phosphate and produced siderophore and NH3. Though supernatant of the bacterial culture did not show any deleterious effect over seed (of the test plants T. aestivum and Z. mays) germination but the seeds inoculated with the strain itself, failed to germinate. The seed turned dormant and grew a pale brown color showing bacterial growth over it. Thus it maybe concluded that the isolated strain of P. aeruginosa has abilities to both promote and at the same time inhibit plant growth (by inhibiting seed germination)

Theoretical Approach of the Propagation of Electromagnetic Waves through Carbon Nanotubes and Behavior of Carbon Nanotubes as Capacitor using Electric Hertz Potential

The electromagnetic waves and its propagation through material medium described by maxwell’s equations. We have identified that electromagnetic waves propagate through carbon nanotubes according to electric hertz potential with solution of Helmholtz equation and satisfied by using the concept of Gaussian beam or wave. When monochromatic electromagnetic wave propagates through a hollow single wall carbon nanotube, its energy absorbed by walls of nanotubes just like a capacitor because of carbon nanotubes have metallic as well as semiconductor characteristic which is shown by density of state and lattice vector. It is verified by Helmholtz equation and Schrödinger’s wave equation. Thus, the electromagnetic waves can propagate through carbon nanotubes and carbon nanotubes absorb the energy as a capacitor

Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus.

Infection with Influenza A virus can lead to the development of encephalitis and subsequent neurological deficits ranging from headaches to neurodegeneration. Post-encephalitic parkinsonism has been reported in surviving patients of H1N1 infections, but not all cases of encephalitic H1N1 infection present with these neurological symptoms, suggesting that interactions with an environmental neurotoxin could promote more severe neurological damage. The heavy metal, manganese (Mn), is a potential interacting factor with H1N1 because excessive exposure early in life can induce long-lasting effects on neurological function through inflammatory activation of glial cells. In the current study, we used a two-hit model of neurotoxin-pathogen exposure to examine whether exposure to Mn during juvenile development would induce a more severe neuropathological response following infection with H1N1 in adulthood. To test this hypothesis, C57BL/6 mice were exposed to MnCl2 in drinking water (50 mg/kg/day) for 30 days from days 21-51 postnatal, then infected intranasally with H1N1 three weeks later. Analyses of dopaminergic neurons, microglia and astrocytes in basal ganglia indicated that although there was no significant loss of dopaminergic neurons within the substantia nigra pars compacta, there was more pronounced activation of microglia and astrocytes in animals sequentially exposed to Mn and H1N1, as well as altered patterns of histone acetylation. Whole transcriptome Next Generation Sequencing (RNASeq) analysis was performed on the substantia nigra and revealed unique patterns of gene expression in the dual-exposed group, including genes involved in antioxidant activation, mitophagy and neurodegeneration. Taken together, these results suggest that exposure to elevated levels of Mn during juvenile development could sensitize glial cells to more severe neuro-immune responses to influenza infection later in life through persistent epigenetic changes

Oral Migalastat HCl Leads to Greater Systemic Exposure and Tissue Levels of Active α-Galactosidase A in Fabry Patients when Co-Administered with Infused Agalsidase.

UnlabelledMigalastat HCl (AT1001, 1-Deoxygalactonojirimycin) is an investigational pharmacological chaperone for the treatment of α-galactosidase A (α-Gal A) deficiency, which leads to Fabry disease, an X-linked, lysosomal storage disorder. The currently approved, biologics-based therapy for Fabry disease is enzyme replacement therapy (ERT) with either agalsidase alfa (Replagal) or agalsidase beta (Fabrazyme). Based on preclinical data, migalastat HCl in combination with agalsidase is expected to result in the pharmacokinetic (PK) enhancement of agalsidase in plasma by increasing the systemic exposure of active agalsidase, thereby leading to increased cellular levels in disease-relevant tissues. This Phase 2a study design consisted of an open-label, fixed-treatment sequence that evaluated the effects of single oral doses of 150 mg or 450 mg migalastat HCl on the PK and tissue levels of intravenously infused agalsidase (0.2, 0.5, or 1.0 mg/kg) in male Fabry patients. As expected, intravenous administration of agalsidase alone resulted in increased α-Gal A activity in plasma, skin, and peripheral blood mononuclear cells (PBMCs) compared to baseline. Following co-administration of migalastat HCl and agalsidase, α-Gal A activity in plasma was further significantly increased 1.2- to 5.1-fold compared to agalsidase administration alone, in 22 of 23 patients (95.6%). Importantly, similar increases in skin and PBMC α-Gal A activity were seen following co-administration of migalastat HCl and agalsidase. The effects were not related to the administered migalastat HCl dose, as the 150 mg dose of migalastat HCl increased α-Gal A activity to the same extent as the 450 mg dose. Conversely, agalsidase had no effect on the plasma PK of migalastat. No migalastat HCl-related adverse events or drug-related tolerability issues were identified.Trial registrationClinicalTrials.gov NCT01196871

Design and Modeling of Membrane-Based Evaporative Cooling Devices for Thermal Management of High Heat Fluxes

We present a high-heat-flux cooling device for advanced thermal management of electronics. The device incorporates nanoporous membranes supported on microchannels to enable thin-film evaporation. The underlying concept takes advantage of the capillary pressure generated by small pores in the membrane, and minimizes the viscous loss by reducing the membrane thickness. The heat transfer and fluid flow in the device were modeled to determine the effect of different geometric parameters. With the optimization of various parameters, the device can achieve a heat transfer coefficient in excess of 0.05 kW/cm²-K, while dissipating a heat flux of 1 kW/cm². When applied to power electronics, such as GaN high-electron-mobility transistors, this membrane-based evaporative cooling device can lower the near-junction temperature by more than 40 K compared with contemporary single-phase microchannel coolers